The goal of the book is to cover the interdisciplinary field of nanoscience beginning with the physical principles and extending to synthesis (chemistry), materials sicnece, nanoelectronics, ...nanobiology, and nanomedicine -- in a concise manner but also taking into account the recent significant developments. Based on lecture courses given by the author at his university and other universities abroad, this volume features many figures reproduced from the original papers, which are selected in order to give a convenient and rapid insight into the various fields. The bibliography encompasses the most recent papers so the reader can find there reference to earlier work, and a subject index is included.
The spread of farming from western Asia to Europe had profound long-term social and ecological impacts, but identification of the specific nature of Neolithic land management practices and the ...dietary contribution of early crops has been problematic. Here, we present previously undescribed stable isotope determinations of charred cereals and pulses from 13 Neolithic sites across Europe (dating ca . 5900–2400 cal B.C.), which show that early farmers used livestock manure and water management to enhance crop yields. Intensive manuring inextricably linked plant cultivation and animal herding and contributed to the remarkable resilience of these combined practices across diverse climatic zones. Critically, our findings suggest that commonly applied paleodietary interpretations of human and herbivore δ ¹⁵N values have systematically underestimated the contribution of crop-derived protein to early farmer diets.
The present paper reports on a combined analytical and structural study of nanocrystalline Fe
Zr
by means of positron annihilation, (analytical) high-resolution transmission electron microscopy ...(HRTEM), and X-ray diffraction. Particular focus is laid on the chemical nature of the intergranular amorphous matrix which occurs between the α-Fe nanocrystallites. Energy-dispersive X-ray measurements (EDX) with an electron nanobeam reveal an increased Zr content at the interface between the nanocrystallites and the intergranular amorphous phase. According to positron lifetime measurements, the intergranular amorphous phase and the interfaces between this phase and the nanocrystallites exhibit structural free volumes of the mean size slightly smaller than a lattice vacancy as in the amorphous precursor material. Coincident Doppler broadening measurements of the positron-electron annihilation photons show that the fraction of Zr in the neighborhood of the structural free volumes is higher in nanocrystalline Fe
Zr
than in the amorphous state indicating an enhanced Zr concentration in the interfaces. These results are in good agreement with the HRTEM/ EDX studies and demonstrate the potentials of the coincident Doppler broadening technique for a chemical characterization of structurally complex materials on an atomistic scale.
Summary
Background
Food allergy is common, especially in childhood, where 6–8% of children are affected. Identification of early and efficient markers for later development of food allergy is very ...important.
Objective
We examined the ability of repeated measurements of food sensitization in early childhood to predict doctor‐diagnosed food allergy (DDFA) at the age of 6 years.
Methods
The analysis was based on data from a prospective birth cohort study. Information was collected by parental questionnaires, and blood samples were obtained at 2 and 6 years of age. Children with repeated determination of sensitization to food allergens at 2 and 6 years of age were categorized into the sensitization phenotypes: no, early onset, late onset and persistent sensitization. The association between sensitization phenotypes and DDFA was prospectively investigated using multiple logistic regression analyses.
Results
Of 3097 children recruited at birth, a complete follow‐up of IgE measurements and questionnaires at 1.5, 2 and 6 years were available for 1082 children. Early food allergen sensitization (fx5) was a strong risk for DDFA at 6 years odds ratio (OR)=4.7; 95% confidence intervals (95% CI) 2.0–11.2 and for a new onset of DDFA at 6 years (OR=4.1; 95% CI 1.5–11.3). Additionally, persistent food allergen sensitization increased the risk of DDFA at 6 years (OR=6.1; 95% CI 2.7–13.7). Early sensitized children with a history of parental atopy showed the highest risk for DDFA at 6 years.
Conclusion
Food‐sensitized children during the first 2 years of life, especially with a family history of atopy, might be considered as a susceptible subgroup that requires specific attention concerning the development of food allergy‐related symptoms.
>Cite this as: E. Schnabel, S. Sausenthaler, B. Schaaf, T. Schäfer, I. Lehmann, H. Behrendt, O. Herbarth, M. Borte, U. Krämer, A. von Berg, H.‐E. Wichmann, J. Heinrich, and for the LISA Study Group, Clinical & Experimental Allergy, 2010 (40) 450–457.
The mining town of Aggeneys is situated in a world-class polymetallic base metal district. The Black Mountain Mining Complex (BMC), located in the Northern Cape, South Africa, contains six known ...orebodies with more than 25.5 Mt contained metal in resources and reserves. Currently, three of the six known orebodies are actively mined. The Big Syncline East prospect is situated directly east of the massive Big Syncline mineral resource of > 150 Mt of open pit and underground resources. Big Syncline is one of the six declared resources at BMC. Recent high-power super conducting quantum interference device transient EM identified a large 3500-Siemens conductor at depths greater than 400 m. Initial follow-up drilling confirmed the presence of mineralized sulfides. A follow-up drone-based magnetic survey was flown, primarily to improve on the poor-quality, high-ground clearance magnetic data recorded with a fixed-wing aeromagnetic system, but also to trial a novel hybrid ground and drone total-field transient EM survey over the extreme topography encountered in the area. Results are very encouraging and now pave the way for more routine implementation of hybrid ground-drone total-field transient EM applications, where a large transmitting loop on the surface is surveyed by a relative fast-moving drone-carried fast-sampling total-field magnetometer.
The growing number of persons suffering from major chronic illnesses face many obstacles in coping with their condition, not least of which is medical care that often does not meet their needs for ...effective clinical management, psychological support, and information. The primary reason for this may be the mismatch between their needs and care delivery systems largely designed for acute illness. Evidence of effective system changes that improve chronic care is mounting. We have tried to summarize this evidence in the Chronic Care Model (CCM) to guide quality improvement. In this paper we describe the CCM, its use in intensive quality improvement activities with more than 100 health care organizations, and insights gained in the process.
Growing energies of particles at modern or planned particle accelerator experiments as well as cosmic ray experiments require particle identification at gamma-factors (γ) of up to ∼105. At present ...there are no detectors capable of identifying charged particles with reliable efficiency in this range of γ. New developments in high granular pixel detectors allow one to perform simultaneous measurements of the energies and the emission angles of generated transition radiation (TR) X-rays and use the maximum available information to identify particles. First results of studies of TR energy-angular distributions using gallium arsenide (GaAs) sensors bonded to Timepix3 chips are presented. The results are compared with those obtained using a silicon (Si) sensor of the same thickness of 500 μm. The analysis techniques used for these experiments are discussed.
X-ray transition radiation detectors (TRDs) are used for particle identification in both high energy physics and astroparticle physics. In most of the detectors, emission of the X-ray transition ...radiation (TR) starts at Lorentz factors above γ∼500 and reaches saturation at γ∼2÷3⋅103. However, many experiments require particle identification up to γ∼105, which is very difficult to achieve with conventional detectors. Semiconductor pixel detectors offer a unique opportunity for precise simultaneous measurements of spectral and angular parameters of TR photons. Test beam studies of the energy and the angular distributions of TR photons emitted by electrons and muons of different momenta crossing several types of radiators were performed at the CERN SPS with a 480 μm thick silicon detector bonded to a Timepix3 chip. High resolution images of the energy−angle phase space of the TR produced by different radiators were obtained and compared with MC simulations. The characteristic interference patterns are in agreement with the theoretical models with an unprecedented level of details. The studies presented in this paper also show that simultaneous measurements of both the energy and the emission angles of the TR X-rays could be used to enhance the particle identification performances of TRDs.
Background: We aimed to determine the prevalence of contact sensitization in the general population and to investigate associations with important sociodemographic and medical characteristics. ...Methods: Within a population-based nested, case-control study in Germany, we performed patch tests with 25 standard allergens in 1141 adults (50.4% female, age median 50 years). Additional information was obtained by a dermatologic examination, a standardized interview, and blood analysis. Results: At least one positive reaction was exhibited by 40.0% of the subjects, with reactions most frequently observed to fragrance mix (15.9%), nickel (13.1%), thimerosal (4.7%), and balsam of Peru (3.8%). Women were sensitized more often than men (50.2% vs 29.9%, OR 2.36, CI 1.84-3.03), and this was also significant for fragrance mix, nickel, turpentine, cobalt chloride, and thimerosal. Contact sensitization was more frequent in subjects who reported adverse skin reactions (53.8% vs. 32.6%; OR 2.41, CI 1.85-3.14), and this was particularly true for sensitization to nickel (45.5% vs 8.8%, OR 8.64, CI 5.67-13.17) and fragrance mix (29.0% vs 14.0%, OR 2.51, CI 1.60-3.91) and the corresponding intolerance of fashion jewelry and fragrances. Contact sensitization decreased with increasing degree of occupational training (unskilled 45.9%, apprenticeship 40.1%, technical college 40.4%, and school of engineering 12.5%; P=0.023; trend test P=0.042). Significant associations of contact sensitization and presence of allergen-specific IgE antibodies, atopic eczema, or psoriasis were not observed. Frequency estimates for the general adult population based on these findings were 28.0% for overall contact sensitization and 11.4% for fragrance mix, 9.9% for nickel, and 3.2% for thimerosal. Conclusions: It is concluded that contact allergy is influenced by sociodemographic parameters and plays an important role in the general population.
In this paper we reconstruct the palaeodietary setting of LBK Vaihingen an der Enz, south-west Germany (later sixth millennium cal. bc) using δ
13
C and δ
15
N values of human and faunal bone ...collagen and of charred plant remains from cereal crops (e.g. emmer and einkorn wheat) and pulses (lentil and pea). Our examination of this Neolithic dietary 'food web' incorporates crop δ
15
N values within a linear-mixing model to examine the estimated proportions of animal and plant protein in the human diet. We interpret the stable isotope dietary model outcomes together with accompanying archaeobotanical and zooarchaeological evidence to shed light on the role of crops in land use strategies and human diet, and conclude that (manured) crops probably formed the dominant protein source.
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