Bifunctional aluminum complexes supported by novel zwitterionic NNO-donor scorpionate ligands were found to be efficient bifunctional catalysts for cyclic carbonate synthesis from terminal and ...internal epoxides in good yields and with broad substrate scope. Neutral scorpionate ligands (1–2) were designed and used as precursors to obtain two novel zwitterionic NNO-heteroscorpionate ligands (3–4). Reaction of 3 or 4 with AlX3 (X = Me, Et) in a 1:1 or 1:2 molar ratio afforded the mononuclear and dinuclear cationic aluminum complexes AlX2{κ2-mbpzbdmape}I2 (X = Me (5), Et (6)), AlX2{κ2-mbpzbdeape}I2 (X = Me (7), Et (8)), {AlX2(κ2-mbpzbdmape)}(μ-O){AlX3}I2 (X = Me (9), Et (10)), and {AlX2(κ2-mbpzbdeape)}(μ-O){AlX3}I2 (X = Me (11), Et (12)) with elimination of the corresponding alkane. These complexes were investigated as catalysts for cyclic carbonate formation from epoxides and carbon dioxide in the absence of a co-catalyst. Complex 7 was found to be the most active catalyst for cyclic carbonate formation from various epoxides and carbon dioxide.
The coupling reaction of carbon dioxide and terminal, internal, and highly substituted epoxides derived from renewable resources such as furfural, limonene, carvone, carvyl acetate, terpinen-4-ol, or ...ionone leads to the synthesis of new bioderived cyclic carbonates using an efficient aluminum catalyst under mild and solvent-free reaction conditions. Interestingly, the synthesis of highly substituted bioderived cyclic carbonates can occur with excellent diastereoselectivity, obtaining in some cases one diastereoisomer as the major product. The X-ray crystal structures of two enantiomerically pure carvone-based cyclic carbonates are reported.
Smallpox vaccination may confer cross-protection to mpox. We evaluated vaccinia virus antibodies in 162 persons ≥50 years of age in Spain; 68.5% had detectable antibodies. Highest coverage (78%) was ...among persons 71-80 years of age. Low antibody levels in 31.5% of this population indicates that addressing their vaccination should be a priority.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, ODKLJ, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
Background and purpose
Influenza is a common cause of acute respiratory infection, with headache being one of the symptoms included in the European Commission case definition. The prevalence of ...headache as a symptom of influenza remains unknown. We aimed to describe the incidence and prevalence of headache in patients with influenza.
Methods
All consecutive patients who met the definition criteria of influenza‐like illness during the influenza seasons 2010–2011 through 2021–2022 were included. The seasonal cumulative incidence of influenza per 1000 patients at risk and the prevalence of headache as an influenza symptom were calculated, including the 95% confidence intervals (CIs). Subgroup analyses were done based on patients' sex, age group, microbiological confirmation, vaccination status, and influenza type/subtype/lineage.
Results
During the study period, 8171 patients were eligible. The incidence of headache in the context of influenza varied between 0.24 cases per 1000 patients (season 2020–2021) and 21.69 cases per 1000 patients (season 2017–2018). The prevalence of headache was 66.1% (95% CI = 65.1%–67.1%), varying between 49.6% (season 2021–2022) and 80.1% (season 2010–2011). The prevalence of headache was higher in women (67.9% vs. 65.7%, p = 0.03) and higher in patients between 15 and 65 years old. Headache was more prevalent in patients infected with B subtypes than A subtypes (68.7% vs. 56.9%, p < 0.001). There were no notable differences regarding vaccination status or microbiological confirmation of the infection.
Conclusions
Headache is a common symptom in patients with influenza, with a prevalence higher than that observed in other viral infections.
A new lanthanum heteroscorpionate complex has shown exceptional catalytic activity for the synthesis of cyclic carbonates from epoxides and carbon dioxide. This catalyst system also promotes the ...reaction of bio‐based epoxides to give an important class of bis(cyclic carbonates) that can be further used for the production of bio‐derived non‐isocyanate polyurethanes. The catalytic process requires low catalyst loading and mild reaction conditions for the synthesis of a wide range of cyclic carbonates.
La La land: A lanthanum heteroscorpionate complex shows exceptional catalytic activity for the synthesis of cyclic carbonates from epoxides and carbon dioxide under mild reaction conditions, and promotes the synthesis of an important class of bis(cyclic carbonates) that can be further used for the production of non‐isocyanate polyurethanes.
Hyperglycaemia has emerged as an important risk factor for death in coronavirus disease 2019 (COVID-19). The aim of this study was to evaluate the association between blood glucose (BG) levels and ...in-hospital mortality in non-critically patients hospitalized with COVID-19.
This is a retrospective multi-centre study involving patients hospitalized in Spain. Patients were categorized into three groups according to admission BG levels: <140 mg/dL, 140-180 mg/dL and >180 mg/dL. The primary endpoint was all-cause in-hospital mortality.
Of the 11,312 patients, only 2128 (18.9%) had diabetes and 2289 (20.4%) died during hospitalization. The in-hospital mortality rates were 15.7% (<140 mg/dL), 33.7% (140-180 mg) and 41.1% (>180 mg/dL), p<.001. The cumulative probability of mortality was significantly higher in patients with hyperglycaemia compared to patients with normoglycaemia (log rank, p<.001), independently of pre-existing diabetes. Hyperglycaemia (after adjusting for age, diabetes, hypertension and other confounding factors) was an independent risk factor of mortality (BG >180 mg/dL: HR 1.50; 95% confidence interval (CI): 1.31-1.73) (BG 140-180 mg/dL; HR 1.48; 95%CI: 1.29-1.70). Hyperglycaemia was also associated with requirement for mechanical ventilation, intensive care unit (ICU) admission and mortality.
Admission hyperglycaemia is a strong predictor of all-cause mortality in non-critically hospitalized COVID-19 patients regardless of prior history of diabetes.
KEY MESSAGE
Admission hyperglycaemia is a stronger and independent risk factor for mortality in COVID-19.
Screening for hyperglycaemia, in patients without diabetes, and early treatment of hyperglycaemia should be mandatory in the management of patients hospitalized with COVID-19.
Admission hyperglycaemia should not be overlooked in all patients regardless prior history of diabetes.
The purpose of this research is to deepen the study of the influence of cognitive proximity has on the innovative performance of firms, as well as the mediating effect of potential and realized ...absorptive capacity in this relationship. For this purpose, an empirical analysis has been carried out. The primary data have been analyzed by means of PLS-SEM technique. The results show that the cognitive proximity of firms has both a direct and an indirect impact on their innovative performance, through their potential and realized absorptive capacity. We conclude that cognitive proximity matters for the innovation performance of firms, as it facilitates the understanding and establishment of positive reciprocity agreements between the companies, especially in terms of knowledge. Nevertheless, firms must develop a great capability to absorb new knowledge to exploit the advantages derived from its cognitive proximity to its stakeholders and leverage all the knowledge within their reach.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
Colorectal cancer (CRC) is a very common life‐threatening malignancy. Transcription factor‐like 5 (TCFL5) has been suggested to be involved in CRC. Here, we describe the expression of four ...alternative transcripts of TCFL5 and their relevance in CRC. Complete deletion of all isoforms drastically decreased pro‐tumoural properties such as spheroids formation and in vivo tumour growth, although increased migration in CRC cell lines. Overexpression of the two main isoforms, TCFL5_E8 and CHA, had opposite effects: TCFL5_E8 reduced proliferation and spheroids formation, while CHA increased them. TCFL5_E8 reduced in vivo tumour formation, while CHA had no effect. In addition, TCFL5_E8 and CHA have different roles in the regulation of the pluripotency‐related genes SOX2 and KLF4. Both isoforms bind directly to their promoters; however, TCFL5_E8 induced SOX2 and reduced KLF4 mRNA levels, whereas CHA did the opposite. Together, our results show that TCFL5 plays an important role in the development of CRC, being however isoform‐specific. This work also points to the need to analyse separately TCFL5 isoforms in cancer, due to their different and opposite functions.
In this study, the authors identify four isoforms of TCFL5 in colorectal cancer, each with strikingly different properties. Complete deletion of the TCFL5 locus reduced tumour cell proliferation and spheroid formation, but increased migration. However, whereas overexpression of the TCFL5_E8 isoform reduced proliferation and spheroid formation, overexpression of the CHA isoform increased them. In addition, CHA and TCFL5_E8 bound to the SOX2 and KLF4 promoters directly, controlling their transcription.
Despite the scientific and human efforts to understand COVID-19, there are questions still unanswered. Variations in the metabolic reaction to SARS-CoV-2 infection could explain the striking ...differences in the susceptibility to infection and the risk of severe disease. Here, we used untargeted metabolomics to examine novel metabolic pathways related to SARS-CoV-2 susceptibility and COVID-19 clinical severity using capillary electrophoresis coupled to a time-of-flight mass spectrometer (CE-TOF-MS) in plasma samples. We included 27 patients with confirmed COVID-19 and 29 healthcare workers heavily exposed to SARS-CoV-2 but with low susceptibility to infection (“nonsusceptible”). We found a total of 42 metabolites of SARS-CoV-2 susceptibility or COVID-19 clinical severity. We report the discovery of new plasma biomarkers for COVID-19 that provide mechanistic explanations for the clinical consequences of SARS-CoV-2, including mitochondrial and liver dysfunction as a consequence of hypoxemia (citrulline, citric acid, and 3-aminoisobutyric acid (BAIBA)), energy production and amino acid catabolism (phenylalanine and histidine), and endothelial dysfunction and thrombosis (citrulline, asymmetric dimethylarginine (ADMA), and 2-aminobutyric acid (2-AB)), and we found interconnections between these pathways. In summary, in this first report several metabolic pathways implicated in SARS-CoV-2 susceptibility and COVID-19 clinical progression were found by CE-MS based metabolomics that could be developed as biomarkers of COVID-19.
The main aim of this paper is to analyze the effect of industrial agglomeration on the degree of interorganizational cooperation and the innovative performance of firms of the electricity supply ...sector in Spain. For this purpose, the agglomeration coefficient in each of the 50 provinces of Spain is calculated, based on secondary data from SABI database. Subsequently, primary data are obtained from a sample of 197 companies through a structured questionnaire. In this case, the PLS-SEM technique is used. The results show that there is a positive and significant relationship between the variables analyzed. It is concluded that industrial agglomeration and cooperation are relevant external factors that boost the innovative performance of firms and that business associations foster interorganizational cooperation.
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