•The phase stability and elemental partitioning of 3Nb alloy was shown in details.•The phases MC and μ-Co7W6 enriched in Nb and W were found in 3Nb alloy.•Both cuboidal and spheroidal-like ...γ′-precipitates were enriched in Ni, Al, and Nb.•The APT results showed that W, Ni, Al, and Nb contents decreased from γ′ to μ.•Most of the Nb partitions to γ′ (∼2.0 at. %) after one week at 1000 °C.
This paper presents the phase stability and elemental partitioning in a Co-40Ni-10Al-7.5W-10Cr-3Nb-0.06B-0.6C (at.%) superalloy (referred to as 3Nb) after a two-step heat treatment. The resulting microstructure consisted of γ, γ′, MC carbides and µ-Co7W6 phase decorating the regions near and at the grain boundaries. Nb preferentially partitioned to the γ′-phase and other elements such as Ni, Cr and W were responsible for the μ-phase formation.
Friction stir welding (FSW) is a solid-state joining process with numerous advantages such as good dimensional stability and repeatability, which is widely used Al alloys and with a great potential ...for critical joining applications involving high melting temperature alloys. Twelve millimeter thick plates of ISO 3183 X80M (API 5L X80) steel was friction stir welded using two passes on both sides of the plate using ceramic tools. Different heat inputs were obtained using a fix travel (welding) speed in combination with several spindle speeds. The fracture toughness of the two-pass joints was evaluated at 25
°C using the critical crack tip opening displacement (CTOD
m), revealing that joints produced with lower spindle speeds presented higher toughness at the heat-affected zone (HAZ) and stir zone (SZ), which are comparable with the base metal (BM) toughness. On the other hand, joints produced using higher spindle speeds presented low fracture toughness at the SZ and elevated CTOD
m toughness at the HAZ. The joints produced with low spindle speeds showed CTOD
m-values above the offshore standard (DNV-OS-F101) requirements.
Biological invasions are rapid evolutionary events in which populations are usually subject to a founder event during introduction followed by rapid adaptation to the new environment. Molecular tools ...and Bayesian approaches have shown their utility in exploring different evolutionary scenarios regarding the invasion routes of introduced species. We examined the situation for the tobacco aphid, Myzus persicae nicotianae, a recently introduced aphid species in Chile. Using seven microsatellite loci and approximate Bayesian computation, we studied populations of the tobacco aphid sampled from several American and European countries, identifying the most likely source populations and tracking the route of introduction to Chile. Our population genetic data are consistent with available historical information, pointing to an introduction route of the tobacco aphid from Europe and/or from other putative populations (e.g. Asia) with subsequent introduction through North America to South America. Evidence of multiple introductions to North America from different genetic pools, with successive loss of genetic diversity from Europe towards North America and a strong bottleneck during the southward introduction to South America, was also found. Additionally, we examined the special case of a widespread multilocus genotype that was found in all American countries examined. This case provides further evidence for the existence of highly successful genotypes or ‘superclones’ in asexually reproducing organisms.
This paper describes the usage of shaders to make parallel operations by improving the CPU–GPU communication, using both rendering and compute shaders. When the number of spheres is large, the ...execution becomes slow and requires a lot of space to store particles. We parallelized the frozen method using an efficient inter-process GPU communication to reduce the operations required. We propose to handle two buffers, one for operations and the other for rendering. While the rendering buffer increases as the number of spheres is required, the operational buffer maintains its size and the number of operations is hold. Experimental results demonstrate that the proposed method shows up 100x throughput improvement over the sequential version. We define a configuration by a 4-tuple as input to the algorithm, and we found a pattern to choose better configurations.
Evaluation was made of friction stir welded joints, identifying conditions that resulted in satisfactory welded joints free from defects and with microstructural characteristics that provided good ...mechanical properties. Microstructural characterization and cooling curve analysis of the joints with lower and higher heat inputs evidenced deformation below and above the non-recrystallization temperature (T
nr
) and dynamic recrystallization during microstructural evolution. Microscopy analyses showed acicular ferrite, bainitic ferrite, and coalesced bainite microstructures in the stir zone of the cold weld (lower heat input), while the stir zone of the hot weld (higher heat input) contained bainitic ferrite, acicular ferrite, coalesced bainite, martensite, and dispersed carbides. Granular bainite and dispersed carbides were observed in all the heat affected zones. Analysis of the microstructural transformations, together with the thermal history of the joints, showed that the variable that had the greatest influence on the morphology of the bainite (granular bainite/bainitic ferrite) was the deformation temperature.
The aim of this study was to evaluate the capability of Lactobacillus reuteri NRRL 14171 and Lactobacillus casei Shirota to remove dietary acrylamide (AA) under simulated gastrointestinal conditions ...using a dynamic system. The effects of different AA levels or bacteria concentration on toxin removal by Lactobacillus strains were assessed. Thereafter, AA-removing capability of bacteria strains under either fasting or postprandial simulated gastrointestinal conditions was evaluated. Commercial potato chips were analyzed for their AA content, and then used as a food model. Average AA content (34,162μg/kg) in potato chips exceeded by ca. 34-fold the indicative values recommended by the EU. Toxin removal ability was dependent on AA content and bacterial cell concentration. A reduction on bacterial viability was observed in the food model and at the end of both digestive processes evaluated. However, bacteria survived in enough concentrations to remove part of the toxin (32–73%). Both bacterial strains were able to remove AA under different simulated gastrointestinal conditions, being L. casei Shirota the most effective (ca. 70% removal). These findings confirmed the risk of potato chips as dietary AA exposure for consumers, and that strains of the genus Lactobacillus could be employed to reduce the bioavailability of dietary AA.
Caveolin-1 (CAV1), an essential structural constituent of caveolae that plays an important role in cellular processes such as transport and signaling, has been implicated in the development of human ...cancers. However, it is unclear whether CAV1 is acting like an oncogene or tumor suppressor gene. We found that CAV1 expression was reduced or absent in 95% of small cell lung cancers (SCLCs; n = 21 lines), whereas it was retained in 76% of non-small cell lung cancers (NSCLCs; n = 25 lines) compared with normal human lung epithelial cultures, where it was abundantly expressed. CAV1 expression was tightly linked to the ability to grow attached to the plastic cell culture surface, whereas CAV1-nonexpressing lung cancers of both SCLC and NSCLC type grew as suspension cultures. In addition, attached lung cancer cultures expressed phosphorylated focal adhesion kinase, whereas suspension cultures did not. Lack of CAV1 expression was tightly associated with CAV1 promoter methylation (P < 0.0001) such that CAV1 methylation was found in 93% of SCLCs (n = 15) and 9% of NSCLCs (n = 11), whereas 5-aza-2'deoxycytidine treatment restored CAV1 expression in SCLCs. Exogenous CAV1 expression in SCLCs significantly inhibited soft-agar colony formation but did not lead to attachment. By contrast, CAV1 knockdown in NSCLCs mediated by small interfering RNA against CAV1 led to inhibition of cellular proliferation and soft-agar and liquid colony formation. Importantly, CAV1 knockdown led to reduced phospho-focal adhesion kinase and RalA, but not RalB, levels in NSCLC cells. These results suggest different roles for CAV1 in SCLC, where CAV1 acts like a tumor suppressor gene, and NSCLC, where it appears required for survival and growth.
A weldment made of two different carbon steel plates using a nickel-based filler alloy was characterized. The studies involved microhardness testing, light optical and scanning electron microscopy, ...energy-dispersive x-ray spectroscopy and electron backscattered diffraction analyses in selected areas that included the base metal and heat-affected zones. It was found that welding promoted the mixture of the molten liquids from the filler alloy with those from the steel plates yielding to different chemical profiles. Microstructural changes within the steel plates were observed to occur, and these were attributed to the characteristics of the steels. The increase in hardness in the heat-affected zone of one of the steels was detected.
ABSTRACT
We present MUSE spectroscopy, Megacam imaging, and Chandra X-ray emission for SPT-CL J0307-6225, a $z = 0.58$ major merging galaxy cluster with a large BCG-SZ centroid separation and a ...highly disturbed X-ray morphology. The galaxy density distribution shows two main overdensities with separations of 0.144 and 0.017 arcmin to their respective BCGs. We characterize the central regions of the two colliding structures, namely 0307-6225N and 0307-6225S, finding velocity derived masses of M200, N = 2.44 ± 1.41 × 1014M⊙ and M200, S = 3.16 ± 1.88 × 1014M⊙, with a line-of-sight velocity difference of |Δv| = 342 km s−1. The total dynamically derived mass is consistent with the SZ derived mass of 7.63 h$_{70}^{-1}$ ± 1.36 × 1014M⊙. We model the merger using the Monte Carlo Merger Analysis Code, estimating a merging angle of 36$^{+14}_{-12}$ ° with respect to the plane of the sky. Comparing with simulations of a merging system with a mass ratio of 1:3, we find that the best scenario is that of an ongoing merger that began 0.96$^{+0.31}_{-0.18}$ Gyr ago. We also characterize the galaxy population using Hδ and O ii λ3727 Å lines. We find that most of the emission-line galaxies belong to 0307-6225S, close to the X-ray peak position with a third of them corresponding to red-cluster sequence galaxies, and the rest to blue galaxies with velocities consistent with recent periods of accretion. Moreover, we suggest that 0307-6225S suffered a previous merger, evidenced through the two equally bright BCGs at the centre with a velocity difference of ∼674 km s−1.
Abstract
We investigate the prompt emission and the afterglow properties of short-duration gamma-ray burst (sGRB) 130603B and another eight sGRB events during 2012–2015, observed by several ...multiwavelength facilities including the Gran Canarias Telescope 10.4 m telescope. Prompt emission high energy data of the events were obtained by INTEGRAL-SPI-ACS, Swift-BAT, and Fermi-GBM satellites. The prompt emission data by INTEGRAL in the energy range of 0.1–10 MeV for sGRB 130603B, sGRB 140606A, sGRB 140930B, sGRB 141212A, and sGRB 151228A do not show any signature of the extended emission or precursor activity and their spectral and temporal properties are similar to those seen in case of other short bursts. For sGRB 130603B, our new afterglow photometric data constrain the pre-jet-break temporal decay due to denser temporal coverage. For sGRB 130603B, the afterglow light curve, containing both our new and previously published photometric data is broadly consistent with the ISM afterglow model. Modeling of the host galaxies of sGRB 130603B and sGRB 141212A using the LePHARE software supports a scenario in which the environment of the burst is undergoing moderate star formation activity. From the inclusion of our late-time data for eight other sGRBs we are able to: place tight constraints on the non-detection of the afterglow, host galaxy, or any underlying ‘kilonova’ emission. Our late-time afterglow observations of the sGRB 170817A/GW170817 are also discussed and compared with the sub-set of sGRBs.
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