This study was conducted to analyze the profile and publication rate of abstracts in indexed journals presented in the cornea section at the Association for Research in Vision and Ophthalmology ...Annual Meeting and to further identify potential predictive factors for better outcomes.
Abstracts accepted for presentation at the 2013 Association for Research in Vision and Ophthalmology Annual Meeting in the cornea section were sought via PubMed and Scopus to identify whether they had been published as full-text manuscripts. First author's name, time of publication, journal's name, and impact factor were recorded. A multivariate regression was performed to explore the association between variables and both the likelihood of publication and the journal's impact factor. A Kaplan-Meier analysis was performed to evaluate the time course of publication of abstracts.
Of the 939 analyzed abstracts, 360 (38.3%) were published in journals with a median impact factor of 3.4. The median time interval between abstract submission and article publication was 22 months. The multivariate analysis revealed that abstracts were more likely to be published if they were funded (OR=1.482, p=0.005), had a control group (OR=1.511, p=0.016), and had a basic science research scope (OR=1.388, p=0.020). The journal's impact factor was higher in funded studies (β=0.163, p=0.002) but lower in multicenter studies (β=-0.170, p=0.001). The Kaplan-Meier analyses revealed significant differences in the publication time distribution for basic science vs clinical abstracts (χ2=7.636), controlled vs uncontrolled studies (χ2=6.921), and funded vs unfunded research (χ2=13.892) (p<0.05).
Almost 40% of Association for Research in Vision and Ophthalmology abstracts were published within 5 years from submission. Funding support, basic research scope, and controlled design were the determinants of better outcomes of publication.
A search for the electroweak pair production of charged sleptons and weak gauginos decaying into final states with two leptons is performed using 4.7 fb−1 of proton–proton collision data at s=7 TeV ...recorded with the ATLAS experiment at the Large Hadron Collider. No significant excesses are observed with respect to the prediction from Standard Model processes. In the scenario of direct slepton production, if the sleptons decay directly into the lightest neutralino, left-handed slepton masses between 85 and 195 GeV are excluded at 95% confidence level for a 20 GeV neutralino. Chargino masses between 110 and 340 GeV are excluded in the scenario of direct production of wino-like chargino pairs decaying into the lightest neutralino via an intermediate on-shell charged slepton for a 10 GeV neutralino. The results are also interpreted in the framework of the phenomenological minimal supersymmetric Standard Model.
We report a search for first generation scalar leptoquarks using 1.03 fb−1 of proton–proton collisions data produced by the Large Hadron Collider at s=7 TeV and recorded by the ATLAS experiment. ...Leptoquarks are sought via their decay into an electron or neutrino and a quark, producing events with two oppositely charged electrons and at least two jets, or events with an electron, missing transverse momentum and at least two jets. Control data samples are used to validate background predictions from Monte Carlo simulation. In the signal region, the observed event yields are consistent with the background expectations. We exclude at 95% confidence level the production of first generation scalar leptoquark with masses mLQ<660(607) GeV when assuming the branching fraction of a leptoquark to a charged lepton is equal to 1.0 (0.5).
The ATLAS Inner Detector commissioning and calibration Abdesselam, A.; Aleksandrov, I. N.; Argyropoulos, T. ...
The European physical journal. C, Particles and fields,
12/2010, Letnik:
70, Številka:
3
Journal Article
Recenzirano
Odprti dostop
The ATLAS Inner Detector is a composite tracking system consisting of silicon pixels, silicon strips and straw tubes in a 2 T magnetic field. Its installation was completed in August 2008 and the ...detector took part in data-taking with single LHC beams and cosmic rays. The initial detector operation, hardware commissioning and in-situ calibrations are described. Tracking performance has been measured with 7.6 million cosmic-ray events, collected using a tracking trigger and reconstructed with modular pattern-recognition and fitting software. The intrinsic hit efficiency and tracking trigger efficiencies are close to 100%. Lorentz angle measurements for both electrons and holes, specific energy-loss calibration and transition radiation turn-on measurements have been performed. Different alignment techniques have been used to reconstruct the detector geometry. After the initial alignment, a transverse impact parameter resolution of 22.1±0.9 μm and a relative momentum resolution
σ
p
/
p
=(4.83±0.16)×10
−4
GeV
−1
×
p
T
have been measured for high momentum tracks.
Five brands of new enamel household paints from Taiwan were analyzed: two multi-nationals and three local. The median lead concentration of 2574 parts per million (ppm) dry weight was more than 30 ...times the current US standard of 90
ppm for new paints and was more than 4 times the former standard of 600
ppm. Lead levels ranged from below detection (4.5
ppm) to 158,000
ppm. Lead concentrations varied significantly by color of paint and paint brand but not by price per liter. Fifty-six percent of Taiwan paints had lead levels above the 90
ppm US limit. One of the multi-national brands and two of the local brands had high levels of lead with the averages ranging from 12,890 to 53,640
ppm. Concentrations were less than 90
ppm in each of the samples from the other two brands. One of the two multi-national paint brands was imported as the house brand for its big box store in Taipei and had lead levels above 600
ppm in four of five samples.
Comparison of the lead concentrations of paints from Taiwan with those that we previously analyzed from mainland China revealed higher levels in Taiwan where the median level was 2574
ppm compared to 46
ppm in mainland China.
► Fifty-six percent of Taiwan paints had lead concentrations above the 90
ppm US limit. ► The median paint lead concentration in China was much lower than in Taiwan. ► The imported house brand of paint in a big box retail store in Taiwan had high lead levels. ► Color and brand were significantly related to concentration of lead in the Taiwan paints. ► Price of paint per liter was not related to paint lead concentration in the Taiwan paints.
An event topology with two secondary vertices compatible with the decay of short-lived particles was found in the analysis of neutrino interactions in the OPERA target. The observed topology is ...compatible with tau neutrino charged current (CC) interactions with charm production and neutrino neutral current (NC) interactions with
c
c
¯
pair production. However, other processes can mimic this topology. A dedicated analysis was implemented to identify the underlying process. A Monte Carlo simulation was developed and complementary procedures were introduced in the kinematic reconstruction. A multivariate analysis technique was used to achieve an optimal separation of signal from background. Most likely, this event is a
ν
τ
CC interaction with charm production, the tau and charm particle decaying into 1 prong and 2 prongs, respectively. The significance of this observation is evaluated.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
Lead concentrations in new enamel decorative paints were determined in three countries in different areas of the world where data were not previously available. The average total lead concentration ...of the enamel decorative paints purchased in Lebanon, Paraguay and Russia was 24,500ppm (ppm, dry weight), more than 270 times the current limit of 90ppm in Canada and in the United States. Sixty-three percent of these paints contained concentrations greater than 90ppm. Fifty-nine percent contained concentrations greater than 600ppm, the current limit in some countries. The maximum concentrations found were 236,000ppm in Lebanon, 169,000ppm in Paraguay and 52,900ppm in Russia. An average of 29% of the samples contained exceedingly high lead concentrations, >=10,000ppm.
Five brands of paint were sampled in each of Lebanon and Paraguay and seven in Russia. Three colors from each brand were analyzed. For five of the six samples of the two brands in Lebanon with affiliations outside the country, the lead concentrations ranged from 1360ppm to 135,000ppm. In Lebanon the maximum concentration in the Egypt-affiliated brand (Sipes) was 135,000ppm and the maximum for the USA-affiliated brand (Dutch Boy) was 32,400ppm. Lead was not detected in any paints from the three of the four brands of paint purchased in Paraguay that had headquarters/affiliations in other countries (Brazil-Coralit), Germany (Suvinil) and USA (Novacor)). Two of the three paints from each of the other Paraguay brands contained high levels of lead with the maximum concentrations of 108,000 and 168,000ppm; one of these brands was manufactured under a license from ICI in the Netherlands. All of the paints purchased in Russia were from Russian brands and were manufactured in Russia. All three paints from one brand contained below detection levels of lead. The maximum levels of lead in the other six brands in Russia ranged from 3230 to 52,900ppm. The two brands with the highest lead concentration, TEKS and LAKRA, were produced by companies in the top three in market share.. Overall, lead concentrations were much higher in the colored paints such as red and yellow than in white paints. In each of the three countries a brand based in that country had a colored paint that either met a 90ppm limit or was close to meeting the limit-demonstrating that practical technology was available in each of these countries to produce low lead bright colored enamel decorative paints. Even though technology for producing paint without added lead existed in each of these countries, twenty-nine (29) percent of the paints analyzed contained exceedingly high concentrations (>=10,000ppm) of lead.
•Paint with high concentrations of lead found in Lebanon, Paraguay and Russia.•Egyptian (Sipes) and U.S.-affiliated (Dutch Boy) brands in Lebanon have high lead.•In Paraguay high lead found in a brand with a license from ICI (Netherlands-based).•In Russia the highest lead was found in paint from the most popular brand (TEKS).•Maximum lead concentration in Russia is much lower than that in Lebanon and Paraguay.
Although staging provides prognostic information and guides therapeutic decisions, 30-50% of patients with localized CRC will relapse despite optimal primary treatment. CEA and imaging studies are ...insufficient to detect micrometastases at an early stage. The identification of prognostic markers beyond TNM is crucial to define high risk of relapse and to establish potential therapeutic strategies to optimize adjuvant treatment.
150 patients diagnosed with localized CRC were prospectively recruited from October 2015 to October 2017 at our institution. Clinicopathological features (stage, grade, vascular/perineural invasion, sidedness, MMR status and CDX2 expression) were collected. DNA and RNA extracted from FFPE samples were assessed with a custom 29-gene panel recurrently mutated in CRC (NGS) and a validated NanoCRCA assay (NanoString). ctDNA from plasma was tracked in serial samples to detect MRD (ddPCR). Plasma Interleukin-6 levels were measured (ELISA). Log-rank test, univariate and multivariate Cox regression analysis and ROC curves were used for statistics.
Known somatic mutations in tumour were found in 120 (80%) patients for mutation tracking ctDNA analysis. After a median follow-up of 24.7 months, 18 patients recurred. Postoperative CEA was not predictive of disease-free survival (P=0.229). ctDNA in serial plasma after surgery predicted metastatic relapse with a median lead time of 10 months over radiologic recurrences HR 11.33; P=0.0001. CMS subtypes were significantly associated with CDX2 expression (loss in CMS1, P=0.03), IL-6 levels (high in CMS1 and CMS4, P=0.002) and perineural invasion (present in CMS1 and CMS4, P=0.001). CMS1 and CMS4 subtypes were significantly associated with relapse (P=0.016). A multivariable analysis confirmed T stage, loss of CDX2 expression and mutation tracking ctDNA were significantly associated with recurrence (P=0.041, P=0.004, P<0.001, respectively).
In localized CRC, plasma ctDNA detects MRD in relapsing patients earlier than clinical methods and opens an opportunity for precision treatment.
The authors.
Instituto de Salud Carlos III (PI15/02180 and PI18/01909 to AC; PI18/01508 to TF). NT was supported by Rio Hortega contract CM15/00246 from the Instituto de Salud Carlos III. DR was supported by Joan Rotes contract 16/00040 from the Instituto de Salud Carlos III. TF was supported by Joan Rodes contract 17/00026 from the Instituto de Salud Carlos III. VG was supported by ESMO 2014 fellowship programme, and by Rio Hortega contract CM18/00241 from the Instituto de salud Carlos III.
A. Cervantes: Advisory / Consultancy, Speaker Bureau / Expert testimony, Research grant / Funding (institution): Merck Serono; Advisory / Consultancy, Speaker Bureau / Expert testimony, Research grant / Funding (institution): Roche; Advisory / Consultancy, Research grant / Funding (institution): Beigene; Advisory / Consultancy, Speaker Bureau / Expert testimony, Research grant / Funding (institution): Bayer; Advisory / Consultancy, Speaker Bureau / Expert testimony, Research grant / Funding (institution): Servier; Advisory / Consultancy, Research grant / Funding (institution): Lilly; Advisory / Consultancy, Research grant / Funding (institution): Novartis; Advisory / Consultancy, Research grant / Funding (institution): Takeda; Advisory / Consultancy, Research grant / Funding (institution): Astellas; Advisory / Consultancy: Pierre Fabre; Speaker Bureau / Expert testimony: Amgen; Speaker Bureau / Expert testimony: Foundation Medicine; Research grant / Funding (institution): MedImmune; Research grant / Funding (institution): BMS; Research grant / Funding (institution): AstraZeneca; Research grant / Funding (institution): MSD; Research grant / Funding (institution): Sierra Oncology. All other authors have declared no conflicts of interest.
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