We prepare mixtures of ultracold CaF molecules and Rb atoms in a magnetic trap and study their inelastic collisions. When the atoms are prepared in the spin-stretched state and the molecules in the ...spin-stretched component of the first rotationally excited state, they collide inelastically with a rate coefficient k_{2}=(6.6±1.5)×10^{-11} cm^{3}/s at temperatures near 100 μK. We attribute this to rotation-changing collisions. When the molecules are in the ground rotational state we see no inelastic loss and set an upper bound on the spin-relaxation rate coefficient of k_{2}<5.8×10^{-12} cm^{3}/s with 95% confidence. We compare these measurements to the results of a single-channel loss model based on quantum defect theory. The comparison suggests a short-range loss parameter close to unity for rotationally excited molecules, but below 0.04 for molecules in the rotational ground state.
GOALS: The Great Observatories All-Sky LIRG Survey Armus, L.; Mazzarella, J. M.; Evans, A. S. ...
Publications of the Astronomical Society of the Pacific,
06/2009, Letnik:
121, Številka:
880
Journal Article
Recenzirano
Odprti dostop
The Great Observatories All-Sky LIRG Survey (GOALS20) combines data from NASA’sSpitzer Space Telescope,
Chandra X-Ray Observatory,
Hubble Space Telescope(HST), andGalaxy Evolution Explorer(GALEX) ...observatories, together with ground-based data, into a comprehensive imaging and spectroscopic survey of over 200 low-redshift (
z < 0.088
z
<
0.088
), Luminous Infrared Galaxies (LIRGs). The LIRGs are a complete subset of theIRASRevised Bright Galaxy Sample (RBGS), which comprises 629 extragalactic objects with 60 μm flux densities above 5.24 Jy, and Galactic latitudes above five degrees. The LIRGs targeted in GOALS span the full range of nuclear spectral types defined via traditional optical line-ratio diagrams (type-1 and type-2 AGN, LINERs, and starbursts) as well as interaction stages (major mergers, minor mergers, and isolated galaxies). They provide an unbiased picture of the processes responsible for enhanced infrared emission in galaxies in the local Universe. As an example of the analytic power of the multiwavelength GOALS data set, we presentSpitzer, Chandra, HST,andGALEXimages and spectra for the interacting system VV 340 (IRAS
F14547 + 2449
F
14547
+
2449
). TheSpitzerMIPS imaging data indicates that between 80–95% of the total far-infrared emission (or about5 × 1011 L
⊙
5
×
10
11
L
⊙
) originates in VV 340 north. While theSpitzerIRAC colors of VV 340 north and south are consistent with star-forming galaxies, both theSpitzerIRS andChandraACIS data indicate the presence of an AGN in VV 340 north. The observed line fluxes, without correction for extinction, imply that the AGN accounts for less than 10%–20% of the observed infrared emission. The X-ray data are consistent with a heavily absorbed (
N
H
≥1024 cm-2
N
H
≥
10
24
cm
-
2
) AGN. The GALEX far and near-UV fluxes imply a extremely large infrared “excess” (IRX) for the system (FIR/Ffuv ∼ 81
F
IR
/
F
fuv
∼
81
) which is well above the correlation seen in starburst galaxies. Most of this excess is driven by VV 340 N, which has an IR excess of nearly 400. The VV 340 system seems to be comprised of two very different galaxies: an infrared luminous edge-on galaxy (VV 340 north) that dominates the long-wavelength emission from the system, which hosts a buried AGN; and a face-on starburst (VV 340 south) that dominates the short-wavelength emission.
The production of guidelines for the management of drug-resistant tuberculosis (TB) fits the mandate of the World Health Organization (WHO) to support countries in the reinforcement of patient care. ...WHO commissioned external reviews to summarise evidence on priority questions regarding case-finding, treatment regimens for multidrug-resistant TB (MDR-TB), monitoring the response to MDR-TB treatment, and models of care. A multidisciplinary expert panel used the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach to develop recommendations. The recommendations support the wider use of rapid drug susceptibility testing for isoniazid and rifampicin or rifampicin alone using molecular techniques. Monitoring by sputum culture is important for early detection of failure during treatment. Regimens lasting ≥ 20 months and containing pyrazinamide, a fluoroquinolone, a second-line injectable drug, ethionamide (or prothionamide), and either cycloserine or p-aminosalicylic acid are recommended. The guidelines promote the early use of antiretroviral agents for TB patients with HIV on second-line drug regimens. Systems that primarily employ ambulatory models of care are recommended over others based mainly on hospitalisation. Scientific and medical associations should promote the recommendations among practitioners and public health decision makers involved in MDR-TB care. Controlled trials are needed to improve the quality of existing evidence, particularly on the optimal composition and duration of MDR-TB treatment regimens.
We present imaging data and photometry for the COSMOS survey in 15 photometric bands between 0.3 and 2.4 mu m. These include data taken on the Subaru 8.3 m telescope, the KPNO and CTIO 4 m ...telescopes, and the CFHT 3.6 m telescope. Special techniques are used to ensure that the relative photometric calibration is better than 1% across the field of view. The absolute photometric accuracy from standard-star measurements is found to be 6%. The absolute calibration is corrected using galaxy spectra, providing colors accurate to 2% or better. Stellar and galaxy colors and counts agree well with the expected values. Finally, as the first step in the scientific analysis of these data we construct panchromatic number counts which confirm that both the geometry of the universe and the galaxy population are evolving.
COSMOS: Hubble Space Telescope Observations Scoville, N; Abraham, R. G; Aussel, H ...
The Astrophysical journal. Supplement series,
09/2007, Letnik:
172, Številka:
1
Journal Article
Recenzirano
Odprti dostop
The Cosmic Evolution Survey (COSMOS) was Initiated with an extensive allocation (590 orbits in Cycles 12-13) using the Hubble Space Telescope (HST) for high-resolution imaging. Here we review the ...characteristics of the HST imaging with the Advanced Camera for Surveys (ACS) and parallel observations with NICMOS and WFPC2. A square field (1.8 deg super(2)) has been imaged with single-orbit ACS I-band F814W exposures with 50% completeness for sources 0.5" in diameter at I sub(AB) = 26.0 mag. The ACS is a key part of the COSMOS survey, providing very high sensitivity and high-resolution (0.09" FWHM and 0.05" pixels) imaging and detecting a million objects. These images yield resolved morphologies for several hundred thousand galaxies. The small HST PSF also provides greatly enhanced sensitivity for weak-lensing investigations of the dark matter distribution.
Abstract
We study inelastic collisions between CaF molecules and
87
Rb atoms in a dual-species magneto-optical trap. The presence of atoms increases the loss rate of molecules from the trap. By ...measuring the loss rates and density distributions, we determine a collisional loss rate coefficient
k
2
= (1.43 ± 0.29) × 10
−10
cm
3
s
−1
at a temperature of 2.4 mK. We show that this is not substantially changed by light-induced collisions or by varying the populations of excited-state atoms and molecules. The observed loss rate is close to the universal rate expected in the presence of fast loss at short range, and can be explained by rotation-changing collisions in the ground electronic state.
Aims/hypothesis
Over 50 regions of the genome have been associated with type 1 diabetes risk, mainly using large case/control collections. In a recent genome-wide association (GWA) study, 18 novel ...susceptibility loci were identified and replicated, including replication evidence from 2,319 families. Here, we, the Type 1 Diabetes Genetics Consortium (T1DGC), aimed to exclude the possibility that any of the 18 loci were false-positives due to population stratification by significantly increasing the statistical power of our family study.
Methods
We genotyped the most disease-predicting single-nucleotide polymorphisms at the 18 susceptibility loci in 3,108 families and used existing genotype data for 2,319 families from the original study, providing 7,013 parent–child trios for analysis. We tested for association using the transmission disequilibrium test.
Results
Seventeen of the 18 susceptibility loci reached nominal levels of significance (
p
< 0.05) in the expanded family collection, with 14q24.1 just falling short (
p
= 0.055). When we allowed for multiple testing, ten of the 17 nominally significant loci reached the required level of significance (
p
< 2.8 × 10
−3
). All susceptibility loci had consistent direction of effects with the original study.
Conclusions/interpretation
The results for the novel GWA study-identified loci are genuine and not due to population stratification. The next step, namely correlation of the most disease-associated genotypes with phenotypes, such as RNA and protein expression analyses for the candidate genes within or near each of the susceptibility regions, can now proceed.
Since their inception in the 1970s, the NOAA Geostationary Operational Environmental Satellite (GOES) system has monitored the sources of space weather on the sun and the effects of space weather at ...Earth. These observations are important for providing forecasts, warnings and alerts to many customers, including satellite operators, the power utilities, and NASA’s human activities in space. The GOES magnetometer provides observations of the geomagnetic field, which can be the first indication that significant space weather has reached Earth. In addition, the magnetic field observations are used to identify and forecast the severity of the space weather activity. This paper reviews the capabilities of the GOES-16 magnetometer (MAG) and presents initial post-launch calibration/validation results including issues found in the data. The GOES-16 MAG requirements and capabilities are similar to those for previously flown instruments, measuring three components of the geomagnetic field but with an improved sampling rate of 10 samples/second. The MAG data are low-pass filtered with a 2.5 Hz cutoff compared to the 0.5 Hz cutoff of previous GOES magnetometers. The MAG is composed of two magnetometers, an inboard (closer to spacecraft bus) and outboard (on tip of boom) magnetometer. Presented are the science and instrument requirements, ground and initial on-orbit instrument calibration and data validation. The on-orbit analysis found magnetic contamination along with temperature dependency effects that resulted in unexpected instrument noise and decreased accuracy, with the issues generally more significant on the inboard magnetometer. The outboard sensor was used for initial analysis of MAG performance. Preliminary comparison, excluding arcjet firing periods, between the outboard magnetometer and the GOES-14 magnetometer found a statistical difference of 5 nT at
3
σ
for the total field. This comparison does not consider inaccuracies in the GOES-14 magnetometer. Future studies will focus on optimizing the outboard sensor performance.
Glioblastoma (GBM), being a highly vascularised and locally invasive tumour, is an attractive target for anti-angiogenic and anti-invasive therapies. The GBM/endothelial cell response to ...gossypol/temozolomide (TMZ) treatment was investigated with a particular aim to assess treatment effects on cancer hallmarks.
Cell viability, endothelial tube formation and GBM tumour cell invasion were variously assessed following combined treatment in vitro. The U87MG-luc2 subcutaneous xenograft model was used to investigate therapeutic response in vivo. Viable tumour response to treatment was interrogated using immunohistochemistry. Combined treatment protocols were also tested in primary GBM patient-derived cultures.
An endothelial/GBM cell viability inhibitory effect, as well as an anti-angiogenic and anti-invasive response, to combined treatment have been demonstrated in vitro. A significantly greater anti-proliferative (P=0.020, P=0.030), anti-angiogenic (P=0.040, P<0.0001) and pro-apoptotic (P=0.0083, P=0.0149) response was observed when combined treatment was compared with single gossypol/TMZ treatment response, respectively. GBM cell line and patient-specific response to gossypol/TMZ treatment was observed.
Our results indicate that response to a combined gossypol/TMZ treatment is related to inhibition of tumour-associated angiogenesis, invasion and proliferation and warrants further investigation as a novel targeted GBM treatment strategy.
The spectrum of tumors associated with oncogenic Ras in humans often differs from those in mice either treated with carcinogens or engineered to sporadically express oncogenic Ras, suggesting that ...the mechanism of Ras transformation may be different in humans. Ras stimulates primarily three main classes of effector proteins, Rafs, PI3-kinase, and RalGEFs, with Raf generally being the most potent at transforming murine cells. Using oncogenic Ras mutants that activate single effectors as well as constitutively active effectors, we find that the RalGEF, and not the Raf or PI3-kinase pathway, is sufficient for Ras transformation in human cells. Thus, oncogenic Ras may transform murine and human cells by distinct mechanisms, and the RalGEF pathway--previously deemed to play a secondary role in Ras transformation--could represent a new target for anti-cancer therapy.
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