We present an analysis of the final data release of the Carnegie Supernova Project I, focusing on the absolute calibration of the luminosity-decline rate relation for Type Ia supernovae (SNe Ia) ...using new intrinsic color relations with respect to the color-stretch parameter, sBV, enabling improved dust extinction corrections. We investigate to what degree the so-called fast-declining SNe Ia can be used to determine accurate extragalactic distances. We estimate the intrinsic scatter in the luminosity-decline rate relation and find it ranges from 0.13 mag to 0.18 mag with no obvious dependence on wavelength. Using the Cepheid variable star data from the SH0ES project, the SN Ia distance scale is calibrated and the Hubble constant is estimated using our optical and near-infrared sample, and these results are compared to those determined exclusively from a near-infrared subsample. The systematic effect of the supernova's host galaxy mass is investigated as a function of wavelength and is found to decrease toward redder wavelengths, suggesting this effect may be due to dust properties of the host. Using estimates of the dust extinction derived from optical and near-infrared wavelengths and applying these to the H band, we derive a Hubble constant , whereas using a simple B − V color correction applied to the B band yields . Photometry of two calibrating SNe Ia from the CSP-II sample, SN 2012ht and SN 2015F, is presented and used to improve the calibration of the SN Ia distance ladder.
IMPORTANCE: Clinical evidence of the potential treatment benefit of mechanical thrombectomy for posterior circulation distal, medium vessel occlusion (DMVO) is sparse. OBJECTIVE: To investigate the ...frequency as well as the clinical and safety outcomes of mechanical thrombectomy for isolated posterior circulation DMVO stroke and to compare them with the outcomes of standard medical treatment with or without intravenous thrombolysis (IVT) in daily clinical practice. DESIGN, SETTING, AND PARTICIPANTS: This multicenter case-control study analyzed patients who were treated for primary distal occlusion of the posterior cerebral artery (PCA) of the P2 or P3 segment. These patients received mechanical thrombectomy or standard medical treatment (with or without IVT) at 1 of 23 comprehensive stroke centers in Europe, the United States, and Asia between January 1, 2010, and June 30, 2020. All patients who met the inclusion criteria were matched using 1:1 propensity score matching. INTERVENTIONS: Mechanical thrombectomy or standard medical treatment with or without IVT. MAIN OUTCOMES AND MEASURES: Clinical end point was the improvement of National Institutes of Health Stroke Scale (NIHSS) scores at discharge from baseline. Safety end point was the occurrence of symptomatic intracranial hemorrhage and hemorrhagic complications were classified based on the Second European-Australasian Acute Stroke Study (ECASSII). Functional outcome was evaluated with the modified Rankin Scale (mRS) score at 90-day follow-up. RESULTS: Of 243 patients from all participating centers who met the inclusion criteria, 184 patients were matched. Among these patients, the median (interquartile range IQR) age was 74 (62-81) years and 95 (51.6%) were female individuals. Posterior circulation DMVOs were located in the P2 segment of the PCA in 149 patients (81.0%) and in the P3 segment in 35 patients (19.0%). At discharge, the mean NIHSS score decrease was −2.4 points (95% CI, −3.2 to −1.6) in the standard medical treatment cohort and −3.9 points (95% CI, −5.4 to −2.5) in the mechanical thrombectomy cohort, with a mean difference of −1.5 points (95% CI, 3.2 to −0.8; P = .06). Significant treatment effects of mechanical thrombectomy were observed in the subgroup of patients who had higher NIHSS scores on admission of 10 points or higher (mean difference, −5.6; 95% CI, −10.9 to −0.2; P = .04) and in the subgroup of patients without IVT (mean difference, −3.0; 95% CI, −5.0 to −0.9; P = .005). Symptomatic intracranial hemorrhage occurred in 4 of 92 patients (4.3%) in each treatment cohort. CONCLUSIONS AND RELEVANCE: This study suggested that, although rarely performed at comprehensive stroke centers, mechanical thrombectomy for posterior circulation DMVO is a safe, and technically feasible treatment option for occlusions of the P2 or P3 segment of the PCA compared with standard medical treatment with or without IVT.
The natural bacterial diversity is regarded as a treasure trove for natural products. However, accessing complex cell mixtures derived from environmental samples in standardized high-throughput ...screenings is challenging. Here, we present a droplet-based microfluidic platform for ultrahigh-throughput screenings able to directly harness the diversity of entire microbial communities. This platform combines extensive cultivation protocols in aqueous droplets starting from single cells or spores with modular detection methods for produced antimicrobial compounds. After long-term incubation for bacterial cell propagation and metabolite production, we implemented a setup for mass spectrometric analysis relying on direct electrospray ionization and injection of single droplets. Even in the presence of dense biomass we show robust detection of streptomycin on the single droplet level. Furthermore, we developed an ultrahigh-throughput screening based on a functional whole-cell assay by picoinjecting reporter cells into droplets. Depending on the survival of reporter cells, droplets were selected for the isolation of producing bacteria, which we demonstrated for a microbial soil community. The established ultrahigh-throughput screening for producers of antibiotics in miniaturized bioreactors in which diverse cell mixtures can be screened on the single cell level is a promising approach to find novel antimicrobial scaffolds.
The Carnegie Supernova Project (CSP) is a five-year survey being carried out at the Las Campanas Observatory to obtain high-quality light curves of ~100 low-redshift Type Ia supernovae (SNe Ia) in a ...well-defined photometric system. Here we present the first release of photometric data that contains the optical light curves of 35 SNe Ia, and near-infrared light curves for a subset of 25 events. The data comprise 5559 optical (ugriBV) and 1043 near-infrared (Y JHKs ) data points in the natural system of the Swope telescope. Twenty-eight SNe have pre-maximum data, and for 15 of these, the observations begin at least 5 days before B maximum. This is one of the most accurate data sets of low-redshift SNe Ia published to date. When completed, the CSP data set will constitute a fundamental reference for precise determinations of cosmological parameters, and serve as a rich resource for comparison with models of SNe Ia.
An analysis of the first set of low-redshift (z < 0.08) Type Ia supernovae (SNe Ia) monitored by the Carnegie Supernova Project between 2004 and 2006 is presented. The data consist of well-sampled, ...high-precision optical (ugriBV) and near-infrared (NIR; YJHKs ) light curves in a well-understood photometric system. Methods are described for deriving light-curve parameters, and for building template light curves which are used to fit SN Ia data in the ugriBVYJH bands. The intrinsic colors at maximum light are calibrated using a subsample of supernovae (SNe) assumed to have suffered little or no reddening, enabling color excesses to be estimated for the full sample. The optical-NIR color excesses allow the properties of the reddening law in the host galaxies to be studied. A low average value of the total-to-selective absorption coefficient, RV 1.7, is derived when using the entire sample of SNe. However, when the two highly reddened SNe (SN 2005A and SN 2006X) in the sample are excluded, a value RV 3.2 is obtained, similar to the standard value for the Galaxy. The red colors of these two events are well matched by a model where multiple scattering of photons by circumstellar dust steepens the effective extinction law. The absolute peak magnitudes of the SNe are studied in all bands using a two-parameter linear fit to the decline rates and the colors at maximum light, or alternatively, the color excesses. In both cases, similar results are obtained with dispersions in absolute magnitudes of 0.12-0.16 mag, depending on the specific filter-color combination. In contrast to the results obtained from the comparison of the color excesses, these fits of absolute magnitude give RV 1-2 when the dispersion is minimized, even when the two highly reddened SNe are excluded. This discrepancy suggests that, beyond the 'normal' interstellar reddening produced in the host galaxies, there is an intrinsic dispersion in the colors of SNe Ia which is correlated with luminosity but independent of the decline rate. Finally, a Hubble diagram for the best-observed subsample of SNe is produced by combining the results of the fits of absolute magnitude versus decline rate and color excess for each filter. The resulting scatter of 0.12 mag appears to be limited by the peculiar velocities of the host galaxies as evidenced by the strong correlation between the distance-modulus residuals observed in the individual filters. The implication is that the actual precision of SNe Ia distances is 3%-4%.
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