La información es el activo intangible más importante del cual dispone la gestión administrativa. El artículo se centra en la implementación de un repositorio de documentos digitales administrativos. ...Se describe el método seguido para su desarrollo, implementación y validación en un contexto universitario, que consta de cuatro fases. Particularmente, la fase 3 trata la construcción del repositorio administrativo de acceso abierto para capturar, manejar, guardar y conservar los documentos digitales, se seleccionó como herramienta informática un Manejador de Contenido Empresarial, en este caso Nuxeo. Los resultados de la implementación permitieron a la Dirección General de Liquidación de Haberes de la Universidad Nacional del Nordeste gestionar la información producida y agilizar la automatización de recepción de las novedades necesarias para las liquidaciones de haberes. Dicho repositorio constituyó una herramienta eficaz para la gestión de información brindando a la universidad una solución integral para la gestión, tramitación y resguardo de los documentos digitales, agilizando la búsqueda y recuperación de la información. Los logros sugieren la mejora de procedimientos mediados por TIC y se constituyen en un aporte al área de repositorios digitales en contextos administrativos.
Wide field images taken in several photometric bands allow simultaneous measurement of redshifts for thousands of galaxies. A variety of algorithms to make this measurement have appeared in the last ...few years, the majority of which can be classified as either template- or training-based methods. Among the latter, nearest neighbour estimators stand out as one of the most successful, in terms of both precision and the quality of error estimation. In this paper we describe the Directional Neighbourhood Fitting (DNF) algorithm based on the following: a new neighbourhood metric (Directional Neighbourhood), a photo-z estimation strategy (Neighbourhood Fitting) and a method for generating the photo-z probability distribution function. We compare DNF with other well-known empirical photometric redshift tools using different public data sets (Sloan Digital Sky Survey, VIMOS VLT Deep Survey and Photo-z Accuracy Testing). DNF achieves high-quality results with reliable error.
La Diabetes Mellitus Tipo 1 (DMT1) es una de las enfermedades actuales más dañinas que afectan a personas de cualquier edad incluyendo niños desde el nacimiento. Las inyecciones de insulina exógena ...siguen siendo el tratamiento más común para estos pacientes, sin embargo, no es el óptimo. La comunidad científica se ha esforzado en optimizar el suministro de insulina usando dispositivos electrónicos y de esta manera mejorar la esperanza de vida de los diabéticos. Existen numerosas limitaciones para que esta evolución biomédica sea realidad tales como la validación de algoritmos controladores, experimentación con dispositivos electrónicos, aplicabilidad en pacientes de diferentes edades, entre otras. Este trabajo presenta el prototipado de un controlador inteligente neuro-fuzzy en la tarjeta LAUNCHXL-F28069M de Texas Instruments para formar un esquema de hardware en el lazo (HIL). Esto es, el controlador embebido manda los datos de la tasa de suministro de insulina al computador donde se capturan por el software Uva/Padova y se integran a la simulación metabólica de pacientes diabéticos virtuales tratados con bomba de insulina. Una tarea principal del algoritmo inteligente embebido es determinar la tasa óptima de infusión insulínica para cada uno de los 30 pacientes virtuales disponibles, los cuales llevan un protocolo de comida. La novedad de este trabajo se centra en superar las limitaciones actuales a través de un primer enfoque de algoritmo de control inteligente aplicable al páncreas artificial (PA) y analizar la factibilidad de esta propuesta en la trascendencia con la edad ya que los resultados corresponden a pruebas in-silico en poblaciones de 10 adultos, 10 adolescentes y 10 niños.
Heat waves are among the most relevant extreme climatic events due to their effects on society, agriculture and environment. The aim of this work is to improve our understanding of heat waves over ...the Mediterranean basin during the 21
century from an ensemble of Regional Climate Models (RCMs). Focus has been placed on sensitivities to forcing global models, emissions scenarios and the RCM resolution, being the first work based on Euro-CORDEX simulations to fully analyze future heat waves in the Mediterranean. Heat wave features are studied with Warm Spell Duration Index (WSDI, duration) and Heat Wave Magnitude Index daily (HWMId, intensity). Results indicate a large increase by the end of the century in both intensity and length of heat waves from all emissions scenarios, global models, and regional models at any resolution. Exceptional heat waves observed early on the century could then become normal by the end of this period. Forcing global models and emissions scenarios play a major role. Clear added value on spatial distribution and heat wave indices are obtained from global to regional models dynamical downscaling, related to the important coastal or orographic aspects widely present over the Mediterranean.
Preclinical mouse models suggest that the gut microbiome modulates tumor response to checkpoint blockade immunotherapy; however, this has not been well-characterized in human cancer patients. Here we ...examined the oral and gut microbiome of melanoma patients undergoing anti-programmed cell death 1 protein (PD-1) immunotherapy (
= 112). Significant differences were observed in the diversity and composition of the patient gut microbiome of responders versus nonresponders. Analysis of patient fecal microbiome samples (
= 43, 30 responders, 13 nonresponders) showed significantly higher alpha diversity (
< 0.01) and relative abundance of bacteria of the Ruminococcaceae family (
< 0.01) in responding patients. Metagenomic studies revealed functional differences in gut bacteria in responders, including enrichment of anabolic pathways. Immune profiling suggested enhanced systemic and antitumor immunity in responding patients with a favorable gut microbiome as well as in germ-free mice receiving fecal transplants from responding patients. Together, these data have important implications for the treatment of melanoma patients with immune checkpoint inhibitors.
The plant circadian clock allows organisms to anticipate the predictable changes in the environment by adjusting their developmental and physiological traits. In the last few years, it was determined ...that responses known to be regulated by the oscillator are also able to modulate clock performance. These feedback loops and their multilayer communications create a complex web, and confer on the clock network a role that exceeds the measurement of time. In this article, we discuss the current knowledge of the wiring of the clock, including the interplay with metabolism, hormone, and stress pathways in the model species Arabidopsis thaliana We outline the importance of this system in crop agricultural traits, highlighting the identification of natural alleles that alter the pace of the timekeeper. We report evidence supporting the understanding of the circadian clock as a master regulator of plant life, and we hypothesize on its relevant role in the adaptability to the environment and the impact on the fitness of most organisms.
Transport of dietary cholesterol from endocytic organelles to the endoplasmic reticulum (ER) is essential for cholesterol homoeostasis, but the mechanism and regulation of this transport remains ...poorly defined. Membrane contact sites (MCS), microdomains of close membrane apposition, are gaining attention as important platforms for non-vesicular, inter-organellar communication. Here we investigate the impact of ER-endocytic organelle MCS on cholesterol transport. We report a role for Niemann-Pick type C protein 1 (NPC1) in tethering ER-endocytic organelle MCS where it interacts with the ER-localised sterol transport protein Gramd1b to regulate cholesterol egress. We show that artificially tethering MCS rescues the cholesterol accumulation that characterises NPC1-deficient cells, consistent with direct lysosome to ER cholesterol transport across MCS. Finally, we identify an expanded population of lysosome-mitochondria MCS in cells depleted of NPC1 or Gramd1b that is dependent on the late endosomal sterol-binding protein STARD3, likely underlying the mitochondrial cholesterol accumulation in NPC1-deficient cells.
We examined associations of childhood physical and sexual abuse with risk of intimate partner violence (IPV). We also evaluated the extent to which childhood abuse was associated with self-reported ...general health status and symptoms of antepartum depression in a cohort of pregnant Peruvian women.
In-person interviews were conducted to collect information regarding history of childhood abuse and IPV from 1,521 women during early pregnancy. Antepartum depressive symptomatology was evaluated using the Patient Health Questionnaire-9. Multivariable logistic regression procedures were used to estimate adjusted odds ratios (aOR) and 95% confidence intervals (95%CI).
Any childhood abuse was associated with 2.2-fold increased odds of lifetime IPV (95%CI: 1.72-2.83). Compared with women who reported no childhood abuse, those who reported both, childhood physical and sexual abuse had a 7.14-fold lifetime risk of physical and sexual IPV (95%CI: 4.15-12.26). The odds of experiencing physical and sexual abuse by an intimate partner in the past year was 3.33-fold higher among women with a history of childhood physical and sexual abuse as compared to women who were not abused as children (95%CI 1.60-6.89). Childhood abuse was associated with higher odds of self-reported poor health status during early pregnancy (aOR = 1.32, 95%CI: 1.04-1.68) and with symptoms of antepartum depression (aOR = 2.07, 95%CI: 1.58-2.71).
These data indicate that childhood sexual and physical abuse is associated with IPV, poor general health and depressive symptoms in early pregnancy. The high prevalence of childhood trauma and its enduring effects of on women's health warrant concerted global health efforts in preventing violence.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
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•Many evidences are showed about favorable uses of zeolite in biological processes.•In aerobic processes zeolite is used as ion-exchanger and biomass carrier.•In anaerobic digestion, ...zeolite is used to remove ammonia and biomass carrier.•In composting, zeolite is used to retain ammonia and to remove heavy metals.•Zeolite has been used at industrial scale mainly in nitrogen removal.
This review reports the use of zeolites in biological processes such as anaerobic digestion, nitrification, denitrification and composting, review that has not been proposed yet. It was found that aerobic processes (activated sludge, nitrification, Anammox) use zeolites as ion-exchanger and biomass carriers in order to improve the seattlebility, the biomass growth on zeolite surface and the phosphorous removal. In the case of anaerobic digestion and composting, zeolites are mainly used with the aim of retaining inhibitors such as ammonia and heavy metals through ion-exchange. The inclusion of zeolite effect on mathematical models applied in biological processes is still an area that should be improved, including also the life cycle analysis of the processes that include zeolites. At the same time, the application of zeolites at industrial or full-scale is still very scarce in anaerobic digestion, being more common in nitrogen removal processes.
Abstract
The identification of several germline and somatic ion channel mutations in aldosterone-producing adenomas (APAs) and detection of cell clusters that can be responsible for excess ...aldosterone production, as well as the isolation of autoantibodies activating the angiotensin II type 1 receptor, have rapidly advanced the understanding of the biology of primary aldosteronism (PA), particularly that of APA. Hence, the main purpose of this review is to discuss how discoveries of the last decade could affect histopathology analysis and clinical practice. The structural remodeling through development and aging of the human adrenal cortex, particularly of the zona glomerulosa, and the complex regulation of aldosterone, with emphasis on the concepts of zonation and channelopathies, will be addressed. Finally, the diagnostic workup for PA and its subtyping to optimize treatment are reviewed.
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