Abstract
We describe the algorithm used to select the emission line galaxy (ELG) sample at z ∼ 0.85 for the extended Baryon Oscillation Spectroscopic Survey of the Sloan Digital Sky Survey IV, using ...photometric data from the DECam Legacy Survey. Our selection is based on a selection box in the g − r versus r − z colour–colour space and a cut on the g-band magnitude, to favour galaxies in the desired redshift range with strong
${{\rm O}\,\small {II}}$
emission. It provides a target density of 200 deg−2 on the North Galactic Cap and of 240 deg−2 on the South Galactic Cap (SGC), where we use a larger selection box because of deeper imaging. We demonstrate that this selection passes the extended Baryon Oscillation Spectroscopic Survey requirements in terms of homogeneity. About 50 000 ELGs have been observed since the observations have started in 2016, September. These roughly match the expected redshift distribution, though the measured efficiency is slightly lower than expected. The efficiency can be increased by enlarging the redshift range and with incoming pipeline improvement. The cosmological forecast based on these first data predict
$\sigma _{D_V}/D_V = 0.023$
, in agreement with previous forecasts. Lastly, we present the stellar population properties of the ELG SGC sample. Once observations are completed, this sample will be suited to provide a cosmological analysis at z ∼ 0.85, and will pave the way for the next decade of massive spectroscopic cosmological surveys, which heavily rely on ELGs. The target catalogue over the SGC will be released along with DR14.
We investigate the cosmological implications of the latest growth of structure measurement from the Baryon Oscillation Spectroscopic Survey (BOSS) CMASS Data Release 11 with particular focus on the ...sum of the neutrino masses, ∑m
ν. We examine the robustness of the cosmological constraints from the baryon acoustic oscillation (BAO) scale, the Alcock–Paczynski effect and redshift-space distortions (D
V/r
s, F
AP, fσ8) of Beutler et al., when introducing a neutrino mass in the power spectrum template. We then discuss how the neutrino mass relaxes discrepancies between the cosmic microwave background (CMB) and other low-redshift measurements within Λ cold dark matter. Combining our cosmological constraints with 9-year Wilkinson Microwave Anisotropy Probe (WMAP9) yields ∑m
ν = 0.36 ± 0.14 eV (68 per cent c.l.), which represents a 2.6σ preference for non-zero neutrino mass. The significance can be increased to 3.3σ when including weak lensing results and other BAO constraints, yielding ∑m
ν = 0.35 ± 0.10 eV (68 per cent c.l.). However, combining CMASS with Planck data reduces the preference for neutrino mass to ∼2σ. When removing the CMB lensing effect in the Planck temperature power spectrum (by marginalizing over A
L), we see shifts of ∼1σ in σ8 and Ωm, which have a significant effect on the neutrino mass constraints. In the case of CMASS plus Planck without the A
L lensing signal, we find a preference for a neutrino mass of ∑m
ν = 0.34 ± 0.14 eV (68 per cent c.l.), in excellent agreement with the WMAP9+CMASS value. The constraint can be tightened to 3.4σ yielding ∑m
ν = 0.36 ± 0.10 eV (68 per cent c.l.) when weak lensing data and other BAO constraints are included.
Test particle codes indicate that electron dynamics due to interactions with low amplitude incoherent whistler mode‐waves can be adequately described by quasi‐linear theory. However there is ...significant evidence indicating that higher amplitude waves cause electron dynamics not adequately described using quasi‐linear theory. Using the method that was introduced in Allanson et al. (2019, https://doi.org/10.1029/2019JA027088), we track the dynamical response of electrons due to interactions with incoherent whistler‐mode waves, across all energy and pitch angle space. We conduct five experiments each with different values of the electromagnetic wave amplitude. We find that the electron dynamics agree well with the quasi‐linear theory diffusion coefficients for low amplitude incoherent waves with (Bw,rms/B0)2≈3.7·10−10, over a time scale T of the order of 1,000 gyroperiods. However, the resonant interactions with higher amplitude waves cause significant nondiffusive dynamics as well as diffusive dynamics. When electron dynamics are extracted and analyzed over time scales shorter than T, we are able to isolate both the diffusive and nondiffusive (advective) dynamics. Interestingly, when considered over these appropriately shorter time scales (of the order of hundreds or tens of gyroperiods), the diffusive component of the dynamics agrees well with the predictions of quasi‐linear theory, even for wave amplitudes up to (Bw,rms/B0)2≈5.8·10−6. Quasi‐linear theory is based on fundamentally diffusive dynamics, but the evidence presented herein also indicates the existence of a distinct advective component. Therefore, the proper description of electron dynamics in response to wave‐particle interactions with higher amplitude whistler‐mode waves may require Fokker‐Planck equations that incorporate diffusive and advective terms.
Plain Language Summary
Electromagnetic waves interact strongly with charged particles in the Earth's inner magnetosphere. It is important to be able to model the evolution of these particles, since we rely on the many satellites that orbit within this hazardous radiation environment. Particle dynamics within the Earth's outer radiation belt are usually modelled using a long‐established theory fundamentally based on diffusive dynamics. We effectively benchmark this treatment for some individual cases in which one would expect agreement, that is, lower amplitude waves. We then utilize our novel method to probe cases for which the application of the standard diffusive model is questionable. We find that the resonant interactions with higher amplitude waves result in advective dynamics as well as expected diffusive behavior. When the problem is properly considered, the diffusive component of the dynamics does in fact agree well with the predictions of quasi‐linear theory. However, this is only one component of the dynamics, and one should also consider the advective component. This work motivates the use of model equations that incorporate both diffusive and other nondiffusive terms.
Key Points
Whistler‐mode waves (Bw,rms/B0)2∼O(10−10)−O(10−6) in uniform B give diffusive and advective dynamics
Over appropriately short time scales the diffusive component of the dynamics agrees with quasilinear theory even for highest amplitude waves
These time scales range from thousands to tens of gyroperiods for the lowest and highest amplitude waves, respectively
Squamous cell cancers of the anal canal (ASCC) are increasing in frequency and lack effective therapies for advanced disease. Although an association with human papillomavirus (HPV) has been ...established, little is known about the molecular characterization of ASCC. A comprehensive genomic analysis of ASCC was undertaken to identify novel genomic alterations (GAs) that will inform therapeutic choices for patients with advanced disease.
Hybrid-capture-based next-generation sequencing of exons from 236 cancer-related genes and intronic regions from 19 genes commonly rearranged in cancer was performed on 70 patients with ASCC. HPV status was assessed by aligning tumor sequencing reads to HPV viral genomes. GAs were identified using an established algorithm and correlated with HPV status.
Sixty-one samples (87%) were HPV-positive. A mean of 3.5 GAs per sample was identified. Recurrent alterations in phosphoinositol-3-kinase pathway (PI3K/AKT/mTOR) genes including amplifications and homozygous deletions were present in 63% of cases. Clinically relevant GAs in genes involved in DNA repair, chromatin remodeling, or receptor tyrosine kinase signaling were observed in 30% of cases. Loss-of-function mutations in TP53 and CDKN2A were significantly enhanced in HPV-negative cases (P < 0.0001).
This is the first comprehensive genomic analysis of ASCC, and the results suggest new therapeutic approaches. Differing genomic profiles between HPV-associated and HPV-negative ASCC warrants further investigation and may require novel therapeutic and preventive strategies.
Pertuzumab (P) combined with trastuzumab (H)-based chemotherapy improves efficacy in early and advanced HER2-positive breast cancer. We assessed the tolerability, with particular focus on cardiac ...safety, of H and P with chemotherapy in the neoadjuvant treatment of HER2-positive early breast cancer.
In this multicenter, open-label phase II study, patients with operable, locally advanced, or inflammatory breast cancer were randomized 1 : 1 : 1 to receive six neoadjuvant cycles q3w (Arm A: 5-fluorouracil, epirubicin, cyclophosphamide FEC + H + P ×3 → docetaxel T + H + P ×3; Arm B: FEC ×3 → T + H + P ×3; Arm C: T + carboplatin + H TCH+P ×6). pCR was assessed at surgery and adjuvant therapy given to complete 1 year of H.
Two hundred twenty-five patients were randomized. During neoadjuvant treatment, two patients (2.7%; Arm B) experienced symptomatic left ventricular systolic dysfunction (LVSD) and 11 patients (Arm A: 4 5.6%; Arm B: 4 5.3%; Arm C: 3 3.9%) had declines in left ventricular ejection fraction of ≥10% points from baseline to <50%. Diarrhea was the most common adverse event. pCR (ypT0/is) was reported for 61.6% (Arm A), 57.3% (Arm B), and 66.2% (Arm C) of patients.
The combination of P with H and standard chemotherapy resulted in low rates of symptomatic LVSD.
We report the beam energy (sqrtsNN=7.7-200 GeV) and collision centrality dependence of the mean (M), standard deviation (σ), skewness (S), and kurtosis (κ) of the net-proton multiplicity ...distributions in Au+Au collisions. The measurements are carried out by the STAR experiment at midrapidity (|y|<0.5) and within the transverse momentum range 0.4<pT<0.8 GeV/c in the first phase of the Beam Energy Scan program at the Relativistic Heavy Ion Collider. These measurements are important for understanding the quantum chromodynamic phase diagram. The products of the moments, Sσ and κσ2, are sensitive to the correlation length of the hot and dense medium created in the collisions and are related to the ratios of baryon number susceptibilities of corresponding orders. The products of moments are found to have values significantly below the Skellam expectation and close to expectations based on independent proton and antiproton production. The measurements are compared to a transport model calculation to understand the effect of acceptance and baryon number conservation and also to a hadron resonance gas model.
Lactobacilli are gram-positive bacteria that are a subdominant element in the human gastrointestinal microbiota, and which are commonly used in the food industry. Some lactobacilli are considered ...probiotic, and have been associated with health benefits. However, there is very little culture-independent information on how consumed probiotic microorganisms might affect the entire intestinal microbiota. We therefore studied the impact of the administration of Lactobacillus salivarius UCC118, a microorganism well characterized for its probiotic properties, on the composition of the intestinal microbiota in two model animals. UCC118 has anti-infective activity due to production of the bacteriocin Abp118, a broad-spectrum class IIb bacteriocin, which we hypothesized could impact the microbiota. Mice and pigs were administered wild-type (WT) L. salivarius UCC118 cells, or a mutant lacking bacteriocin production. The microbiota composition was determined by pyrosequencing of 16S rRNA gene amplicons from faeces. The data show that L. salivarius UCC118 administration had no significant effect on proportions of major phyla comprising the mouse microbiota, whether the strain was producing bacteriocin or not. However, L. salivarius UCC118 WT administration led to a significant decrease in Spirochaetes levels, the third major phylum in the untreated pig microbiota. In both pigs and mice, L. salivarius UCC118 administration had an effect on Firmicutes genus members. This effect was not observed when the mutant strain was administered, and was thus associated with bacteriocin production. Surprisingly, in both models, L. salivarius UCC118 administration and production of Abp118 had an effect on gram-negative microorganisms, even though Abp118 is normally not active in vitro against this group of microorganisms. Thus L. salivarius UCC118 administration has a significant but subtle impact on mouse and pig microbiota, by a mechanism that seems at least partially bacteriocin-dependent.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
Estimates of the prevalence of Parkinson's disease in North America have varied widely and many estimates are based on small numbers of cases and from small regional subpopulations. We sought to ...estimate the prevalence of Parkinson's disease in North America by combining data from a multi-study sampling strategy in diverse geographic regions and/or data sources. Five separate cohort studies in California (2), Minnesota (1), Hawaii USA (1), and Ontario, Canada (1) estimated the prevalence of PD from health-care records (3), active ascertainment through facilities, large group, and neurology practices (1), and longitudinal follow-up of a population cohort (1). US Medicare program data provided complementary estimates for the corresponding regions. Using our age- and sex-specific meta-estimates from California, Minnesota, and Ontario and the US population structure from 2010, we estimate the overall prevalence of PD among those aged ≥45 years to be 572 per 100,000 (95% confidence interval 537-614) that there were 680,000 individuals in the US aged ≥45 years with PD in 2010 and that that number will rise to approximately 930,000 in 2020 and 1,238,000 in 2030 based on the US Census Bureau population projections. Regional variations in prevalence were also observed in both the project results and the Medicare-based calculations with which they were compared. The estimates generated by the Hawaiian study were lower across age categories. These estimates can guide health-care planning but should be considered minimum estimates. Some heterogeneity exists that remains to be understood.
Rapidity-odd directed flow (v1) measurements for charged pions, protons, and antiprotons near midrapidity (y=0) are reported in sNN=7.7, 11.5, 19.6, 27, 39, 62.4, and 200 GeV Au+Au collisions as ...recorded by the STAR detector at the Relativistic Heavy Ion Collider. At intermediate impact parameters, the proton and net-proton slope parameter dv1/dy|y=0 shows a minimum between 11.5 and 19.6 GeV. In addition, the net-proton dv1/dy|y=0 changes sign twice between 7.7 and 39 GeV. The proton and net-proton results qualitatively resemble predictions of a hydrodynamic model with a first-order phase transition from hadronic matter to deconfined matter, and differ from hadronic transport calculations.
Early‐life environmental conditions can provide a source of individual variation in life‐history strategies and senescence patterns. Conditions experienced in early life can be quantified by ...measuring telomere length, which can act as a biomarker of survival probability in some species. Here, we investigate whether seasonal changes, weather conditions and group size are associated with early‐life and/or early‐adulthood telomere length in a wild population of European badgers (Meles meles). We found substantial intra‐annual changes in telomere length during the first 3 years of life, where within‐individual effects showed shorter telomere lengths in the winter following the first spring and a trend for longer telomere lengths in the second spring compared to the first winter. In terms of weather conditions, cubs born in warmer, wetter springs with low rainfall variability had longer early‐life (3–12 months old) telomeres. Additionally, cubs born in groups with more cubs had marginally longer early‐life telomeres, providing no evidence of resource constraint from cub competition. We also found that the positive association between early‐life telomere length and cub survival probability remained when social and weather variables were included. Finally, after sexual maturity, in early adulthood (i.e., 12–36 months) we found no significant association between same‐sex adult group size and telomere length (i.e., no effect of intrasexual competition). Overall, we show that controlling for seasonal effects, which are linked to food availability, is important in telomere length analyses, and that variation in telomere length in badgers reflects early‐life conditions and also predicts first year cub survival.
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