In 2007, the M-type binary Asteroid 22 Kalliope reached one of its annual equinoxes. As a consequence, the orbit plane of its small moon, Linus, was aligned closely to the Sun's line of sight, giving ...rise to a mutual eclipse season. A dedicated international campaign of photometric observations, based on amateur–professional collaboration, was organized and coordinated by the IMCCE in order to catch several of these events. The set of the compiled observations is released in this work. We developed a relevant model of these events, including a topographic shape model of Kalliope refined in the present work, the orbit solution of Linus as well as the photometric effect of the shadow of one component falling on the other. By fitting this model to the only two full recorded events, we derived a new estimation of the equivalent diameter of Kalliope of
166.2
±
2.8
km
, 8% smaller than its IRAS diameter. As to the diameter of Linus, considered as purely spherical, it is estimated to
28
±
2
km
. This substantial “shortening” of Kalliope, gives a bulk density of
3.35
±
0.33
g
/
cm
3
, significantly higher than past determinations but more consistent with its taxonomic type. Some constraints can be inferred on the composition.
Studies at the Nuclotron in JINR indicate the presence of a previously unknown resonance-like structure in the two-photon mass spectrum in the region of 300–400 MeV/
c
2
, observed in nucleus–nucleus ...interactions. The goal of this work is to search for such structures in the two-photon mass spectrum in meson–nuclear interactions at a momentum of 7 GeV/
c
at the Hyperon-M experiment of the U-70 accelerator complex. An upper limit has been established on the ratio of the cross section for the formation of unknown resonance structures to the cross section for the production of
-meson
at the 95% confidence level.
The analysis of amplitude spectra from a thin polystyrene-based scintillation counter on muon-enriched and hadron beams of channel 18 of the U-70 accelerator complex in Protvino has been presented. ...On the basis of statistics of 150 million events on the Hyperon-M setup, the contribution of the
-fragmentation processes are highlighted and the cross sections of these processes on hadron and pion beams with a momentum of 7 GeV/
c
have been measured. In the future, the obtained result may be of interest for the method of analyzing the age of gas fields based on the concentration of helium in natural gas, the formation of which is possible in the reaction of
fragmentation of carbon nuclei in
interactions induced by high-energy cosmic muons.
The invariant cross sections for forward charged-hadron production at zero angle in carbon–carbon collisions at a beam kinetic energy of 19.6 GeV per nucleon were measured at the U-70 accelerator in ...an experiment performed with the aid of a combined spectrometer including beam line 22 and detectors of the modified FODS setup. The beam line rigidity was varied between 7 and 70 GeV/
. The results are compared with the predictions of the FTFP model and a self-similar solution for nucleus–nucleus collisions.
The inclusive differential cross sections for the production of
and
mesons, protons, and antiprotons with momenta between 6 and 50 GeV/
c
and nuclear fragments of mass number
in the momentum range ...between 20 and 220 GeV/
c
were measured in carbon–lead collisions at a beam kinetic energy of 19.6 GeV per nucleon (
GeV). A comparison with the respective cross sections for carbon–carbon interactions is performed, and the dependence on the target mass number (
) is estimated. The present analysis shows that the observed particles originate predominantly from peripheral interactions.
The inclusive differential cross sections for forward production of nuclear fragments at an angle of 0∘ in CC collisions at beam energy 20.5 GeV/nucleon (SNN=6.3GeV) are presented. Measurements have ...been performed at the U-70 Accelerator Complex (Protvino) using a combined spectrometer on base of the beamline. Fragments selection was carried out by measuring of ionization in scintillation counters taking into account the data from threshold Cherenkov counters and hadron calorimeter. Fragment mass was determined through Cherenkov light emission angle measured in the spectrometer of ring imaging Cherenkov radiation. Data are given for fragments with charge 1≤Z≤6, atomic number 1≤A≤10 and A/Z<3.4 with momenta from 20 to 210 GeV/c. The measurements are compared with Fritiof model, statistical models and theoretical parameterizations. The discovered differences between theory and experiment are discussed.
A procedure for finding the trajectories of charged particles on the FODS (focusing double-arm spectrometer) is described, which includes channel calibration (
r
(
t
)-dependence) of drift detectors ...for calculating the coordinates of particles and reconstruction of tracks. The organization of time measurements and construction of a least-squares functional on their basis is considered. The criteria for selecting candidates for the tracks are discussed. A procedure has been developed for obtaining geodesic corrections for drift chambers and tubes at the analysis of physical events. Accuracies of measuring the coordinates in drift chambers of 600 μm and chambers on drift tubes of 500 μm were obtained. The distribution of particle trajectories in the target is given.
—
The issues of determining the momentum of charged particles at the focusing double-arm spectrometer (FODS) are discussed. The coordinate detectors are located at the exit from the analyzing magnet, ...while a profilometer of the center of gravity of the beam at the target during an accelerator cycle is at its entrance. ANSIS finite-element analysis software is used to obtain a regular grid of magnetic field vector values measured by the Hall sensor in a part of the magnet. The charged-particle momentum is determined based on the algorithm of decision tables with a polynomial approximation. Tables are produced by the Monte Carlo method by reconstructing the motion of a particle with a prescribed momentum in the magnetic field. The accuracies in determining the particle momentum and the particle production angles while accounting for the contributions from multiple scattering, measurement errors, and approximation uncertainties are presented. The distribution of the reconstructed trajectories in the target and the momentum spectrum of particles are shown.
Glioma is a diverse category of tumors originating from glial cells encompasses various subtypes, based on the specific type of glial cells involved. The most aggressive is glioblastoma multiforme ...(GBM), which stands as the predominant primary malignant tumor within the central nervous system in adults. Despite the application of treatment strategy, the median survival rate for GBM patients still hovers around 15 months. Oncolytic viruses (OVs) are artificially engineered viruses designed to selectively target and induce apoptosis in cancer cells. While clinical trials have demonstrated encouraging results with intratumoral OV injections for some cancers, applying this approach to GBM presents unique challenges. Here we elaborate on current trends in oncolytic viral therapy and their delivery methods. We delve into the various methods of delivering OVs for therapy, exploring their respective advantages and disadvantages and discussing how selecting the optimal delivery method can enhance the efficacy of this innovative treatment approach.
•Current GBM therapeutic approaches have limited potential on the prognosis and show 15 months of median survival.•Oncolytic viral therapy is a cutting-edge therapeutic approach that has shown significant promise due to their ability selectively targeting and inducing apoptosis in cancer cells.•Recent findings suggest that OV therapy may enhance the effectiveness of the “gold standard” treatment, potentially alleviating side effects and improving patient outcomes.
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