Data from the Pharmacogenomics and Risk of Cardiovascular Disease (PARC) study and the Cardiovascular Health Study (CHS) provide independent and confirmatory evidence for association between common ...polymorphisms of the HNF1A gene encoding hepatocyte nuclear factor-1α and plasma C-reactive protein (CRP) concentration. Analyses with the use of imputation-based methods to combine genotype data from both studies and to test untyped SNPs from the HapMap database identified several SNPs within a 5 kb region of HNF1A intron 1 with the strongest evidence of association with CRP phenotype. PUBLICATION ABSTRACT
Abstract
Leucaena leucocephala (leucaena) is an important agroforestry tree of tropics and subtropics due to its protein rich foliages, ability to grow on poor soils, and high level of tolerance to ...various stresses including drought and diseases. We hypothesized that leucaena have a unique set of genes which confer tolerance to various abiotic and biotic stresses and these genes are either absent or not expressed in other legumes that are susceptible to these stress conditions. Interspecies suppression subtractive hybridization (iSSH) was performed to identify some unique genes from leucaena using cDNAs from leucaena and Acacia confusa (acacia) as the tester and driver, respectively. We identified 100 leucaena genes showing homology to various plant genes with known functions, of which 23 genes had homology to various stress-related proteins including chitinase, PR-10 protein, wound-stress protein, type-2 metallothionein, thaumatin-like protein, disease resistance response protein, cysteine proteinase, and kunitz trypsin inhibitor. We also identified 50 leucaena genes which either had homology to hypothetical proteins (HyPs) or had no homology at all. Putative functions of 15 HyPs were predicted using conserved domain and PSI-BLAST analyses. Linear motif analyses identified 17 HyPs with MAPK recognition motif, which is involved in signaling pathways, including stress responses. This study identified 23 known and some putative unique stress-related genes from leucaena which may serve as a useful source of stress-tolerance genes for tree and crop improvement in the future.
IntroductionPrimary prevention (PP) ICD are increasingly placed in children with Hypertrophic Cardiomyopathy (HCM) to prevent SCD using adult criteria. The reliability of PPICD to prevent SCD is ...unclear.MethodsWe collected data on HCM children ≤20 years with PPICD. Risk factors (RF) for SCD were 1) family history (FH) of SCD 2) syncope; 3) maximal Left ventricular (LV) wall thickness (LVWT) Z value > 5; 4) non-sustained VT (NSVT) on ambulatory ECG; and 5) abnormal BP response to exercise (ABPR).ResultsOf 347 patients (age 14.61± 4.18), with PP-ICD, appropriate interventions (AI) occurred in 55 (16%). RF presence pre-ICD implant was FH-SCD in 114 (33%); LVWT in 230 (66%); NSVT in 25 (7%); ABPR in 105 (30%) and syncope in 84 (20%). Follow up after ICD implant was 0.07 to 32.95 (mean 8.82 ± 6.03) years and incidence of AI was 18.40 cases per 1000 person-years. AI incidence for each RF wasFH-SCD20/114 (17.5%); LVWT 36/230 (15.7%); NSVT 4/25 (16.0%); ABPR 18/105 (17.1%) and syncope 22/84( 26.2%). Risk of AI based on # of RF were5/31 (16%) for 0 RF; 16/126 (13%) for 1 RF; 20/146 (14%) for 2 RF; 12/36 (33%) for 3 RF and 2/8 (25%) for 4 RF.ConclusionsThe incidence of AI in HCM children with PP-ICD based on adult criteria was high. Syncope was the commonest RF associated with AI. All other RF’s had similar incidence in patients with AI. Presence of ≥ 3 RF was associated with AI.
Glacial science could benefit tremendously from autonomous robots, but previous glacial robots have had perception issues in these colorless and featureless environments, specifically with visual ...feature extraction. This translates to failures in visual odometry and visual navigation. Glaciologists use near-infrared imagery to reveal the underlying heterogeneous spatial structure of snow and ice, and we theorize that this hidden near-infrared structure could produce more and higher quality features than available in visible light. We took a custom camera rig to Igloo Cave at Mt. St. Helens to test our theory. The camera rig contains two identical machine vision cameras, one which was outfitted with multiple filters to see only near-infrared light. We extracted features from short video clips taken inside Igloo Cave at Mt. St. Helens, using three popular feature extractors (FAST, SIFT, and SURF). We quantified the number of features and their quality for visual navigation by comparing the resulting orientation estimates to ground truth. Our main contribution is the use of NIR longpass filters to improve the quantity and quality of visual features in icy terrain, irrespective of the feature extractor used.
Mapping Water Contamination of Jet Fuel Holmes, Christopher; Brocklesby, William S.; Wood, Christopher ...
2019 IEEE Avionics and Vehicle Fiber-Optics and Photonics Conference (AVFOP),
2019-Nov.
Conference Proceeding
We shall report the latest progress on AWESOME (Airbus Water Emulsification Sensor using Optical Monitoring Equipment), which seeks to use spectrally multiplexed guided and leaky mode Bragg gratings ...to quantify dissolved (5ppm-v resolution), free and emulsified water contamination at multiple physical points within a fuel tank.
A new series of potent nonpeptide vitronectin receptor antagonists, based on a novel carbocyclic Gly-Asp mimetic, has been discovered. A representative of this series, SB 265123 (
4), has 100% oral ...bioavailability in rats, and is orally active in vivo in the ovariectomized rat model of osteoporosis.
A new series of potent nonpeptide vitronectin receptor antagonists, based on a novel carbocyclic Gly-Asp mimetic, has been discovered. A representative of this series, SB 265123 (
4), has 100% oral bioavailability in rats, and is orally active in vivo in the ovariectomized rat model of osteoporosis.
