Context.The THz atmospheric “windows”, centered at roughly 1.3 and 1.5 THz, contain numerous spectral lines of astronomical importance, including three high-J CO lines, the N II line at 205 μm, and ...the ground transition of para-H2D+. The CO lines are tracers of hot (several 100 K), dense gas; N II is a cooling line of diffuse, ionized gas; the H2D+ line is a non-depleting tracer of cold (~20 K), dense gas. Aims.As the THz lines benefit the study of diverse phenomena (from high-mass star-forming regions to the WIM to cold prestellar cores), we have built the CO N+ Deuterium Observations Receiver (CONDOR) to further explore the THz windows by ground-based observations. Methods.CONDOR was designed to be used at the Atacama Pathfinder EXperiment (APEX) and Stratospheric Observatory For Infrared Astronomy (SOFIA). CONDOR was installed at the APEX telescope and test observations were made to characterize the instrument. Results.The combination of CONDOR on APEX successfully detected THz radiation from astronomical sources. CONDOR operated with typical $T_{\rm rec}=1600$ K and spectral Allan variance times of ~30 s. CONDOR's “first light” observations of CO 13-12 emission from the hot core Orion FIR 4 (= OMC1 South) revealed a narrow line with $T_{\rm MB}\approx 210$ K and $\Delta V\approx 5.4$ km s-1. A search for N II emission from the ionization front of the Orion Bar resulted in a non-detection. Conclusions.The successful deployment of CONDOR at APEX demonstrates the potential for making observations at THz frequencies from ground-based facilities.
CONDOR – A heterodyne receiver at 1.25-1.5 THz Wiedner, M. C.; Wieching, G.; Bielau, F. ...
Proceedings of the International Astronomical Union,
08/2006, Letnik:
2, Številka:
S237
Journal Article
Recenzirano
Odprti dostop
The CON+Deuterium Observations Receiver (CONDOR) is a heterodyne receiver that operates between 1250–1530 GHz. Its primary goal is to observe star-forming regions in CO, N+, and H2D+ emission.
The THz atmospheric windows centered at roughly 1.3 and 1.5~THz, contain
numerous spectral lines of astronomical importance, including three high-J CO
lines, the N+ line at 205 microns, and the ...ground transition of para-H2D+. The
CO lines are tracers of hot (several 100K), dense gas; N+ is a cooling line of
diffuse, ionized gas; the H2D+ line is a non-depleting tracer of cold (~20K),
dense gas. As the THz lines benefit the study of diverse phenomena (from
high-mass star-forming regions to the WIM to cold prestellar cores), we have
built the CO N+ Deuterium Observations Receiver (CONDOR) to further explore the
THz windows by ground-based observations. CONDOR was designed to be used at the
Atacama Pathfinder EXperiment (APEX) and Stratospheric Observatory For Infrared
Astronomy (SOFIA). CONDOR was installed at the APEX telescope and test
observations were made to characterize the instrument. The combination of
CONDOR on APEX successfully detected THz radiation from astronomical sources.
CONDOR operated with typical Trec=1600K and spectral Allan variance times of
30s. CONDOR's first light observations of CO 13-12 emission from the hot core
Orion FIR4 (= OMC1 South) revealed a narrow line with T(MB) = 210K and
delta(V)=5.4km/s. A search for N+ emission from the ionization front of the
Orion Bar resulted in a non-detection. The successful deployment of CONDOR at
APEX demonstrates the potential for making observations at THz frequencies from
ground-based facilities.
Antipsychotic medications are generally effective in ameliorating psychotic symptoms in schizophrenia spectrum disorders (SSDs). Identifying predictors associated with poor treatment response is ...important for a personalized treatment approach. Childhood trauma (CT) may have a general and differential effect on the effectiveness of different types of antipsychotics in SSDs. The Bergen-Stavanger-Trondheim-Innsbruck (BeSt InTro) study is a pragmatic, researcher-initiated, semi-randomized trial. The present study aimed to investigate symptom change (the Positive and Negative Syndrome Scale) from baseline to 1, 3, 6, 12, 26, 39 and 52 weeks of antipsychotic treatment (amisulpride, aripiprazole and olanzapine) by group (CT/no CT). Participants (n = 98) with diagnoses within the schizophrenia spectrum (F20–29 in the International Classification of Diseases — 10th Revision) were randomized to receive amisulpride, aripiprazole or olanzapine, and for this study categorized into groups of none and low CT, and moderate to severe CT according to thresholds defined by the Childhood Trauma Questionnaire Short-Form manual. CT in SSDs predicted an overall slower treatment response and less antipsychotic effectiveness after 26 weeks of treatment, which was statistically nonsignificant at 52 weeks. Secondary analyses showed a differential effect of CT related to type of antipsychotic medication: patients with SSDs and CT who received olanzapine showed less antipsychotic effectiveness throughout 52 weeks of treatment. The intention-to-treat and per-protocol analyses were convergent. Our findings indicate that in patients with SSD and CT, delayed response to antipsychotics could be expected, and a longer evaluation period before considering change of medication may be recommended.
The THz atmospheric windows centered at roughly 1.3 and 1.5~THz, contain numerous spectral lines of astronomical importance, including three high-J CO lines, the N+ line at 205 microns, and the ...ground transition of para-H2D+. The CO lines are tracers of hot (several 100K), dense gas; N+ is a cooling line of diffuse, ionized gas; the H2D+ line is a non-depleting tracer of cold (~20K), dense gas. As the THz lines benefit the study of diverse phenomena (from high-mass star-forming regions to the WIM to cold prestellar cores), we have built the CO N+ Deuterium Observations Receiver (CONDOR) to further explore the THz windows by ground-based observations. CONDOR was designed to be used at the Atacama Pathfinder EXperiment (APEX) and Stratospheric Observatory For Infrared Astronomy (SOFIA). CONDOR was installed at the APEX telescope and test observations were made to characterize the instrument. The combination of CONDOR on APEX successfully detected THz radiation from astronomical sources. CONDOR operated with typical Trec=1600K and spectral Allan variance times of 30s. CONDOR's first light observations of CO 13-12 emission from the hot core Orion FIR4 (= OMC1 South) revealed a narrow line with T(MB) = 210K and delta(V)=5.4km/s. A search for N+ emission from the ionization front of the Orion Bar resulted in a non-detection. The successful deployment of CONDOR at APEX demonstrates the potential for making observations at THz frequencies from ground-based facilities.
Antipsychotic treatment may improve clinical insight. However, previous studies have reported inconclusive findings on whether antipsychotics improve insight over and above the reduction in symptoms ...of psychosis. These studies assessed homogeneous samples in terms of stage of illness. Randomised studies investigating a mixed population of first- and multiepisode schizophrenia spectrum disorders might clarify this disagreement.
Our data were derived from a pragmatic, rater-blinded, semi-randomised trial that compared the effectiveness of amisulpride, aripiprazole and olanzapine. A sample of 144 patients with first- or multiepisode schizophrenia spectrum disorders underwent eight assessments during a 1-year follow-up. Clinical insight was assessed by item General 12 from the Positive and Negative Syndrome Scale (PANSS). We analysed latent growth curve models to test if the medications had a direct effect on insight that was over and above the reduction in total psychosis symptoms. Furthermore, we investigated whether there were differences between the study drugs in terms of insight.
Based on allocation analysis, all three drugs were associated with a reduction in total psychosis symptoms in the initial phase (weeks 0-6). Amisulpride and olanzapine were associated with improved insight over and above what was related to the reduction in total psychosis symptoms in the long-term phase (weeks 6-52). However, these differential effects were lost when only including the participants that chose the first drug in the randomisation sequence. We found no differential effect on insight among those who were antipsychotic-naïve and those who were previously medicated with antipsychotics.
Our results suggest that antipsychotic treatment improves insight, but whether the effect on insight surpasses the effect of reduced total psychosis symptoms is more uncertain.
ClinicalTrials.gov Identifier: NCT01446328, 05.10.2011.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
Sickle cell disease is an autosomal recessive, multisystem disorder, characterised by chronic haemolytic anaemia, painful episodes of vaso-occlusion, progressive organ failure and a reduced life ...expectancy. Sickle cell disease is the most common monogenetic disease, with millions affected worldwide. In well-resourced countries, comprehensive care programs have increased life expectancy of sickle cell disease patients, with almost all infants surviving into adulthood. Therapeutic options for sickle cell disease patients are however, still scarce. Predictors of sickle cell disease severity and a better understanding of pathophysiology and (epi)genetic modifiers are warranted and could lead to more precise management and treatment. This review provides an extensive summary of the pathophysiology and management of sickle cell disease and encompasses the characteristics, complications and current and future treatment options of the disease.
Abstract Bemfola (follitropin alfa) (Finox AG, Switzerland), a new recombinant FSH, has a comparable pharmacological profile to that of Gonal-f (Merck Serono, Germany), the current standard for ...ovarian stimulation. A randomized, multi-centre, Phase 3 study in women undergoing IVF or intracytoplasmic sperm injection ( n = 372) showed Bemfola yielding similar efficacy and safety profiles to Gonal-f. Women aged 20–38 years of age were randomized 2:1 to receive a single, daily, subcutaneous 150 IU dose of either Bemfola or Gonal-f. This study tested equivalence in the number of retrieved oocytes using a pre-determined clinical equivalence margin of ±2.9 oocytes. Compared with Gonal-f, Bemfola treatment resulted in a statistically equivalent number of retrieved oocytes (Bemfola 10.8 ± 5.11 versus Gonal-f 10.6 ± 6.06, mean difference: 0.27 oocytes, 95% confidence interval: −1.34, 1.32) as well as a similar clinical pregnancy rate per embryo transfer in first and second cycles (Bemfola: 40.2% and 38.5%, respectively; Gonal-f: 48.2% and 27.8%, respectively). No difference in severe ovarian hyperstimulation syndrome was observed between treatment groups (Bemfola: 0.8%; Gonal-f: 0.8%). This study demonstrates similar clinical efficacy and safety profiles between Bemfola and Gonal-f, and suggests that Bemfola can be an appropriate alternative in ovarian stimulation protocols.
Depression occurs frequently in all phases of schizophrenia spectrum disorders. Altered activity in the immune system is seen in both depression and schizophrenia. We aimed to uncover depressive ...trajectories in a sample of 144 adult individuals with schizophrenia spectrum disorders followed for one year, in order to identify possible cytokine profile differences. Patients were assessed longitudinally with the Positive and Negative Syndrome Scale (PANSS) and the Calgary Depression Scale for Schizophrenia (CDSS), where a score above 6 predicts depression. The serum cytokine concentrations for tumor necrosis factor (TNF)-alpha, interferon (IFN)-gamma, interleukin (IL)-1beta, IL-2, IL-4, IL-6, IL-10, IL-12p70 and IL-17A were measured using immunoassays. Latent growth curve models, multilevel models and latent class growth analysis (LCGA) were applied. The LCGA model supported three latent classes (trajectories) with differing CDSS profiles during the one-year follow-up: a high CDSS group (40.8 % of participants), a moderate CDSS group (43.9 %) and a low CDSS group (15.3 %). Five single PANSS items predicted affiliation to depressive trajectory: hallucinations, difficulty in abstract thinking, anxiety, guilt feelings and tension. In the high CDSS group, despite diminishing psychotic symptoms, depressive symptoms persisted throughout one year. The pro-inflammatory cytokines IFN-γ, IL-1β and TNF-α were differentially distributed between the depressive trajectories, although levels remained remarkably stable throughout 12 months. Significant changes were found for the anti-inflammatory cytokine IL-10 at baseline with an accompanying difference in change over time. More research is required to optimize future treatment stratification and investigate the contribution of inflammation in depressed patients with schizophrenia spectrum disorders.
PDF
