Ménétrier's disease is an infrequent clinical entity characterized by thickening of the gastric folds secondary to hyperplasia of the foveolar mucosa cells, frequently associated with loss of enteric ...proteins and hypoalbuminemia. Its etiology is unknown, although in the last few years it has been related to Helicobacter pylori infection. We present the case of a 38-year-old man with protein-losing gastroenteropathy caused by Ménétrier's disease, in whom eradication of H. pylori infection was followed by symptom improvement and resolution of hypoalbuminemia. In agreement with the criteria of other authors, we investigate the presence of H. pylori infection in all patients with Ménétrier's disease. When positive, the first-line treatment consists of eradication therapy.
1
A simple and mild procedure is described for the isolation of equine growth hormone from frozen pituitary glands: it involves water extractions of the glands at pH 7.2 and 9.5, fractionation by ...ammonium sulfate precipitation and gel nitrations on a Sephadex G‐100 column. The yield is 1.7 mg growth hormone per gram of fresh glands with a biological specific activity of 1.6 USP units/mg.
2
The protein obtained is homogeneous judged by disc electrophoresis, ultracentrifugation, gel electro focusing, gel filtration and end‐group analyses.
3
A weight‐average molecular weight of 20200 was determined by sedimentation equilibrium analysis. Comparative values were found by gel electrophoresis and exclusion chromatography. Its Stokes radius and frictional ratio were 2.25 nm and 1.21, respectively.
4
The amino acid composition of equine growth hormone shows considerable analogy with those of bovine, ovine and porcine growth hormones.
