We report on the results from a search for dark matter axions with the HAYSTAC experiment using a microwave cavity detector at frequencies between 5.6 and 5.8 GHz. We exclude axion models with two ...photon coupling gaγγ≳2×10−14 GeV−1, a factor of 2.7 above the benchmark KSVZ model over the mass range 23.15<ma<24.0 μeV. This doubles the range reported in our previous paper. We achieve a near-quantum-limited sensitivity by operating at a temperature T<hν/2kB and incorporating a Josephson parametric amplifier (JPA), with improvements in the cooling of the cavity further reducing the experiment’s system noise temperature to only twice the standard quantum limit at its operational frequency, an order of magnitude better than any other dark matter microwave cavity experiment to date. This result concludes the first phase of the HAYSTAC program utilizing a conventional copper cavity and a single JPA.
We present new constraints on the dark matter-induced annual modulation signal using 1.7 years of COSINE-100 data with a total exposure of 97.7 kg yr. The COSINE-100 experiment, consisting of 106 kg ...of NaI(Tl) target material, is designed to carry out a model-independent test of DAMA/LIBRA's claim of WIMP discovery by searching for the same annual modulation signal using the same NaI(Tl) target. The crystal data show a 2.7 cpd/kg/keV background rate on average in the 2-6 keV energy region of interest. Using a χ-squared minimization method we observe best fit values for modulation amplitude and phase of 0.0092±0.0067 cpd/kg/keV and 127.2±45.9 d, respectively.
The manipulation of quantum states of light
holds the potential to enhance searches for fundamental physics. Only recently has the maturation of quantum squeezing technology coincided with the ...emergence of fundamental physics searches that are limited by quantum uncertainty
. In particular, the quantum chromodynamics axion provides a possible solution to two of the greatest outstanding problems in fundamental physics: the strong-CP (charge-parity) problem of quantum chromodynamics
and the unknown nature of dark matter
. In dark matter axion searches, quantum uncertainty manifests as a fundamental noise source, limiting the measurement of the quadrature observables used for detection. Few dark matter searches have approached this limit
, and until now none has exceeded it. Here we use vacuum squeezing to circumvent the quantum limit in a search for dark matter. By preparing a microwave-frequency electromagnetic field in a squeezed state and near-noiselessly reading out only the squeezed quadrature
, we double the search rate for axions over a mass range favoured by some recent theoretical projections
. We find no evidence of dark matter within the axion rest energy windows of 16.96-17.12 and 17.14-17.28 microelectronvolts. Breaking through the quantum limit invites an era of fundamental physics searches in which noise reduction techniques yield unbounded benefit compared with the diminishing returns of approaching the quantum limit.
The analysis of modular gene co-expression networks is a well-established method commonly used for discovering the systems-level functionality of genes. In addition, these studies provide a basis for ...the discovery of clinically relevant molecular pathways underlying different diseases and conditions.
In this paper, we present a fast and easy-to-use Bioconductor package named CEMiTool that unifies the discovery and the analysis of co-expression modules. Using the same real datasets, we demonstrate that CEMiTool outperforms existing tools, and provides unique results in a user-friendly html report with high quality graphs. Among its features, our tool evaluates whether modules contain genes that are over-represented by specific pathways or that are altered in a specific sample group, as well as it integrates transcriptomic data with interactome information, identifying the potential hubs on each network. We successfully applied CEMiTool to over 1000 transcriptome datasets, and to a new RNA-seq dataset of patients infected with Leishmania, revealing novel insights of the disease's physiopathology.
The CEMiTool R package provides users with an easy-to-use method to automatically implement gene co-expression network analyses, obtain key information about the discovered gene modules using additional downstream analyses and retrieve publication-ready results via a high-quality interactive report.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
In experiments searching for axionic dark matter, the use of the standard threshold-based data analysis discards valuable information. We present a Bayesian analysis framework that builds on an ...existing processing protocol B. M. Brubaker, L. Zhong, S. K. Lamoreaux, K. W. Lehnert, and K. A. van Bibber, Phys. Rev. D 96, 123008 (2017) to extract more information from the data of coherent axion detectors such as operating haloscopes. The analysis avoids logical subtleties that accompany the standard analysis framework and enables greater experimental flexibility on future data runs. Performing this analysis on the existing data from the HAYSTAC experiment, we find improved constraints on the axion-photon coupling gγ while also identifying the most promising regions of parameter space within the 23.15 – 24.0 μ eV mass range. A comparison with the standard threshold analysis suggests a 36% improvement in scan rate from our analysis, demonstrating the utility of this framework for future axion haloscope analyses.
A search for inelastic boosted dark matter (IBDM) using the COSINE-100 detector with 59.5 days of data is presented. This relativistic dark matter is theorized to interact with the target material ...through inelastic scattering with electrons, creating a heavier state that subsequently produces standard model particles, such as an electron-positron pair. In this study, we search for this electron-positron pair in coincidence with the initially scattered electron as a signature for an IBDM interaction. No excess over the predicted background event rate is observed. Therefore, we present limits on IBDM interactions under various hypotheses, one of which allows us to explore an area of the dark photon parameter space that has not yet been covered by other experiments. This is the first experimental search for IBDM using a terrestrial detector.
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