...we also tested a few initiatives marketers can use to encourage people to choose a higher-quality experience that requires them to be apart from their companion. ...when can time apart from your ...partner actually strengthen the relationship? Ximena Garcia-Rada, Assistant Professor of Marketing, Texas A&M University Michael Norton, Professor of Business Administration, Harvard University Rebecca K. Ratner, Professor of Marketing, University of Maryland
C onsider the following examples: Michael J. Fox suffered from Parkinson’s disease and became a highly visible booster of research on Parkinson’s disease. Cicely Tyson lost her sister to lung cancer ...and was featured in
a nationwide ad campaign to encourage women to stop smoking. Many who give
to help AIDS patients are themselves members of the gay community (Snyder &
Omoto, 1992). Do all of these examples confirm the widespread perception that
people are primarily self-interested and care most about those causes to which
they have a personal connection (Miller & Ratner, 1996, 1998; Wuthnow, 1991)?
That people often explain their own acts of compassion in self-interested terms
further implies a central role of self-interest in charitable giving and volunteerism
behaviors (Wuthnow, 1991).
•Parents reported that educational videos were helpful in understanding genetics.•Satisfaction with genetic counseling was equivalent for standard care and videos.•Genetic counselors did not report ...significant differences between the two groups.•Creating effective and efficient educational tools is challenging.•Standardized measures of educational tools need to be developed and validated.
Growing use of clinical exome sequencing (CES) has led to an increased burden of genomic education. Self-guided educational tools can minimize the educational burden for genetic counselors (GCs). The effectiveness of these tools must be evaluated.
Parents of patients offered CES were randomized to watch educational videos before their visit or to receive routine care. Parents and GCs were surveyed about their experiences following the sessions. The responses of the video (n = 102) and no-video (n = 105) groups were compared.
GCs reported no significant differences between parents in the video and no-video groups on genetics knowledge or CES knowledge. In contrast, parents’ scores on genetics knowledge questions were lower in the video than no-video group (p = 0.007). Most parents reported the videos were informative, and the groups did not differ in satisfaction with GCs or decisions to have CES.
GCs and parents perceived the videos to be beneficial. However, lower scores on genetics knowledge questions highlight the need for careful development of educational tools.
Educational tools should be developed and assessed for effectiveness with the input of all stakeholders before widespread implementation. Better measures of the effectiveness of these educational tools are needed.
The human T-cell leukemia retrovirus type-1 (HTLV-1) p30(II) protein is a multifunctional latency-maintenance factor that negatively regulates viral gene expression and deregulates host signaling ...pathways involved in aberrant T-cell growth and proliferation. We have previously demonstrated that p30(II) interacts with the c-MYC oncoprotein and enhances c-MYC-dependent transcriptional and oncogenic functions. However, the molecular and biochemical events that mediate the cooperation between p30(II) and c-MYC remain to be completely understood. Herein we demonstrate that p30(II) induces lysine-acetylation of the c-MYC oncoprotein. Acetylation-defective c-MYC Lys→Arg substitution mutants are impaired for oncogenic transformation with p30(II) in c-myc(-/-) HO15.19 fibroblasts. Using dual-chromatin-immunoprecipitations (dual-ChIPs), we further demonstrate that p30(II) is present in c-MYC-containing nucleoprotein complexes in HTLV-1-transformed HuT-102 T-lymphocytes. Moreover, p30(II) inhibits apoptosis in proliferating cells expressing c-MYC under conditions of genotoxic stress. These findings suggest that c-MYC-acetylation is required for the cooperation between p30(II)/c-MYC which could promote proviral replication and contribute to HTLV-1-induced carcinogenesis.
The human T-cell leukemia retrovirus type-1 (HTLV-1) p30 super(II) protein is a multifunctional latency-maintenance factor that negatively regulates viral gene expression and deregulates host ...signaling pathways involved in aberrant T-cell growth and proliferation. We have previously demonstrated that p30 super(II) interacts with the c-MYC oncoprotein and enhances c-MYC-dependent transcriptional and oncogenic functions. However, the molecular and biochemical events that mediate the cooperation between p30 super(II) and c-MYC remain to be completely understood. Herein we demonstrate that p30 super(II) induces lysine-acetylation of the c-MYC oncoprotein. Acetylation-defective c-MYC Lys arrow right Arg substitution mutants are impaired for oncogenic transformation with p30 super(II) in c-myc super(-/-) HO15.19 fibroblasts. Using dual-chromatin-immunoprecipitations (dual-ChIPs), we further demonstrate that p30 super(II) is present in c-MYC-containing nucleoprotein complexes in HTLV-1-transformed HuT-102 T-lymphocytes. Moreover, p30 super(II) inhibits apoptosis in proliferating cells expressing c-MYC under conditions of genotoxic stress. These findings suggest that c-MYC-acetylation is required for the cooperation between p30 super(II)/c-MYC which could promote proviral replication and contribute to HTLV-1-induced carcinogenesis.
Abstract The human T-cell leukemia retrovirus type-1 (HTLV-1) p30II protein is a multifunctional latency-maintenance factor that negatively regulates viral gene expression and deregulates host ...signaling pathways involved in aberrant T-cell growth and proliferation. We have previously demonstrated that p30II interacts with the c-MYC oncoprotein and enhances c-MYC-dependent transcriptional and oncogenic functions. However, the molecular and biochemical events that mediate the cooperation between p30II and c-MYC remain to be completely understood. Herein we demonstrate that p30II induces lysine-acetylation of the c-MYC oncoprotein. Acetylation-defective c-MYC Lys→Arg substitution mutants are impaired for oncogenic transformation with p30II in c-myc −/− HO15.19 fibroblasts. Using dual-chromatin-immunoprecipitations (dual-ChIPs), we further demonstrate that p30II is present in c-MYC-containing nucleoprotein complexes in HTLV-1-transformed HuT-102 T-lymphocytes. Moreover, p30II inhibits apoptosis in proliferating cells expressing c-MYC under conditions of genotoxic stress. These findings suggest that c-MYC-acetylation is required for the cooperation between p30II /c-MYC which could promote proviral replication and contribute to HTLV-1-induced carcinogenesis.
A novel but controversial method to increase the utilization of aged donor kidneys is the transplantation of both kidneys as a dual transplant. Initial single-center reports demonstrated outcomes ...similar to single kidneys from younger donors. In this report, we compare outcome in recipients of kidneys from donors > or =54 years of age who received a single kidney transplant reported to the United Network for Organ Sharing Scientific Registry versus a dual kidney transplant reported to the Dual Kidney Registry.
A retrospective analysis was performed, comparing four donor and nine recipient and outcome variables between recipients of a single versus a dual transplant between March 1993 and March 1999.
Dual versus single transplants from donors > or =54 years of age have a significantly decreased incidence of delayed graft function, and lower serum creatinines up to 2 years after transplant despite having kidneys from significantly older donors with poorer HLA matching.
Dual kidney transplants improve graft performance and outcome in recipients of kidneys from donors > or =54 years of age.
PDF
