SARS-CoV-2 Antibodies in Breast Milk After Vaccination Romero Ramírez, Dolores Sabina; Lara Pérez, María Magdalena; Carretero Pérez, Mercedes ...
Pediatrics (Evanston),
11/2021, Letnik:
148, Številka:
5
Journal Article
Recenzirano
Odprti dostop
Passive and active immunity transfer through human milk (HM) constitutes a key element in the infant's developing immunity. Certain infectious diseases and vaccines have been described to induce ...changes in the immune components of HM.
We conducted a prospective cohort single-institution study from February 2 to April 4, 2021. Women who reported to be breastfeeding at the time of their coronavirus disease 2019 (COVID-19) vaccination were invited to participate. Blood and milk samples were collected on day 14 after their second dose of the vaccine. Immunoglobulin G (IgG) antibodies against nucleocapsid protein as well as IgG, immunoglobulin M and immunoglobulin A (IgA) antibodies against the spike 1 protein receptor-binding domain against severe acute respiratory syndrome coronavirus 2 (anti-SARS-CoV-2 RBD-S1) were analyzed in both serum and HM samples.
Most of the participants (ie, 94%) received the BNT162b2 messenger RNA COVID-19 vaccine. The mean serum concentration of anti-SARS-CoV-2 RBD-S-IgG antibodies in vaccinated individuals was 3379.6 ± 1639.5 binding antibody units per mL. All vaccinated study participants had anti-SARS-CoV-2 RBD-S1-IgG, and 89% of them had anti-SARS-CoV-2 RBD-S-IgA in their milk. The antibody concentrations in the milk of mothers who were breastfeeding 24 months were significantly higher than in mothers with breastfeeding periods <24 months (
< .001).
We found a clear association between COVID-19 vaccination and specific immunoglobulin concentrations in HM. This effect was more pronounced when lactation periods exceeded 23 months. The influence of the lactation period on immunoglobulins was specific and independent of other variables.
The parotid gland is an anatomical
variation that may be present in up to 20%
of the population, being, in most cases,
asymptomatic and, in many of them, of
unknown existence. In this article we ...include a
review of the bibliography of this anatomical
variant which is presented as a result of a
clinical case diagnosed in a newborn in our
hospital. Our patient is a preterm newborn
of 34 weeks who was hospitalized in neonatal
ICU due to prematurity, underweight and
IUGR type II. During his hospitalization doctors
find out a swelling in both cheeks which was
confirmed with ultrasounds and diagnosed of
bilateral accessory parotid gland
La glándula parótida accesoria es una
variante anatómica que puede estar presente
hasta en un 20% de la población, siendo, en
la mayoría de los casos asintomática y, en
muchos de ellos, de existencia desconocida.
En este artículo se presenta una revisión de la
bibliografía de esta variante anatómica a raíz
de un caso clínico diagnosticado en un recién
nacido en nuestro hospital. Se trata de un
recién nacido pretérmino de 34 semanas de
edad gestacional que ingresa en UCI neonatal
por prematuridad, bajo peso y CIR tipo II.
Durante su estancia hospitalaria se objetiva
la presencia de una tumefacción en ambas
mejillas que tras estudio ultrasonográfico se
diagnostica de glándula parótida accesoria
bilateral, indicando la observación como
única actitud terapéutica
We know as wet navel those which, after
the fall of the umbilical cord, presents se- cretion. We can divide the causes of wet
navel in infectious (omphalitis) or malfor- mative, due to lack of ...obliteration of the
embryonic structures (persistence of the
omphalomesenteric or urachal duct). This
article presents a review of the bibliogra- phy of these anomalies due to a case in
a newborn in our hospital. It is a preterm
newborn of 31 + 4 weeks of gestational
age who is admitted to the Neonatal In- tensive Unit Care because of prematurity
and respiratory distress. During his hospi- talization we notice a wet umbilical cord
secondary to a malformation, whose diag- nosis is not settled down until surgery.
Se conoce como ombligo húmedo aquel
que después de la caída del cordón umbili- cal presenta secreción. Podemos dividir en
dos las causas de ombligo húmedo: infec- ciosas (onfalitis) o malformativos, por falta
de obliteración de las estructuras embrio- narias (persistencia del conducto onfalo- mesentérico o del uraco). En este artículo
se presenta una revisión de la bibliografía
de estas anomalías a raíz de un caso clínico
de quiste de uraco en un recién nacido en
nuestro hospital. Se trata de un recién na- cido pretérmino de 31+4 semanas de edad
gestacional que ingresa en UCI neonatal
por prematuridad y dificultad respiratoria.
Durante su estancia hospitalaria se objeti- va un cordón umbilical húmedo secunda- rio a causa malformativa cuyo diagnóstico
no es del todo claro hasta su intervención
quirúrgica.
PDF
