Predictive maintenance holds a crucial role in various industries such as the automotive, aviation and factory automation industries when it comes to expensive engine upkeep. Predicting engine ...maintenance intervals is vital for devising effective business management strategies, enhancing occupational safety and optimising efficiency. To achieve predictive maintenance, engine sensor data are harnessed to assess the wear and tear of engines. In this research, a Long Short-Term Memory (LSTM) architecture was employed to forecast the remaining lifespan of aircraft engines. The LSTM model was evaluated using the NASA Turbofan Engine Corruption Simulation dataset and its performance was benchmarked against alternative methodologies. The results of these applications demonstrated exceptional outcomes, with the LSTM model achieving the highest classification accuracy at 98.916% and the lowest mean average absolute error at 1.284%.
A transition from a d2 to a d law is observed in molecular dynamics (MD) simulations when the diameter (d) of an evaporating droplet reduces to the order of the vapor's mean free path; this cannot be ...explained by classical theory. This Letter shows that the d law can be predicted within the Navier-Stokes-Fourier (NSF) paradigm if a temperature-jump boundary condition derived from kinetic theory is utilized. The results from this model agree with those from MD in terms of the total lifetime, droplet radius, and temperature, while the classical d2 law underpredicts the lifetime of the droplet by a factor of 2. Theories beyond NSF are also employed in order to investigate vapor rarefaction effects within the Knudsen layer adjacent to the interface.
In response to the growing concerns surrounding water pollution and the presence of multiple metal ions in environmental matrices, we conducted a comprehensive study to explore the potential of a ...thiosemicarbazone Schiff base in the Zeolitic Imidazolate Framework (TSC‐ZIF‐1) as an efficient adsorbent for removing harmful metal ions from aqueous solutions. Our investigation assessed the adsorption capacity and efficiency of TSC‐ZIF 1 towards three key metal ions—Hg(II), Ag(I), and Pb(II)—in homo‐ionic, tertiary, and multi‐metal ion systems. TSC‐ZIF 1 exhibited unprecedented adsorption behavior towards all three metal ions in the homo‐ionic system, with the Langmuir isotherm models fitting well (R2 ~ 0.98 to 0.99). The maximum adsorption capacities were found to be 1,667 mg/g for Hg(II), as previously reported; 285 mg/g for Ag(I); and 769 mg/g for Pb(II); these values serve as baseline values. Subsequently, we conducted a comparative analysis for a tertiary system, Hg(II)/Ag(I)/Pb(II), where the three metals co‐existed in one solution. The adsorption capacity for each metal ion was reduced to varying extents; notably, the adsorption capacity for Pb(II) experienced the most significant reduction, reaching a qm value of 57 mg/g, representing an ~93% decrease compared to the homo‐ionic metal system. Conversely, the adsorption capacity for Ag(I) exhibited a minor decrease of ~3%. Despite a decrease in the adsorption capacity for Hg(II) by approximately 34%, the removal capacity remains the highest among the other metals. Our investigation of the competitive adsorption among the metal ions in the Hg(II)/Ag(I)/Pb(II) system revealed an antagonistic effect, indicating strong adsorption competition for available sites on TSC‐ZIF 1. When extending this study to a more complex multi‐metal ion system containing six metal ions, TSC‐ZIF 1 exhibited high selectivity (higher than 60% removal) towards Hg(II), Ag(I), and Pb(II) in a multi‐ionic system, including Hg(II), Ag(I), Pb(II), Cd(II), Ni(II), and Mg(II).
TSC‐ZIF‐1 is developed as an adsorbent to tackle water pollution caused by metal ions. Our research examined its potential to remove Hg(II), Ag(I), and Pb(II) from aqueous solutions, considering different ion systems. Results highlight its efficacy in addressing environmental metal ion contamination.
It has been proven that stress, mainly in the early years of life, can lead to anxiety and mood problems. Current treatments for psychiatric disorders are not enough, and some of them show ...intolerable side effects, emphasizing the urgent need for new treatment targets. Hence, a better understanding of the different brain networks, which are involved in the response to anxiety and depression, may evoke treatments with more specific targets. One of these targets is β‐catenin that regulates brain circuits. β‐Catenin has a dual response toward stress, which may influence coping or vulnerability to stress response. Indeed, β‐catenin signaling involves several processes such as inflammation‐directed brain repair, inflammation‐induced brain damage, and neurogenesis. Interestingly, β‐catenin reduction is accompanied by low neurogenesis, which leads to anxiety and depression. However, in another state, this reduction activates a compensatory mechanism that enhances neurogenesis to protect against depression but may precipitate anxiety. Thus, understanding the molecular mechanism of β‐catenin could enhance our knowledge about anxiety and depression's pathophysiology, potentially improving clinical results by targeting it. Herein, the different states of β‐catenin were discussed, shedding light on possible drugs that showed action on psychiatric disorders through β‐catenin.
Abstract
Early during the era of cosmic inflation, rotational invariance may have been broken, only later emerging as a feature of low-energy physics. This motivates ongoing searches for residual ...signatures of anisotropic space-time, for example in the power spectrum of the cosmic microwave background. We propose that dipolar Bose–Einstein condensates (BECs) furnish a laboratory quantum simulation platform for the anisotropy evolution of fluctuation spectra during inflation, exploiting the fact that the speed of dipolar condensate sound waves depends on direction. We construct the anisotropic analogue space-time metric governing sound, by linking the time-varying strength of dipolar and contact interactions in the BEC to the scale factors in different coordinate directions. Based on these, we calculate the dynamics of phonon power spectra during an inflation that renders the initially anisotropic Universe isotropic. We find that the expansion speed provides an experimental handle to control and study the degree of final residual anisotropy. Gravity analogues using dipolar condensates can thus provide tuneable experiments for a field of cosmology that was until now confined to a single experiment, our Universe.
Biotechnology has revolutionized the development of sustainable energy sources by harnessing biomass as a feedstock for energy production. However, challenges such as recalcitrant feedstocks and ...inefficient metabolic pathways hinder the large-scale integration of renewable energy systems. Enzyme engineering has emerged as a powerful tool to address these challenges by enhancing enzyme activity, specificity, and stability. Generative machine learning (ML) models have shown great promise in accelerating protein design, allowing for the generation of novel protein sequences with desired properties by navigating vast spaces. This review paper aims to summarize the state of the art in generative models for protein design and how they can be applied to bioenergy applications, including the underlying architectures and training strategies. Additionally, it highlights the importance of high-quality datasets for training and evaluating generative models, organizes available datasets for generative protein design, and discusses the potential of applying generative models to strain design for bioenergy production.
An observational study to discover the common conditions affecting the lumbosacral region that may affect lumbosacral position and tension. All the patients, underwent MRI exaamination (magnetic ...resonance imaging) in the supine position, were examined by the same consultant radiologist. The article was revised by the institutional ethical approval committee. The position of the nerve roots was observed, and the number of nerve roots was calculated anterior to a line passing between the mid-transvers process of L3(third lumbar vertebra). The number of nerve roots ahead of this line was calculated by the radiologist at the level of the right intervertebral foramen and at the left one. This procedure was applied to the normal group, and 5 common pathological diseases were repeated including single-level lumbar disc prolapse, multiple-disc prolapse, multiple bulge, spinal stenosis and spondylolisthesis (at the level of L45 (fourth to fifth lumbar vertebrae) or L5S1 (fifth lumbar to first sacral vertebrae) being outside the study area, i.e., L3). We noticed significant difference in the number of the nerve roots between the cases with herniated discs, spinal stenosis, and spondylolisthesis with the normal group and the significance was in ascending increment in significance being the highest in cases with spondylolisthesis, and even in the groups of other pathologies which are statistically not significant, we noticed that the significance is proportional to the severity of the disease being the least in single level cases (p 0.427), to be more significant on cases with multiple prolapses(p 0.319) to be more in cases with multiple bulges to start to be statistically significant in herniated, higher significance in cases with spinal stenosis to be the highest in cases with spondylolisthesis.
The HIV epidemic in Bangladesh is largely being driven by people who inject drugs (PWID) and mainly concentrated in Dhaka city. Intregrated biological and behavioural survey (IBBS) data of 2016 ...showed that a considerable percentage of the HIV positive PWID had unsafe sex with their female sex partners. Prevalence of HIV, risk behaviorus and vulnerabilities among the female sex partners of the PWID still remain unexplored.
To measure HIV prevalence, risk behaviours (drugs/injection/sexual) and vulnerabilities (treatment of and knowledge of sexually transmitted infections (STIs) and HIV/uptake of the routine HIV testing and HIV prevention services/physical and sexual violence), a quantitative survey was conducted among 227 female sex partners of the HIV positive PWID in Dhaka city in 2019 by adopting a take-all sampling technique.
The median age of participants was 34.0 years. Prevalence of HIV was 16.7% (95% CI: 12.4-22.2). Only 6.8% to 18.7% of the participants used condoms consistently with different male sex partners; only 6.8%cto 18.7% during last year. Seventy five percent (95% CI: 69.2-80.8) had no knowledge on STI symptoms. Self-reported symptoms of STIs were reported by 26% (95% CI: 20.7-32.1) and half sought treatment during last year. Nineteen percent (95% CI: 14.7-25.1) had comprehensive knowledge of HIV. As part of the routine HIV prevention services by the PWID drop-in-centres (DICs), 42.7% (95% CI: 36.4-49.3) of the participants were tested for HIV and knew their result within the last year. One-third never received HIV prevention services. During the last one year preceding the survey, 46% (95% CI: 39.3-52.6) reported been beaten and 20.2% (95% CI: 15.3-26.1) been raped.
It is urgently necessary to consider the high-risk behaviours and vulnerabilities in designing or to strengthen targeted interventions for female sex partners of the HIV positive PWID in Dhaka city to ensure equality in accessing and utilization of services.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
Age and Gender are vital determinants for the micronutrient demands of normal indviduals. Among these micronutrients are vitamins that are required in small amounts for optimum metabolism, ...homeostasis, and a healthy lifestyle, acting as coenzymes in several biochemical reactions. The majority of previous studies have examined such issues that relates to a specific vitamin or life stage, with the majority merely reporting the effect of either excess or deficiency. Vitamins are classified into water-soluble and fat-soluble components. The fat-soluble vitamins include vitamins (A, D, E, and K). Fat-soluble vitamins were found to have an indisputable role in an array of physiological processes such as immune regulation, vision, bone and mental health. Nonetheless, the fat-soluble vitamins are now considered a prophylactic measurement for a multitude of diseases such as autism, rickets disease, gestational diabetes, and asthma. Herein, in this review, a deep insight into the orchestration of the four different fat-soluble vitamins requirements is presented for the first time across the human life cycle beginning from fertility, pregnancy, adulthood, and senility with an extensive assessment ofthe interactions among them and their underlying mechanistic actions. The influence of sex for each vitamin is also presented at each life stage to highlight the different daily requirements and effects.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK, VSZLJ
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