RESUMO A crescente discussão a respeito do desenvolvimento sustentável e os problemas inerentes à temática trazem à tona a necessidade do meio corporativo adaptar seus processos, simultaneamente à ...manutenção da competitividade. Nessa busca, a inovação se mostra como um fator essencial, pois ela permite a reestruturação de processos organizacionais, além do desenvolvimento de novos produtos, tecnologias e processos. Porém, o entendimento acadêmico da competitividade, sustentabilidade e inovação tem sido fragmentado. Portanto o objetivo deste artigo consiste em sistematizar a literatura existente nessas três áreas, buscando levantar evidências de como estão interligadas, para a proposição de pesquisas futuras, que investiguem a fundo tais relações. Para isso, foi realizada uma pesquisa qualitativa exploratória, por meio de um trabalho bibliográfico e bibliométrico, onde foi contabilizado um total de 379.971 trabalhos nas três áreas e suas interseções, no período de 1970 a 2015. Dentre os resultados, observa-se que, em curto prazo, há um movimento de investimento em inovação sustentável para obter competitividade, seja através dos benefícios da ecoeficiência ou do aumento do valor intangível. Porém, em longo prazo, os problemas da sustentabilidade exigem investimento em inovação radical, devendo-se estudar como as empresas poderiam investir em inovação radical, ao mesmo tempo em que mantém a competitividade.
Measure the sound pressure levels in classrooms of a university as well to verify the self-perception of noise in the educational environment and its influence on the activities carried out by ...students and professors.
The study was carried out with students and professors who answered a questionnaire regarding self-perception of noise in the classroom, as well as the presence of auditory and non-auditory complaints. Measurement of sound pressure levels was performed in ten classrooms of Pontifical Catholic University of Minas Gerais. The points for measuring the sound pressure level inside the classrooms were selected according to the literature and legislation: three distinct points, totaling nine measurements in each room.
Participated in this study students and professors from the Institute of Biological and Health Sciences. The classrooms of the morning shift had the highest noise measurement. Classrooms at lunch time had the lowest average noise. The first floor has the highest average noise, being classified as the noisiest floor. Noise is perceived by both students and professors as an interfering factor in the activities performed inside the classrooms, however, professors have a greater perception of noise interference in their activities than students.
Noise is present in all classrooms with values higher than those recommended by national legislation. This noise is perceived by students and professors and negatively interferes in the teaching-learning activities.
ResumoCampos rupestres constituem uma vegetação típica de montanhas da Cadeia do Espinhaço e com elevado grau de endemismo de plantas, contendo algumas áreas com histórico de perturbações por garimpo ...e pisoteio. O presente estudo foca em duas perguntas principais: 1) Campos rupestres que foram perturbados pelo garimpo há cerca de 15 anos atrás possuem composição florística e estrutura similares a áreas sem perturbação? 2) A riqueza e abundância de espécies exóticas invasoras e de espécies nativas de ampla distribuição tendem a ser mais elevadas nessas áreas garimpadas ou pisoteadas? Quatro campos rupestres foram amostrados em Igatu, Andaraí, Chapada Diamantina, Bahia, Brasil: dois onde a atividade de garimpo cessou há 15 anos, um sob perturbação atual por pisoteio, mas sem histórico de garimpo e outro em uma área conservada (vegetação amostrada por 16 parcelas de 10x10 m, quatro em cada área). A distribuição geográfica das espécies foram determinadas com base na literatura e análises de classificação e ordenação foram feitas. A composição florística dos campos rupestres foi afetada pelas perturbações, mas apenas a perturbação por garimpo teve efeito marcante sobre a estrutura da vegetação. Espécies de ampla distribuição mais generalistas e a espécie invasora Melinis minutiflora P.Beauv. foram restritas às áreas perturbadas, mostrando a necessidade de monitoramento de espécies invasoras nas áreas garimpadas do Parque Nacional da Chapada Diamantina.
Methylglyoxal (MGO) is an endogenous toxin, mainly produced as a by-product of glycolysis that has been associated to aging, Alzheimer’s disease, and inflammation. Cell culture studies reported that ...MGO could impair the glyoxalase, thioredoxin, and glutathione systems. Thus, we investigated the effect of in vivo MGO administration on these systems, but no major changes were observed in the glyoxalase, thioredoxin, and glutathione systems, as evaluated in the prefrontal cortex and the hippocampus of mice. A previous study from our group indicated that MGO administration produced learning/memory deficits and depression-like behavior. Confirming these findings, the tail suspension test indicated that MGO treatment for 7 days leads to depression-like behavior in three different mice strains. MGO treatment for 12 days induced working memory impairment, as evaluated in the Y maze spontaneous alternation test, which was paralleled by low dopamine and serotonin levels in the cerebral cortex. Increased DARPP32 Thr75/Thr34 phosphorylation ratio was observed, suggesting a suppression of phosphatase 1 inhibition, which may be involved in behavioral responses to MGO. Co-treatment with a dopamine/noradrenaline reuptake inhibitor (bupropion, 10 mg/kg, p.o.) reversed the depression-like behavior and working memory impairment and restored the serotonin and dopamine levels in the cerebral cortex. Overall, the cerebral cortex monoaminergic system appears to be a preferential target of MGO toxicity, a new potential therapeutic target that remains to be addressed.
Measles is a highly contagious acute febrile disease responsible for sporadic but explosive outbreaks worldwide. Although it was considered eliminated from the Americas, the disease reemerged in ...2017. This reemergence was linked to reduced immunization rates. Vaccination, early identification of cases, and blocking of the transmission chain are the most effective tools to combat measles, for which there is not a specific antiviral treatment. In this Brazilian prospective cross-sectional study, we investigated the prevalence of measles antibodies in children, a population vulnerable to significant morbidity and mortality from exposure to infection. Between December 2018 to November 2019, blood samples from 252 children were collected and assessed for the presence of measles-specific IgG antibodies and an overall prevalence of 75.8% was observed. We further stratified the cohort into age subgroups, none of which exhibited antibody presence levels above the herd immunity threshold of 94%. Moreover, the calculated number of secondary cases resulting from a case in any age group ranged from 3 to 4, demonstrating that even with partial vaccination coverage this disease is still concerning and highly transmissible. Despite global warnings about measles and previous efforts to combat the advance of the disease, data on antibody prevalence and vaccination coverage in several countries are still concerning and indicate that significant parts of the population could be affected. Seroprevalence studies like this one are important to highlight actual epidemiological conditions and emphasize the need for additional strategies to encourage immunization and avoid the potential impacts of measles, particularly in children who can be severely affected.
Granulosa cell tumour, an ovarian neoplasm of stromal origin, is an important tumour related to oestrogenic dominance syndrome and cystic endometrial hyperplasia–pyometra complex. In order to analyse ...ovarian tumour´s malignant potential, immunohistochemical markers can be used, such as anti‐HER2 and anti‐Ki‐67. The aim of this study was to evaluate the expression of immunohistochemical markers HER‐2 and Ki‐67 in granulosa cell tumour from bitches´ ovaries. In HER‐2 immunomarker analysis using the HercepTest® method, most tumours were classified as 2+ (moderate labelling). Concerning Ki‐67 immunomarker, only one case was described as having a high proliferative index. An association was found between immunostained cell percentage by anti‐HER‐2 antibodies and high pleomorphism, represented by the pattern of follicular/trabecular tumour arrangement. There was no correlation between anti‐Ki‐67 and anti‐HER‐2 antibody immunostaining intensities, probably due to only one case with a high Ki‐67 index. With an effective protocol for HER‐2 and Ki‐67 immunohistochemical identification in granulosa cell tumours in bitches, it was possible to characterize this neoplasm proliferation profile.
The use of salt stress attenuators is considered an important tool to minimize the deleterious effects of salts. However, its application to chives (Allium schoenoprasum L.) has not been studied. ...This study aimed to evaluate the induction of salt stress tolerance in chives plants in relation to growth and enzymatic reactions, when subjected to different salinity levels of the nutrient solution, after acclimation of seeds with hydrogen peroxide (H2O2) for 24 h. The experiment was conducted in a greenhouse, where chives seeds were acclimated by H2O2 at concentrations of 0.0, 0.15, 0.30, 0.45 and 0.60 mmol. After germination, the plants were cultivated in hydroponic system with electrical conductivities of 1.0, 2.0, 3.0, 4.0 and 5.0 dS m-1. Plant height, length and number of leaves, H2O2 content, malondialdehyde and catalase (CAT) activity were evaluated in chives plants. The increase in the salinity of the nutrient solution up to 5 dS m-1 reduced by 5.88%, 17% and 9.63% plant height, leaf length and number of leaves, respectively. It was observed that the acclimation of chives seeds with H2O2 at 0.45 mmol g-1 fresh mass in plants that were cultivated in nutrient solution of 3.73 dS m-1 led to maximum CAT activity, minimizing the deleterious effects of nutrient solution salinity on plant growth.
Neste texto lançaremos luz sobre quatro experiências de adoecimento em corpos negros, femininos e infantis, na segunda metade do século XIX. Estas vivências, de duas crianças e duas mulheres ...trabalhadoras, foram pinçadas de um significativo conjunto de casos que envolve escravizados e libertos, publicados no periódico médico Gazeta Médica da Bahia. Interessa sublinhar a presença dos corpos negros na prática da medicina acadêmica, no Nordeste imperial. Os casos que apresentamos trazem à baila cenários do cotidiano na escravidão e corroboram com a historiografia que aponta as relações entre a medicina acadêmica e a escravidão durante o Oitocentos.
Objetivos: Analisar as notificações de morte encefálica (ME) recebidas pela Central de Transplantes (CET) do estado de Roraima (RR) de 2017 a 2021. Métodos: Trata-se de estudo transversal, ...quantitativo e observacional no qual foram analisadas todas as notificações recebidas pela CET no período de 2017 a 2021, resultando em 120 pacientes, dos seguintes centros de saúde: Hospital Geral de Roraima (HGR), Hospital Confederação Nacional das Cooperativas Médicas (UNIMED), Hospital da Criança Santo Antônio (HCSA), Hospital das Clínicas (HC) e Hospital Lotty Íris (HLI). Os dados foram coletados do sistema de gerenciamento de dados da central e repassados para a ficha de coleta desenvolvida pela pesquisadora. Resultados: Este estudo analisou 119 notificações após a exclusão de uma devido a dados conflitantes. Houve predominância do sexo masculino (58%), com trauma cranioencefálico sendo a causa mais frequente de ME. Ao todo, foram realizadas seis captações de órgãos, todas no HGR. Este estudo não encontrou associações significativas entre a captação de órgãos e sexo, idade, local de internação e ano. Conclusão: Há grandes desafios em relação à doação de órgãos em RR, com uma taxa de captação baixa ao longo de 5 anos. Apenas o HGR obteve sucesso em realizar captações de órgãos, diferentemente de outros hospitais notificadores. São necessárias melhorias, destacando a importância de se realizarem mais estudos para uma análise mais aprofundada dos dados.
Quality of life (QoL) characteristics are important in patients with diabetes mellitus (DM 1 and 2). Aim: Evaluate QoL and DM-associated factors among diabetic patients. Methods: Patients attending a ...University Hospital were interviewed about their sociodemographic, clinical and QoL characteristics, with QoL measured via the EQ-5D. Descriptive analysis, correlation, linear regression, univariate and multivariate analysis were performed. Results: 346 patients took part, comprising 67% women, 59% with DM2, and 32% DM1. DM 1 patients had a mean QoL score of 0.7369, with retinopathy, depression, dyslipidemia and a serious hypoglycemic crisis significantly reducing QoL. Patients with DM type 2 had a mean QoL score of 0.6582, with hypertension, neuropathy, depression, cancer and dyslipidemia significantly reducing QoL. Reduced QoL also correlated with a lack of physical exercise. Males with both DM1 and 2 had a better QoL than females. Conclusion: Need for better disease monitoring and control combined with effective activities to improve self-care, reduce complications and improve patients' QoL.
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