Medir el impacto del programa de intervención comunitaria «Educación para la salud en la adolescencia» llevado a cabo en el barrio de Parquesol, Valladolid, durante los años 2015-2019.
Ensayo ...comunitario de intervención cuasi experimental analítico pre- y postest con grupo control. Se recogieron 407 encuestas de adolescentes. Se utilizó el test CHIP-AE validado para España. Se analizaron los resultados pre- y postest y se compararon con el grupo control.
Se encontraron mejoras en el grupo de intervención femenino frente al grupo control en las variables resistencia (3,68 vs. 3,41; p<0,01), salud y seguridad en el hogar (4,30 vs. 4,00; p <0,01), actividades físicas (3,16 vs. 2,60; p <0,01) y autoestima (3,17 vs. 2,79; p <0,05).
La intervención comunitaria realizada mejora el perfil de salud de los/las adolescentes. La percepción basal de la salud presenta diferencias por sexo, con mayor puntuación en los hombres. La mejoría posintervención es sustancial en las mujeres en resistencia, actividades físicas y salud y seguridad en el hogar. Además, se corrige en la variable autoestima el empeoramiento debido al paso de los años descrito en estudios previos.
To measure the impact of the community health programme “Education for health in adolescence” carried out in the Parquesol neighborhood, Valladolid (Spain), during the years 2015-2019.
Community-based quasi-experimental pre- and post-test analytical intervention trial with control group. A total of 407 adolescent surveys were collected. The CHIP-AE test validated for Spain was used. Pre- and post-test results were analyzed and compared with the control group.
Improvements were found in the female intervention group compared to the control group in the variables resilience (3.68 vs. 3.41; p <0.01), health and safety at home (4.30 vs. 4.00; p <0.01), physical activities (3.16 vs. 2.60; p <0.01) and self-esteem (3.17 vs. 2.79; p <0.05).
The community intervention carried out improves the health profile of adolescents. The baseline perception of health presents differences by gender, with higher scores in males. Post-intervention improvement is substantial in females in resilience, physical activities and health and safety at home. In addition, the worsening due to the passage of time described in previous studies is corrected in the variables self-esteem, satisfaction and well-being.
Resumen: Objetivo: Medir el impacto del programa de intervención comunitaria «Educación para la salud en la adolescencia» llevado a cabo en el barrio de Parquesol, Valladolid, durante los años ...2015-2019. Método: Ensayo comunitario de intervención cuasi experimental analítico pre- y postest con grupo control. Se recogieron 407 encuestas de adolescentes. Se utilizó el test CHIP-AE validado para España. Se analizaron los resultados pre- y postest y se compararon con el grupo control. Resultados: Se encontraron mejoras en el grupo de intervención femenino frente al grupo control en las variables resistencia (3,68 vs. 3,41; p < 0,01), salud y seguridad en el hogar (4,30 vs. 4,00; p < 0,01), actividades físicas (3,16 vs. 2,60; p < 0,01) y autoestima (3,17 vs. 2,79; p < 0,05). Conclusiones: La intervención comunitaria realizada mejora el perfil de salud de los/las adolescentes. La percepción basal de la salud presenta diferencias por sexo, con mayor puntuación en los hombres. La mejoría posintervención es sustancial en las mujeres en resistencia, actividades físicas y salud y seguridad en el hogar. Además, se corrige en la variable autoestima el empeoramiento debido al paso de los años descrito en estudios previos. Abstract: Objective: To measure the impact of the community health programme “Education for health in adolescence” carried out in the Parquesol neighborhood, Valladolid (Spain), during the years 2015-2019. Method: Community-based quasi-experimental pre- and post-test analytical intervention trial with control group. A total of 407 adolescent surveys were collected. The CHIP-AE test validated for Spain was used. Pre- and post-test results were analyzed and compared with the control group. Results: Improvements were found in the female intervention group compared to the control group in the variables resilience (3.68 vs. 3.41; p < 0.01), health and safety at home (4.30 vs. 4.00; p < 0.01), physical activities (3.16 vs. 2.60; p < 0.01) and self-esteem (3.17 vs. 2.79; p < 0.05). Conclusions: The community intervention carried out improves the health profile of adolescents. The baseline perception of health presents differences by gender, with higher scores in males. Post-intervention improvement is substantial in females in resilience, physical activities and health and safety at home. In addition, the worsening due to the passage of time described in previous studies is corrected in the variables self-esteem, satisfaction and well-being.
Adoptive T cellular immunotherapies have emerged as relevant approaches for treating cancer patients who have relapsed or become refractory (R/R) to traditional cancer treatments. Chimeric antigen ...receptor (CAR) T-cell therapy has improved survival in various hematological malignancies. However, significant limitations still impede the widespread adoption of these therapies in most cancers. To advance in this field, six research groups have created the "NEXT Generation CART MAD Consortium" (NEXT CART) in Madrid's Community, which aims to develop novel cell-based immunotherapies for R/R and poor prognosis cancers. At NEXT CART, various basic and translational research groups and hospitals in Madrid concur to share and synergize their basic expertise in immunotherapy, gene therapy, and immunological synapse, and clinical expertise in pediatric and adult oncology. NEXT CART goal is to develop new cell engineering approaches and treatments for R/R adult and pediatric neoplasms to evaluate in multicenter clinical trials. Here, we discuss the current limitations of T cell-based therapies and introduce our perspective on future developments. Advancement opportunities include developing allogeneic products, optimizing CAR signaling domains, combining cellular immunotherapies, multi-targeting strategies, and improving tumor-infiltrating lymphocytes (TILs)/T cell receptor (TCR) therapy. Furthermore, basic studies aim to identify novel tumor targets, tumor molecules in the tumor microenvironment that impact CAR efficacy, and strategies to enhance the efficiency of the immunological synapse between immune and tumor cells. Our perspective of current cellular immunotherapy underscores the potential of these treatments while acknowledging the existing hurdles that demand innovative solutions to develop their potential for cancer treatment fully.
A new Ir(ii) complex {Ir(μ-κCNHC,η(6)Dipp-IDipp)(H)}2BF42 has been prepared and fully characterised. This complex acts as a catalyst for the hydroalkynylation of imines according to an unprecedented ...diiridium-mediated mechanism.
A well-defined NHC-Ir(
iii
) catalyst, Ir(H)
2
(IPr)(py)
3
BF
4
(IPr = 1,3-bis-(2,6-diisopropylphenyl)imidazol-2-ylidene), that provides access to a wide range of aryl- and heteroaryl-silanes by ...intermolecular dehydrogenative C-H bond silylation has been prepared and fully characterized. The directed and non-directed functionalisation of C-H bonds has been accomplished successfully using an arene as the limiting reagent and a variety of hydrosilanes in excess, including Et
3
SiH, Ph
2
MeSiH, PhMe
2
SiH, Ph
3
SiH and (EtO)
3
SiH. Examples that show unexpected selectivity patterns that stem from the presence of aromatic substituents in hydrosilanes are also presented. The selective bisarylation of bis(hydrosilane)s by directed or non-directed silylation of C-H bonds is also reported herein. Theoretical calculations at the DFT level shed light on the intermediate species in the catalytic cycle and the role played by the ligand system on the Ir(
iii
)/Ir(
i
) mechanism.
A well-defined NHC-Ir(
iii
) catalyst provides access to a wide range of aryl- and heteroarylsilanes by intermolecular dehydrogenative C-H bond silylation.
A well-defined NHC-Ir(
iii
) catalyst provides access to a wide range of aryl- and heteroarylsilanes by intermolecular dehydrogenative C–H bond silylation.
A well-defined NHC–Ir(
iii
) catalyst, ...Ir(H)
2
(IPr)(py)
3
BF
4
(IPr = 1,3-bis-(2,6-diisopropylphenyl)imidazol-2-ylidene), that provides access to a wide range of aryl- and heteroaryl-silanes by intermolecular dehydrogenative C–H bond silylation has been prepared and fully characterized. The directed and non-directed functionalisation of C–H bonds has been accomplished successfully using an arene as the limiting reagent and a variety of hydrosilanes in excess, including Et
3
SiH, Ph
2
MeSiH, PhMe
2
SiH, Ph
3
SiH and (EtO)
3
SiH. Examples that show unexpected selectivity patterns that stem from the presence of aromatic substituents in hydrosilanes are also presented. The selective bisarylation of bis(hydrosilane)s by directed or non-directed silylation of C–H bonds is also reported herein. Theoretical calculations at the DFT level shed light on the intermediate species in the catalytic cycle and the role played by the ligand system on the Ir(
iii
)/Ir(
i
) mechanism.
Novel nutraceutic therapies for the treatment of metabolic syndrome Esperanza Martínez-Abundis;Miriam Mendez-del Villar;Karina G Pérez-Rubio;Laura Y Zuniga;Marisol Cortez-Navarrete;Alejandra Ramírez-Rodriguez;Manuel González-Ortiz
World journal of diabetes,
04/2016, Letnik:
7, Številka:
7
Journal Article
Odprti dostop
Nutraceutic therapies such as berberine, bitter melon,Gymnema sylvestre , Irvingia gabonensis, resveratrol and ursolic acid have been shown to help control metabolic syndrome (MetS). The effect of ...berberine on glucose and lipid metabolism, hypertension, obesity and MetS has been evaluated in animal models and humans.Most clinical trials involving bitter melon have been conducted to evaluate its effect on glucose metabolism;nevertheless, some studies have reported favorable effects on lipids and blood pressure although there is little information about its effect on body weight.Gymnema sylvestre helps to decrease body weight and blood sugar levels; however, there is limited information on dyslipidemia and hypertension. Clinical trials of Irvingia gabonensis have shown important effects decreasing glucose and cholesterol concentrations as well decreasing body weight. Resveratrol acts through different mechanisms to decrease blood pressure,lipids, glucose and weight, showing its effects on the population with MetS. Finally, there is evidence of positive effects with ursolic acid in in vitro and in vivo studies on glucose and lipid metabolism and on body weight and visceral fat. Therefore, a review of the beneficial effects and limitations of the above-mentioned nutraceutic therapies is presented.
A new Ir(
ii
) complex {Ir(μ-κC
NHC
,η
6
Dipp
-IDipp)(H)}
2
BF
4
2
has been prepared and fully characterised. This complex acts as a catalyst for the hydroalkynylation of imines according to an ...unprecedented diiridium-mediated mechanism.
A new Ir(
ii
) complex {Ir(μ-κC
NHC
,η
6
Dipp
-IDipp)(H)}
2
BF
4
2
acts as a catalyst for the hydroalkynylation of imines according to an unprecedented mechanism.
The catalytic activity of a Co
2(CO)
8/dppe (
C3) solution system is compared with binuclear complexes Co
2(CO)
6P(Ph)
3
2 (
C1) and Co
2(CO)
6P(OPh)
3
2 (
C2). The
C3 system, likewise
C1 and
C2, ...catalyses the Pauson–Khand (PK) reaction employing strained olefins and does not promote double carbonylation as occurs with
C2. Under more drastic reaction conditions, the use of
C2 and
C3 in presence of less structural strained olefins yields a mixture of products: PK and alkyne cyclotrimerization leading to aromatic compounds. Alkyne cyclotrimerization under these PK reaction conditions appears to be the first example reported. IR studies suggest the formation of an alkynyl–Co
2(CO)
4-μ
2-(Ph)
2PCH
2CH
2P(Ph)
2 symmetric complex as the catalytic species active in the system.
An efficient preformed chiral palladium catalyzed direct diastereo- and enantioselective reductive amination of un- and substituted cycloaliphatic ketones with primary aryl amines has been developed.
...Chiral cycloaliphatic amines were obtained from the direct asymmetric reductive amination of cycloaliphatic ketones using a preformed chiral palladium catalyst.
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