Investigating how classical systems may manifest dynamics analogous to those of quantum systems is a broad subject of fundamental interest. Walking droplets, which self-propel through a resonant ...interaction with their own wave field, provide a unique macroscopic realization of wave-particle duality that exhibits behaviors previously thought exclusive to quantum particles. Despite significant efforts, elucidating the precise origin and form of the wave-mediated forces responsible for the walker's quantumlike behavior remained elusive. Here, we demonstrate that, owing to wave interference, the force responsible for orbital quantization originates from waves excited near stationary points on the walker's past trajectory. Moreover, we derive a minimal model with the essential ingredients to capture quantized orbital dynamics, including quasiperiodic and chaotic orbits. Notably, this minimal model provides an explicit distinction between local forces, which account for the walker's preferred speed and wave-induced added mass, and spatiotemporal nonlocal forces responsible for quantization. The quantization mechanism revealed here is generic, and will thus play a role in other hydrodynamic quantum analogs.
Familial hypercholesterolemia (FH) is the most common genetic disorder associated with premature atherosclerotic cardiovascular disease (ASCVD). There are sparse data on attainment of treatment ...targets; large registries that reflect real-life clinical practice can uniquely provide this information.
We sought to evaluate the achievement of low-density lipoprotein cholesterol (LDL-C) treatment goals in FH patients enrolled in a large national registry.
The SAFEHEART study (Spanish Familial Hypercholesterolemia Cohort Study) is a large, ongoing registry of molecularly defined patients with heterozygous FH treated in Spain. The attainment of guideline-recommended plasma LDL-C goals at entry and follow-up was investigated in relation to use of lipid-lowering therapy (LLT).
The study recruited 4,132 individuals (3,745 of whom were ≥18 years of age); 2,752 of those enrolled were molecularly diagnosed FH cases. Mean follow-up was 5.1 ± 3.1 years; 71.8% of FH cases were on maximal LLT, and an LDL-C treatment target <100 mg/dl was reached by only 11.2% of patients. At follow-up, there was a significant increase in the use of ezetimibe, drug combinations with statins, and maximal LLT. The presence of type 2 diabetes mellitus, a defective allele mutation, ezetimibe use, and the absence of previous ASCVD were predictors of the attainment of LDL-C goals.
Despite the use of intensified LLT, many FH patients continue to experience high plasma LDL-C levels and, consequently, do not achieve recommended treatment targets. Type of LDL-receptor mutation, use of ezetimibe, coexistent diabetes, and ASCVD status can bear significantly on the likelihood of attaining LDL-C treatment goals.
The theoretical framework of the self-determination theory establishes that the satisfaction of basic psychological needs and more self-determined motivational forms are related to positive ...behavioral consequences and, therefore, may increase the intention to be physically active in Physical Education students. In this sense, the need for novelty has been proposed as a psychological need by recent scientific evidence, so it is necessary to prove its possible contribution to the prediction of young people's behavior. Therefore, the main objective of the study was to test a model that analyzed the power of prediction of the satisfaction of the needs for autonomy, competence, relatedness, and novelty as well as the motivation experienced in Physical Education on the intention to be physically active. A questionnaire was administered to 1665 Physical Education students with an average age of 12.43 years (SD = 1.87), of which 835 were boys and 830 were girls. An adaptation of the Spanish educational context of the Basic Psychological Needs in Exercise Scale (BPNES) that includes the need for novelty, the Perceived Locus of Causality Scale (PLOC), and the Intention to be Physically Active Scale (IPAS) was used. Path analysis results showed that the satisfaction of the psychological needs for autonomy, competence, relatedness, and novelty predicted autonomous motivation. On the other hand, the need for autonomy positively predicted controlled motivation, while the satisfaction of relatedness did so negatively. The need for competence and autonomous motivation positively predicted the intention to be physically active in Physical Education students, obtaining an explained variance of 33%. However, controlled motivation was not related in a statistically significant way to the intention to be physically active. In conclusion, the results of the hypothesized model highlight the importance of satisfying all the basic psychological needs (including novelty) and give special emphasis to the need for competence, since it predicts autonomous motivation and the intention to be physically active outside of the educational context.
The research on well‐being and physical exercise point to the possibility of a placebo effect. This study analyzes the effect of expectancy manipulation on psychological (well‐being and self‐esteem) ...and physical (agility and cardiorespiratory fitness) outcomes after a seven‐week program of aerobic training. 114 undergraduate students (age M = 19.81, SD = 1.75; 86.1% women) were randomized into G1 – No Exercise (n = 13), G2 – Exercise only (n = 15), G3 – Exercise + Manipulation of expectations: No psychological effect (n = 17) and G4 – Exercise + Manipulation of expectations: Psychological effect (n = 21). Outcome measures were the Rosenberg Self‐Esteem Scale, the Well‐Being subscale of the Subjective Exercise Experiences Scale, the Agility T‐test and the 20‐meter Shuttle Run Test. Paired t‐tests showed significant improvements from baseline in self‐esteem, agility, and cardiovascular fitness for the exercise groups. G4 also showed a significant improvement in well‐being. ANCOVA with adjustments for the baseline measures was used to test between‐group differences at the end of the program. The only significant differences at posttest were between G1 and the exercise groups. The data do not support a differential effect of elevated expectations of psychological benefits on the participants’ self‐esteem or psychological well‐being after an aerobic training program. Future research should analyze whether reinforcing expectations more frequently throughout the program might show a more robust influence.
Millimetric liquid droplets can walk across the surface of a vibrating fluid bath, self-propelled through a resonant interaction with their own guiding or ‘pilot’ wave fields. These walking droplets, ...or ‘walkers’, exhibit several features previously thought to be peculiar to the microscopic, quantum realm. In particular, walkers confined to circular corrals manifest a wave-like statistical behaviour reminiscent of that of electrons in quantum corrals. Here we demonstrate that localized topological inhomogeneities in an elliptical corral may lead to resonant projection effects in the walker’s statistics similar to those reported in quantum corrals. Specifically, we show that a submerged circular well may drive the walker to excite specific eigenmodes in the bath that result in drastic changes in the particle’s statistical behaviour. The well tends to attract the walker, leading to a local peak in the walker’s position histogram. By placing the well at one of the foci, a mode with maxima near the foci is preferentially excited, leading to a projection effect in the walker’s position histogram towards the empty focus, an effect strongly reminiscent of the quantum mirage. Finally, we demonstrate that the mean pilot-wave field has the same form as the histogram describing the walker’s statistics.
The aim of this study was to identify the most relevant dental factors and iatrogenic causes in the development of pathological changes to the sinus membrane and to analyse their possible influence ...on the development of odontogenic sinusitis. A descriptive, observational study was designed, with 276 patients who had been evaluated via cone beam computed tomography, analysing possible sinus thickening factors, such as apical infections, endodontic treatments, periodontitis, radicular cysts and impacted teeth, as well as iatrogenic factors caused by implant treatments or the development of oroantral communications produced during tooth extraction manoeuvres. Among the dental factors, periodontitis (47.1%), apical pathology (23.5%) and endodontic treatments (23.1%) were the predominant causes of sinus membrane thickening that most frequently produced an occupancy between 2 and 10 mm. Regarding the implant treatments, the placement of implants through the floor of the maxillary sinus was the main cause (9.8%), followed by sinus elevation techniques (6.2%). Dental extraction was the first cause of oroantral communication (5.0%), being the procedure that caused the greatest thickening of the sinus membrane. This study highlights the importance of dental treatments and iatrogenic factors in sinus pathology, and the need for diagnostic interrelations between the different specialists who address this pathology.
Since their discovery by Yves Couder and Emmanuel Fort, droplets walking on a vibrating liquid bath have attracted considerable attention because they unexpectedly exhibit certain features ...reminiscent of quantum particles. While the behaviour of walking droplets in unbounded geometries has to a large extent been rationalized theoretically, no such rationale exists for their behaviour in the presence of boundaries, as arises in a number of key quantum analogue systems. We here present the results of a combined experimental and theoretical study of the interaction of walking droplets with a submerged planar barrier. Droplets exhibit non-specular reflection, with a small range of reflection angles that is only weakly dependent on the system parameters, including the angle of incidence. The observed behaviour is captured by simulations based on a theoretical model that treats the boundaries as regions of reduced wave speed, and rationalized in terms of momentum considerations.
Nowadays it is increasingly important in many applications to understand how different factors influence a variable of interest in a predictive modeling process. This task becomes particularly ...important in the context of Explainable Artificial Intelligence. Knowing the relative impact of each variable on the output allows us to acquire more information about the problem and about the output provided by a model.
This paper proposes a new methodology, XAIRE, that determines the relative importance of input variables in a prediction environment, considering multiple prediction models in order to increase generality and avoid bias inherent in a particular learning algorithm. Concretely, we present an ensemble-based methodology that promotes the aggregation of results from several prediction methods to obtain a relative importance ranking. Also, statistical tests are considered in the methodology in order to reveal significant differences between the relative importance of the predictor variables. As a case study, XAIRE is applied to the arrival of patients in a Hospital Emergency Department, which has resulted in one of the largest sets of different predictor variables in the literature. Results show the extracted knowledge related to the relative importance of the predictors involved in the case study.
•XAIRE: a new methodology to determine the relative importance of the predictor variables.•Relative importance of predictors of the arrivals at an Emergency Department.•Design and use of a large extensive set of exogenous or predictor variables.•XAI knowledge obtained from the arrivals at an ED prediction process.•Most relative important variables in ED: calendar and arrival (certain lags) variables.
Macroscale analogues
of microscopic spin systems offer direct insights into fundamental physical principles, thereby advancing our understanding of synchronization phenomena
and informing the design ...of novel classes of chiral metamaterials
. Here we introduce hydrodynamic spin lattices (HSLs) of 'walking' droplets as a class of active spin systems with particle-wave coupling. HSLs reveal various non-equilibrium symmetry-breaking phenomena, including transitions from antiferromagnetic to ferromagnetic order that can be controlled by varying the lattice geometry and system rotation
. Theoretical predictions based on a generalized Kuramoto model
derived from first principles rationalize our experimental observations, establishing HSLs as a versatile platform for exploring active phase oscillator dynamics. The tunability of HSLs suggests exciting directions for future research, from active spin-wave dynamics to hydrodynamic analogue computation and droplet-based topological insulators.
The objective of this study was to examine possible antecedents and consequences of teachers’ emotions in the classroom. Based on a cognitive-social perspective and self-determination theory, we ...examined the relationship between basic psychological needs (BPNs), teachers’ class-related emotions and teachers’ life satisfaction. A sample of 595 teachers from Andalusia (Spain) participated in an online survey. A structural equation model was tested, in which BPNs predicted teachers’ emotions (β = .69; p < .001 positive emotions and β = -.42; p < .001 negative emotions). In addition, BPNs (β = .36; p < .001) and positive emotions (β = .23; p < .001) predicted satisfaction with life. The results show that the fulfilment of work-related BPNs is important to generate positive emotions and well-being in teachers. In addition, the study is the first to provide extensive details on the psychometric properties for assessing teacher emotions with the Achievement Emotions Questionnaire - Teachers (AEQ-T) in a Spanish sample.
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