Scanamorphos is public software available to postprocess scan observations performed with the Herschel photometer arrays. This postprocessing mainly consists in subtracting the total low-frequency ...noise (both its thermal and nonthermal components), masking high-frequency artefacts such as cosmic ray hits, and projecting the data onto a map. Although it was developed for Herschel, it is also applicable with minimal adjustment to scan observations made with some other imaging arrays subjected to low-frequency noise, provided they entail sufficient redundancy; it was successfully applied to P-Artémis, an instrument operating on the APEX telescope. Contrary to matrix-inversion softwares and high-pass filters, Scanamorphos does not assume any particular noise model, and does not apply any Fourier-space filtering to the data, but is an empirical tool using purely the redundancy built in the observations-taking advantage of the fact that each portion of the sky is sampled at multiple times by multiple bolometers. It is an interactive software in the sense that the user is allowed to optionally visualize and control results at each intermediate step, but the processing is fully automated. This paper describes the principles and algorithm of Scanamorphos and presents several examples of application.
Various programed death ligand 1 (PD-L1) immunohistochemistry (IHC) assays have been developed and used in clinical trials in association with different drugs. In order to harmonize and make PD-L1 ...testing in non-small-cell lung cancer (NSCLC) widely available, we conducted a multicenter study comparing PD-L1 standardized assays and laboratory-developed tests (LDTs).
IHC with five anti-PD-L1 monoclonal antibodies (28-8, 22C3, E1L3N, SP142 and SP263) was performed concomitantly on 41 NSCLC surgical specimens in 7 centers using Dako Autostainer Link 48 (3 centers), Leica Bond (2 centers) or Ventana BenchMark Ultra (2 centers) platforms. For each matching platform, 22C3, 28-8 and SP263 assays were performed. For nonmatching platforms and other antibodies, LDTs were developed in each center. A total of 35 stainings were performed for each case across different platforms and antibodies. PD-L1 staining was assessed in tumor cells and immune cells by seven trained thoracic pathologists. For statistical analysis, 1%, 50% and 1%, 5%, 10% expression thresholds were used for tumor cells and immune cells, respectively.
28-8, 22C3 and SP263 assays were highly concordant for tumor cells staining across the five Dako or Ventana platforms. Among 27 LDTs developed in 7 centers on Dako, Ventana and Leica platforms, 14 (51.8%) demonstrated similar concordance when compared with reference assays for tumor cell staining. Clone SP263 achieved the highest concordance rate across all platforms. Lower concordance was observed for immune cells staining when using a four categories scale.
28-8, 22C3 and SP263 assays had close analytical performance for tumor cell staining across seven centers. Some LDTs on Dako, Ventana and Leica platforms achieved similar concordance, but caution is warranted for their validation. These LDTs will be further validated in order to provide recommendations for the use of assays and LDT for PD-L1 testing in NSCLC.
Interstellar dust and starlight are modeled for the galaxies of the project "Key Insights on Nearby Galaxies: A Far-Infrared Survey with Herschel." The galaxies were observed by the Infrared Array ...Camera and the Multiband Imaging Photometer for Spitzer on Spitzer Space Telescope, and the Photodetector Array Camera and Spectrometer and the Spectral and Photometric Imaging Receiver on Herschel Space Observatory. With data from 3.6 to 500 m, dust models are strongly constrained. Using a physical dust model, for each pixel in each galaxy we estimate (1) dust surface density, (2) dust mass fraction in polycyclic aromatic hydrocarbons (PAHs), (3) distribution of starlight intensities heating the dust, (4) total infrared (IR) luminosity emitted by the dust, and (5) IR luminosity originating in subregions with high starlight intensity. The dust models successfully reproduce the observed global and resolved spectral energy distributions. With the angular resolution of Herschel, we obtain well-resolved maps (available online) for the dust properties. As in previous studies, we find the PAH fraction to be an increasing function of metallicity, with a threshold oxygen abundance Z/Z 0.1, but we find the data to be fitted best with increasing linearly with above a threshold value of 0.15(O/H) . We obtain total dust masses for each galaxy by summing the dust mass over the individual map pixels; these "resolved" dust masses are consistent with the masses inferred from a model fit to the global photometry. The global dust-to-gas ratios obtained from this study are found to correlate with galaxy metallicities. Systems with Z/Z 0.5 have most of their refractory elements locked up in dust, whereas in systems with Z/Z 0.3 most of these elements tend to remain in the gas phase. Within galaxies, we find that is suppressed in regions with unusually warm dust with . With knowledge of one long-wavelength flux density ratio (e.g., f160/f500), the minimum starlight intensity heating the dust ( ) can be estimated to within ∼50%, despite a variation in of more than two orders of magnitude. For the adopted dust model, dust masses can be estimated to within ∼0.2 dex accuracy using the f160/f500 flux ratio and the integrated dust luminosity, and to ∼0.07 dex accuracy using the 500 m luminosity alone. There are additional systematic errors arising from the choice of dust model, but these are hard to estimate. These calibrated prescriptions for estimating starlight heating intensity and dust mass may be useful for studies of high-redshift galaxies.
With the goal of investigating the degree to which the MIR emission traces the SFR, we analyze Spitzer 8 and 24 mu m data of star-forming regions in a sample of 33 nearby galaxies with available HST ...NICMOS images in the Pa alpha (1.8756 mu m) emission line. The galaxies are drawn from the SINGS sample and cover a range of morphologies and a factor similar to 10 in oxygen abundance. Published data on local low-metallicity starburst galaxies and LIRGs are also included in the analysis. Both the stellar continuum-subtracted 8 mu m emission and the 24 mu m emission correlate with the extinction-corrected Pa alpha line emission, although neither relationship is linear. Simple models of stellar populations and dust extinction and emission are able to reproduce the observed nonlinear trend of the 24 mu m emission versus number of ionizing photons, including the modest deficiency of 24 mu m emission in the low-metallicity regions, which results from a combination of decreasing dust opacity and dust temperature at low luminosities. Conversely, the trend of the 8 mu m emission as a function of the number of ionizing photons is not well reproduced by the same models. The 8 mu m emission is contributed, in larger measure than the 24 mu m emission, by dust heated by nonionizing stellar populations, in addition to the ionizing ones, in agreement with previous findings. Two SFR calibrations, one using the 24 mu m emission and the other using a combination of the 24 mu m and H alpha luminosities (Kennicutt and coworkers), are presented. No calibration is presented for the 8 mu m emission because of its significant dependence on both metallicity and environment. The calibrations presented here should be directly applicable to systems dominated by ongoing star formation.
ABSTRACT
The mass growth of protostars is a central element to the determination of fundamental stellar population properties such as the initial mass function. Constraining the accretion history of ...individual protostars is therefore an important aspect of star formation research. The goal of the study presented here is to determine whether high-mass (proto)stars gain their mass from a compact (<0.1 pc) fixed-mass reservoir of gas, often referred to as dense cores, in which they are embedded, or whether the mass growth of high-mass stars is governed by the dynamical evolution of the parsec-scale clump that typically surrounds them. To achieve this goal, we performed a 350-μm continuum mapping of 11 infrared dark clouds, along side some of their neighbouring clumps, with the ArTéMiS camera on APEX. By identifying about 200 compact ArTéMiS sources, and matching them with Herschel Hi-GAL 70 -μm sources, we have been able to produce mass versus temperature diagrams. We compare the nature (i.e. starless or protostellar) and location of the ArTéMiS sources in these diagrams with modelled evolutionary tracks of both core-fed and clump-fed accretion scenarios. We argue that the latter provide a better agreement with the observed distribution of high-mass star-forming cores. However, a robust and definitive conclusion on the question of the accretion history of high-mass stars requires larger number statistics.
When combined with infrared observations with the Spitzer telescope (3 to 160 μm), the Herschel
Space Observatory now fully samples the thermal dust emission up to 500 μm and enables us to better ...estimate the total infrared-submm energy budget (L
TIR) of nearby galaxies. We present new empirical calibrations to estimate resolved and integrated total infrared luminosities from Spitzer and Herschel bands used as monochromatic or combined tracers. We base our calibrations on resolved elements of nearby galaxies (3 to 30 Mpc) observed with Herschel. We perform a resolved spectral energy distribution (SED) modelling of these objects using the Draine & Li dust models and investigate the influence of the addition of Spectral and Photometric Imaging Receiver (SPIRE) measurements in the estimation of L
TIR. We find that using data up to 250 μm leads to local L
TIR values consistent with those obtained with a complete coverage (up to 500 μm) within ±10 per cent for most of our resolved elements. We then study the distribution of energy in the resolved SEDs of our galaxies. The bulk of energy (30-50 per cent) is contained in the 70-160 μm band. The 24-70 μm fraction decreases with increasing metallicity. The 160-1100 μmsubmillimetre band can account for up to 25 per cent of the L
TIR in metal-rich galaxies. We investigate the correlation between the total infrared (TIR) surface brightnesses/luminosities and monochromatic Spitzer and Herschel surface brightnesses/luminosities. The three Photodetector Array Camera and Spectrometer (PACS) bands can be used as reliable monochromatic estimators of the L
TIR, the 100 μm band being the most reliable monochromatic tracer. There is also a strong correlation between the SPIRE 250 μm and L
TIR, although with more scatter than for the PACS relations. We also study the ability of our monochromatic relations to reproduce integrated L
TIR of nearby galaxies as well as L
TIR of z ∼ 1-3 sources. Finally, we provide calibration coefficients that can be used to derive TIR surface brightnesses/luminosities from a combination of Spitzer and Herschel surface brightnesses/fluxes and analyse the associated uncertainties.
Single crystalline platelets of the nanolaminated Cr2AlC phase have been produced by high temperature solution growth, with typical areas in the range of a few mm2. We present a set of ...characterization experiments which confirm the single crystalline character of the samples and focus on some specific aspects, all related to the nano-lamellar structure of this material. We show that the crystals can be cleaved or delaminated parallel to the basal plane, and we present atomic force microscope observations of those cleaved surfaces.
•We report the growth of the first bulk single crystals of the Cr2AlC MAX phase ever produced.•Single crystalline character is confirmed by X-ray pole figures.•We confirm many of the structural properties already measured on polycrystalline phases.•We show that the crystals can be cleaved parallel to their basal plane and observe the resulting surface using AFM microscopy.
We present a sample of low-resolution 5-38 km Spitzer IRS spectra of the inner few square kiloparsecs of 59 nearby galaxies spanning a large range of star formation properties. A robust method for ...decomposing mid-infrared galaxy spectra is described and used to explore the behavior of PAH emission and the prevalence of silicate dust extinction. Evidence for silicate extinction is found in6 of the sample, at strengths that indicate that most normal galaxies undergo A sub(V) 3 mag averaged over then-centers. The contribution of PAH emission to the total infrared power is found to peak near 10% and extend up to 620% and is suppressed at metallicities Z Z /4, as well as in low-luminosity AGN environments. Strong interband PAH feature strength variations (2-5 times) are observed, with the presence of a weak AGN and, to a lesser degree, increasing metallicity shifting power to the longer wavelength bands. A peculiar PAH emission spectrum with markedly diminished 5-8 km features arises among the sample solely in systems with relatively hard radiation fields harboring low-luminosity AGNs. The AGNs may modify the emitting grain distribution and provide the direct excitation source of the unusual PAH emission, which cautions against using absolute PAH strength to estimate star formation rates in systems harboring active nuclei. Alternatively, the low star formation intensity often associated with weak AGNs may affect the spectrum. The effect of variations in the mid-infrared spectrum on broadband infrared surveys is modeled and points to more than a factor of 2 uncertainty in results that assume a fixed PAH emission spectrum, for redshifts z = 0-2.5.
Polycrystalline fluorine-doped SnO2 thin films with a given thickness of about 250nm have been grown by ultrasonic spray pyrolysis with a growth temperature in the range of 360–480°C. A texture ...transition from 〈101〉 to 〈100〉 and 〈301〉 crystallographic orientations has experimentally been found by X-ray diffraction measurements as growth temperature is raised, revealing that a process of abnormal grain growth has occurred. The texture effects have been investigated within a thermodynamic approach considering that grain growth is driven by the minimization of total free energy. The anisotropic character of the physical quantities and the effects of growth temperature have been shown both on the surface energy per unit volume through its dependence on the oxygen chemical potential and on the strain energy density through its variation with the elastic strain and biaxial modulus. Importantly, it is demonstrated by thermodynamic simulations that the oxygen chemical potential increases with growth temperature in the spray pyrolysis conditions, showing that the atmosphere is less and less reducing. For low growth temperature, it is revealed that the 〈101〉 preferred orientation is due to surface energy minimization since the (101) reduced surfaces have a surface energy lower than the (100) reduced surfaces. In contrast, as growth temperature is raised, the 〈100〉 crystallographic orientation becomes predominant owing to strain energy minimization. A texture map is finally determined, revealing the expected texture as a function of elastic strain and oxygen chemical potential.
Context. Herschel observations of nearby molecular clouds suggest that interstellar filaments and prestellar cores represent two fundamental steps in the star formation process. The observations ...support a picture of low-mass star formation according to which filaments of ~0.1 pc width form first in the cold interstellar medium, probably as a result of large-scale compression of interstellar matter by supersonic turbulent flows, and then prestellar cores arise from gravitational fragmentation of the densest filaments. Whether this scenario also applies to regions of high-mass star formation is an open question, in part because the resolution of Herschel is insufficient to resolve the inner width of filaments in the nearest regions of massive star formation. Aims. In an effort to characterize the inner width of filaments in high-mass star-forming regions, we imaged the central part of the NGC 6334 complex at a resolution higher by a factor of >3 than Herschel at 350 μm. Methods. We used the large-format bolometer camera ArTéMiS on the APEX telescope and combined the high-resolution ArTéMiS data at 350 μm with Herschel/HOBYS data at 70–500 μm to ensure good sensitivity to a broad range of spatial scales. This allowed us to study the structure of the main narrow filament of the complex with a resolution of 8″ or <0.07 pc at d ~ 1.7 kpc. Results. Our study confirms that this filament is a very dense, massive linear structure with a line mass ranging from ~500 M⊙/pc to ~2000 M⊙/pc over nearly 10 pc. It also demonstrates for the first time that its inner width remains as narrow as W ~ 0.15 ± 0.05 pc all along the filament length, within a factor of <2 of the characteristic 0.1 pc value found with Herschel for lower-mass filaments in the Gould Belt. Conclusions. While it is not completely clear whether the NGC 6334 filament will form massive stars in the future, it is two to three orders of magnitude denser than the majority of filaments observed in Gould Belt clouds, and has a very similar inner width. This points to a common physical mechanism for setting the filament width and suggests that some important structural properties of nearby clouds also hold in high-mass star-forming regions.
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