The transformation of today's electric power sector to a more sustainable energy production based on renewable energies will change the structure of the industry. Consequently, utilities as the major ...stakeholders in this transformation will face new challenges in their way of doing business. They will have to adapt their business models to remain competitive in the new energy landscape. The present review of business model literature shows that two basic choices exist: utility-side business models and customer-side business models. The two approaches follow a very different logic of value creation. While the former is based on a small number of large projects, the latter is based on a large number of small projects. The article reveals that blueprints for utility-side business models are available, whereas customer-side business models are in an early stage of development. Applying the business model framework as an analytical tool, it is found that existing utility-side business models comprise a series of advantages for utilities in terms of revenue potential and risk avoidance. This study provides new insights about why utilities will favor utility-side business models over customer-side business models and why they also should engage in customer-side business models in their quest for more sustainable future business models.
The transformation of the energy industry towards a more sustainable production of electricity increases the importance of distributed generation from renewable sources such as solar photovoltaic ...(PV). German utilities have largely failed to benefit from this development and lost 97% of the distributed PV generation market to investors from outside the electric power industry. Recent studies indicate that utilities have to react to prevent revenue erosion and loss of profits. This study identifies threats and opportunities of distributed PV generation for utilities based on a series of interviews with German utility managers. The key finding is that utilities do not perceive distributed PV as a threat to their current business models nor do they see it as a potential market for them. Relating these findings to the existing literature on transformation processes in other industries leads to the conclusion that the solution for utilities lies in changing their perspective on distributed PV. Utilities could greatly benefit if they did not treat PV as just another source of electricity generation in competition with traditional sources (as they do today), but as a strategic gateway into the emerging distributed generation and service market. Distributed PV could function as a basis for further business model innovation in new growth markets such as energy efficiency and distributed storage. Specific recommendations are provided and a modular value proposition is suggested to help utilities to turn distributed PV from a threat into an attractive business opportunity.
► The energy transition creates a serious business model challenge for utilities. ► German utilities lack adequate business models to benefit from distributed PV generation. ► Changing the perspective on PV could help utilities to overcome existing innovation barriers. ► Recommendations are provided and a modular value proposition is proposed.
Specific sites of lysine methylation on histones correlate with either activation or repression of transcription. The tumour suppressor p53 (refs 4-7) is one of only a few non-histone proteins known ...to be regulated by lysine methylation. Here we report a lysine methyltransferase, Smyd2, that methylates a previously unidentified site, Lys 370, in p53. This methylation site, in contrast to the known site Lys 372, is repressing to p53-mediated transcriptional regulation. Smyd2 helps to maintain low concentrations of promoter-associated p53. We show that reducing Smyd2 concentrations by short interfering RNA enhances p53-mediated apoptosis. We find that Set9-mediated methylation of Lys 372 inhibits Smyd2-mediated methylation of Lys 370, providing regulatory cross-talk between post-translational modifications. In addition, we show that the inhibitory effect of Lys 372 methylation on Lys 370 methylation is caused, in part, by blocking the interaction between p53 and Smyd2. Thus, similar to histones, p53 is subject to both activating and repressing lysine methylation. Our results also predict that Smyd2 may function as a putative oncogene by methylating p53 and repressing its tumour suppressive function.
Celotno besedilo
Dostopno za:
DOBA, IJS, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
Il n’est pas facile de trouver un poète français qui, plus que Baudelaire, ait suscité un aussi grand intérêt chez les traducteurs italiens. Ce sont également, pour la plupart, en particulier ces ...soixante dernières années, des poètes, et souvent des poètes remarquables (je pense à Diego Valeri et Alessandro Parronchi, mais surtout à Giorgio Caproni, Attilio Bertolucci, Carlo Muscetta, Gesualdo Bufalino, Cosimo Ortesta, Mario Luzi, Antonio Prete, Giovanni Raboni...). Si on voulait dresser ici ...
Variables pertaining to the person of the psychotherapist have been neglected in psychotherapy research for some time. Concerning personality in particular, however, research has mostly focused on ...its relation with the psychotherapist's choice of method, or differences between the various major therapy approaches. That is, psychotherapists were compared to each other without specifying how exactly psychotherapists are in comparison to "ordinary people." We wanted to know: Are there specific personality styles that distinguish psychotherapists from the norm? A sample of 1,027 psychotherapists from Germany, Austria, and Switzerland filled out the short version of the Personality Style and Disorder Inventory (PSDI-S) via online survey. The PSDI-S is a self-report questionnaire that assesses 14 personality styles, partly related to the non-pathological equivalents of classifiable personality disorders. The psychotherapists were compared to a normative sample of 3,392 people of different professions. The results could be divided into three groups: (1) Large differences in four personality styles that might contribute to relationship skills and may enable psychotherapists to put their own personal opinion aside, show empathy and appreciation, open themselves to the emotional experience of the patient, and provide a trusting relationship. (2) Moderate differences in seven personality styles that are equally indicative of the professional social skills of the psychotherapists, i.e., they were neither submissive nor passive, not excessively helpful, but also not too self-assertive. (3) Hardly any or no differences regarding a charming (histrionic) style, optimism, and conscientiousness. Gender-specific results revealed that male psychotherapists differed from their female colleagues, but they did so differently than men and women in the normative sample do. The main limitations were that we relied on self-report and did not statistically control for gender, age, and education, when comparing to the norm. As a conclusion, German-speaking psychotherapists show personality styles that we interpret as functional for psychotherapeutic practice but this needs corroboration from studies that use different methods and measures.
PDF
