To the Editor:
In a recent study, Moran et al. (April 26 issue)
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demonstrated that misoprostol, a prostaglandin E
1
analogue, markedly reduced the incidence of acute rejections in renal-transplant ...recipients treated with cyclosporine and prednisone. The decreased rate of acute graft rejection was attributed to a significant improvement in renal function, whereas a direct immunosuppressive effect of misoprostol was excluded. However, a possible effect of misoprostol on cyclosporine-mediated immunosuppression was not considered.
We have previously reported that cyclosporine inhibits the function of human lectin-inducible cytotoxic effector cells by stimulating the production of prostaglandin E.
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Furthermore, the depression of . . .
