Thermal activation of transient receptor potential (TRP) cation channels is one of the most striking examples of temperature-controlled processes in cell biology. As the evidence indicating the ...fundamental role of such processes in thermosensation builds at a fast pace, adequately accurate tools that would allow heat receptor logic behind thermosensation to be examined on a single-cell level are in great demand. Here, we demonstrate a specifically designed fiber-optic probe that enables thermal activation with simultaneous online thermometry of individual cells expressing genetically encoded TRP channels. This probe integrates a fiber-optic tract for the delivery of laser light with a two-wire microwave transmission line. A diamond microcrystal fixed on the fiber tip is heated by laser radiation transmitted through the fiber, providing a local heating of a cell culture, enabling a well-controlled TRP-assisted thermal activation of cells. Online local temperature measurements are performed by using the temperature-dependent frequency shift of optically detected magnetic resonance, induced by coupling the microwave field, delivered by the microwave transmission line, to nitrogen--vacancy centers in the diamond microcrystal. Activation of TRP channels is verified by using genetically encoded fluorescence indicators, visualizing an increase in the calcium flow through activated TRP channels.
Baikal-GVD is a cubic-kilometer scale neutrino telescope, which is currently under construction in Lake Baikal. Baikal-GVD is an array of optical modules arranged in clusters. The first cluster of ...the array has been deployed and commissioned in April 2015. To date, Baikal-GVD consists of 3 clusters with 864 optical modules. One of the vital conditions for optimal energy, position and direction reconstruction of the detected particles is the time calibration of the detector. In this article, we describe calibration equipment and methods used in Baikal-GVD and demonstrate the accuracy of the calibration procedures.
Abstract
The high-energy muon neutrino events of the IceCube telescope, that are triggered as neutrino alerts in one of two probability ranks of astrophysical origin, “gold” and “bronze”, have been ...followed up by the Baikal-GVD in a fast quasi-online mode since September 2020. Search for correlations between alerts and GVD events reconstructed in two modes, muon-track and cascades (electromagnetic or hadronic showers), for the time windows ±1 h and ±12 h does not indicate statistically significant excess of the measured events over the expected number of background events. Upper limits on the neutrino fluence will be presented for each alert.
The status of the Baikal-GVD neutrino telescope under construction and its main scientific results are presented. The detector consists of 2916 optical sensors located at 81 vertical strings deep ...below the surface of Lake Baikal. Its geometric configuration is optimized for detecting neutrinos with energies above 100 TeV. Events from muon neutrinos were identified, the flux of which is consistent with the expectation for the flux of atmospheric neutrinos. The data obtained during the alerts of the ANTARES and IceCube telescopes were analyzed. Candidate events for high-energy neutrinos of astrophysical origin have been obtained.
Baikal-GVD: first results and prospects Avrorin, A.D.; Avrorin, A.V.; Aynutdinov, V.M. ...
EPJ Web of Conferences,
2019, Letnik:
209
Journal Article, Conference Proceeding
Recenzirano
Odprti dostop
Next generation cubic kilometer scale neutrino telescope Baikal-GVD is currently under construction in Lake Baikal. The detector is specially designed for search for high energies neutrinos whose ...sources are not yet reliably identified. Since April 2018 the telescope has been successfully operated in complex of three functionally independent clusters i.e. sub-arrays of optical modules (OMs) where now are hosted 864 OMs on 24 vertical strings. Each cluster is connected to shore by individual electro-optical cables. The effective volume of the detector for neutrino initiated cascades of relativistic particles with energy above 100 TeV has been increased up to about 0.15 km
3
. Preliminary results obtained with data recorded in 2016 and 2017 are discussed.
Abstract
Baikal-GVD (Gigaton Volume Detector) is a neutrino telescope located in pure water of Lake Baikal. At the current stage (season 2021), detector is composed of 2304 optical modules arranged ...in 8 clusters. In searching for neutrino cascade events, light patterns produced via discrete stochastic energy losses along muon tracks create the most abundant background. Methods to separate cascade-like events from tracks and neutrino cascades in a single cluster have been developed and optimized. One of the method tries to find the maximum number of track hits amongst cascade hits, which are present in the muon bundle event. Other ones rely on the distributions of charges and positions of hits on optical modules associated with cascade events. All suppression methods were optimized by the Monte Carlo simulation datasets.
Abstract
The Baikal-GVD is a neutrino telescope situated in the deepest freshwater lake in the world — Lake Baikal. The design of the Baikal-GVD trigger system allows also to study the ambient light ...of the lake. The analysis of the optical light activity of Baikal water, particularly, time and spatial variations of the luminescence activity for data collected in years 2018, 2019, and 2020 is presented. For the first time we observed highly luminescent layer moving upwards with maximal speed of 28 m/day in January 2021.
Abstract
The Large-scale deep underwater Cherenkov neutrino telescopes like Baikal-GVD, ANTARES or KM3NeT, require calibration and testing methods of their optical modules. These methods usually ...include laser-based systems which allow us to check the telescope responses to the light and for real-time monitoring of the optical parameters of water such as absorption and scattering lengths, which show seasonal changes in natural reservoirs of water. We will present a testing method of a laser calibration system and a set of dedicated tools developed for Baikal-GVD, which includes a specially designed and built, compact, portable, and reconfigurable scanning station. This station is adapted to perform fast quality tests of the underwater laser sets just before their deployment in the telescope structure, even on ice, without a darkroom. The testing procedure includes the energy stability test of the laser device, 3D scan of the light emission from the diffuser and attenuation test of the optical elements of the laser calibration system. The test bench consists primarily of an automatic mechanical scanner with a movable Si detector, beam splitter with a reference Si detector and, optionally, Q-switched diode-pumped solid-state laser used for laboratory scans of the diffusers. The presented test bench enables a 3D scan of the light emission from diffusers, which are designed to obtain the isotropic distribution of photons around the point of emission. The results of the measurement can be easily shown on a 3D plot immediately after the test and may be also implemented to a dedicated program simulating photons propagation in water, which allows us to check the quality of the diffuser in the scale of the Baikal-GVD telescope geometry.
Time synchronization system of Baikal-GVD Allakhverdyan, V.A.; Avrorin, A.D.; Avrorin, A.V. ...
Journal of instrumentation,
09/2021, Letnik:
16, Številka:
9
Journal Article
Recenzirano
The Baikal-GVD neutrino telescope currently consists of 8 clusters of 288 optical modules (photodetectors). One cluster comprises 8 strings, each of which is subdivided into 3 sections of 12 optical ...modules. This paper presents the methods of time synchronization between the different GVD components (optical modules, sections, clusters) and estimations of time synchronization accuracy.
Abstract
The first stage of the construction of the Baikal-GVD deep underwater neutrino telescope is planned to be completed in 2024. For the second stage of the detector deployment, a data ...acquisition system based on fiber-optic technologies has been proposed, which will allow for increased data throughput and more flexible trigger conditions. A dedicated test facility has been built and deployed at the Baikal-GVD site to test the new technological solutions. We present the principles of operation and results of tests of the new data acquisition system.
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