Exceptional magnetic properties of magnetite, Fe3O4, nanoparticles make them one of the most intensively studied inorganic nanomaterials for biomedical applications. We report successful gram-scale ...syntheses, via hydrothermal route or controlled coprecipitation in an automated reactor, of colloidal Fe3O4 nanoparticles with sizes of 12.9 ± 5.9, 17.9 ± 4.4, and 19.8 ± 3.2 nm. To investigate structure–property relationships as a function of the synthetic procedure, we used multiple techniques to characterize the structure, phase composition, and magnetic behavior of these nanoparticles. For the iron oxide cores of these nanoparticles, powder X-ray diffraction and electron microscopy both confirm single-phase Fe3O4 composition. In addition to the core composition, the magnetic performance of nanoparticles in the 13–20 nm size range can be strongly influenced by the surface properties, which we analyzed by three complementary techniques. Raman scattering and X-ray photoelectron spectroscopy (XPS) measurements indicate overoxidation of nanoparticle surfaces, while transmission electron microscopy (TEM) shows no distinct core–shell structure. Considered together, Raman, XPS, and TEM observations suggest that our nanoparticles have a gradually varying nonstoichiometric Fe3O4+δ composition, which could be attributed to the formation of Fe3O4–γ-Fe2O3 solid solutions at their outermost surface. Detailed analyses by TEM reveal that the hydrothermally produced samples include single-domain nanocrystals coexisting with defective twinned and dimer nanoparticles, which form as a result of oriented-attachment crystal growth. All our nanoparticles exhibit superparamagnetic-like behavior with a characteristic blocking temperature above room temperature. We attribute the estimated saturation magnetization values up to 84.01 ± 0.25 emu/g at 300 K to the relatively large size of the nanoparticles (13–20 nm) coupled with the syntheses under elevated temperature; alternative explanations, such as surface-mediated effects, are not supported by our spectroscopy or microscopy measurements. For these colloids, the heating efficiency in magnetic hyperthermia correlates with their saturation magnetization, making them appealing for therapeutic and other biomedical applications that rely on high-performance nanoparticle-mediated hyperthermia.
In this work the content of seven heavy metals (Cd, Cr, Cu, Hg, Ni, Pb and Zn) and other parameters (the pH, organic matter, carbonates and granulometric fraction) in agricultural topsoil in the Ebro ...basin are quantified, based on 624 samples collected according to an 8 by 8
km square mesh. The average concentrations (mg/kg) obtained were: Cd 0.415
±
0.163, Cr 20.27
±
13.21, Cu 17.33
±
14.97, Ni 20.50
±
22.71, Pb 17.54
±
10.41, Zn 17.53
±
24.19 and Hg 35.6
±
42.05
μg/kg. The concentration levels are relatively low in areas of high pH and low organic matter content concentration. The results of factor analysis group Cd, Cu, Hg, Pb and Zn in F1 and Cr y Ni in F2. The spatial heavy metals component maps based on geostatistical analysis, show definite association of these factors with the soil parent material. The local anomalies (found in Cu, Zn and Pb) are attributed to anthropogenic influence.
Geostatistical analyses showed definite association of metals with soil parent materials.
A series of colloidal M x Fe3–x O4 (M = Mn, Co, Ni; x = 0–1) nanoparticles with diameters ranging from 6.8 to 11.6 nm was synthesized by hydrothermal reaction in aqueous medium at low temperature ...(200 °C). Energy-dispersive X-ray microanalysis and inductively coupled plasma spectrometry confirm that the actual elemental compositions agree well with the nominal ones. The structural properties of the obtained nanoparticles were investigated by powder X-ray diffraction, Raman spectroscopy, Mössbauer spectroscopy, X-ray and neutron pair distribution function analysis, and electron microscopy. The results demonstrate that our synthesis technique leads to the formation of chemically uniform single-phase solid solution nanoparticles with cubic spinel structure, confirming intrinsic doping. The local structure of the Fe3O4 NPs is distorted with respect to the cubic inverse-spinel structure, while chemical substitution of Fe by Mn or Ni partially eliminates the local distortions. Magnetic studies showed that, in comparison to nondoped Fe3O4, the saturation magnetization (M s) of M x Fe3–x O4 (M = Mn, Ni) decreases with increasing dopant concentration, while Co-doped samples showed similar M s. On the other hand, whereas Mn- and Ni-doped nanoparticles exhibit superparamagnetic behavior at room temperature, ferrimagnetism emerges for Co x Fe3–x O4 nanoparticles, which can be tuned by the level of Co doping.
For the past few decades, there has been great interest in determining if even the most massive stars in our galaxy (namely the spectral O-type stars) are formed in a similar manner as the low- and ...intermediate-mass stars, that is, through the presence of accreting disks and powerful outflows. Here, using sensitive observations of the Atacama Large Millimeter/Submillimeter Array, we report a resolved Keplerian disk (with 15 synthesized beams across its major axis) surrounding the deeply embedded O-type protostar IRAS 16547−4247. The disk shows some asymmetries that could arise because the disk is unstable and fragmenting or because of different excitation conditions within the disk. The enclosed mass estimated from the disk Keplerian radial velocities is 25 3 M . The molecular disk is at the base of an ionized thermal radio jet and is approximately perpendicular to the jet axis orientation. We additionally find the existence of a binary system of compact dusty objects at the center of the accreting disk, which indicates the possible formation of an O-type star and a companion of lower mass. This is not surprising due to the high binary fraction reported in massive stars. Subtracting the contribution of the dusty disk plus the envelope and the companion, we estimated a mass of 20 M for the central star.
Honey Bee Colonies Remote Monitoring System Gil-Lebrero, Sergio; Quiles-Latorre, Francisco Javier; Ortiz-López, Manuel ...
Sensors (Basel, Switzerland),
01/2017, Letnik:
17, Številka:
1
Journal Article
Recenzirano
Odprti dostop
Bees are very important for terrestrial ecosystems and, above all, for the subsistence of many crops, due to their ability to pollinate flowers. Currently, the honey bee populations are decreasing ...due to colony collapse disorder (CCD). The reasons for CCD are not fully known, and as a result, it is essential to obtain all possible information on the environmental conditions surrounding the beehives. On the other hand, it is important to carry out such information gathering as non-intrusively as possible to avoid modifying the bees' work conditions and to obtain more reliable data. We designed a wireless-sensor networks meet these requirements. We designed a remote monitoring system (called WBee) based on a hierarchical three-level model formed by the wireless node, a local data server, and a cloud data server. WBee is a low-cost, fully scalable, easily deployable system with regard to the number and types of sensors and the number of hives and their geographical distribution. WBee saves the data in each of the levels if there are failures in communication. In addition, the nodes include a backup battery, which allows for further data acquisition and storage in the event of a power outage. Unlike other systems that monitor a single point of a hive, the system we present monitors and stores the temperature and relative humidity of the beehive in three different spots. Additionally, the hive is continuously weighed on a weighing scale. Real-time weight measurement is an innovation in wireless beehive-monitoring systems. We designed an adaptation board to facilitate the connection of the sensors to the node. Through the Internet, researchers and beekeepers can access the cloud data server to find out the condition of their hives in real time.
After myocardial infarction (MI), extensive remodelling of the extracellular matrix contributes to scar formation. While aiming to preserve tissue integrity, this fibrotic response is also associated ...with adverse events, including a markedly increased risk of heart failure, ventricular arrhythmias, and sudden cardiac death. Cardiac fibrosis is characterized by extensive deposition of collagen and also by increased stiffness as a consequence of enhanced collagen cross-linking. Members of the lysyl oxidase (LOX) family of enzymes are responsible for the formation of collagen cross-links. This study investigates the contribution of LOX family members to the heart response to MI.
Experimental MI was induced in C57BL/6 mice by permanent ligation of the left anterior descending coronary artery. The expression of LOX isoforms (LOX and LOXL1-4) was strongly increased upon MI, and this response was accompanied by a significant accumulation of mature collagen fibres in the infarcted area. LOX expression was observed in areas of extensive remodelling, partially overlapping with α-smooth muscle actin-expressing myofibroblasts. Tumour growth factor-β as well as hypoxia-activated pathways contributed to the induction of LOX expression in cardiac fibroblasts. Finally, in vivo post-infarction treatment with the broadband LOX inhibitor β-aminopropionitrile or, selectively, with a neutralizing antibody against the canonical LOX isoform attenuated collagen accumulation and maturation and also resulted in reduced ventricular dilatation and improved cardiac function.
LOX family members contribute significantly to the detrimental effects of cardiac remodelling, highlighting LOX inhibition as a potential therapeutic strategy for post-infarction recovery.
We present sensitive and high angular-resolution (∼0 2-0 3) (sub)millimeter (230 and 345 GHz) continuum and CO(2−1)/CO(3−2) line archive observations of the disk star system in UX Tauri carried out ...with the Atacama Large Millimeter/Submillimeter Array. These observations reveal the gas and dusty disk surrounding the young star UX Tauri A with a large signal-to-noise ratio (>400 in the continuum and >50 in the line), and for the first time we detect the molecular gas emission associated with the disk of UX Tauri C (with a size for the disk of <56 au). No (sub)millimeter continuum emission is detected at the 5 level (0.2 mJy at 0.85 mm) associated with UX Tauri C. For the component UX Tauri C, we estimate a dust disk mass of ≤0.05 M⊕. Additionally, we report a strong tidal disk interaction between both disks, UX Tauri A/C, separated 360 au in projected distance. The CO line observations reveal marked spiral arms in the disk of UX Tauri A and an extended redshifted stream of gas associated with the UX Tauri C disk. No spiral arms are observed in the dust continuum emission of UX Tauri A. Assuming a Keplerian rotation we estimate the enclosed masses (disk+star) from their radial velocities in 1.4 0.6 M for UX Tauri A, and 70 30/sin i Jupiter masses for UX Tauri C (the latter coincides with the mass upper limit value for a brown dwarf). The observational evidence presented here lead us to propose that UX Tauri C has a close approach of a possible wide, evolving, and eccentric orbit around the disk of UX Tauri A, causing the formation of spiral arms and a stream of molecular gas falling toward UX Tauri C.
We present new Atacama Large Millimeter/submillimeter Array (ALMA) Band 6 observations including the CO(2−1) line and 1.3 mm continuum emission from the surroundings of the young stellar object DO ...Tauri. The ALMA CO molecular data show three different series of rings at different radial velocities. These rings have radii around 220 and 800 au. We make individual fits to the rings and note that their centers are aligned with DO Tauri and its optical high-velocity jet. In addition, we notice that the velocity of these structures increases with the separation from the young star. We discuss the data under the hypothesis that the rings represent velocity cuts through three outflowing shells that are possibly driven by a wide-angle wind, dragging the environment material along a direction close to the line of sight (i = 19°). We estimate the dynamical ages, the mass, the momentum, and the energy of each individual outflow shell and those of the whole outflow. The results are in agreement with those found in outflows from Class II sources. We make a rough estimate for the size of the jet/wind launching region, which needs to be of 15 au. We report the physical characteristics of DO Tauri's disk continuum emission (almost face-on and with a projected major axis in the north-south direction) and its velocity gradient orientation (north-south), indicative of disk rotation for a 1-2 M central star. Finally, we show a Hubble Space Telescope S ii image of the optical jet and report a measurement of its orientation in the plane of the sky.
Background
Portopulmonary hypertension (PoPH) is a rare condition with poorer survival compared to idiopathic/familial pulmonary arterial hypertension (IPAH/FPAH).
Aims
To compare the ...characteristics, survival, prognostic factors and management of PoPH and IPAH/FPAH patients and to assess the impact of treatment on survival of PoPH patients.
Methods
Analysis of data of prevalent and incident PoPH patients enrolled in the Spanish registry of PAH (REHAP) from January 1998 to December 2017 and comparison with IPAH/FPAH patients. Variables analysed: patient and disease (PAH and liver) characteristics, first‐line PAH‐targeted therapy, causes of death, prognostic factors and survival (according to aetiology and treatment in PoPH patients).
Results
Compared to IPAH/FPAH patients (n = 678), patients with PoPH (n = 237) were predominantly men, older and had better functional class and higher prevalence of ascites. Haemodynamics were better. Biomarkers for heart failure were worse. Age‐ and sex‐adjusted 5‐year survival rate from diagnosis was 49.3% for PoPH patients and 68.7% for IPAH patients (P < 0.001). Treated PoPH had better survival than non‐treated. PAH‐ and liver‐related causes accounted for 30.2% and 24.7% of deaths in PoPH patients. PoPH patients were less likely to receive first‐line PAH‐targeted therapy and this was associated with greater mortality. Increasing age, worse exercise capacity and ascites were independent prognostic factors of poorer survival; first‐line oral monotherapy was associated with improved survival. Eight (3.4%) PoPH patients underwent liver transplantation.
Conclusions
PoPH patients are undertreated and show poorer survival than IPAH/FPAH patients. First‐line treatment with PAH‐targeted therapy was associated with better survival. Presence of ascites was a predictor of mortality.
C3 glomerulonephritis is a clinicopathologic entity defined by the presence of isolated or dominant deposits of C3 on immunofluorescence. To explore the effect of immunosuppression on C3 ...glomerulonephritis, we studied a series of 60 patients in whom a complete registry of treatments was available over a median follow-up of 47months. Twenty patients had not received immunosuppressive treatments. In the remaining 40 patients, 22 had been treated with corticosteroids plus mycophenolate mofetil while 18 were treated with other immunosuppressive regimens (corticosteroids alone or corticosteroids plus cyclophosphamide). The number of patients developing endstage renal disease was significantly lower among treated compared with untreated patients (3 vs. 7 patients, respectively). No patient in the corticosteroids plus mycophenolate mofetil group doubled serum creatinine nor developed end-stage renal disease, as compared with 7 (significant) and 3 (not significant), respectively, in patients treated with other immunosuppressive regimens. Renal survival (100, 80, and 72% at 5years) and the number of patients achieving clinical remission (86, 50, and 25%) were significantly higher in patients treated with corticosteroids plus mycophenolate mofetil as compared with patients treated with other immunosuppressive regimens and untreated patients, respectively. Thus, immunosuppressive treatments, particularly corticosteroids plus mycophenolate mofetil, can be beneficial in C3 glomerulonephritis.
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