Brainstem BOLD response to visual and acoustic stimuli Han, Chungmin; Ress, David; Ramos Nunez, Aurora I. ...
2020 42nd Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC),
07/2020
Conference Proceeding
Odprti dostop
Understanding the fundamental roles of brainstem function resulting in proper motor control is critical to motor-rehabilitation after brain injuries. In particular, vestibular and reticular formation ...nuclei are thought to be associated with spasticity in chronic stroke patients. We used two kinds of stimuli in 10 healthy subjects to activate these nuclei while collecting high-resolution (1.5-mm) fMRI across the majority of brainstem. Optokinetic stimuli evoked illusory self-motion to activate the vestibular nuclei. Acoustic-startle stimuli were sets of loud tones designed to activate of the reticular formation. We summarized the response represented in a form of activation volume, mean percent signal change, and the phase delay (time lag) following the stimulus. We observed patterns of significant activations in the brainstem but did not find significant differences between the stimulus. We conclude that more sensitive measurement techniques are needed to reliably detect vestibular and reticular formation nuclei responses.
Structural GenomiX, Inc. (SGX), four New York area institutions, and two University of California schools have formed the New York Structural GenomiX Research Consortium (NYSGXRC), an ...industrial/academic Research Consortium that exploits individual core competencies to support all aspects of the NIH-NIGMS funded Protein Structure Initiative (PSI), including protein family classification and target selection, generation of protein for biophysical analyses, sample preparation for structural studies, structure determination and analyses, and dissemination of results. At the end of the PSI Pilot Study Phase (PSI-1), the NYSGXRC will be capable of producing 100-200 experimentally determined protein structures annually. All Consortium activities can be scaled to increase production capacity significantly during the Production Phase of the PSI (PSI-2). The Consortium utilizes both centralized and de-centralized production teams with clearly defined deliverables and hand-off procedures that are supported by a web-based target/sample tracking system (SGX Laboratory Information Data Management System, LIMS, and NYSGXRC Internal Consortium Experimental Database, ICE-DB). Consortium management is provided by an Executive Committee, which is composed of the PI and all Co-PIs. Progress to date is tracked on a publicly available Consortium web site (http://www.nysgxrc.org) and all DNA/protein reagents and experimental protocols are distributed freely from the New York City Area institutions. In addition to meeting the requirements of the Pilot Study Phase and preparing for the Production Phase of the PSI, the NYSGXRC aims to develop modular technologies that are transferable to structural biology laboratories in both academe and industry. The NYSGXRC PI and Co-PIs intend the PSI to have a transforming effect on the disciplines of X-ray crystallography and NMR spectroscopy of biological macromolecules. Working with other PSI-funded Centers, the NYSGXRC seeks to create the structural biology laboratory of the future. Herein, we present an overview of the organization of the NYSGXRC and describe progress toward development of a high-throughput Gene-->Structure platform. An analysis of current and projected consortium metrics reflects progress to date and delineates opportunities for further technology development.
Taller para profesores, desarrollado para la Jornada de Enseñanza de la Tabla Periódica, ¿base de datos o piedra filosofal? Siguiendo una didáctica de Aprendizaje Basado en Problemas, propongo que la ...Tabla Periódica se enseñe con una función heurística simbólica, como una herramienta para el estudiante desarrolle Habilidades de Pensamiento de Orden Superior (HPOS), y para ejercitar la argumentación científica.
T-NOVA: An Open-Source MANO Stack for NFV Infrastructures Kourtis, Michail-Alexandros; McGrath, Michael J.; Gardikis, Georgios ...
IEEE eTransactions on network and service management,
2017-Sept., 2017-9-00, 20170901, Letnik:
14, Številka:
3
Journal Article
Recenzirano
Odprti dostop
One of the primary challenges associated with network functions virtualization (NFV) is the automated management of the service lifecycle. In this paper, we present a full software-based management ...and orchestration (MANO) stack which operates with OpenStack and OpenDaylight controllers and has the in-built functionality to automate the key phases of the NFV service lifecycle, namely resource discovery and matching, service mapping, service deployment, and monitoring. The MANO stack is being implemented by the EU FP7 project T-NOVA, with the components being released as open-source software. Service mapping and service deployment solutions developed in the scope of T-NOVA are presented in detail. As a proof-of-concept, we evaluate the performance of a virtualized traffic classifier network function, demonstrating the gains of virtualized hardware acceleration.
Smartphones took the world by storm in the 2000s. Over the years, smartphones have become vital in everyday life. Each generation responds to technology differently. The younger generation is much ...more involved with smartphones as well as technology as a whole. Thus, spending too much time on a smartphone could be related to individual’s well-being. The purpose of the present study is to measure Emotional Intelligence (EI), mindfulness, and social competence among different age cohorts and see if there are differences in phone use. Our hypothesis is that participants who score higher on EI, Social Skills, and Mindfulness will score lower on the Problematic Phone Usage Scale. Younger adults will score lower on EI, Social Skills, and Mindfulness and higher on Problematic Phone Usage than middle aged and older adults. We ran correlational analyses among, mindfulness, social competence, and problematic phone usage and an ex-post facto comparison between the four cohorts with ages ranging 18-30 (n=105), 31-40 years old (n= 30), 41-50 (n= 30), and 51 and older (n= 21). Survey questions included the Trait Emotional Intelligence Questionnaire- Short Form (TEIQ-SF), Kentucky Inventory of Mindfulness Skills, Social Competence, and Problematic Phone Usage Scale. Data showed that as age increased phone use decreased. EI, mindfulness, and social competence scores for younger adults were much lower than for middle aged and older adults while younger adults had a significantly larger problematic phone use than middle aged.
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