The synthesis of 1-(2-mercaptocyclopentyl)carbonyl-L-prolines, 1-(2-mercaptocyclobutyl)carbonyl-L-prolines and related benzoyl derivatives as pure isomers is described. The abilities of all the ...compounds to inhibit angiotensin converting enzyme (ACE) in vitro and in vivo and to lower the systolic blood pressure in renal hypertensive dogs were determined. Three of them, namely 1-2-(benzoylthio)cyclopentylcarbonyl-L-proline (10f(R,S, 1-(2-mercaptocyclopentyl)carbonyl-L-proline (10g(R,S, and 1-2-(benzoylthio)cyclobutylcarbonyl-L-proline (16f(R,S, were found to be as potent as captopril in reducing blood pressure. The influence of chirality and ring size on the ACE inhibition is described.
Five young patients with Niemann-Pick disease type B were treated with repeated implantations of amniotic epithelial cells, as a source of exogenous sphingomyelinase. This treatment abolished the ...recurrent infections, mainly of the respiratory tract, and led to other improvements of the general conditions of the patients. In particular, we noticed a disappearance of vomiting, a recovery from muscular hypotrophy, and significantly reduced pulmonary distress. In four subjects, who were in a prepuberal state, there was a puberal spurt with a concomitant burst of growth. In two cases, characterized by a greater than normal content of sphingomyelin in urinary sediments, a single implantation caused a sustained normalization of sphingomyelin and total phospholipids in the urine. Finally, sphingomyelinase activity of peripheral leukocytes, when assayed 0.5 to 4 months after some of the implantations, showed a rise to heterozygous values in 30-40% of the assays.
We described two sibs born to consanguineous Sicilian parents who died of severe congenital heart malformation. Both had dextrocardia; however, only the girl had situs viscerum inversus. At necropsy ...she was found to have a right spleen and right pulmonary isomerism (three lobes in each lung, as commonly found in the asplenia syndrome). This observation, together with other literature reports, suggest that isolated dextrocardia, situs viscerum inversus, and the asplenia-polysplenia complex may be different end results of a unique dysmorphogenetic process involving the embryonic midline.
Vacances au soleil / Guido Zenari, chant et le Trio Zetusc Romeo (19..-.... ; musicien actif en 1958). Auteur ou responsable intellectuel; Modugno, Domenico (1928-1994). Auteur ou responsable intellectuel; Migliacci, Francesco. Auteur ou responsable intellectuel ...
1958
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Provider: - Institution: - Data provided by Europeana Collections- Titre uniforme : Nel blu, dipinto di blu = Dans le bleu du ciel bleu = Volare- Titre uniforme : Nel blu, dipinto di blu = Dans le ...bleu du ciel bleu = Volare- Titre uniforme : Piccolissima serenata = Du moment qu'on s'aime- Comprend : LUNGO IL LAGO DI LUGANO / Manzotti et Zenari - BOCCUCCIA DI ROSA / Testa et Cichellero - LO FACCIO PERCHE T'AMO / Faele et Guerrini - LUNA SAN REMESE / Kramer ; Garinei et Giovannini - PICCOLISSIMA SERENATA / Amurri et Ferrio - NEL BLU DIPINTO DI BLU / Migliaci et Modugno - RIESTA ABRACCIATA CU'ME / Chiarello et Colonnese - SCUGNIZZE / Romeo- BnF-Partenariats, Collection sonore - Believe- Contient une table des matières- All metadata published by Europeana are available free of restriction under the Creative Commons CC0 1.0 Universal Public Domain Dedication. However, Europeana requests that you actively acknowledge and give attribution to all metadata sources including Europeana
