Cardiovascular (CV) and neuro-psychiatric (NP) diseases are highly prevalent in the elderly and frequently co-occur. Which is the impact of their combination on mobility limitation and disability is ...not known. We here assess the longitudinal association between CV and NP multimorbidity and mobility limitation and disability in older adults.
Population-based study involving 3353 60+ year-old participants from the Swedish National Study of Aging and Care (SNAC-K). Multimorbidity was defined as the presence of 2+ diseases. We used linear mixed models to assess the impact of CV and NP multimorbidity on walking speed (m/s) and 6 activities of daily living (ADL), over a 9-year follow-up period. Trajectories of walking speed and ADL are provided.
In our sample, (mean age 75 years; 65% females), participants with one CV disease (-0.14 m/s; 95%CI -0.22 to -0.06) and those with CV multimorbidity (-0.12 m/s; 95%CI -0.22 to -0.01) presented the highest decrease in walking speed after 9 years, as compared with participants free from CV and NP diseases. Conversely, participants with NP multimorbidity, alone (-1.58 ADL; 95%CI -1.09 to -2.08) or in association with CV diseases (-1.70 ADL; 95%CI -1.15 to -2.24) presented the highest decrease in ADL after 9 years, as compared with participants free from CV and NP diseases.
Cardiovascular and neuro-psychiatric multimorbidity affect differently mobility and functional ability of older adults.
Abstract
Pseudo‐octahedral M
II
6
L
4
capsules result from the subcomponent self‐assembly of 2‐formylphenanthroline, threefold‐symmetric triamines, and octahedral metal ions. Whereas neutral ...tetrahedral guests and most of the anions investigated were observed to bind within the central cavity, tetraphenylborate anions bound on the outside, with one phenyl ring pointing into the cavity. This binding configuration is promoted by the complementary arrangement of the phenyl rings of the intercalated guest between the phenanthroline units of the host. The peripherally bound, rapidly exchanging tetraphenylborate anions were found to template an otherwise inaccessible capsular structure in a manner usually associated with slow‐exchanging, centrally bound agents. Once formed, this cage was able to bind guests in its central cavity.
Pseudo-octahedral M(II) 6 L4 capsules result from the subcomponent self-assembly of 2-formylphenanthroline, threefold-symmetric triamines, and octahedral metal ions. Whereas neutral tetrahedral ...guests and most of the anions investigated were observed to bind within the central cavity, tetraphenylborate anions bound on the outside, with one phenyl ring pointing into the cavity. This binding configuration is promoted by the complementary arrangement of the phenyl rings of the intercalated guest between the phenanthroline units of the host. The peripherally bound, rapidly exchanging tetraphenylborate anions were found to template an otherwise inaccessible capsular structure in a manner usually associated with slow-exchanging, centrally bound agents. Once formed, this cage was able to bind guests in its central cavity.
Statt fest gebundener Moleküle in einem zentralen Hohlraum nutzten J. R. Nitschke et al. zur supramolekularen Templatbildung ein in schnellem Austausch an die Peripherie eines Assoziats gebundenes ...Templat, wie sie in der Zuschrift auf S. 8090 ff. berichten. Damit konnten sie einen pseudooktaedrischen Koordinationskäfig erzeugen, der in Gegenwart eines zentral bindenden Agens nicht entstehen kann. Dank dieses Designprinzips konnte ein templatgebundener Käfig an Wirt‐Gast‐Chemie teilnehmen, ohne dass das peripher gebundene Templat entfernt werden musste.
Pseudo-octahedral M super(II) sub(6)L sub(4 ) capsules result from the subcomponent self-assembly of 2-formylphenanthroline, threefold-symmetric triamines, and octahedral metal ions. Whereas neutral ...tetrahedral guests and most of the anions investigated were observed to bind within the central cavity, tetraphenylborate anions bound on the outside, with one phenyl ring pointing into the cavity. This binding configuration is promoted by the complementary arrangement of the phenyl rings of the intercalated guest between the phenanthroline units of the host. The peripherally bound, rapidly exchanging tetraphenylborate anions were found to template an otherwise inaccessible capsular structure in a manner usually associated with slow-exchanging, centrally bound agents. Once formed, this cage was able to bind guests in its central cavity.Original Abstract: Einer drinnen, einer drausen: Eine Reihe pseudooktaedrischer M super(II) sub(6)L sub(4 )-Komplexe kann gleichzeitig ausen und im Inneren Gastspezies binden. Allerdings finden sich die Komponenten nur in Gegenwart des ausen bindenden Tetraphenylborat-Anions unter Bildung der gewuenschten Architektur zusammen. Die resultierende Struktur kann dann ein Carborat-Anion in ihrem Hohlraum einschliesen.
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