Quantitative approaches to evolutionary biology traditionally consider evolutionary change in isolation from an important pressure in natural selection: the demography of coevolving populations. In ...Analysis of Evolutionary Processes, Fabio Dercole and Sergio Rinaldi have written the first comprehensive book on Adaptive Dynamics (AD), a quantitative modeling approach that explicitly links evolutionary changes to demographic ones. The book shows how the so-called AD canonical equation can answer questions of paramount interest in biology, engineering, and the social sciences, especially economics. After introducing the basics of evolutionary processes and classifying available modeling approaches, Dercole and Rinaldi give a detailed presentation of the derivation of the AD canonical equation, an ordinary differential equation that focuses on evolutionary processes driven by rare and small innovations. The authors then look at important features of evolutionary dynamics as viewed through the lens of AD. They present their discovery of the first chaotic evolutionary attractor, which calls into question the common view that coevolution produces exquisitely harmonious adaptations between species. And, opening up potential new lines of research by providing the first application of AD to economics, they show how AD can explain the emergence of technological variety.
Knowledge of the shape of the mass spectrum of compact objects can be used to help break the degeneracy between the mass and redshift of the gravitational wave (GW) sources and thus can be used to ...infer cosmological parameters in the absence of redshift measurements obtained from electromagnetic observations. In this paper, we study extensively different aspects of this approach, including its computational limits and achievable accuracy. Focusing on ground-based detectors with current and future sensitivities, we first perform the analysis of an extensive set of simulated data using a hierarchical Bayesian scheme that jointly fits the source population and cosmological parameters. We consider a population model (power-law plus Gaussian) which exhibits characteristic scales (extremes of the mass spectrum, presence of an accumulation point modeled by a Gaussian peak) that allow an indirect estimate of the source redshift. Our analysis of this catalog highlights and quantifies the tight interplay between source population and cosmological parameters, as well as the influence of initial assumptions (whether formulated on the source or cosmological parameters). We then validate our results by an "end-to-end" analysis using simulated GW h (t) data and posterior samples generated from Bayesian samplers used for GW parameter estimation, thus mirroring the analysis chain used for observational data for the first time in literature. Our results then lead us to re-examine the estimation of H0 obtained with GWTC-1 in Abbott et al. LIGO Scientific, Virgo Collaborations, Astrophys. J. 909, 218 (2021), and we show explicitly how population assumptions impact the final H0 result. Together, our results underline the importance of inferring source population and cosmological parameters simultaneously (and not separately as is often assumed). The only exception, as we discuss, is if an electromagnetic counterpart was to be observed for all the BBH events; then, the population assumptions have less impact on the estimation of cosmological parameters.
Background
Complex regional pain syndrome type I (CRPS I), formerly known as reflex sympathetic dystrophy (RSD), is a chronic painful disorder that usually develops after a minor injury to a limb. ...This topical review gives a synopsis of CRPS I and discusses the current concepts of our understanding of CRPS I in adults, the diagnosis, and treatment options based on the limited evidence found in medical literature. CRPS I is a multifactorial disorder. Possible pathophysiological mechanisms of CRPS I are classic and neurogenic inflammation, and maladaptive neuroplasticity. At the level of the central nervous system, it has been suggested that an increased input from peripheral nociceptors alters the central processing mechanisms.
Methods
A literature search was conducted using, as electronic bibliographic database, Medline from 1980 until 2014.
Results
An early diagnosis and multidisciplinary treatment are necessary to prevent permanent disability.
Conclusions
The pharmacological treatment of CRPS I is empirical and insufficiently effective. Further research is needed regarding the therapeutic modalities discussed in the guidelines. Physical therapy is widely recommended as a first‐line treatment. The efficacy of local anesthetic sympathetic blockade as treatment for CRPS I is questionable.
We aimed to investigate the differences in plasma concentrations and in intakes of amino acids between male meat-eaters, fish-eaters, vegetarians and vegans in the Oxford arm of the European ...Prospective Investigation into Cancer and Nutrition.
This cross-sectional analysis included 392 men, aged 30-49 years. Plasma amino acid concentrations were measured with a targeted metabolomic approach using mass spectrometry, and dietary intake was assessed using a food frequency questionnaire. Differences between diet groups in mean plasma concentrations and intakes of amino acids were examined using analysis of variance, controlling for potential confounding factors and multiple testing.
In plasma, concentrations of 6 out of 21 amino acids varied significantly by diet group, with differences of -13% to +16% between meat-eaters and vegans. Concentrations of methionine, tryptophan and tyrosine were highest in fish-eaters and vegetarians, followed by meat-eaters, and lowest in vegans. A broadly similar pattern was seen for lysine, whereas alanine concentration was highest in fish-eaters and lowest in meat-eaters. For glycine, vegans had the highest concentration and meat-eaters the lowest. Intakes of all 18 dietary amino acids differed by diet group; for the majority of these, intake was highest in meat-eaters followed by fish-eaters, then vegetarians and lowest in vegans (up to 47% lower than in meat-eaters).
Men belonging to different habitual diet groups have significantly different plasma concentrations of lysine, methionine, tryptophan, alanine, glycine and tyrosine. However, the differences in plasma concentrations were less marked than and did not necessarily mirror those seen for amino acid intakes.
The cradle to grave carbon footprint (CF) and energy footprint (EF) analysis of extra virgin olive oil (EVOO) produced in the Province of Perugia (Umbria, Italy) is assessed. In this study, olive ...orchard cultivation, EVOO extraction, bottling, packaging, storage at −18°C and distribution in the main importing countries were studied from a life cycle assessment perspective, with the main objective of identifying the processes with the largest environmental impacts. The selected functional unit was 1L of EVOO, packaged for distribution. Inventory data was gathered mainly through both direct communication using questionnaires and direct measurements. To determine the CF the ISO/TS 14067:2013 was followed while the EF was evaluated according to ISO standards 14040 and 14044. Results showed that the most impacting process is the distribution, mainly due to the choice of employing air transport. The main other hot spots identified were the olive orchard fertilization, EVOO freezing during its storage at the olive mill factory and the manufacture of glass bottles. Suggested improvement opportunities included shifts in the EVOO transportation policy, the introduction of lighter glass bottles in the bottling process, the use of cooling agent with lower global warming potential and the employment of biodiesel in the farming machineries.
•Carbon footprint and energy footprint are calculated by LCA methodology.•Extra virgin olive oil supply chain is investigated by “cradle-to-grave” analysis.•IPCC approach is used to calculate direct and indirect N2O emissions from fertilizer use.•Product distribution to customer and final disposal are included in system boundaries.•Main GHG emission sources are identified and possibilities for reduction are proposed.
•Ternary PLA nano-biocomposites with synthesized cellulose and silver were developed.•The functionalization of the CNC surface favoured its dispersion in the PLA matrix.•The combination of cellulose ...and silver particles increased the barrier properties.•Overall and specific migration values were well below the limits indicated by EFSA.•Nano-biocomposites showed a significant antibacterial activity due to the Ag effect.
Ternary nano-biocomposite films based on poly(lactic acid) (PLA) with modified cellulose nanocrystals (s-CNC) and synthesized silver nanoparticles (Ag) have been prepared and characterized. The functionalization of the CNC surface with an acid phosphate ester of ethoxylated nonylphenol favoured its dispersion in the PLA matrix. The positive effects of the addition of cellulose and silver on the PLA barrier properties were confirmed by reductions in the water permeability (WVP) and oxygen transmission rate (OTR) of the films tested. The migration level of all nano-biocomposites in contact with food simulants were below the permitted limits in both non-polar and polar simulants. PLA nano-biocomposites showed a significant antibacterial activity influenced by the Ag content, while composting tests showed that the materials were visibly disintegrated after 15 days with the ternary systems showing the highest rate of disintegration under composting conditions.
Is labour, both at term and preterm, associated with alterations in decidual lymphocyte densities and widespread changes to the decidual transcriptome?
The onset of parturition, both at term and ...preterm, is associated with widespread gene expression changes in the decidua, many of which are related to inflammatory signalling, but is not associated with changes in the number of any of the decidual lymphocyte populations examined.
Given its location, directly at the maternal-foetal interface, the decidua is likely to play a pivotal role in the onset of parturition, however, the molecular events occurring in the decidua in association with the onset of labour, both at term and preterm, remain relatively poorly defined. Using flow cytometry and microarray analysis, the present study aimed to investigate changes to the immune cell milieu of the decidua in association with the onset of parturition and define the decidual gene signature associated with term and preterm labour (PTL).
This study used decidual samples collected from 36 women across four clinical groups: term (38-42 weeks of gestation) not in labour, TNL; term in labour, TL; preterm (<35 weeks of gestation)not in labour, PTNL; and preterm in labour, PTL.
Decidual lymphocytes were isolated from fresh decidual tissue collected from women in each of our four patient groups and stained with a panel of antibodies (CD45, CD3, CD19, CD56, CD4, CD8 and TCRVα24-Jα18) to investigate lymphocyte populations present in the decidua (TNL, n = 8; TL, n = 7; PTNL, n = 5; PTL, n = 5). RNA was extracted from decidual tissue and subjected to Illumina HT-12v4.0 BeadChip expression microarrays (TNL, n = 11; TL, n = 8; PTNL, n = 7; PTL, n = 10). Quantitative real-time PCR (qRT-PCR) was used to validate the microarray results.
The relative proportions of decidual lymphocytes (T cells, NK cells, B cells and invariant natural killer (iNKT) cells) were unaffected by either gestation or labour status. However, we found elevated expression of the non-classical MHC-protein, CD1D, in PTL decidua samples (P < 0.05), suggesting the potential for increased activation of decidual invariant NKT (iNKT) cells in PTL. Both term and PTL were associated with widespread gene expression changes, particularly related to inflammatory signalling. Up-regulation of candidate genes in TL (IL-6, PTGS2, ATF3, IER3 and TNFAIP3) and PTL (CXCL8, MARCO, LILRA3 and PLAU) were confirmed by qRT-PCR analysis.
Microarray data are available at www.ebi.ac.uk/arrayexpress under accession number E-MTAB-5353.
Whilst no changes in lymphocyte number were observed across our patient samples, we did not investigate the activation state of any of the immune cell sub-populations examined, therefore, it is possible that the function of these cells may be altered in association with labour onset. Additionally, the results of our transcriptomic analyses are descriptive and at this stage, we cannot prove direct causal link with the up-regulation of any of the genes examined and the onset of either term or PTL.
Our findings demonstrate that the onset of parturition is associated with widespread changes to the decidual transcriptome, and there are distinct gene expression changes associated with term and PTL. We confirmed that an inflammatory signature is present within the decidua, and we also report the up-regulation of several genes involved in regulating the inflammatory response. The identification of genes involved in regulating the inflammatory response may provide novel molecular targets for the development of new, more effective therapies for the prevention of preterm birth (PTB). Such targets are urgently required.
This work was supported by Medical Research Council (grant number MR/L002657/1) and Tommy's, the baby charity. Jane Norman has had research grants from the charity Tommy's and from the National Institute for Health Research on PTB during the lifetime of this project. Jane Norman also sits on a data monitoring committee for GSK for a study on PTB prevention and her institution receives financial recompense for this. The other authors do not have any conflicts of interest to declare.
Aims
Increased N deposition may cause nutritional imbalances in tropical ecosystems, by shifting N:P stoichiometry (as they are typically P-limited) and NH
4
-N:NO
3
-N ratios throughout their ...compartments. Based on this assumption, we aimed at verifying if the anthropogenic N deposition are inducing nutritional imbalances in trees, litter and soil in the remaining Atlantic Forest in SE Brazil.
Methods
Three forest remnants were selected, one of them supposedly exposed to lower levels anthropogenic N deposition (peri-urban forest) than the other two (urban and agricultural-urban forests). We measured NO
2
concentrations, wet and dry deposition of NH
4
-N, NO
3
-N and PO
4
-P and determined total/soluble N and P contents in samples of pioneer and non-pioneer trees, litter and soil. NH
4
-N:NO
3
-N and N:P ratios were calculated in all compartments.
Results
Multivariate analysis indicated associations between NH
4
-N, PO
4
-P and NH
4
:NO
3
ratios in atmospheric deposition or NO
2
concentrations and N and P contents in trees, litter and soil of all forest remnants. The comparison of N:P ratios in tree species and litter with those from studies conducted in the 1980–2000 indicated a tendency of N enrichment and increasing P scarcity in the Atlantic Forest remnants studied.
Conclusions
Confirming the hypothesis, anthropogenic N deposition increases nutritional imbalances in the ecosystem compartments of forest remnants studied. The peri-urban forest showed to be more vulnerable to nutritional imbalances than the other forests, based on the comparisons with data from 30 to 40 years ago.
Summary Background Associations between circulating concentrations of oestrogens, progesterone, and androgens with breast cancer and related risk factors in premenopausal women are not well ...understood. We aimed to characterise these associations with a pooled analysis of data from seven studies. Methods Individual participant data for prediagnostic sex hormone and sex hormone-binding globulin (SHBG) concentrations were contributed from seven prospective studies. We restricted analyses to women who were premenopausal and younger than 50 years at blood collection, and to women with breast cancer diagnosed before age 50 years. We estimated odds ratios (ORs) with 95% CIs for breast cancer associated with hormone concentrations by conditional logistic regression in cases and controls matched for age, date of blood collection, and day of cycle, with stratification by study and further adjustment for cycle phase. We examined associations of hormones with risk factors for breast cancer in control women by comparing geometric mean hormone concentrations in categories of these risk factors, adjusted for study, age, phase of menstrual cycle, and body-mass index (BMI). All statistical tests were two-sided. Findings We included data for up to 767 women with breast cancer and 1699 controls in the risk analyses. Breast cancer risk was associated with a doubling in concentrations of oestradiol (OR 1·19, 95% CI 1·06–1·35), calculated free oestradiol (1·17, 1·03–1·33), oestrone (1·27, 1·05–1·54), androstenedione (1·30, 1·10–1·55), dehydroepiandrosterone sulphate (1·17, 1·04–1·32), testosterone (1·18, 1·03–1·35), and calculated free testosterone (1·08, 0·97–1·21). Breast cancer risk was not associated with luteal phase progesterone (doubling in concentration OR 1·00, 95% CI 0·92–1·09), and adjustment for other factors had little effect on any of these ORs. Cross-sectional analyses in control women showed several associations of sex hormones with breast cancer risk factors. Interpretation Circulating oestrogens and androgens are positively associated with the risk for breast cancer in premenopausal women. Funding Cancer Research UK.
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