Three-dimensional Couette flow of an incompressible Jeffrey fluid is formulated and discussed analytically and graphically. The suction is applied over uniformly moving upper plate and its equivalent ...deduction by injection at the lower stationary plate. Because of this type of suction/injection, this flow turns into three-dimensional. An analytical method is applied to get main flow velocity, secondary flows velocities and pressure components. Also skin friction components along the main and secondary flow directions have been calculated. The effects of different physical parameters, for example, the Deborah number, suction/injection parameter, the ratio of relaxation time to the retardation time and Reynolds number have been discussed graphically. It is witnessed that the Deborah number plays vital role to control the main flow velocity.
Bulk etch rates for CR-39 detector were measured and studied over a wide range of NaOH aqueous solution concentrations (2-20 N) with different ethanol volumes. This wide range of etching ...concentration is divided into two major parts: soft etching part (2-8 N NaOH) and dense etching part (8-20 N NaOH). This classification will be explained and discussed. The etchant viscosity in the two parts was measured and compared. The effect of ethanol in both parts was deduced through a new parameter called 'reduced bulk etch rate'. This new parameter helps in analyzing the dependence of bulk etching on the amount of ethanol in the etchant. It was found that conducting the etching process in the dense etching part reduces the etching time significantly. Etching in the dense part is not far away from equilibrium where Mushtaq, Multi-hit and Arrhenius fitting equations are applicable. The fitting of measured bulk etching data was carried out in the soft (low), dense (high) and the whole etching concentration ranges. Generally, a good agreement was found between physical data and model calculations.
Celotno besedilo
Dostopno za:
BFBNIB, DOBA, GIS, IJS, IZUM, KILJ, KISLJ, NUK, PILJ, PNG, SAZU, UILJ, UKNU, UL, UM, UPUK
Background Isotretinoin is a commonly prescribed agent mainly used to treat acne vulgaris. Since its Food and Drug Administration (FDA) approval, the subject of its associations with various medical ...conditions has become a growing interest in many investigational studies. Methodology A retrospective study was conducted using the validated Standardized Patient Evaluation of Eye Dryness (SPEED) questionnaire. All statistical calculations were performed using the Statistical Package for the Social Sciences (SPSS) version 27.0.1 (IBM SPSS Statistics, Armonk, NY). Results The research study involved 107 participants, predominantly Saudi nationals (98.1%), with an average age of 22 years. Regarding the total cumulative dose (TCD), 40.2% had less than 50 mg/kg, 33.6% had between 50 and 100 mg/kg, and 15.9% had more than 100 mg/kg. The majority (73.8%) did not stop using isotretinoin. The average Ocular Surface Disease Index (OSDI) score, indicating ocular surface disease symptoms, was 26.78. There was no significant association between gender, dose/duration of isotretinoin, TCD, and age, and OSDI scores. However, participants with severe OSDI scores were more likely to have worsened pre-existing eye symptoms compared to those with non-severe OSDI scores (35.1% versus 11.4%, p = 0.011). Conclusions This study contributes to the understanding of the impact of isotretinoin usage on ocular surface health. While no significant associations were found between gender, dose, duration, TCD, and age, and OSDI scores, participants with pre-existing eye symptoms were more likely to experience worsened symptoms during isotretinoin treatment.
The Simbu serogroup is one of the serogroups that belong to the Orthobunyavirus genus of the family Peribunyaviridae. Simbu serogroup viruses are transmitted mainly by Culicoides biting midges. ...Meager information is available on Simbu serogroup virus infection in ruminants in Sudan. Therefore, in this study, serological surveillance of Simbu serogroup viruses in cattle in seven states in Sudan was conducted during the period from May, 2015, to March, 2016, to shed some light on the prevalence of this group of viruses in our country. Using a cross-sectional design, 184 cattle sera were collected and tested by a commercial SBV ELISA kit which enables the detection of antibodies against various Simbu serogroup viruses. The results showed an overall 86.4% prevalence of antibodies to Simbu serogroup viruses in cattle in Sudan. Univariate analysis showed a significant association (p=0.007) between ELISA seropositivity and states where samples were collected. This study suggests that Simbu serogroup virus infection is present in cattle in Sudan. Further epizootiological investigations on Simbu serogroup viruses infection and virus species involved are warranted.
This study examines the change in health-related quality of life (HRQoL) among (≥60 years) elderly persons as a result of health education intervention. A community-based intervention study was ...performed in eight randomly selected villages (Intervention: n = 4; Control: n = 4) in rural Bangladesh. A total of 1135 elderly persons was selected for this study. The analyses include 839 participants (Intervention: n = 425; Control: n = 414) who participated in both baseline and post-intervention surveys. Participants in the intervention area were further stratified into compliant (n = 315) and non-compliant (n = 110) groups based on the reported compliance to the intervention activities. The intervention includes, for example, physical activity, advice on healthy food intake and other aspects of management. To create an enabling environment, social awareness was provided by means of information about the contribution of and challenges faced by elderly persons at home and the community, including information about elderly persons' health and health care. The intervention activities were provided to the elderly persons, caregivers, household members and community people for 15 months. The HRQoL was assessed using a multi-dimensional generic instrument designed for elderly persons. Multivariate analyses revealed that in the non-compliant group the probabilities of increased scores were less likely in overall HRQoL (OR 0.52, 95% CI 0.32–0.82). Among the Control group, increased scores were less likely in the physical (OR 73, 95% CI 0.54–0.99), social (OR 0.37, 95% CI 0.27–0.50), spiritual (OR 0.60, 95% CI 0.34–0.94), environment (OR 0.36, 95% CI 0.26–0.49) dimensions and overall HRQoL (OR 0.44, 95% CI 0.32–0.59) (adjusted for age, sex, literacy, marital status and economic status). This study concludes that provision of community-based health education intervention might be a potential public health initiative to enhance the HRQoL in old age.
A 60‐year‐old woman with stage IV rectal cancer received adoptive cell therapy with autologous cancer antigen (AC‐ACT) causing induction of anti‐oncogenic and anti‐PD‐L1 miRNAs as assessed by miRNA ...microarray. More than 1 year after AC‐ACT, metastases have been arrested, and the patient reports good quality of life.
A 60‐year‐old woman with stage IV rectal cancer received adoptive cell therapy with autologous cancer antigen (AC‐ACT) causing induction of anti‐oncogenic and anti‐PD‐L1 miRNAs as assessed by miRNA microarray. More than 1 year after AC‐ACT, metastases have been arrested, and the patient reports good quality of life.
The purpose of this study was to validate the World Health Organization Disability Assessment Schedule (WHODAS) 2.0 12-Item Version in persons with Fibromyalgia Syndrome (FMS). Three hundred and two ...individuals with FMS completed an online survey consisting of the WHODAS 2.0 12-item version and measures of a variety of biopsychosocial variables. The results indicate that the WHODAS 2.0 12-item version exhibits a two-factor structure (Social and Cognitive Functioning and Self-Care Functioning), and the factors correlate with the selected biopsychosocial variables (pain intensity, fatigue, cognitive impairment, sleep problems, depression, and social support) in the expected directions. These results suggest that, although the WHODAS 2.0 12-item version does not exhibit the one-factor structure that has been found in other validation studies, it can be thoughtfully used to explore the impact of FMS on individuals' lives in clinical and research settings.
Celotno besedilo
Dostopno za:
DOBA, FSPLJ, IZUM, KILJ, NUK, ODKLJ, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK, VSZLJ
Mutations of
PCDH15
, encoding protocadherin 15, can cause either combined hearing and vision impairment (type 1 Usher syndrome; USH1F) or nonsyndromic deafness (DFNB23). Human
PCDH15
is reported to ...be composed of 35 exons and encodes a variety of isoforms with 3–11 ectodomains (ECs), a transmembrane domain and a carboxy-terminal cytoplasmic domain (CD). Building on these observations, we describe an updated gene structure that has four additional exons of
PCDH15
and isoforms that can be subdivided into four classes. Human
PCDH15
encodes three alternative, evolutionarily conserved unique cytoplasmic domains (CD1, CD2 or CD3). Families ascertained on the basis of prelingual hearing loss were screened for linkage of this phenotype to markers for
PCDH15
on chromosome 10q21.1. In seven of twelve families segregating USH1, we identified homozygous mutant alleles (one missense, one splice site, three nonsense and two deletion mutations) of which six are novel. One family was segregating nonsyndromic deafness DFNB23 due to a homozygous missense mutation. To date, in our cohort of 557 Pakistani families, we have found 11 different
PCDH15
mutations that account for deafness in 13 families. Molecular modeling provided mechanistic insight into the phenotypic variation in severity of the
PCDH15
missense mutations. We did not find pathogenic mutations in five of the twelve USH1 families linked to markers for
USH1F
, which suggest either the presence of mutations of yet additional undiscovered exons of
PCDH15
, mutations in the introns or regulatory elements of
PCDH15
, or an additional locus for type I USH at chromosome 10q21.1.
In an approach aimed at defining interacting partners of ceramide synthases (CerSs), we found that fatty acyl-CoA synthase ACSL5 interacts with all CerSs. We demonstrate that ACSL5-generated FA-CoA ...was utilized with de novo ceramide for the generation of acylceramides, poorly studied ceramide metabolites. Functionally, inhibition of ceramide channeling to acylceramide enhanced accumulation of de novo ceramide and resulted in augmentation of ceramide-mediated apoptosis. Mechanistically, we show that acylceramide generation is catalyzed by diacylglycerol acyltransferase 2 (DGAT2) on lipid droplets. In summary, this study identifies a metabolic pathway of acylceramide generation and its sequestration in LDs in cells and in livers of mice on a high-fat diet. The study also implicates this pathway in ceramide-mediated apoptosis, and has implications in co-regulation of triglyceride and sphingolipid metabolisms.
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•Ceramide synthases (CerSs) associate with fatty acyl-CoA synthase ACSL5•CerS-ACSL-DGAT catalyzes acylceramide generation from ceramide in lipid droplets•High-fat diet induces accumulation of acylceramides in liver lipid droplets•Acylceramide formation in lipid droplets acts as a storage for ceramide
Senkal et al. identify a pathway whereby ceramide is converted to acylceramides by a CerS-ACSL-DGAT complex in lipid droplets for storage. These results raise interesting questions as to the metabolic interplay of TG/DAG and ceramide/acylceramide and the roles of ACSL5 and CerS in regulating these balances.
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