Songah (Songsong Citengah) merupakan sebuah kesenian yangberkembang di wilayah Desa Citengah Kecamatan Sumedang SelatanKabupaten Sumedang. Menarik untuk diungkap secara mendalam denganfokus pada ...sejarah, proses pewarisan, dan fungsi sosial nilaikebersamaan. Ditulis dengan menggunakan pendekatan kualitatif deskriptifuntuk memahami kearifan lokal terkait dengan fenomena kehidupanpendukungnya, sehingga secara ilmiah diharapkan dapat merangsangsemua pihak untuk mempertahankan eksistensi kesenian kebudayaantradisional yang ternyata mampu dikembangkan menjadi mediapengembangan transformasi nilai kebersamaan bagi masyarakat, dandiharapkan dapat merangsang penelitian dan pengembangan ilmupengetahuan.
Ki Madhari Simon, Ridwan; Narawati, Tati
Mudra : jurnal seni budaya,
06/2022, Letnik:
37, Številka:
3
Journal Article
Recenzirano
Tujuan penulisan artikel ini adalah untuk mengungkap kiprah seorang tokoh dalam membangun dan mengembangkan Lembaga Adat RurukanNabawadatala yang merupakan wadah untuk menyerap aspirasi masyarakat ...melalui berbagai kegiatan untuk meningkatkan citra, nilai, dan tatanan budaya sebagai implementasi dari program Sumedang Puseur Budaya Sunda (SPBS). Pola tri tangtu yang dijadikan pijakan dalam membangun dan mengembangkan budaya daerah setempat masih relevan diterapkan. Penelitian ini menggunakan pendekatan etnografi dan metode kualitatif deskriptif dalam mengungkap berbagai fenomena menarik terkait pesona budaya dan alam Desa Citengah, dengan keterlibatan Ki Madhari sebagai salah satu tokoh masyarakat yang berupaya membangun nilai kebermanfaatan dari kekayaan seni dan budaya, serta anugrah geografis alam yang indah. Hasilnya menunjukkan bahwa tata kelola yang baik dengan pendekatan humanis dari seorang tokoh mampu mencitrakan nilai, dan manfaat kebudayaan menjadi sesuatu yang bernilai estetika dan ekonomi.
Ki Madhari Ridwan Simon; Tati Narawati
Mudra : jurnal seni budaya,
06/2022, Letnik:
37, Številka:
3
Journal Article
Recenzirano
Odprti dostop
Tujuan penulisan artikel ini adalah untuk mengungkap kiprah seorang tokoh dalam membangun dan mengembangkan Lembaga Adat RurukanNabawadatala yang merupakan wadah untuk menyerap aspirasi masyarakat ...melalui berbagai kegiatan untuk meningkatkan citra, nilai, dan tatanan budaya sebagai implementasi dari program Sumedang Puseur Budaya Sunda (SPBS). Pola tri tangtu yang dijadikan pijakan dalam membangun dan mengembangkan budaya daerah setempat masih relevan diterapkan. Penelitian ini menggunakan pendekatan etnografi dan metode kualitatif deskriptif dalam mengungkap berbagai fenomena menarik terkait pesona budaya dan alam Desa Citengah, dengan keterlibatan Ki Madhari sebagai salah satu tokoh masyarakat yang berupaya membangun nilai kebermanfaatan dari kekayaan seni dan budaya, serta anugrah geografis alam yang indah. Hasilnya menunjukkan bahwa tata kelola yang baik dengan pendekatan humanis dari seorang tokoh mampu mencitrakan nilai, dan manfaat kebudayaan menjadi sesuatu yang bernilai estetika dan ekonomi.
Interleukin 6 (IL-6) is a prominent proinflammatory cytokine and has been discussed as a potential biomarker for delayed cerebral ischemia (DCI) following aneurysmal subarachnoid hemorrhage. In the ...present study we have analyzed the time course of serum and cerebrospinal fluid (CSF) IL-6 levels in 82 patients with severe aneurysmal subarachnoid hemorrhage (SAH) requiring external ventricular drains in correlation to angiographic vasospasm, delayed cerebral ischemia, secondary infarctions and other clinical parameters. We observed much higher daily mean IL-6 levels (but also large interindividual variations) in the CSF than the serum of the patients with a peak between days 4 and 14 including a maximum on day 5 after SAH. Individual CSF peak levels correlated significantly with DCI (mean day 4-14 peak, DCI: 26,291 ± 24,159 pg/ml vs. no DCI: 16,184 ± 13,163 pg/ml; P = 0.023). Importantly, CSF IL-6 levels differed significantly between cases with DCI and infarctions and patients with DCI and no infarction (mean day 4-14 peak, DCI with infarction: 37,209 ± 26,951 pg/ml vs. DCI, no infarction: 15,123 ± 11,239 pg/ml; P = 0.003), while findings in the latter patient group were similar to cases with no vasospasm (mean day 4-14 peak, DCI, no infarction: 15,123 ± 11,239 vs. no DCI: 15,840 ± 12,979; P = 0.873). Together, these data support a potential role for elevated CSF IL-6 levels as a biomarker for DCI with infarction rather than for DCI in general. This fits well with a growing body of evidence linking neuroinflammation to ischemia and infarction, but (together with the large interindividual variations observed) limits the diagnostic usefulness of CSF IL-6 levels in SAH patients.
Early postoperative seizures (EPS) are a common complication of brain tumour surgery. This paper investigates risk factors, management and clinical relevance of EPS. We retrospectively analysed the ...occurrence of EPS, clinical and laboratory parameters, imaging and histopathological findings in a cohort of 679 consecutive patients who underwent craniotomies for intracranial tumours between 2015 and 2017. EPS were observed in 34/679 cases (5.1%), with 14 suffering at least one generalized seizure. Patients with EPS had a worse postoperative Karnofsky performance index (KPI; with EPS, KPI < 70 vs. 70-100: 11/108, 10.2% vs. 23/571, 4.0%; p = 0.007). Preoperative seizure history was a predictor for EPS (none vs. 1 vs. ≥ 2 seizures: p = 0.037). Meningioma patients had the highest EPS incidence (10.1%, p < 0.001). Cranial imaging identified a plausible cause in most cases (78.8%). In 20.6%, EPS were associated with a persisting new neurological deficit that could not otherwise be explained. 34.6% of the EPS patients had recurrent seizures within one year. EPS require an emergency work-up. Multiple EPS and recurrent seizures are frequent, which indicates that EPS may also reflect a more chronic condition i.e. epilepsy. EPS are often associated with persisting neurological worsening.
Chronic subdural hematoma (CSDH) is a common neurosurgical condition, especially among elderly patients. Here we have analyzed our institutional experience with surgical management of CSDH. We aimed ...at identifying predictors of hematoma recurrence and cure, and the respective time course.
Pertinent data were collected from all 208 patients (136 males; median age, 78 years) treated for unilateral CSDH in our department from 2014 to 2016 after exclusion of cases with CSDH following previous head surgery or missing postoperative imaging. Pre- and postoperative neuroimaging studies were subjected to computer-assisted volumetric analyses. CSDH composition and anatomy were assessed using a modified Nakaguchi classification.
A total of 67.8% of the patients presented with neurologic deficits, and 51.4% were at least on 1 anticoagulant agent. Burr hole trephinations were performed in 94.7%. The median residual hematoma volume was 35.0 mL (44.1 mL including air). Surgical recurrences were seen in 17.8%. The median time to repeat surgery was 17 days, and 91.9% of recurrences occurred within 60 days. Recurrence rates varied between 36.4% (separated or trabecular subtypes and postoperative CSDH volume ≥35.0 mL) and 3.7% (all other subtypes and postoperative CSDH volume <35.0 mL). A neuroimaging proven cure could be documented in an estimated 90% of cases at 145 days after first surgery.
Postoperative CSDH volume and the Nakaguchi classification subtypes proved the most powerful predictors of recurrence, cure, and the time to recurrence and cure. Although our results demonstrate the important impact of CSDH volume, composition, and anatomy, they also show that other so far unknown factors play a significant role as well.
With increasing rates of cesarean section worldwide and international guidelines advising pre‐incision antibiotics, neonatal exposure to pre‐birth antibiotics is higher than ever before. Emerging ...evidence has raised concern regarding the impact of such antibiotics on the neonatal intestinal microbiota, immune system development and health conditions later in life. This narrative review investigates current protocols for intrapartum prophylactic antibiotics in cesarean section, how this and other factors may affect the neonatal intestinal microbiota and whether intrapartum antibiotics used for cesarean section are linked to the development of allergic disease.
Current guidelines recommend prophylactic antibiotics for all patients having cesarean section. Mode of delivery and antibiotic exposure impact the infant microbiota. The effect of intrapartum antibiotic exposure on longer‐term offspring outcomes requires further evaluation.
The Ensembl project (http://www.ensembl.org) provides genome information for sequenced chordate genomes with a particular focus on human, mouse, zebrafish and rat. Our resources include ...evidenced-based gene sets for all supported species; large-scale whole genome multiple species alignments across vertebrates and clade-specific alignments for eutherian mammals, primates, birds and fish; variation data resources for 17 species and regulation annotations based on ENCODE and other data sets. Ensembl data are accessible through the genome browser at http://www.ensembl.org and through other tools and programmatic interfaces.
Lifestyle factors like poor maternal diet or antibiotic exposure disrupt early life microbiome assembly in infants, increasing the risk of severe lower respiratory infections (sLRI). Our prior ...studies in mice indicated that a maternal low‐fibre diet (LFD) exacerbates LRI severity in infants by impairing recruitment of plasmacytoid dendritic cells (pDC) and consequently attenuating expansion of lung regulatory T (Treg) cells during pneumonia virus of mice (PVM) infection. Here, we investigated whether maternal dietary fibre intake influences Treg cell phenotypes in the mediastinal lymph nodes (mLN) and lungs of PVM‐infected neonatal mice. Using high dimensional flow cytometry, we identified distinct clusters of regulatory T cells (Treg cells), which differed between lungs and mLN during infection, with notably greater effector Treg cell accumulation in the lungs. Compared to high‐fibre diet (HFD)‐reared pups, frequencies of various effector Treg cell subsets were decreased in the lungs of LFD‐reared pups. Particularly, recruitment of chemokine receptor 3 (CXCR3+) expressing Treg cells was attenuated in LFD‐reared pups, correlating with lower lung expression of CXCL9 and CXCL10 chemokines. The recruitment of this subset in response to PVM infection was similarly impaired in pDC depleted mice or following anti‐CXCR3 treatment, increasing immunopathology in the lungs. In summary, PVM infection leads to the sequential recruitment and expansion of distinct Treg cell subsets to the lungs and mLN. The attenuated recruitment of the CXCR3+ subset in LFD‐reared pups increases LRI severity, suggesting that strategies to enhance pDCs or CXCL9/CXCL10 expression will lower immune‐mediated pathogenesis.
High dimensional flow cytometry reveals unique subsets of regulatory T cells essential for preventing severe lung damage in neonatal mice experiencing acute lower respiratory infection.
Negative pressure wound therapy (NPWT) for deep spinal wound infections after exposure or opening of the dura can carry significant risks (i.e., cerebrospinal fluid infections and fistulas). In the ...present study, we reviewed a fairly large and recent experience with such patients.
We identified 25 patients with exposure and/or incision of the dura who had undergone NPWT from January 2014 to June 2018 for deep spinal wound infections. The demographic data, specifics of primary surgery and NPWT (i.e., dressing changes, duration, time required for wound healing), patients' clinical course, outcomes, and microbiological findings were studied. Application of a Granufoam vacuum dressing with a continuous negative pressure of 60 mm Hg was performed after proper debridement.
Of the 25 patients, 13 were women and 12 were men (median age, 69 years). They had primarily undergone treatment for spinal tumors (n = 7), infections and degenerative disease (n = 8 each), or fractures (n = 2), with instrumentation in 18 patients (72%). The dura was exposed in all 25 patients and had been incised in 10 (40%) patients (intended incision, 3; accidental incision, 7). Most patients had been treated for a lumbar wound infection (64%). A microorganism was detected in 84% of the cases, with Staphylococcus aureus accounting for most of the infections (48%). NPWT was concluded after a median of 4 dressing changes (range, 2–14) and 19 days (range, 10–70), with no implant removal required in any patient. NPWT application was observed to be safe without cerebrospinal fluid-related complications. The presence of comorbidities (28% had diabetes) had no effect on the treatment results.
NPWT can be safely applied for deep spinal wound infections after dura exposure or durotomy during previous spine surgery.
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