Forest edges influence more than half of the world's forests and contribute to worldwide declines in biodiversity and ecosystem functions. However, predicting these declines is challenging in ...heterogeneous fragmented landscapes. Here we assembled a global dataset on species responses to fragmentation and developed a statistical approach for quantifying edge impacts in heterogeneous landscapes to quantify edge-determined changes in abundance of 1,673 vertebrate species. We show that the abundances of 85% of species are affected, either positively or negatively, by forest edges. Species that live in the centre of the forest (forest core), that were more likely to be listed as threatened by the International Union for Conservation of Nature (IUCN), reached peak abundances only at sites farther than 200-400 m from sharp high-contrast forest edges. Smaller-bodied amphibians, larger reptiles and medium-sized non-volant mammals experienced a larger reduction in suitable habitat than other forest-core species. Our results highlight the pervasive ability of forest edges to restructure ecological communities on a global scale.
The isolation of various two-dimensional (2D) materials, and the possibility to combine them in vertical stacks, has created a new paradigm in materials science: heterostructures based on 2D ...crystals. Such a concept has already proven fruitful for a number of electronic applications in the area of ultrathin and flexible devices. Here, we expand the range of such structures to photoactive ones by using semiconducting transition metal dichalcogenides (TMDCs)/graphene stacks. Van Hove singularities in the electronic density of states of TMDC guarantees enhanced light-matter interactions, leading to enhanced photon absorption and electron-hole creation (which are collected in transparent graphene electrodes). This allows development of extremely efficient flexible photovoltaic devices with photoresponsivity above 0.1 ampere per watt (corresponding to an external quantum efficiency of above 30%).
•Coffee is a prominent commodity extensively used worldwide as beverage.•Coffee green seed residue from fixed oil extraction has not been studied yet.•The antioxidant action and the chemical profile ...of this residue were assessed.•This residue can be used as raw material to obtain antioxidant compounds.•This study values green chemistry principles and the reuse of by-products.
Oil extraction from green coffee seeds generates residual mass that is discarded by agribusiness and has not been previously studied. Bioactive secondary metabolites in coffee include antioxidant phenolic compounds, such as chlorogenic acids. Coffee seeds also contain caffeine, a pharmaceutically important methylxanthine. Here, we report the chemical profile, antioxidant activity, and cytotoxicity of hydroethanolic extracts of green Coffea arabica L. seed residue. The extracts of the green seeds and the residue have similar chemical profiles, containing the phenolic compounds chlorogenic acid and caffeine. Five monoacyl and three diacyl esters of trans-cinnamic acids and quinic acid were identified by ultra-performance liquid chromatography/electrospray ionization-quadruple time of flight mass spectrometry. The residue extract showed antioxidant potential in DPPH, ABTS, and pyranine assays and low cytotoxicity. Thus, coffee oil residue has great potential for use as a raw material in dietary supplements, cosmetic and pharmaceutical products, or as a source of bioactive compounds.
The recurrent nova M31N 2008-12a experiences annual eruptions, contains a near-Chandrasekhar-mass white dwarf, and has the largest mass accretion rate in any nova system. In this paper, we present ...Hubble Space Telescope (HST) WFC3/UVIS photometry of the late decline of the 2015 eruption. We couple these new data with archival HST observations of the quiescent system and Keck spectroscopy of the 2014 eruption. The late-time photometry reveals a rapid decline to a minimum luminosity state, before a possible recovery/rebrightening in the run up to the next eruption. Comparison with accretion disk models supports the survival of the accretion disk during the eruptions, and uncovers a quiescent disk mass accretion rate of the order of 10 − 6 M yr − 1 , which may rise beyond 10 − 5 M yr − 1 during the super-soft source phase-both of which could be problematic for a number of well-established nova eruption models. Such large accretion rates, close to the Eddington limit, might be expected to be accompanied by additional mass loss from the disk through a wind and even through collimated outflows. The archival HST observations, combined with the disk modeling, provide the first constraints on the mass donor: L donor = 103 − 11 + 12 L , R donor = 14.14 − 0.47 + 0.46 R , and T eff , donor = 4890 110 K, which may be consistent with an irradiated M31 red-clump star. Such a donor would require a system orbital period 5 days. Our updated analysis predicts that the M31N 2008-12a WD could reach the Chandrasekhar mass in < 20 kyr.
The Andromeda Galaxy recurrent nova M31N 2008-12a had been caught in eruption eight times. The inter-eruption period of M31N 2008-12a is ~1 yr, making it the most rapidly recurring system known, and ...a strong single-degenerate Type Ia supernova progenitor candidate. Following the 2013 eruption, a campaign was initiated to detect the predicted 2014 eruption and to then perform high cadence optical photometric and spectroscopic monitoring using ground-based telescopes, along with rapid UV and X-ray follow-up with the Swift satellite. Here we report the results of a high cadence multi-colour optical monitoring campaign, the spectroscopic evolution, and the UV photometry. We also discuss tantalising evidence of a potentially related, vastly-extended, nebulosity. The 2014 eruption was discovered, before optical maximum, on October 2, 2014. We find that the optical properties of M31N 2008-12a evolve faster than all Galactic recurrent novae known, and all its eruptions show remarkable similarity both photometrically and spectroscopically. Optical spectra were obtained as early as 0.26 days post maximum, and again confirm the nova nature of the eruption. A significant deceleration of the inferred ejecta expansion velocity is observed which may be caused by interaction of the ejecta with surrounding material,possibly a red giant wind. We find a low ejected mass and low ejection velocity, which are consistent with high mass-accretion rate, high mass white dwarf, and short recurrence time models of novae. We encourage additional observations, especially around the predicted time of the next eruption, towards the end of 2015.
Background
Xeroderma pigmentosum (XP) patients present a high risk of developing skin cancer and other complications at an early age. This disease is characterized by mutations in the genes related ...to the DNA repair system.
Objectives
To describe the clinical and molecular findings in a cohort of 32 Brazilian individuals who received a clinical diagnosis of XP.
Methods
Twenty‐seven families were screened for germline variants in eight XP‐related genes.
Results
All patients (N = 32) were diagnosed with bi‐allelic germline pathogenic or potentially pathogenic variants, including nine variants previously undescribed. The c.2251‐1G>C XPC pathogenic variant, reported as the founder mutation in Comorian and Pakistani patients, was observed in 15 cases in homozygous or compound heterozygous. Seven homozygous patients for POLH/XPV variants developed their symptoms by an average age of 7.7 years. ERCC2/XPD, DDB2/XPE and ERCC5/XPG variants were found in a few patients. Aside from melanoma and non‐melanoma skin tumours, a set of patients developed skin sebaceous carcinoma, leiomyosarcoma, angiosarcoma, mucoepidermoid carcinoma, gastric adenocarcinoma and serous ovarian carcinoma.
Conclusions
We reported a high frequency of XPC variants in 32 XP Brazilian patients. Nine new variants in XP‐related genes, unexpected non‐skin cancer lesions and an anticipation of the clinical manifestation in POLH/XPV cases were also described.
Objective
To evaluate the maternal–fetal outcomes of CAB-induced pregnancies in patients with prolactinoma in a large cohort.
Methods
The prevalence of tumor growth, miscarriage, preterm, low birth ...weight, congenital malformations and impairment in neuropsychological development in children among women treated with CAB were assessed in a Brazilian multicentre retrospective observational study,
Results
We included 194 women with a mean age of 31 (17–45) years, 43.6% presenting microadenomas and 56.4% macroadenomas, at prolactinoma diagnosis. In 233 pregnancies, CAB was withdrawn in 89%, after pregnancy confirmation. Symptoms related to tumor growth occurred in 25 cases, more frequently in macroadenomas. The overall miscarriage rate was 11%, although higher in the subgroup of patients with CAB maintainance after pregnancy confirmation (38% vs. 7.5%). Amongst the live-birth deliveries, preterm occurred in 12%, low birth weight in 6% and congenital malformations in 4.3%. Neuropsychological development impairment was reported in 7% of cases.
Conclusions
Our findings confirm previous results of safety in maternal and fetal outcomes in CAB-induced pregnancies; nevertheless, CAB maintenance after pregnancy confirmation was associated with higher miscarriage rate; result that must be further confirmed.
Abstract
It is now well established that exogenous β-1,4-xylanases improve the nutritive value of wheat-based diets for poultry. Among other factors, the mechanism of action of exogenous enzymes may ...involve a microbial route resulting from the generation of prebiotic xylo-oligosaccharides (XOS) in the birds' gastro-intestinal (GI) tract. In a series of three experiments, the effect of XOS on the performance of broilers fed wheat or corn-based diets was investigated. In experiment 1, birds receiving diets supplemented with XOS displayed an increased weight gain (P = 0.08). The capacity of XOS to improve the performance of animals during a longer trial (42 d) was investigated (Experiment 2). The data revealed that diet supplementation with XOS, tested at two incorporation rates (0.1 and 1 g/kg), or with an exogenous β-1,4-xylanase resulted in an increased nutritive value of the wheat-based diet. An improvement in animal performance was accompanied by a shift in the microbial populations colonizing the upper portions of the GI tract. XOS were also able to improve the performance of broilers fed a corn-based diet, although the effects were not apparent at incorporation rates of 10 g/kg. Together these studies suggest that in some cases the capacity of β-1,4-xylanases to improve the nutritive value of wheat-based diets is more related to their ability to produce prebiotic XOS than to their ability to degrade arabinoxylans. The extremely low quantities of XOS used in this study also challenge the depiction of a prebiotic being a quantitatively fermented substrate. These data also bring into question the validity of the "cell wall" mechanism, as XOS elicited an effect with clearly no action on endosperm cell wall integrity and yet the performance effects noted were equivalent or superior to the added enzymes.
ABSTRACT
As the largest radio telescope in the world, the Square Kilometre Array (SKA) will lead the next generation of radio astronomy. The feats of engineering required to construct the telescope ...array will be matched only by the techniques developed to exploit the rich scientific value of the data. To drive forward the development of efficient and accurate analysis methods, we are designing a series of data challenges that will provide the scientific community with high-quality data sets for testing and evaluating new techniques. In this paper, we present a description and results from the first such Science Data Challenge 1 (SDC1). Based on SKA MID continuum simulated observations and covering three frequencies (560, 1400, and 9200 MHz) at three depths (8, 100, and 1000 h), SDC1 asked participants to apply source detection, characterization, and classification methods to simulated data. The challenge opened in 2018 November, with nine teams submitting results by the deadline of 2019 April. In this work, we analyse the results for eight of those teams, showcasing the variety of approaches that can be successfully used to find, characterize, and classify sources in a deep, crowded field. The results also demonstrate the importance of building domain knowledge and expertise on this kind of analysis to obtain the best performance. As high-resolution observations begin revealing the true complexity of the sky, one of the outstanding challenges emerging from this analysis is the ability to deal with highly resolved and complex sources as effectively as the unresolved source population.
Transition metal-doped semiconductors are promising to conduct the future of environmental remediation from photocatalysis. In this study, the role of Mn-doping on the structural, electronic, ...morphological, optical, and photocatalytic properties of the ZnO matrix was investigated combining experimental and theoretical techniques. The Zn
1−
x
Mn
x
O (
x
= 1, 2, 4, and 8 mol%) samples were obtained using the microwave-assisted hydrothermal (MAH) method, while DFT calculations were carried out to complement the experimental characterization. Structural analysis indicates that Mn-doped samples exhibit structural defects that govern their electronic structure, generating singular band-gap values attributed to the perturbation of electronic levels in the vicinity of the Fermi level. The morphological analysis indicates that the Mn doping modifies the morphology of the ZnO powders exhibiting rods, flower-like, and spherical shapes. From photocatalytic measurements, it was observed that Zn
1−
x
Mn
x
O (
x
= 2 and 4 mol%) performs the best for dye degradation, which was associated with a new distribution of the electronic levels and charge carrier mobility. This combined approach was useful for interpreting the photocatalytic activity of Mn-doped ZnO.
Connecting structural, morphological, and electronic features of ZnO:Mn, one improved photocatalyst for dye degradation complemented by DFT calculations.
PDF
