Experimental animals were fed with semisynthetic rations with sugar-containing powder (40% of carbohydrate energy value) during 10 months. It has been found that this ration does not influence the ...levels of glucose in the blood, glycogen in the liver, and the content of triglycerides, total cholesterol and alpha-lipoprotein cholesterol in the blood serum. Similar quantity of refined sugar in the ration led to elevation of the levels of glucose in the blood, of triglycerides and total cholesterol in the blood serum by the end of the experiment. Correlation between biochemical and morphological investigation data has been recorded.
A trial has been performed of a new sweetening agent saccharol, glycosides complex, on energy metabolism in rats with experimental alloxan diabetes. Elevated glucose level observed in rats with ...insulin insufficiency was associated with hexokinase activity inhibition and changes in the activity of the enzymes involved in glucose-6-phosphate transformation: enhanced activity of glucose-6-phosphatase and glucose-6-phosphate dehydrogenase against inhibition of phosphoglucomutase activity. Introduction of saccharose aggravated the above shifts in the rat liver, whereas saccharol possesses a protective action on hexokinase hepatic reaction and enzymes of glucose-6-phosphate conversion, reduced blood glucose. Positive changes induced by saccharol on energy metabolism in animals with insulin insufficiency can be attributed to the effect of saccharol glycosides.
Chemical composition, energy value and 137Cs and 90Sr content in daily diets were assessed in rural population from the region controlled after the Chernobyl accident. As shown by low urine excretion ...of vitamins (thiamine, ascorbic acid, riboflavin, N1-methylnicotinamide), the population suffer from vitamin deficiency, especially in winter and spring. Levels of the radionuclides rose 1.3-19.7 and 3.4-24.8-fold for 137Cs and 90Sr, respectively.
Animals received saccharol adequate (by sweetness) to sugar, and in 10- and 50-fold increased amounts. The data of chronic 10-month experiments studied in the time course after 2, 5, 10 months have ...permitted a conclusion that saccharol included into the ration during long periods, does not produce a significant effect on the parameters of metabolic processes and morphological picture of the internal organs in test animals. Saccharol in 50-fold increased amounts inhibits the activity of oxidative phosphorylation in the hepatic tissue of rats.
The influence of new exopolysaccharide, synthesized by Candida tropicalis and Pseudomonas sp. consortium in ethanol, on the animal body was studied in chronic experiments conducted in 200 non-inbred ...white rats. The animals were sacrificed after 3, 10 and 18 months of follow-up. The results of the investigations permit a conclusion that exopolysaccharide given to the animals during a long period does not produce a significant effect on the animal's growth and development, on the antitoxic function of the liver, on the parameters of protein, lipid and carbohydrate metabolism, on oxidizing phosphorylation in the mitochondria of the liver, and is low-hazard with respect to allergenic properties.
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