Abstract
Directional sensitivity to nuclear recoils would provide a smoking gun for a possible discovery of dark matter in the form of WIMPs (Weakly Interacting Massive Particles). A hint of ...directional dependence of the response of a dual-phase argon Time Projection Chamber (TPC) was found in the SCENE experiment. Given the potential importance of such a capability in the framework of dark matter searches, a new dedicated experiment, ReD (Recoil Directionality), was designed by the Global Argon Dark Matter Collaboration, in order to scrutinise this hint. A small dual-phase argon TPC was irradiated with neutrons produced by the p(
7
Li,
7
Be)n reaction using the 15 MV TANDEM accelerator of the INFN - Laboratori Nazionali del Sud, Catania, Italy, so as to produce argon nuclear recoils in the range (20 - 100) keV of interest for dark matter searches. Energy and direction of nuclear recoils are inferred by the detection of the elastically-scattered neutron by a set of scintillation detectors. Events were selected by gating of the associated
7
Be, which is detected by a telescope of Si detectors.
Abstract
The stability of a dark matter detector on the timescale of a few years is a key
requirement due to the large exposure needed to achieve a competitive sensitivity. It is
especially crucial ...to enable the detector to potentially detect any annual event rate modulation,
an expected dark matter signature. In this work, we present the performance history of the
DarkSide-50 dual-phase argon time projection chamber over its almost three-year
low-radioactivity argon run. In particular, we focus on the electroluminescence signal that
enables sensitivity to sub-keV energy depositions. The stability of the electroluminescence yield
is found to be better than 0.5%. Finally, we show the temporal evolution of the observed event
rate around the sub-keV region being consistent to the background prediction.
The Recoil Directionality (ReD) Experiment Sanfilippo, S; Agnes, P; Albergo, S ...
Journal of physics. Conference series,
11/2022, Letnik:
2374, Številka:
1
Journal Article
Recenzirano
Odprti dostop
Directional sensitivity to nuclear recoils would provide a smoking gun for a possible discovery of dark matter in the form of WIMPs (Weakly Interacting Massive Particles). A hint of directional ...dependence of the response of a dual-phase argon Time Projection Chamber (TPC) was found in the SCENE experiment. Given the potential importance of such a capability in the framework of dark matter searches, a new dedicated experiment, ReD (Recoil Directionality), was designed by the Global Argon Dark Matter Collaboration, in order to scrutinize this hint. Prior to the irradiation with a neutron beam, the ReD TPC underwent a long campaign of characterization and optimization: some selected results are presented in this contribution.
Fire blight, caused by the bacterium Erwinia amylovora, is one of the most dangerous diseases in pome fruit growing. Two major aims in apple breeding are the selection of apple cultivars resistant to ...fire blight and understanding the genetics of fire blight resistance. Although no gene-to-gene relationship has been reported for the interaction between Malus and E. amylovora, a specific strain-cultivar interaction has been demonstrated in several studies. The fire blight resistant wild species accession Malus × robusta 5 (Mr5) carries a major QTL for resistance to fire blight on LG3, explaining up to 80% of the phenotypic variation. This QTL was confirmed using two different strains that did not overcome the resistance of Mr5, and no minor QTL could be detected. In this study a strain overcoming the resistance of Mr5, i.e., E. amylovora Ea3049, was used to phenotype grafted scions of the progeny ‘Idared’ × Mr5. From one to eight replicates/seedling were inoculated with Ea3049, by cutting the tips of the two youngest leaves with scissors dipped in inoculums containing 10(9) cfu/ml. Four weeks after inoculation the necrosis length was determined and susceptibility assessed as percentage necrosis length. Grafted scions of the two parents Mr5 and ‘Idared’ showed 97 and 95% necrosis length, respectively, and the necrosis length of the progenies varied from 7 to 100% with an average of 80%. Interval mapping of susceptibility resulted in the total breakdown of the QTL on LG3 but generated a new QTL on LG5. This minor QTL could explain up to 10% of the phenotypic variation.
Roughly 20–30% of patients with Attention-deficit/hyperactivity disorder (ADHD) fail to respond to central stimulant (CS) medication. Genetic, neuroimaging, biochemical and behavioral biomarkers for ...CS response have been investigated, but currently there are no biomarkers available for clinical use that help identify CS responders and non-responders.
In the present paper, we studied if incentive salience and hedonic experience evaluated after a single-dose CS medication could predict response and non-response to CS medication. We used a bipolar visual analogue ‘wanting’ and ‘liking’ scale to gauge incentive salience and hedonic experience in 25 healthy controls (HC) and 29 ADHD patients. HC received 30 mg methylphenidate (MPH) and ADHD patients received either MPH or lisdexamphetamine (LDX) as selected by their clinician, with dosage individually determined for optimal effect. Clinician-evaluated global impression – severity (CGI-S) and improvement (CGI-I) and patient-evaluated improvement (PGI-I) were used to assess response to CS medication. Resting state functional magnetic resonance imaging (fMRI) was conducted before and after single-dose CS to correlate wanting and liking scores to changes in functional connectivity.
Roughly 20% of the ADHD patients were CS non-responders (5 of 29). CS responders had significantly higher incentive salience and hedonic experience scores compared to healthy controls and CS non-responders. Resting state fMRI showed that wanting scores were significantly associated to changes in functional connectivity in ventral striatum including nucleus accumbens.
Incentive salience and hedonic experience evaluated after a single-dose CS medication segregate CS responders and non-responders, with corresponding neuroimaging biomarkers in the brain reward system.
Abstract only
8555
Background: Defactinib is an oral Focal Adhesion Kinase (FAK) inhibitor with preclinical activity in MPM. We assessed responses to defactinib treatment prior to planned surgical ...resection in naive patients with MPM. Methods: Three cohorts of 10 participants each received defactinib 400mg BID for 12, 35 and 21 days. Pre- and post-treatment blood, tumor biopsies and imaging were obtained for biomarker, immune cell and tumor response (modified RECIST, Tumor volume and SUV max) assessment. Toxicity was monitored for 30 days post treatment. Results: Between 12/2013 and 12/2017, 31 participants were registered at our center; 1 withdrew prior to intervention. Among 30 treated, 24 (80%) were male; median age 70 (47-83) years; surgery was EPP 7%, complete pleurectomy decortication (PD) 10%, extended PD 60%, partial PD 10%, unresectable 13%; MPM subtype was epithelioid 67%, biphasic 17%, sarcomatoid 17%. Expected complications of FAK inhibition, diagnostic/staging/operative procedures occurred in 83% (grade 1, 30%; grade 2, 43%; grade 3, 10%). Unexpected adverse events occurred in 77% (grade 1, 63%; grade 2, 20%; grade 3, 17% wound-infection, prolonged QT interval, and hyperglycemia in 3% each; increased INR in 7%; grade 5, 7% due to progressive disease in 3%, intraoperative anaphylactoid reaction unrelated to the drug in 3%). Objective partial response was observed in 13%, stable disease in 67%, progression in 17%. Tumor volume decreased 3-72% in 47% patients and increased 1-82% in 53%. SUV max decreased 3-69% in 50% and increased 1-61% in 50%. Biological correlates of treatment included target inhibition (75% pFAK reduction); tumor immune microenvironment changes: increased naïve (CD45RA+PD-1+CD69+) CD4 and CD8 T cells, reduced myeloid and Treg immuno-suppressive cells, reduced exhausted T cells (PD-1+CD69+), reduced peripheral MDSCs; and histological subtype change (pleomorphic or biphasic to epithelioid) in 13% of cases. Conclusions: Brief preoperative defactinib exposure was well tolerated, did not alter resectability or mortality compared to prior series, and showed evidence of therapeutic and immunomodulatory effects. Clinical trial information: NCT02004028.
Highlights • We identified a group of R/M SCCHN tumors with an inflamed immunophenotype. • We identified a non-inflamed tumor immunophenotype in the same population. • Patients with the inflamed ...tumor phenotype had improved survival. • Patients with the inflamed tumor phenotype may benefit from checkpoint blockade.
Fischer indole synthesis of indole by using phenyl‐hydrazine and acetaldehyde resulted 1H‐Indole while phenyl‐hydrazine reacted with malonaldehyde gives 1H‐Indole‐3‐carbaldehyde. Also Vilsmeier‐Haack ...formylation of 1H‐Indole gives 1H‐Indole‐3‐carbaldehyde. 1H‐Indole‐3‐carbaldehyde were oxidized to form 1H‐Indole‐3‐carboxylic acid. 1H‐Indole reacted with excess of BuLi at −78 °C using dry ice also gives 1H‐Indole‐3‐carboxylic acid. Obtained 1H‐Indole‐3‐carboxylic acid was converted to ester and ester in to acid hydrazide. Finally 1H‐Indole‐3‐carboxylic acid hydrazide reacted with substituted carboxylic acid gives microbial active indole substituted oxadiazoles. Synthesized compounds 9a–j showing promising in vitro anti microbial activities against S. aureus bacteria compared with Streptomycin. Compound 9a, 9f and 9g showing activities against E. coli compared with standards. Compound 9a and 9f are found potent active against B. subtilis compared with reference standard while compound 9a, 9c and 9j active against S. typhi.
PDF
