Proton CT nowadays aims at improving hadron therapy treatment planning by mapping the stopping power of materials. In order to optimize a spatial resolution of the reconstructed images, the most ...likely path (MLP) of each proton can be computed. We investigated the errors in the computation of this path due to the configuration of the system, i.e. the spatial resolution of the tracking planes, their material budget, and their positioning. A method for computing the uncertainty in the estimated paths for a given system was derived. The uncertainties upon the entrance and exit of the object were propagated analytically in the path computation. This procedure was then used to evaluate the impact of each parameter, and to compare different systems. We show that the intrinsic characteristics of the system generate an uncertainty in the positions and directions of the particles propagated during the MLP computation. The spatial resolution and material budget of the trackers in particular may affect the path estimation, and thus the spatial resolution of an image.
Proton imaging is developed in order to improve the accuracy of charged particle therapy treatment planning. It makes it possible to directly map the relative stopping powers of the materials using ...the information on the energy loss of the protons. In order to reach a satisfactory spatial resolution in the reconstructed images, the position and direction of each particle is recorded upstream and downstream from the patient. As a consequence of individual proton detection, information on the transmission rate and scattering of the protons is available. Image reconstruction processes are proposed to make use of this information. A proton tomographic acquisition of an anthropomorphic head phantom was simulated. The transmission rate of the particles was used to reconstruct a map of the macroscopic cross section for nuclear interactions of the materials. A two-step iterative reconstruction process was implemented to reconstruct a map of the inverse scattering length of the materials using the scattering of the protons. Results indicate that, while the reconstruction processes should be optimized, it is possible to extract quantitative information from the transmission rate and scattering of the protons. This suggests that proton imaging could provide additional knowledge on the materials that may be of use to further improve treatment planning.
Ion beam therapy enables a highly accurate dose conformation delivery to the tumor due to the finite range of charged ions in matter (i.e. Bragg peak (BP)). Consequently, the dose profile is very ...sensitive to patients anatomical changes as well as minor mispositioning, and so it requires improved dose control techniques. Proton interaction vertex imaging (IVI) could offer an online range control in carbon ion therapy. In this paper, a statistical method was used to study the sensitivity of the IVI technique on experimental data obtained from the Heidelberg Ion-Beam Therapy Center. The vertices of secondary protons were reconstructed with pixelized silicon detectors. The statistical study used the χ2 test of the reconstructed vertex distributions for a given displacement of the BP position as a function of the impinging carbon ions. Different phantom configurations were used with or without bone equivalent tissue and air inserts. The inflection points in the fall-off region of the longitudinal vertex distribution were computed using different methods, while the relation with the BP position was established. In the present setup, the resolution of the BP position was about 4-5 mm in the homogeneous phantom under clinical conditions (106 incident carbon ions). Our results show that the IVI method could therefore monitor the BP position with a promising resolution in clinical conditions.
A detailed knowledge of the light ions interaction processes with matter is of great interest in basic and applied physics. As an example, particle therapy and space radioprotection require highly ...accurate fragmentation cross-section measurements to develop shielding materials and estimate acute and late health risks for manned missions in space and for treatment planning in particle therapy. The Fragmentation of Ions Relevant for Space and Therapy experiment at the Helmholtz Center for Heavy Ion research (GSI) was designed and built by an international collaboration from France, Germany, Italy, and Spain for studying the collisions of a C-12 ion beam with thin targets. The collaboration's main purpose is to provide the double-differential cross-section measurement of carbon-ion fragmentation at energies that are relevant for both tumor therapy and space radiation protection applications. Fragmentation cross sections of light ions impinging on a wide range of thin targets are also essential to validate the nuclear models implemented in MC simulations that, in such an energy range, fail to reproduce the data with the required accuracy. This paper presents the single differential carbon-ion fragmentation cross sections on a thin gold target, measured as a function of the fragment angle and kinetic energy in the forward angular region (theta less than or similar to 6 degrees), aiming to provide useful data for the benchmarking of the simulation softwares used in light ions fragmentation applications. The C-12 ions used in the measurement were accelerated at the energy of 400 MeV/nucleon by the SIS (heavy ion synchrotron) GSI facility.
Hadrontherapy treatments use charged particles (e.g. protons and carbon ions) to treat tumors. During a therapeutic treatment with carbon ions, the beam undergoes nuclear fragmentation processes ...giving rise to significant yields of secondary charged particles. An accurate prediction of these production rates is necessary to estimate precisely the dose deposited into the tumours and the surrounding healthy tissues. Nowadays, a limited set of double differential carbon fragmentation cross-section is available. Experimental data are necessary to benchmark Monte Carlo simulations for their use in hadrontherapy. The purpose of the FIRST experiment is to study nuclear fragmentation processes of ions with kinetic energy in the range from 100 to 1000MeV/u. Tracks are reconstructed using information from a pixel silicon detector based on the CMOS technology. The performances achieved using this device for hadrontherapy purpose are discussed. For each reconstruction step (clustering, tracking and vertexing), different methods are implemented. The algorithm performances and the accuracy on reconstructed observables are evaluated on the basis of simulated and experimental data.
Improving the detection efficiency in nuclear emulsion trackers Alexandrov, A.; Bozza, C.; Buonaura, A. ...
Nuclear instruments & methods in physics research. Section A, Accelerators, spectrometers, detectors and associated equipment,
03/2015, Letnik:
776
Journal Article
Recenzirano
Nuclear emulsion films are a tracking device with unique space resolution. Their use in nowadays large-scale experiments relies on the availability of automated microscope operating at very high ...speed. In this paper we describe the features and the latest improvements of the European Scanning System, a last-generation automated microscope for emulsion scanning. In particular, we present a new method for the recovery of tracking inefficiencies. Stacks of double coated emulsion films have been exposed to a 10GeV/c pion beam. Efficiencies as high as 98% have been achieved for minimum ionising particle tracks perpendicular to the emulsion films and of 93% for tracks with tan(θ)≃0.8.
A fast automatic plate changer for the analysis of nuclear emulsions Balestra, S.; Bertolin, A.; Bozza, C. ...
Nuclear instruments & methods in physics research. Section A, Accelerators, spectrometers, detectors and associated equipment,
07/2013, Letnik:
716
Journal Article
Recenzirano
This paper describes the design and performance of a computer controlled emulsion Plate Changer for the automatic placement and removal of nuclear emulsion films for the European Scanning System ...microscopes. The Plate Changer is used for mass scanning and measurement of the emulsions of the OPERA neutrino oscillation experiment at the Gran Sasso lab on the CNGS neutrino beam. Unlike other systems it works with both dry and oil objectives. The film changing takes less than 20s and the accuracy on the positioning of the emulsion films is about 10μm. The final accuracy in retrieving track coordinates after fiducial marks measurement is better than 1μm.
Proton imaging can be seen as a powerful technique for on-line monitoring of ion range during carbon ion therapy irradiation. The protons detection technique uses, as three-dimensional tracking ...system, a set of CMOS sensor planes. A simulation toolkit based on GEANT4 and ROOT is presented including detector response and reconstruction algorithm.
The PEANUT experiment was designed to study the NuMi neutrino beam at Fermilab. The detector uses a hybrid technique, being made of nuclear emulsions and scintillator trackers. Emulsion films act as ...a micrometric tracking device and are interleaved with lead plates used as passive material. The detector is designed to precisely reconstruct the topology of neutrino interactions and hence to measure the different contributions to the cross section. We present here the full reconstruction and analysis of 147 neutrino interactions and the measurement of the quasi-elastic, resonance and deep-inelastic contributions to the total charged current cross section at the energies of the NuMi neutrino beam. This technique could be applied for beam monitoring in future neutrino facilities, and this paper shows its proof-of-principle.
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