Recent findings have questioned the replicability of functional magnetic resonance imaging (fMRI) in the study of affective processing, reporting low replicability of emotional enhancement during a ...face‐matching task. However, poor replicability may instead reflect a lack of emotional engagement for face matching. In the current study, replicability of emotional enhancement was tested in a large (N = 160) sample when emotional engagement was assessed during pleasant, neutral, and unpleasant picture viewing, which reliably engages affective reactions in both the brain and the body. Replicability was computed using a subsampling technique, in which random sets of subjects of different sample sizes (N = 20, 40, 60, 80) were selected from the entire dataset, and replicability of emotional enhancement for peaks, clusters, and voxels were averaged across 500 permutations for each sample size. Consistent with previous findings, fMRI replicability increased with increasing sample size. On the other hand, even with relatively small samples, fMRI replicability for peaks, clusters, and voxels during emotional, compared to neutral, scene viewing was good to excellent. Importantly, replicability varied in different brain regions, with excellent replicability at both the cluster and peak level with an N of 40, at the most conservative threshold (p < .001), in the amygdala and the visual cortex. The data argue against general recommendations regarding sample size in fMRI studies of emotion, suggesting instead that degree of replicability depends on successful emotional engagement in task‐related brain regions.
Replicability of functional neural activity during emotional processing is critical to understanding both healthy and dysfunctional emotional engagement. In the current study, fMRI replicability during affective scene viewing increased with sample size, was excellent even with relatively small samples, and was better in regions reliably engaged during emotional processing, including the amygdala and the visual cortex. The goodness of fMRI replicability will depend, to some extent, on both the emotional challenge task and the specific regions activated during emotional processing.
Visual exploration of the world is supported by eye movements which can be speeded up or delayed depending on bottom-up stimulation, top-down goals, and prior associations. Previous studies observed ...faster initiation of saccades toward emotional than neutral natural scenes; however, less is known concerning saccades which originate from emotional, compared with neutral, scenes. Here, we addressed this issue by examining a task in which participants continuously moved their gaze from and toward pictures (natural scenes), which could be emotional or neutral, and changed position in every trial. Saccades were initiated later when the starting picture was emotional compared to neutral, and this slowing was associated with the arousal value of the picture, suggesting that ocular disengagement does not vary with stimulus valence but is affected by engaging picture contents such as erotica and threat/injuries.
Volumetric reductions in the hippocampus and the amygdala are considered a hallmark for many psychiatric and neurodegenerative disorders. Because brain atrophy is often observed in disorders that ...have a higher prevalence in females than males, it has been proposed that sex differences in the aging brain represent a vulnerability factor for developing more severe psychiatric conditions.
Sexual dimorphism was assessed in the amygdala volume and hippocampal volume in a large sample (N = 554) of healthy individuals ranging from 20 to 79 years old, using structural brain data available from a public dataset.
In both the hippocampus and the amygdala, a quadratic association was found between age and brain volume. Using uncorrected data for head size total intracranial volume (TIV), males clearly demonstrated larger amygdala and hippocampal volume across all ages, and an interaction between age and sex in the hippocampus supported the hypothesis of accelerated atrophy in the hippocampus in later life (60-79 years old). However, when volumetric data adjusted for TIV were used, sex differences were not observed in the hippocampus nor the amygdala.
These findings support the extensive series of studies suggesting that sex differences in brain volume are likely related to the confounding effect of head size. While continued effort is allocated to identify sex-related biomarkers, increasing evidence suggests that sexual dimorphism in the hippocampus or the amygdala does not appear to be the primary candidates for precision medicine to identify sex-related biomarkers that index potential vulnerabilities.
Past research has shown that healthcare workers (HCWs) experience high levels of psychological distress during epidemics and pandemics, resulting in cascading effects that have led to chronically ...understaffed hospitals and healthcare centers. Due to the nature of their responsibilities and workplace stress, HCWs are among vulnerable groups especially during global health crises. During COVID-19 many healthcare workers reported greater symptoms of anxiety, depression, and COVID-19 related worries. Furthermore, adverse childhood experiences increase vulnerability for psychological conditions, especially during pandemics. This study sets out to (1) investigate the moderating effects of adverse childhood experiences on healthcare workers’ COVID-19 related stressors and depression/anxiety symptoms, and (2) investigate the moderating effects of adverse childhood experiences on proximity to the COVID-19 virus and depression/anxiety symptoms. Participants included 438 employed HCWs recruited from academic medical centers and smaller healthcare agencies in northcentral Florida between October to December 2020. Mean age of participants was 38.23 (
SD
= 11.5) with most of the HCWs being white (72.1%), non-Hispanic (86.8%) and female (82%). Healthcare workers completed several online questionnaires, including the Adverse Childhood Experiences scale, Patient Health Questionnaire, Generalized Anxiety Disorder Scale, a COVID-19 specific worries scale, and a Social Proximity to COVID-19 scale. Healthcare workers experiencing specific COVID-19 worries reported experiencing anxiety and depressive symptoms. A significant positive interaction was seen between childhood adverse experiences globally and COVID-19 worries on anxiety symptoms. A significant positive interaction was observed between childhood maltreatment specifically and COVID-19 worries on depressive symptoms. Additionally, a positive interaction effect was seen between childhood adverse experiences and COVID-19 social proximity for both depression symptoms and anxiety symptoms. Findings from the present study indicate that adverse childhood experiences strengthen the relationship between COVID-19 worry/proximity and negative psychological symptoms. Vulnerable populations such as individuals who have experienced ACEs could benefit from targeted and specific interventions to cope with the collective trauma experienced globally due to COVID-19. As COVID-19 becomes endemic, hospital leadership and authorities should continue addressing COVID-19 worries and HCWs’ psychological symptoms through mental health support and organizational interventions.
Healthcare workers (HCWs) experienced high levels of stress and mental health consequences associated with the COVID-19 pandemic, which may have contributed to unhealthy coping behaviors, such as ...substance use coping (SUC). This study aimed to understand the extent of and predictors of SUC.
The sample consisted of 263 HCWs in North Central Florida. Univariable and multivariable logistic regression analyses investigated whether moral injury and other work risk factors, protective factors, and clinically relevant symptoms (i.e., work exhaustion, interpersonal disengagement, depression, anxiety, and/or PTSD) were associated with likelihood of SUC.
Clinically relevant levels of interpersonal disengagement and anxiety increased the likelihood of SUC. Mediational analyses found that interpersonal disengagement and anxiety explained 54.3% of the relationship between Self Moral Injury and SUC and explained 80.4% of the relationship between professional fulfillment and SUC.
Healthcare supervisors should be aware that providers who are experiencing moral injury and less professional fulfillment may be experiencing significant interpersonal disengagement and anxiety, which could lead to SUC. Future studies should examine the effects of implementing targeted prevention and treatment interventions, along with longitudinal outcomes related to SUC behaviors.
Dispositional traits of wellbeing and stress-reaction are strong predictors of mood symptoms following stressful life events, and the COVID-19 pandemic introduced many life stressors, especially for ...healthcare workers.
We longitudinally investigated the relationships among positive and negative temperament group status (created according to wellbeing and stress-reaction personality measures), burnout (exhaustion, interpersonal disengagement), COVID concern (e.g., health, money worries), and moral injury (personal acts, others' acts) as predictors of generalized anxiety, depression, and post-traumatic stress symptoms in 435 healthcare workers. Participants were employees in healthcare settings in North Central Florida who completed online surveys monthly for 8 months starting in October/November 2020. Multidimensional Personality Questionnaire subscale scores for stress-reaction and wellbeing were subjected to K-means cluster analyses that identified two groups of individuals, those with high stress-reaction and low wellbeing (negative temperament) and those with the opposite pattern defined as positive temperament (low stress-reaction and high wellbeing). Repeated measures ANOVAs assessed all time points and ANCOVAs assessed the biggest change at timepoint 2 while controlling for baseline symptoms.
The negative temperament group reported greater mood symptoms, burnout, and COVID concern, than positive temperament participants overall, and negative participants' scores decreased over time while positive participants' scores increased over time. Burnout appeared to most strongly mediate this group-by-time interaction, with the burnout exhaustion scale driving anxiety and depression symptoms. PTSD symptoms were also related to COVID-19 health worry and negative temperament. Overall, results suggest that individuals with higher stress-reactions and more negative outlooks on life were at risk for anxiety, depression, and PTSD early in the COVID-19 pandemic, whereas individuals with positive temperament traits became more exhausted and thus more symptomatic over time. Targeting interventions to reduce mood symptoms in negative temperament individuals and prevent burnout/exhaustion in positive temperament individuals early in an extended crisis may be an efficient and effective approach to reduce the mental health burden on essential workers.
The concordance between radiograph-derived Kellgren-Lawrence (KL) scores for knee osteoarthritis (KOA) and experimental and clinical pain and KOA-related physical function is conflicting.
We ...investigate whether the inclusion of dispositional traits reduces variability between KOA radiographic findings, experimental pain, clinical pain, and function in individuals with knee pain.
This study is a cross-sectional, secondary analysis of data collected from the UPLOAD-II study.
Adults aged 45-85 years with and without knee pain were enrolled. Data collected included sociodemographics, knee radiographs, experimental pain, clinical pain and function, and trait affect. Vulnerable and protective dispositional traits were classified from combined positive and negative trait affect measures. KL scores were determined from the knee radiographs. Unadjusted and adjusted (age, sex, comorbidities, and body mass index) regression analyses were completed with SAS version 9.4 (Cary, NC, USA).
The study included 218 individuals with a mean age of 58 years, 63.6% women, and 48.2% non-Hispanic black adults. Dispositional traits were associated with the experimental pain measures. No association between radiographic KOA and experimental pain was observed. In a combined and adjusted analysis, dispositional traits were predictive of knee punctate pain temporal summation (
= 0.0382). Both dispositional traits and radiographic KOA scores independently and combined were predictive of Graded Chronic Pain Scale pain and function, and Western Ontario and McMaster University pain and function (
s ⩽ 0.01). Improvements in
were noted across all models with the inclusion of dispositional traits.
Consideration of dispositional traits reduces the variability between radiographic KOA and pain and function. Non-pathological and associated pain-related psychological factors and dispositional traits might serve as parsimonious proxy tools to improve clinical assessments.
N/A.
Much of the past research on how reward motivation and emotional information influence brain and behavior has been conducted separately. Recently, a few behavioral and brain imaging studies have ...investigated how reward and emotional information co-jointly impact brain and behavior. The present chapter reviews findings from this recent line of work to summarize our current knowledge about the influence of reward expectancy on brain and behavior in the context of emotional information. The available findings suggest that behaviorally reward counteracts the adverse impact of potent emotional distractors on task performance. Additionally, brain findings suggest that the ventral striatum plays an active role in upregulating attentional control processes to limit the influence of emotional distractors. Overall, task relevance seems to play an important role in shaping interactions between reward and emotional processing. We conclude by outlining a few open questions for future research.
