This systematic review and meta-analysis examined the dose-response relationship between exercise and cognitive function in older adults with and without cognitive impairments. We included ...single-modality randomized controlled aerobic, anaerobic, multicomponent or psychomotor exercise trials that quantified training frequency, session and program duration and specified intensity quantitatively or qualitatively. We defined total exercise duration in minutes as the product of program duration, session duration, and frequency. For each study, we grouped test-specific Hedges' d (n = 163) and Cohen's d (n = 23) effect sizes in the domains Global cognition, Executive function and Memory. We used multilevel mixed-effects models to investigate dose-related predictors of exercise effects. In healthy older adults (n = 23 studies), there was a small positive effect of exercise on executive function (d = 0.27) and memory (d = 0.24), but dose-parameters did not predict the magnitude of effect sizes. In older adults with cognitive impairments (n = 13 studies), exercise had a moderate positive effect on global cognition (d = 0.37). For older adults with cognitive impairments, we found evidence for exercise programs with a short session duration and high frequency to predict higher effect sizes (d = 0.43-0.50). In healthy older adults, dose-parameters did not predict the magnitude of exercise effects on cognition. For older adults with cognitive impairments, exercise programs with shorter session duration and higher frequency may generate the best cognitive results. Studies are needed in which different exercise doses are directly compared among randomized subjects or conditions.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
The hydrolysis of ATP drives virtually all of the energy-requiring processes in living cells. A prerequisite of living cells is that the concentration of ATP needs to be maintained at sufficiently ...high levels to sustain essential cellular functions. In eukaryotic cells, the AMPK (AMP-activated protein kinase) cascade is one of the systems that have evolved to ensure that energy homoeostasis is maintained. AMPK is activated in response to a fall in ATP, and recent studies have suggested that ADP plays an important role in regulating AMPK. Once activated, AMPK phosphorylates a broad range of downstream targets, resulting in the overall effect of increasing ATP-producing pathways whilst decreasing ATP-utilizing pathways. Disturbances in energy homoeostasis underlie a number of disease states in humans, e.g. Type 2 diabetes, obesity and cancer. Reflecting its key role in energy metabolism, AMPK has emerged as a potential therapeutic target. In the present review we examine the recent progress aimed at understanding the regulation of AMPK and discuss some of the latest developments that have emerged in key areas of human physiology where AMPK is thought to play an important role.
We present ALMA observations of the CO(1–0) and CO(3–2) line emission tracing filaments of cold molecular gas in the central galaxy of the cluster PKS 0745−191. The total molecular gas mass of
...$4.6\pm 0.3\times 10^{9} {\rm \, M_{{\odot}}}$
, assuming a Galactic X
CO factor, is divided roughly equally between three filaments each extending radially 3-5 kpc from the galaxy centre. The emission peak is located in the SE filament ∼ 1 arcsec (2 kpc) from the nucleus. The velocities of the molecular clouds in the filaments are low, lying within
$\pm 100 {\rm \, km \rm \, s^{-1}}$
of the galaxy's systemic velocity. Their full width at half-maximum (FWHM) are less than
$150 {\rm \, km \rm \, s^{-1},}$
which is significantly below the stellar velocity dispersion. Although the molecular mass of each filament is comparable to a rich spiral galaxy, such low velocities show that the filaments are transient and the clouds would disperse on < 107 yr time-scales unless supported, likely by the indirect effect of magnetic fields. The velocity structure is inconsistent with a merger origin or gravitational free-fall of cooling gas in this massive central galaxy. If the molecular clouds originated in gas cooling even a few kpc from their current locations their velocities would exceed those observed. Instead, the projection of the N and SE filaments underneath X-ray cavities suggests they formed in the updraft behind bubbles buoyantly rising through the cluster atmosphere. Direct uplift of the dense gas by the radio bubbles appears to require an implausibly high coupling efficiency. The filaments are coincident with low temperature X-ray gas, bright optical line emission and dust lanes indicating that the molecular gas could have formed from lifted warmer gas that cooled in situ.
J-factors (or D-factors) describe the distribution of dark matter in an astrophysical system and determine the strength of the signal provided by annihilating (or decaying) dark matter respectively. ...We provide simple analytic formulas to calculate the J-factors for spherical cusps obeying the empirical relationship between enclosed mass, velocity dispersion and half-light radius. We extend the calculation to the spherical Navarro-Frenk-White model, and demonstrate that our new formulas give accurate results in comparison to more elaborate Jeans models driven by Markov chain Monte Carlo methods. Of the known ultrafaint dwarf spheroidals, we show that Ursa Major II, Reticulum II, Tucana II and Horologium I have the largest J-factors and so provide the most promising candidates for indirect dark matter detection experiments. Amongst the classical dwarfs, Draco, Sculptor and Ursa Minor have the highest J-factors. We show that the behavior of the J-factor as a function of integration angle can be inferred for general dark halo models with inner slope gamma and outer slope beta. The central and asymptotic behavior of the J-factor curves are derived as a function of the dark halo properties. Finally, we show that models obeying the empirical relation on enclosed mass and velocity dispersion have J-factors that are most robust at the integration angle equal to the projected half-light radius of the dwarf spheroidal (dSph) divided by heliocentric distance. For most of our results, we give the extension to the D-factor which is appropriate for the decaying dark matter picture.
Rapid progress in identifying the genes underlying autism spectrum disorder (ASD) has provided the substrate for a first wave of analyses into the underlying neurobiology. This review describes the ...consensus across these diverse analyses, highlighting two distinct sets of genes: 1) Genes that regulate chromatin and transcription, especially in cortical projection neurons and striatal medium spiny neurons during mid-fetal development; and 2) Genes involved in synapse development and function, especially during infancy and early childhood, and differentially expressed in the post mortem ASD brain. Both gene sets are also regulatory targets of the ASD genes CHD8 and FMRP . It remains to be seen whether these represent two independent paths to the ASD phenotype or two components of a common path.
We present a new technique for choosing spatial regions for X-ray spectroscopy, called ‘contour binning’. The method chooses regions by following contours on a smoothed image of the object. In ...addition, we re-explore a simple method for adaptively smoothing X-ray images according to the local count rate, we term ‘accumulative smoothing’, which is a generalization of the method used by fadapt. The algorithms are tested by applying them to a simulated cluster data set. We illustrate the techniques by using them on a 50 ks Chandra observation of the Cassiopeia A supernova remnant. Generated maps of the object showing abundances in eight different elements, absorbing column density, temperature, ionization time-scale and velocity are presented. Tests show that contour binning reproduces surface brightness considerably better than other methods. It is particularly suited to objects with detailed spatial structure such as supernova remnants and the cores of galaxy clusters, producing aesthetically pleasing results.
We explore the effects of particle size and solvent environment on the thermodynamic stability of two pairs of polymorphs subjected to ball-mill neat grinding (NG) and liquid assisted grinding (LAG). ...Two systems were studied: (i) forms I and II of a 1 : 1 theophylline : benzamide cocrystal and (ii) forms A and B of an aromatic disulfide compound. For both systems, the most stable-bulk polymorph converted to the metastable-bulk polymorph upon NG. LAG experiments yielded different outcomes depending on the amount of solvent used. This was further investigated by performing carefully controlled LAG experiments with increasing μL amounts of solvents of different nature. With these experiments, we were able to monitor form A to B and form I to II conversions as a function of solvent concentration and derive polymorph equilibrium curves. The concentration required for a switch in polymorphic outcome was found to be dependent on solvent nature. We propose that these experiments demonstrate a switch in thermodynamic stability of the polymorphs in the milling jar. Form B, the stable-bulk polymorph, has less stable surfaces than form A, thus becoming metastable at the nanoscale when surface effects become important.
diffraction and electron microscopy data confirm crystal sizes in the order of tens of nanometers after the ball mill grinding experiments reach equilibrium. DFT-d computations of the polymorph particles stabilities support these findings and were used to calculate cross-over sizes of forms A and B as a function of solvent. Attachment energies and surface stabilities of the various crystalline faces exposed were found to be very sensitive to the solvent environment. Our findings suggest that surface effects are significant in polymorphism at the nanoscale and that the outcomes of equilibrium ball-mill NG and LAG experiments are in general controlled by thermodynamics.
The immune system responds vigorously to microbial infection while permitting lifelong colonization by the microbiome. Mechanisms that facilitate the establishment and stability of the gut microbiota ...remain poorly described. We found that a regulatory system in the prominent human commensal
modulates its surface architecture to invite binding of immunoglobulin A (IgA) in mice. Specific immune recognition facilitated bacterial adherence to cultured intestinal epithelial cells and intimate association with the gut mucosal surface in vivo. The IgA response was required for
(and other commensal species) to occupy a defined mucosal niche that mediates stable colonization of the gut through exclusion of exogenous competitors. Therefore, in addition to its role in pathogen clearance, we propose that IgA responses can be co-opted by the microbiome to engender robust host-microbial symbiosis.
We present the results from extensive, new observations of the Perseus Cluster of galaxies, obtained as a Suzaku Key Project. The 85 pointings analysed span eight azimuthal directions out to 2° = 2.6 ...Mpc, to and beyond the virial radius r
200 ∼ 1.8 Mpc, offering the most detailed X-ray measurements of the intracluster medium (ICM) at large radii in any cluster to date. The azimuthally averaged density profile for r > 0.4r
200 is relatively flat, with a best-fitting power-law index δ = 1.69 ± 0.13, significantly smaller than expected from numerical simulations. The entropy profile in the outskirts lies systematically below the power-law behaviour expected from large-scale structure formation models which include only the heating associated with gravitational collapse. Conversely, the pressure profile beyond ∼0.6r
200 shows an excess with respect to the best-fitting model describing the SZ measurements for a sample of clusters observed with the Planck satellite. The differences between the expected and measured density, entropy and pressure profiles can be explained by a systematic overestimation of the ICM density at large radii caused by homogeneous modelling of inhomogeneous gas distributions (i.e. gas clumping), with the density overestimates ranging from factors of ∼1.2 to 2 or more at r
200 along different directions. We find no evidence for a bias in the temperature measurements within the virial radius. Along the cluster minor axis, we find a flattening of the entropy profiles outside ∼0.6r
200, while along the major axis, the entropy rises all the way to the outskirts.
PDF
