The Aragats Space-Environmental Center provides monitoring of different species of secondary cosmic rays at two altitudes and with different energy thresholds. One-minute data is available on-line ...from
http://crdlx5.yerphi.am/DVIN/index2.php. We present description of the main monitors along with data acquisition electronics. Also we demonstrate the sensitivity of the different species of secondary cosmic ray flux to geophysical conditions, taking as examples the extremely violent events of October–November 2003. We introduce correlation analysis of the different components of registered time-series as a new tool for the classification of the geoeffective (events on earth affected by solar activity) events and for the forecasting of the severity of the upcoming geomagnetic storm.
Primary hyperparathyroidism (PHPT) is the third most
frequent endocrine disorder and has a variable clinical
presentation. Asymptomatic PHPT became the predominant
form of the disease with increase ...of its incidence after the
introduction of automated serum calcium measurement in
North America and Europe. Data from Russia is lacking. Aim:
To present the clinical profile of PHPT in Russia. Materials
and Methods: This retrospective study was conducted at
endocrinology centers in 8 regions of Russia. We analyzed
the clinical presentation, and treatment options in patients
with confirmed PHPT (1995-2010). Results: 738 patients (F:
M-8:1) with age ranging from 13 to 83,4 years (mean 54,3)
were analyzed. 54% was from Moscow (n=397), 11% - from
Moscow region (n=79) and 35% - from 53 regions of Russia
(n=262). Symptomatic PHPT was the most common form (74%)
and was revealed with osteoporosis in 56%, nephrolithiasis - in
45% and ulcer disease - in 18%. Our data showed an increase
in the incidence of PHPT (especially mild PHPT) after 2005
compared with earlier period. 64,9% of patients were treated
surgically, 17 patients undergone repeated parathyroid surgery.
28,3% received bisphosphonates, calcitonin and/or cinacalcet .
11,5% was observed without treatment. Conclusions: This
data analyzes some causes of delayed diagnosis of PHPT in
Russia, characterized age and gender distribution of patients
with PHPT and demonstrates the changes in clinical profile of
disease from 1995 to 2010. PHPT still remains symptomatic
disorder in our country most frequently with skeletal and renal
manifestations.
Приведены 2 клинических случая поздней диагностики тяжелых форм первичного гиперпаратиреоза. повлекшие за собой неоправданные врачебные манипуляции, и развитие тяжелых осложнений заболевания. В ...первом случае из-за ошибочного диагноза остео... и нерасп ПГПТ пациентки подверглись многократным операциям на нижней челюсти. Во втором случае поздний диагноз ПГПТ у молодого пациента, несмотря на успешное хирургическое вмешательство привел к прогрессирующей ХПН и развитию вторичного гиперпаратиреоза.
Bone metabolism and changes in bone mineral density (BMD) are very important in patients with multiple endocrine neoplasia
(MEN) type 1 syndrome. Case report: we present a clinical case of primary ...hyperparathyroidism (PHPT) in a patient with a familal MEN
1 syndrome and severe PHPT debuted at a young age w. Pituitary Cushing syndrome was diagnosed in 16 years old patient. He had marked
osteoporosis due to hypercorticism and deficiency of sex hormones (-12% from the age norm). There was significant positive dynamics
in BMD (+7% by Z-score) after remission of hypercorticism by two courses of radiation treatment and effective hormone replacement therapy
of hypogonadism. PHPT with marked decrease in BMD at three sites was revealed at age of 19 years. Obvious increase in BMD was observed
during a year after effective surgical treatment and antiosteoporotic therapy. In conclusion, this clinical case demonstrates the combined
influence of various factors on bone metabolism in patients with MEN type 1 syndrome, which requires integrated approach to successful
therapy.
The Sagnac experiment with X-radiation Vysotskii, V I; Vorontsov, V I; Kuz'min, R N ...
Physics Uspekhi,
03/1994, Letnik:
37, Številka:
3
Journal Article
Ionizing radiation is widely applied in food production as preservation technology and for correction of the gut microbiome of cancer patients, rescuers, astronauts etc. Lactic acid bacteria (LAB) ...can be used for the same reason. The main goal of this study was to investigate the effect of irradiation on some activities of Lactobacillus rhamnosus MDC 9661 and its effect on the survival of irradiated rats. The results indicate that both ultraviolet (during 45 min) and X‐ray irradiations (with 2 Sv) decreased the CFU and the antibacterial activity of the strain. Higher than 700 Sv dose of X‐ray irradiation resulted in the total inhibition of antibacterial activity with the total reduction of colony forming units less than 10 cells ml−1, while irradiated with 1000 Sv dose L. rhamnosus MDC 9661 did not lose its proteolytic activity. It was also shown that L. rhamnosus MDC 9661 was not immunogenic in the organism of the rats and cannot lead to the development of autoimmune responses. L. rhamnosus MDC 9661 demonstrated the necessary properties for probiotics and can be effectively used for the correction of the gut microbiome of all target groups. The co‐aggregation of the cells is one of the mechanisms for resistance of LAB to irradiation.
Significance and Impact of the Study: Ionizing radiation is widely applied for food preservation and for correction of the gut microbiome of patients treated with radiation, rescuers, astronauts, etc. Some lactic acid bacteria (LAB) are of great potential in restoring the microbiome of patients, or in food bio‐preservation. This investigation revealed the radioresistance of Lactobacillus rhamnosus MDC 9661 with only some loss of antibacterial activity, maintaining other activities and the absence of an immunogenic effect. So, it is a potential probiotic organism for the treatment of target people groups. The results showed that co‐aggregation is one of the LAB resistance mechanisms which can be used in future to select effective strains.
A
bstract
Missing kinematic information of known invisible particles, such as neutrinos, limit several high-energy physics analysis. The undetected particle carries away momentum and energy ...information, preventing the total reconstruction of such an event. This paper presents a new method to handle this missing information, referred to as the Generalised Known Kinematics (GKK) approach. Its event-by-event probability density distributions that describe the physically allowed kinematics of an event. For GKK, we consider the available kinematic information and constraints given by the assumed final state. Summing these event-wise distributions over large data sets allows the determination of parameters that influence the event kinematics. Examples are particle masses obscured by the missing information on the invisible final-state particles. The method is demonstrated in simulation studies with
τ
+
τ
−
events in
e
+
e
−
collisions at the
Υ
(4S) resonance, presenting a new, promising approach for measuring the
τ
lepton mass.
Patients with Xq26.3 microduplication present with X-linked acrogigantism (X-LAG) syndrome, an early-childhood form of gigantism due to marked growth hormone (GH) hypersecretion from mixed GH-PRL ...adenomas and hyperplasia. The microduplication includes GPR101, which is upregulated in patients' tumor tissue. The GPR101 gene codes for an orphan G protein coupled receptor that is normally highly expressed in the hypothalamus. Our aim was to determine whether GPR101 loss of function mutations or deletions could be involved in patients with congenital isolated GH deficiency (GHD). Taking advantage of the cohort of patients from the GENHYPOPIT network, we studied 41 patients with unexplained isolated GHD. All patients had Sanger sequencing of the GPR101 gene and array comparative genome hybridization (aCGH) to look for deletions. Functional studies (cell culture with GH secretion measurements, cAMP response) were performed. One novel GPR101 variant, c.589 G>T (p.V197L), was seen in the heterozygous state in a patient with isolated GHD. In silico analysis suggested that this variant could be deleterious. Functional studies did not show any significant difference in comparison with wild type for GH secretion and cAMP response. No truncating, frameshift, or small insertion-deletion (indel) GPR101 mutations were seen in the 41 patients. No deletion or other copy number variation at chromosome Xq26.3 was found on aCGH. We found a novel GPR101 variant of unknown significance, in a patient with isolated GH deficiency. Our study did not identify GPR101 abnormalities as a frequent cause of GH deficiency.
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