The effect of cross‐linker 3‐glycidyloxypropyl trimethoxysilane (GPTMS) on the injectability, bioactivity, rheology, washout resistance, and cellular behavior of bio‐nano composite pastes containing ...a sol–gel derived bioactive glass (BG), chitosan (Cn), and gelatin (Gel), were studied. The results indicated that the structural integrity of the samples in the stimulated body fluid (SBF) was improved from 80% to 90% with the increase in the GPTMS content. In addition, the viscosity and injectability of the paste were affected, so that the later changed from 96% to 73% and the former changed from 132 × 103 to 210 × 103 Pa.s, with addition of 20 wt% GPTMS. Furthermore, the bioactivity of the pastes was improved with the use of GPTMS. No toxicity was observed in the cellular studies of the GPTMS containing paste after 7 days, and the cells kept their shape and were attached firmly to the paste surface. The results of the present work showed that the use of GPTMS was beneficial in enhancing the properties of injectable paste.
3D final paste molecular structure consisting of BG/Cn/Gel/GPT.
K2CO3/Glycerin as a deep eutectic solvent (DES) was anchored covalently onto functionalized magnetic nanoparticles and showed a significant activity towards the oxidation of various alcohols under ...mild conditions with a short reaction time and good to high yield. A combination of the magnetic nanoparticles and deep eutectic solvent offers a novel, green, reusable catalyst with easy separation. Also, the catalyst structure was well characterized using techniques such as FT‐IR spectroscopy, XRD, SEM, TGA, BET, VSM, TEM, and energy‐dispersive X‐ray spectroscopy (EDS).
K2CO3/Glycerine as a deep eutectic solvent was anchored covalently onto magnetic Fe3O4@SiO2 core‐shell nanoparticles. This heterogeneous catalyst was effectively used for the selective oxidation of alcohols to corresponding carbonyl products with up to 95 % yields.
Atenolol has been used to treat angina and hypertension, either alone or with other antihypertensives. Despite its usefulness, it shows some side effects such as diarrhea and nausea in some patients. ...A method for slow release of atenolol in intestine is helpful to prevent such side effects.
A facile co-precipitation microwave-assisted method was used to fabricate mesoporous hydroxyapatite nanoparticles (mHAp). It was then functionalized to have SO3H groups. The synthesized material was used for storage/slow release study of atenolol.
Atenolol loaded mHAp shows immediate release of atenolol in pH 8, whileafter functionalizing shows up to ca. 30% release at the beginning. In pH 1, 50% of drug was released after 10 h from AT@mHAp and after 18h the drug was almost completely released.The drug release profiles of functionalized HAp at pH value 1 and 8reveals the complete release of atenolol in intestine pH, while no complete release is observed in stomach environment.
The aims of this work were synthesis and characterization of mesoporous HAp through the microwave-assisted co-precipitation method and elucidate the underlying drug release capability of mesoporous HAp nanoparticles. The SO3H group was incorporated into the mesoporous HAp and then used as drug delivery carriers using atenolol as a model drug to investigate their drug storage/release properties in simulated body fluid (SBF). Increasing pH value to 8 causes increase in the drug release.
As medical research progresses, the derivation and development of biological materials such as hydrogels have steadily gained more interest. The biocompatibility and non-toxicity of chitosan make ...chitosan hydrogels potential carriers for drug delivery. This work aims to develop two multi-reactive, safe, and highly swellable bio-hydrogels consisting of chitosan-graft-glycerol (CS-g-gly) and carboxymethyl chitosan-graft-glycerol (CMCS-g-gly), for sustained and controlled drug release, improved bioavailability along with entrapment in nanocarriers, which reduces side effects of vincristine sulphate. CS-g-gly and CMCS-g-gly are successfully prepared and fully characterized using analytical techniques. Under various conditions, the prepared hydrogels exhibit a high swelling ratio. Vincristine-loaded CS-g-gly (VCR/CS-g-gly), and CMCS-g-gly (VCR/CMCS-g-gly) show high encapsulation efficiency between 72.28-89.97%, and 56.97-71.91%, respectively. VCR/CS-g-gly show a sustained release behavior, and the maximum release of VCR from hydrogels reached 82% after 120 h of incubation. MCF-7 (breast cancer cell line) and MCF-10 (normal breast cell line) are evaluated for cell viability and apoptosis induction. The in-vitro anti-tumor efficacy is investigated using flow cytometry. The tetrazolium-based MTT assay of hydrogels shows no evidence of significant cytotoxicity in MCF-7 and MCF-10 cells. According to these findings, these hydrogels can effectively deliver drugs to MCF-7 and other breast cancer cells.
Based on the significant and diverse pharmacophore features of triazole ring and considering the potent antimicrobial properties of quinoline scaffold, a novel series of 1,2,3‐triazole‐based ...polyaromatic compounds containing chloroquinoline moiety were synthesized through a well‐established synthetic methodology, named click chemistry. The structure of the synthetic compounds was characterized by various spectroscopic methods. The final products of triazole/quinoline hybrids and ((prop‐2‐yn‐1‐yloxy)methyl)benzene intermediates were screened for their antibacterial (Staphylococcus aureus, Escherichia coli, Shigella flexneri, and Salmonella enterica), antifungal (Candida albicans, Saccharomyces cerevisiae, and Aspergillus fumigatus), and cytotoxic activities. The best antifungal compounds exhibited minimum inhibitory concentration (MIC), in the range of 0.35–0.63 µM, against S. cerevisiae without any cytotoxic effect. These compounds can be selected as the potential candidates for treating invasive fungal infections caused by S. cerevisiae, after further investigation. Preliminary in silico ADME studies also predicted the favorable pharmacokinetic attributes of most compounds.
A novel series of 1,2,3‐triazole/quinoline hybrids were synthesized using click chemistry reaction (the copper‐catalyzed azide‐alkyne cycloaddition CuAAC reaction). The final products and ((prop‐2‐yn‐1‐yloxy)methyl)benzene intermediates were screened for their antimicrobial and cytotoxic activities. The best antifungal compounds exhibited minimum inhibitory concentration (MIC), in the range of 0.35–0.63 µM, against S. cerevisiae without any cytotoxic effect.
The nanoporous compound SBA-15 was functionalized using (3-aminopropyl)trimethoxysilane (APTES). Then the obtained product was modified with ellagic acid (ELA), a bioactive polyphenolic compound. The ...structure of the prepared nanoporous composition SBA-15@ELA was extensively characterized and confirmed by various techniques, such as Fourier-transform infrared (FT-IR) spectroscopy, Energy dispersive X-ray (EDX) elemental analysis, scanning electron microscopy (SEM), thermogravimetric analysis (TGA), X-ray diffraction (XRD), transmission electron microscopy (TEM) and N
adsorption-desorption isotherms (BET). The novel, recoverable, heterogenous SBA-15@ELA nanoporous compound was used to investigate its catalytic effect in the synthesis of 4-oxo-quinazoline derivatives (19 examples) with high yields (78-96%), as an important class of nitrogen-containing heterocyclic compounds. The use of an inexpensive mesoporous catalyst with a high surface area, along with easy recovery by simple filtration are among the advantages of this catalysis research work. The catalyst has been used in at least 6 consecutive runs without a significant loss of its activity.
The synthesis of 1,2,3-triazoles with immobilized Cu(I) in thiosemicarbazide-functionalized β-cyclodextrin (Cu@TSC-β-CD) as a supramolecular catalyst was discussed. The catalyst was characterized by ...Fourier-transform infrared spectroscopy (FT-IR), thermogravimetric analysis (TGA), X-ray diffraction (XRD), scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDS), and Inductively Coupled Plasma Optical Emission Spectroscopy (ICP-OES) measurements. The catalyst showed high activity (up to 95% yields of triazole products under optimized reaction conditions), providing a one-pot, atom-economic, and highly regioselective green method for 1,2,3-triazoles synthesis in an azide-alkyne cycloaddition (AAC) protocol in water. High stability and no appreciable leaching of Cu(I) were observed, owing to its strong binding via the coordination with thiosemicarbazide functionality.
Abstract
MOFs compounds with open metal sites, particularly Cu-BTC, have great potential for adsorption and catalysis applications. However, the powdery morphology limits their applications. One of ...the almost new ways to overcome this problem is to trap them in a standing and flexible aerogel matrix to form a hierarchical porous composite. In this work, Cu-BTC/CNC (crystalline nanocellulose) and Cu-BTC/NFC (nanofibrillated cellulose) aerogel composites were synthesized using a direct mixing method by the addition of Cu-BTC powder to the liquid precursor solution followed by gelation and freeze-drying. Also, pure nanocellulose aerogels (CNC and NFC aerogels) have been synthesized from cellulose isolated from peanut shells. Scanning electron microscopy (SEM), Fourier transform infrared (FT-IR) spectra, and X-ray diffraction (XRD) were utilized to evaluate the structure and morphology of the prepared materials. The adsorption ability of pure CNC aerogel and Cu-BTC/NFC aerogel composite for organic dye (Congo Red) and heavy metal ion (Mn
7+
) was studied and determined by the UV–Vis spectrophotometry and inductively-coupled plasma optical emission spectrometry (ICP-OES), respectively. It was concluded that Cu-BTC/NFC aerogel composite shows excellent adsorption capacity for Congo Red. The adsorption process of this composite is better described by the pseudo-second-order kinetic model and Langmuir isotherm, with a maximum monolayer adsorption capacity of 39 mg/g for Congo Red. Nevertheless, CNC aerogel shows no adsorption for Congo Red. Both CNC aerogel and Cu-BTC/NFC aerogel composite act as a monolith standing solid reducer, which means they could remove permanganate ions from water by reducing it into manganese dioxide without releasing any secondary product in the solution.
This manuscript reports an impressive and facile strategy for synthesizing isoxazole derivatives using immobilized Cu (I) in metformin-functionalized β-cyclodextrin as a catalyst. The architecture of ...this catalyst was characterized by different analytical techniques such as Fourier transform infrared spectroscopy, Thermogravimetric analysis, X-ray diffraction, Field emission scanning electron microscopy, and Energy-dispersive X-ray spectroscopy. The catalyst showed remarkable reusability even after 7 consecutive runs.
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