Antimicrobial effects of six Algerian propolis extracts Boufadi, Yasmina Mokhtaria; Soubhye, Jalal; Nève, Jean ...
International journal of food science & technology,
December 2016, Letnik:
51, Številka:
12
Journal Article
Recenzirano
Summary
This study aimed to study the antimicrobial effect of propolis and determine the essential compounds which give it the antimicrobial activity. The antimicrobial effect was investigated for ...six ethyl acetate extracts of propolis (EAPs) collected from different regions of Algeria on four pathogenic strains (Shigella dysenteriae, Shigella sonnei, Staphylococcus aureus and Escherichia coli) and two benefit strains (Bifidobacterium animalis and Lactobacillus rhamnosus). The results obtained in this study indicated that the different EAPs showed potential inhibitory effects on tested pathogenic strains with variable minimum inhibitory concentration (MIC) values of 0.3 and 9 mg ml−1, while the beneficial bacteria showed resistance against EAPs of propolis. The results demonstrated also that the flavonoid compounds have very low MIC values, while phenolic acid compounds have variables MIC values of 1–10 mg ml−1. These results indicated that propolis contains proven substances with antimicrobial activity and are a prelude to the investigations aimed at empowerment of the bee substance as a potential source of antimicrobial agents with multiple outlets.
This study has demonstrated that propolis has good antimicrobial effects against pathogenic strains (but not beneficial bacteria). Polyphenol compounds give this natural product the antimicrobial effects.
Cover Image Tabesh, Homayoun; Riazi, Ali; Mahmoodkhani, Mehdi ...
Clinical case reports,
03/2023, Letnik:
11, Številka:
3
Journal Article
Recenzirano
The cover image is based on the Case Report
Surgical outcomes of calvaria reconstruction in cranial pansynostosis associated with Arnold‐Chiari type 1.5 malformation, a case report
by Homayoun Tabesh ...et al.,
https://doi.org/10.1002/ccr3.6981
.
BACKGROUND The central nervous system (CNS) is a rare point of origin for mature or immature teratomas. However, immature teratomas are extremely rare. CNS teratomas have been known for poor patient ...prognosis and recovery and also reduce survival. However, chemoradiotherapy has been reported to increase patient survival. CASE REPORT This study presents a rare giant immature teratoma invading a newborn infant's brain tissue and CNS. The tumor was surgically removed, and in a further 1-year follow-up, it did not need chemotherapy or radiotherapy according to alpha-fetoprotein (aFP) level and other serum markers. The teratoma had affected multiple loci of his brain's left hemisphere, including parietal, frontal, temporal, and occipital lobes. A teratoma was diagnosed lateral to the midline, which is not common in CNS teratomas, as they mainly occur in or near the midline. The tumor was excised completely. The patient was followed up for 1 year, and no further recurrence was observed. CONCLUSIONS Early diagnosis and treatment of immature teratomas are essential in patient prognosis. Chemotherapy is not always needed, but complete surgical removal and patient follow-up are always a necessity. In addition, adequate follow-up of these patients is critical to evaluate their further treatment plan and recurrence risk.
Celotno besedilo
Dostopno za:
DOBA, IJS, IZUM, KILJ, NUK, PILJ, PNG, SAZU, UILJ, UKNU, UL, UM, UPUK
65.
Cover Image Tabesh, Homayoun; Riazi, Ali; Mahmoodkhani, Mehdi ...
Clinical case reports,
March 2023, Letnik:
11, Številka:
3
Journal Article
Recenzirano
The cover image is based on the Case Report Surgical outcomes of calvaria reconstruction in cranial pansynostosis associated with Arnold‐Chiari type 1.5 malformation, a case report by Homayoun Tabesh ...et al., https://doi.org/10.1002/ccr3.6981.
For the first time, this study presented the use of raw locust bean gum (LBG) as a prebiotic, with one probiotic strain in synbiotic fermented milk or combined with Na-alginate as a biopolymer, for a ...targeted release of bacteria under colon-like conditions. For this purpose, the fermentative characteristics (biomass, pH), bacterial survival, and developed viscosities of the stored fermented milks were determined. The survival rates of microencapsulated bacteria using the emulsion technique under simulated gastrointestinal conditions (stomach: pH 2 + 0.3% pepsin; colon: pH 6.5 + 1% pancreatin + 0.3% bile) were also evaluated. Results showed that all the tested bacteria maintained better biomass and acidifying activities in the presence of LBG, especially at 2%. During cold storage, the viscosities of the LBG-fermented milks were regulated and better appreciated, especially at 2%. Lactobacillus rhamnosus LbRE-LSAS and Bifidobacterium animalis subsp. lactis Bb12 microencapsulated separately in Ca-alginate-raw carob gum maintained good survival rates (51 - 66%) as compared to free cells (21 - 59%) under simulated digestive conditions, and were released under colon-like conditions. Therefore, the formulation of LBG-enriched fermented milks containing probiotic bacteria could represent a very good candidate for industrial application. Ca-alginate-raw LBG beads for the specific release of probiotics in the colon could benefit consumers with celiac disease or other digestive disorders because LBG is naturally gluten-free.
Stinging nettle (Urtica dioica) is a perennial herb that has been used for centuries as a remedy and food ingredient. This study aims to investigate the polyphenolic profile of an extract of U. ...dioica and to evaluate its antioxidant and antimicrobial activity. The total polyphenol content of the extract was determined to be 8.065 mg gallic acid equivalent (± 0.0125), while flavonoids were determined to be 3.93 mg quercetin equivalent (± 0.056) and hy-droxynnamic acids were determined to be 2.159 mg caffeic acid equivalent (± 0.01). Nine flavonoids and seven hydroxycinnamic acids and their derivatives were identified by HPLC-PDA ESI/MS, rutin and ferrulic acid were the most abundant with respectively 2005 and 215 μg/g of fresh nettle. The extract showed significant anti-free radical and antioxidant activity in correlation with its polyphenol content. For the antimicrobial tests evaluated against Gram-positive and Gram-negative bacteria, the polyphenols of U. dioica had an effect on most strains tested, the most sensitive of which were S. aureus and C. albicans. The results obtained confirm the bioactive potentials of nettle polyphenols and their possible food and pharmaceutical applications.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
Background: Traumatic brain injury (TBI) is a major cause of death and disability. TBI can result in neuropsychiatric and cognitive problems as well as neurodegenerative pathologies that can appear ...right after or develop and persist years after injury. Method: We conducted a double-blind, randomized, placebo-controlled clinical trial on patients who suffered from TBI three months to three years ago. The patients were randomized to placebo (n = 34) or K-Vie™ group (n = 46) for a treatment period of 3 months. The main primary outcomes include cognitive assessment in the Rey Auditory Verbal Learning Test-Recognition Test (RAVLT), Wechsler adult intelligence Digit Symbol Substitution Test (DSST) and trail-making test part B (TMT-B). Assessments were performed at baseline and at the month 3 follow-up visit. Linear mixed models were carried out to evaluate cognitive changes from baseline across all cognitive assessment tests. Result: The current study showed significant (p < 0.05) improvement in cognitive function of patients who were given K-Vie™ compared with placebo across the RAVLT, DSST and TMT-B performance assessments. A larger cohort would be beneficial to further confirm the clinical utility of K-Vie™ and assess its effects in acute phases of TBI.
Recent therapeutic approaches for Alzheimer's disease (AD) have had limited success. Considering the association of neuroinflammation with AD symptoms as demonstrated in multiple studies, assessment ...of the clinical efficacy of molecules that reduce systemic or brain inflammation is warranted.
This clinical trial assessed whether boswellic acids can improve cognitive and neuropsychiatric symptoms while reducing inflammation in AD patients.
A double-blind, placebo-controlled, study was conducted on 85 AD patients randomized to boswellic acids (K-Vie™ as the main ingredient in Memowell™) or placebo for 6 months. Clinical Dementia Rating-Sum of Boxes (CDR-SOB) and Mini-Mental State Examination (MMSE) scores were compared to baseline and between groups and constituted the co-primary clinical efficacy endpoints. Secondary outcomes included neuropsychiatric assessment (Neuropsychiatric Inventory-Questionnaire, NPI-Q) and assessment of AD and inflammation biomarkers.
Patients on K-Vie™ showed a 3.1- and 1.6-unit improvement in MMSE and CDR-SOB scores, respectively, when compared to patients on placebo. NPI-Q analysis revealed significant improvement in the K-Vie™ but not in the placebo group. Only mild gastrointestinal side effects were reported in a few patients. Patients on K-Vie™ showed improvement in plasma AD biomarkers and reduction of key inflammatory cytokines including IL-6 and TNF.
Our results support the positive cognitive effects of boswellic acids by reducing the systemic inflammation.
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