Advances in carbohydrate chemistry have certainly made common oligosaccharides much more accessible. However, many current methods still rely heavily upon specialized knowledge of carbohydrate ...chemistry. The application of automated technologies to chemical and life science applications such as genomics and proteomics represents a vibrant field. These automated technologies also present opportunities for their application to organic synthesis, including that of the synthesis of oligosaccharides. However, application of automated methods to the synthesis of carbohydrates is an underdeveloped area as compared to other classes of biomolecules. The overarching goal of this review article is to present the advances that have been made at the interface of carbohydrate chemistry and automated technology.
Abstract
Sand traps in irrigation networks are typically used in mitigating canal sedimentation. In irrigation networks located in basins of high sediment yield due to the presence of volcanoes, it ...is essential to assess the vulnerability of sand traps. Using sediment yield at irrigation scheme inlets, sand trap vulnerability can be evaluated. This study aims to understand the vulnerability of irrigation sand traps throughout the Progo–Opak–Serang (POS) Volcanic River Basin, Indonesia, via mapping the sediment yield distributions in the basin. We employed the Revised Universal Soil Loss Equation to estimate soil loss, where the results show that the average soil loss in the POS River Basin is 179.69 tons/ha/year that falls under the category of moderate erosion potential, while the average sediment yield for the whole basin is 51.04 tons/ha/year. Parts of the basin with high yields of more than 180 tons/ha/year were mostly found along the volcanic mountains such as Sindoro, Sumbing, Merapi, Merbabu, and Telomoyo, and the Menoreh Hills. The model demonstrated relatively high performance with R
2
, NSE, RMSE, and MAE of 0.89, 0.82, 0.14, and 0.11, respectively. Within the POS Basin, Badran, Kalibawang, and Blawong are the three most vulnerable irrigation sand traps, with sediment yield values of 252.83, 178.92, and 63.49 tons/ha/year, respectively; they are all located in sub-watershed outlets. The vulnerability assessment conducted in this study can be used for the decision support system to prioritize irrigation sand traps towards a more effective irrigation system development.
O-Picoloyl groups at remote positions can mediate the course of glycosylation reactions by providing high facial selectivity for the H-bond-mediated attack of the glycosyl acceptor. A new practical ...method for the stereoselective synthesis of β-mannosides at ambient temperature is presented.
The Greenland Ice Sheet is losing mass at accelerated rates in the 21st century, making it the largest single contributor to rising sea levels. Faster flow of outlet glaciers has substantially ...contributed to this loss, with the cause of speedup, and potential for future change, uncertain. Here we combine more than three decades of remotely sensed observational products of outlet glacier velocity, elevation, and front position changes over the full ice sheet. We compare decadal variability in discharge and calving front position and find that increased glacier discharge was due almost entirely to the retreat of glacier fronts, rather than inland ice sheet processes, with a remarkably consistent speedup of 4–5% per km of retreat across the ice sheet. We show that widespread retreat between 2000 and 2005 resulted in a step-increase in discharge and a switch to a new dynamic state of sustained mass loss that would persist even under a decline in surface melt.
Glacier retreat is the main process behind Greenland Ice Sheet dynamic mass loss over the past three decades, according to an analysis of discharge variability and calving front positions.
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•We evaluated the global and local land use data to simulate hydrology.•SWAT model simulate hydrology in the downstream better than upstream of the basin.•The use of ESACCI product ...can better simulate annual discharge, wet season flow, and baseflow.•The use of MCD12Q1 product can better simulate high flow and dry season flow.•The use of LDD product can better simulate low flow compared to other products.
Recently, the availability of global landuse and land cover data has made hydrological simulation studies possible in data scarce regions. However, the suitability of these products as inputs in the hydrological modeling has not been investigated in detail. Therefore, this study aims to evaluate the use of global landuse and land cover products to simulate the hydrology of the Upper Yom River Basin located in the Northern part of Thailand. Three types of global landuse and landcover products i.e. ESACCI, MCD12Q1, GLC2000 were compared with the landuse product from Land Development Department (LDD) of Thailand. All of these products were used as input in hydrological model, Soil and Water Assessment Tool (SWAT), and performance of the model was compared to simulate hydrological regime including high flow, low flow and seasonal discharge at the outlet and upstream of the basin. The results show that the performance of the hydrological model in simulating the discharge at the basin outlet is better than in the upstream areas while using all types of landuse and land cover data. The model well simulated the annual discharge, wet-season discharge and base flow while using landuse and land cover products of ESACCI and MCD12Q1. Similarly, the high flow and dry-season discharge is well simulated while using MCD12Q1 landuse and landcover products compared to other three products. The results of this study is useful in selecting landuse and land cover products in simulating hydrology for water resources planning and management in data scarce regions.
Previous studies have underscored the importance of breastfeeding and parental care on offspring development and behavior. However, their contribution as dynamic variables in animal models of early ...life stress are often overlooked. In the present study, we investigated how lipopolysaccharide (LPS)-induced maternal immune activation (MIA) on postnatal day (P)10 affects maternal care, milk, and offspring development. MIA was associated with elevated milk corticosterone concentrations on P10, which recovered by P11. In contrast, both milk triglyceride and percent creamatocrit values demonstrated a prolonged decrease following inflammatory challenge. Adolescent MIA offspring were heavier, which is often suggestive of poor early life nutrition. While MIA did not decrease maternal care quality, there was a significant compensatory increase in maternal licking and grooming the day following inflammatory challenge. However, this did not protect against disrupted neonatal huddling or later-life alterations in sensorimotor gating, conditioned fear, mechanical allodynia, or reductions in hippocampal parvalbumin expression in MIA offspring. MIA-associated changes in brain and behavior were likely driven by differences in milk nutritional values and not by direct exposure to LPS or inflammatory molecules as neither LPS binding protein nor interleukin-6 milk levels differed between groups. These findings reflected comparable microbiome and transcriptomic patterns at the genome-wide level. Animal models of early life stress can impact both parents and their offspring. One mechanism that can mediate the effects of such stressors is changes to maternal lactation quality which our data show can confer multifaceted and compounding effects on offspring physiology and behavior.
Acute gastrointestinal (GI) bleeding is a common cause of both emergency department visits and hospitalizations in the USA and can have a high morbidity and mortality if not treated rapidly. Imaging ...is playing an increasing role in both the diagnosis and management of GI bleeding. In particular, CT angiography (CTA) is a promising initial test for acute GI bleeding as it is universally available, can be performed rapidly and may provide diagnostic information to guide management. The purpose of this review was to provide an overview of the uses of imaging in the diagnosis and management of acute GI bleeding, with a focus on CTA.
HSV infections, both type 1 and type 2, are among the most widespread viral diseases affecting people of all ages. Their symptoms could be mild, with cold sores up to 10 days of infection, blindness ...and encephalitis caused by HSV-1 affecting immunocompetent and immunosuppressed individuals. The severe effects derive from co-evolution with the host, resulting in immune evasion mechanisms, including latency and growing resistance to acyclovir and derivatives. An efficient alternative to controlling the spreading of HSV mutations is the exploitation of new drugs, and the possibility of enhancing their delivery through the encapsulation of drugs into nanoparticles, such as liposomes. In this work, liposomes were loaded with a series of 2-aminomethyl- 3-hydroxy-1,4-naphthoquinones derivatives with n-butyl (compound 1), benzyl (compound 2) and nitrobenzene (compound 3) substituents in the primary amine of naphthoquinone. They were previously identified to have significant inhibitory activity against HSV-1. All of the aminomethylnaphthoquinones derivatives encapsulated in the phosphatidylcholine liposomes were able to control the early and late phases of HSV-1 replication, especially those substituted with the benzyl (compound 2) and nitrobenzene (compound 3), which yields selective index values that are almost nine times more efficient than acyclovir. The growing interest of the industry in topical administration against HSV supports our choice of liposome as a drug carrier of aminomethylnaphthoquinones derivatives for formulations of in vivo pre-clinical assays.
Groundwater exploitation for different sectors in Cambodia is expanding. Groundwater levels have already begun to decline in some parts of the country. Monitoring and assessing groundwater storage ...(GWS) change, aquifer stress and aquifer resilience will support the proper planning and management of the country’s groundwater resources; however, information regarding groundwater in Cambodia is currently scarce. Thus, GWS change in Cambodia over the 15 years from April 2002 to March 2017 was assessed using remote-sensing-based Gravity Recovery and Climate Experiment (GRACE) and Global Land Data Assimilation System (GLDAS) datasets, with a comprehensive validation of the GRACE-derived groundwater storage anomaly (GWSA) with respect to in-situ field-based observations. The current study also investigated the impact of surface water storage (SWS) change in Tonle Sap Lake, South-East Asia’s largest freshwater lake, on deriving the GWS change in Cambodia. The groundwater aquifer stresses (GAS), and aquifer resilience (AR) were also evaluated. The validation results were promising, with the correlation coefficient between satellite-based estimations and ground-based measurements ranging from 0.82 to 0.88 over four subbasins. The overall decreasing rate of GWS was found to be –0.63 mm/month, with two basins having the highest declining rate of more than 1.4 mm/month. Meanwhile, the aquifer experiencing stress during the dry season had a very low ability to quickly recover from these stresses. These findings emphasise that appropriate management is urgently needed to ensure the sustainability of the groundwater resource system in this country.
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