Background: The medicinal use of onion dates back to ancient China and India. Men with epilepsy have reduced fertility, and antiepileptic drugs may affect semen quality. Disturbances of reproductive ...endocrine hormones are more often found in men with epilepsy than in the general population. There is an ongoing debate whether this can be attributed to chronic use of antiepileptic drugs or to the epilepsy itself. Objective: The aim of the present study was to evaluate the beneficial degree of sexual behavior in male rats after inducement onion in lamotrigine receiving groups. Methods: Forty wistar rats, randomized into four groups (n = 10), were used for this study, five of them male and five of them female. Animals in Group A served as the control and was drinking distilled water. Animals in Groups B: treated with 3cc/rat of onion juice, in Groups C: received10mg/kg/day lamotrigine, in Groups D: received10mg/kg/day lamotrigine plus 3cc/rat of onion juice. In All treatments were for 5 weeks. 48 hours before end of study estradiol benzoate (25 micro gr/kg/day, s.c.) and 6 hours before end of study progesterone 0.3muM were injected. Results: Results showed the percentage of erections and couplings and serum testosterone in onion treated groups were significantly increased (p<0/01) when compared to other groups. onion and its constituents are stated to has antioxidant. Enhanced oxidative stress and changes in antioxidant capacity are considered to play an important role in the pathogenesis in diseases. Conclusion: These findings lead to the conclusion that onion significantly lowered the adverse effects of lamotrigine, and can do beneficial effect on sexual behavior in male rat.
Background
Common variable immunodeficiency (CVID) is an inborn error of immunity (IEI) characterized by various clinical manifestations such as hypogammaglobulinemia, recurrent infections, and ...autoimmune diseases. Among different clinical manifestations, skin manifestations have been less reported in these patients.
Methods
In this study, we investigated the prevalence of dermatologic features in 387 CVID patients. Demographic information, clinical manifestations, laboratory data, and genetic findings were collected from medical records. All data were analyzed based on the presence or absence of skin disorders in CVID patients.
Results
We observed at least one skin manifestation in about 40% of these patients. Among these complications, skin infection (
n
= 64, 42.1%) was the most frequent presentation, followed by non-infectious skin lesions (
n
= 54, 35.6%). Among skin infections, abscesses (
n
= 34, 22.4%) were the most common complication. Skin infections such as cellulitis, impetigo, measles, and warts were also documented. Eczema (
n
= 34, 22.4%) was the most common complication in atopic lesions, and vitiligo (
n
= 13, 8.5%) was prevalent in autoimmune/pigmentation disorders. Among all the patients with genetic mutations, one-quarter had a deleterious mutation in the LRBA gene, relating to the autoimmune and atopic skin lesions.
Conclusion
This rate of skin disorders in our cohort demonstrating these manifestations could be significant in CVID patients, and they are not rare. Low data of skin complications in CVID patients could be attributed to insufficient attention of physicians and also might alert dermatologists to perform immunological investigations in children with certain skin manifestations.
This paper presents a mixed-integer programming model for a capacitated location-routing problem with customer satisfaction under disruption risk. The aim of this problem is to find the location of ...medical service centers (MSCs) and the best route of vehicles to serve customers. To solve the problem, a hybrid NSGA-II algorithm is proposed and the related results are compared with the traditional NSGA-II as a well-known evolutionary algorithm. The Taguchi method is used to tune the best values of parameters to run the algorithms. The computational results represent that the hybrid NSGA-II has a better performance than the NSGA-II.
Different food products such as corn, wheat and peanut have shown high potential to be contaminated in suitable environmental conditions, such as temperature and humidity. Some fungi can produce ...toxins, like Aflatoxin, and some of them are carcinogen. The purpose of this research was to study fungal contamination in peanuts being sold in the BAZAR of the city of Zanjan. 20 samples of 50g roasted and salted peanuts and 16 samples of 50g unsalted peanuts (pure) were collected from Zanjan BAZAR. Ambient conditions such as light intensity, temperature and air flow of the BAZAR and also the relative humidity of peanuts were measured. Samples were analyzed for fungal colony and were identified using slide culture technique. Results showed that Mold fungi were dominant among the colonies as. Aspergillus flavus (39.1%), Penicillium (9.2%), Rhizopus (7.2%), Mucor (2.5%), Alternaria (1.03%) and Nigrospora (0.5%). Temperature and the samples relative humidity were higher than the standard range. The results indicated a significant relation between relative humidity, light intensity, temperature and peanuts' type (pure or salted) with level of fungal contamination. Also, roasting and processing reduced the relative humidity of peanuts and the level of contamination. Hence roasting, salting and provision of appropriate ambient conditions can be useful to peanut storage.
Different food products such as corn, wheat and peanut have shown high
potential to be contaminated in suitable environmental conditions, such
as temperature and humidity. Some fungi can produce ...toxins, like
Aflatoxin, and some of them are carcinogen. The purpose of this
research was to study fungal contamination in peanuts being sold in the
BAZAR of the city of Zanjan. 20 samples of 50g roasted and salted
peanuts and 16 samples of 50g unsalted peanuts (pure) were collected
from Zanjan BAZAR. Ambient conditions such as light intensity,
temperature and air flow of the BAZAR and also the relative humidity of
peanuts were measured. Samples were analyzed for fungal colony and were
identified using slide culture technique. Results showed that Mold
fungi were dominant among the colonies as. Aspergillus flavus
(39.1%), Penicillium (9.2%), Rhizopus (7.2%), Mucor (2.5%),
Alternaria (1.03%) and Nigrospora (0.5%). Temperature and the
samples relative humidity were higher than the standard range. The
results indicated a significant relation between relative humidity,
light intensity, temperature and peanuts' type (pure or salted)
with level of fungal contamination. Also, roasting and processing
reduced the relative humidity of peanuts and the level of
contamination. Hence roasting, salting and provision of appropriate
ambient conditions can be useful to peanut storage
Ataxia-telangiectasia (AT) is an autosomal recessive disease characterized by telangiectasia, progressive ataxia, sinopulmonary infection, hypersensitivity to ionizing radiation, and a combined ...immunodeficiency, usually consisting of selective IgA and IgG, deficiencies, cutaneous anergy, and often depressed but not absent in vitro lymphocyte responsiveness. Reviewing the medical records of 50 patients with AT during 1975 through 1998 admitted to our center, we have noted the following results: the mean age of the patients was 8.3 (range 3 to 14) years, parents of 33 patients were consanguinous, and the sex ratio was 6:5, occuring more in boys than in girls. All 50 patients showed cerebellar ataxia and telangiectasia, 67% were mentally retarded, and 75% have had sinobronchitis and pulmonary infections. 36 patients were tested for ccj-fetoprotein, all of whom showed a positive test. Liver enzymes and plasma glucose levels were not signifi¬cantly abnormal. 24 patients had IgA deficiency, and 8 patients had IgG2 defi¬ciency and 15 patients showed low IgE levels. All patients were tested for T-cells which were abnormal in 17 patients and 20 patients were tested for B-cells, which were abnormal in 18 patients. One patient had growth hormone deficiency. 17 patients had malignancies.
