Aims. In this Letter we present results from INTEGRAL and RXTE observations of the spectral and timing behavior of the High Mass X-ray Binary A 0535+26 during its August/September 2005 normal (type ...I) outburst with an average flux $F_{(5-100)}\,_{\mathrm{keV}} \sim400$ mCrab. The search for cyclotron resonance scattering features (fundamental and harmonic) is one major focus of the paper. Methods. Our analysis is based on data from INTEGRAL and RXTE Target of Opportunity Observations performed during the outburst. The pulse period is determined. X-ray pulse profiles in different energy ranges are analyzed. The broad band INTEGRAL and RXTE pulse phase averaged X-ray spectra are studied. The evolution of the fundamental cyclotron line at different luminosities is analyzed. Results.The pulse period P is measured to be 103.39315(5) s at MJD 53614.5137. Two absorption features are detected in the phase averaged spectra at $E_{1}\sim 45$ keV and $E_{2}\sim 100$ keV. These can be interpreted as the fundamental cyclotron resonance scattering feature and its first harmonic and therefore the magnetic field can be estimated to be $B\sim 4\times 10^{12}$ G.
The Cherenkov Telescope Array (CTA) is a future gamma-ray observatory that is planned to significantly improve upon the sensitivity and precision of the current generation of Cherenkov telescopes. ...The observatory will consist of several dozens of telescopes with different sizes and equipped with different types of cameras. Of these, the FlashCam camera system is the first to implement a fully digital signal processing chain which allows for a traceable, configurable trigger scheme and flexible signal reconstruction. As of autumn 2016, a prototype FlashCam camera for the medium-sized telescopes of CTA nears completion. First results of the ongoing system tests demonstrate that the signal chain and the readout system surpass CTA requirements. The stability of the system is shown using long-term temperature cycling.
•A full-scale prototype of the FlashCam Cherenkov camera is in operation.•System level testing and characterisation in a dark room is ongoing.•The performances of the data acquisition and the signal chain have been verified.•The system is stable over long periods and robust against temperature variations.
EUSO-Balloon
is a pathfinder for
JEM-EUSO
, the mission concept of a spaceborne observatory which is designed to observe Ultra-High Energy Cosmic Ray (UHECR)-induced Extensive Air Showers (EAS) by ...detecting their UltraViolet (UV) light tracks “from above.” On August 25, 2014,
EUSO-Balloon
was launched from Timmins Stratospheric Balloon Base (Ontario, Canada) by the balloon division of the French Space Agency CNES. After reaching a floating altitude of 38 km,
EUSO-Balloon
imaged the UV light in the wavelength range ∼290–500 nm for more than 5 hours using the key technologies of
JEM-EUSO
. The flight allowed a good understanding of the performance of the detector to be developed, giving insights into possible improvements to be applied to future missions. A detailed measurement of the photoelectron counts in different atmospheric and ground conditions was achieved. By means of the simulation of the instrument response and by assuming atmospheric models, the absolute intensity of diffuse light was estimated. The instrument detected hundreds of laser tracks with similar characteristics to EASs shot by a helicopter flying underneath. These are the first recorded laser tracks measured from a fluorescence detector looking down on the atmosphere. The reconstruction of the direction of the laser tracks was performed. In this work, a review of the main results obtained by
EUSO-Balloon
is presented as well as implications for future space-based observations of UHECRs.
In an effort to better understand the phenomenon of lipotoxicity in human beta-cells, we evaluated the effects of 48-h preculture with 1.0 or 2.0 mmol/l free fatty acid (FFA) (2:1 oleate to ...palmitate) on the function and survival of isolated human islets and investigated some of the possible mechanisms. Compared with control islets, triglyceride content was significantly increased and insulin content and glucose-stimulated insulin release were significantly reduced in islets precultured with increased FFA concentrations. These changes were accompanied by a significant reduction of glucose utilization and oxidation. By cell death detection techniques, it was observed that exposure to FFAs induced a significant increase of the amount of dead cells. Electron microscopy showed the involvement of beta-cells, with morphological appearance compatible with the presence of apoptotic phenomena. FFA-induced islet cell death was blocked by inhibition of upstream caspases and partially prevented by inhibiton of ceramide synthesis or serine protease activity, whereas inhibition of nitric oxide synthesis had no effect. RT-PCR studies revealed no major change of iNOS and Bax mRNA expression and a marked decrease of Bcl-2 mRNA expression in the islets cultured with FFA. Thus, prolonged exposure to FFAs has cytostatic and pro-apoptotic effects on human pancreatic beta-cells. The cytostatic action is likely to be due to the FFA-induced reduction of intraislet glucose metabolism, and the proapoptotic effects are mostly caspase mediated, partially dependent on ceramide pathway, and possibly Bcl-2 regulated.
Water is a key probe of shocks and outflows from young stars because it is extremely sensitive to both the physical conditions associated with the interaction of supersonic outflows with the ambient ...medium and the chemical processes at play. Our goal is to investigate the spatial and velocity distribution of Hsub 2O along outflows, its relationship with other tracers, and its abundance variations. The results of our analysis show that the bulk of the observed Hsub 2O lines comes from post-shocked regions where the gas, after being heated to high temperatures, has already been cooled down to a few hundred K. The relatively low derived abundances, however, call for some mechanism that diminishes the Hsub 2O gas in the post-shock region. Among the possible scenarios, we favor Hsub 2O photodissociation, which requires the superposition of a low-velocity nondissociative shock with a fast dissociative shock able to produce a far-ultraviolet field of sufficient strength.
We argue that X-ray flaring variability observed in the transient X-ray pulsar A0535+26 is due to low-mode magnetospheric instability. This instability develops at the onset of accretion, in the thin ...boundary layer between the accretion disk and neutron star magnetosphere. As a result, the matter collected in the boundary layer can rapidly fall onto the NS surface close to the magnetic poles, but not exactly along the field lines by which the stationary accretion proceeds. This explains the shift in cyclotron line energy measured using RXTE data in a pre-outburst spike, with respect to the line energy observed during the main outburst. Furthermore, the instability can account for the difference in pulse profiles, and their energy evolution that is different in the pre-outburst flare and main outburst.
Context. In July 2015, the high-mass X-ray binary V0332+53 underwent a giant outburst, a decade after the previous one. V0332+53 hosts a strongly magnetized neutron star. During the 2004–2005 ...outburst, an anti-correlation between the centroid energy of its fundamental cyclotron resonance scattering features (CRSFs) and the X-ray luminosity was observed. Aims. The long (≈100 d) and bright (Lx ≈ 1038 erg s-1) 2015 outburst provided the opportunity to study the unique properties of the fundamental CRSF during another outburst and to study its dependence on the X-ray luminosity. Methods. The source was observed by the INTEGRAL satellite for ~330 ks. We exploit the spectral resolution at high energies of the SPectrometer on INTEGRAL (SPI) and the Joint European X-ray Monitors to characterize its spectral properties, focusing in particular on the CRSF-luminosity dependence. We complement the data of the 2015 outburst with those collected by SPI in 2004–2005, which have so far been left unpublished. Results. We find a highly significant anti-correlation of the centroid energy of the fundamental CRSF and the 3–100 keV luminosity of E1 ∝ −0.095(8)L37 keV. This trend is observed for both outbursts. We confirm the correlation between the width of the fundamental CRSF and the X-ray luminosity previously found in the JEM-X and IBIS dataset of the 2004–2005 outburst. By exploiting the RXTE/ASM and Swift/BAT monitoring data, we also report on the detection of a ~34 d modulation superimposed on the mean profiles and roughly consistent with the orbital period of the pulsar. We discuss possible interpretations of such variability.
Translational research requires data at multiple scales of biological organization. Advancements in sequencing and multi-omics technologies have increased the availability of these data, but ...researchers face significant integration challenges. Knowledge graphs (KGs) are used to model complex phenomena, and methods exist to construct them automatically. However, tackling complex biomedical integration problems requires flexibility in the way knowledge is modeled. Moreover, existing KG construction methods provide robust tooling at the cost of fixed or limited choices among knowledge representation models. PheKnowLator (Phenotype Knowledge Translator) is a semantic ecosystem for automating the FAIR (Findable, Accessible, Interoperable, and Reusable) construction of ontologically grounded KGs with fully customizable knowledge representation. The ecosystem includes KG construction resources (e.g., data preparation APIs), analysis tools (e.g., SPARQL endpoint resources and abstraction algorithms), and benchmarks (e.g., prebuilt KGs). We evaluated the ecosystem by systematically comparing it to existing open-source KG construction methods and by analyzing its computational performance when used to construct 12 different large-scale KGs. With flexible knowledge representation, PheKnowLator enables fully customizable KGs without compromising performance or usability.
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