Mucoepidermoid Carcinoma in a Young Patient: Case Report DOS SANTOS, ANA PAULA CANDIDO; COELHO, ANA PATRÍCIA CARNEIRO GONÇALVES BEZERRA; MOURA, RENATA MENDES ...
Oral surgery, oral medicine, oral pathology and oral radiology,
February 2014, Letnik:
117, Številka:
2
Journal Article
To determine the usefulness of the rapid parathyroid hormone (PTH) assay during venous localization for primary hyperparathyroidism (1 degrees HPTH).
Remedial exploration for persistent 1 degrees ...HPTH poses a significant challenge when noninvasive preoperative localization studies are negative. Based on experience with the intraoperative rapid PTH assay, this technique was extrapolated to the interventional radiology suite and generated near real-time data for the interventional radiologist employing on-site hormone analysis, with a 12-minute turnaround time from blood sampling to assay result.
Between November 1997 and July 2002, 446 patients with 1 degrees HPTH were referred for treatment. Of these, 56 (12.5%) represented remedial patients who had each undergone one or more previous cervical explorations. Noninvasive imaging studies were positive for or suggestive of localized disease in 49/56 (87.5%) of these patients, who therefore proceeded directly to surgical exploration. Seven patients with persistent 1 degrees HPTH and negative noninvasive studies underwent selective venous sampling employing a rapid PTH assay in the interventional suite.
Venous localization demonstrated an apparent PTH gradient in six of the seven patients. In three, a subtle gradient demonstrated in near real-time prompted additional sampling, which confirmed an unequivocal hormone gradient. In an additional case, the absence of a gradient on initial sampling prompted further sampling, which was positive. All of the patients were explored, and in five of the six patients with a positive PTH gradient, a parathyroid adenoma (mean weight 636 +/- 196 mg) was resected from a location predicted by venous localization. In the sixth patient with a positive gradient, parathyroid tissue was not identified; however, there was a significant fall in the intraoperative PTH values, and immediate postoperative and follow-up laboratory data at 1 month are indicative of a cure. In the one patient with negative localization, abnormal parathyroid tissue could not be located during surgical exploration.
The rapid PTH assay is a major adjunct for obtaining informative venous localization in patients with persistent 1 degrees HPTH. This information is extremely helpful to the surgeon in this challenging group of patients and resulted in a 100% cure rate when a venous gradient was demonstrated. The authors now employ this technique routinely in remedial patients with negative noninvasive imaging studies.
Context: The specie Vernonanthura patens (Kunth) H. Rob. (Asteraceae) is a South American native wild bush that grows in various provinces of Ecuador and it has been used in traditional medicine for ...several diseases, highliting its use in treatment of leishmaniasis, a condition of high incidence in the country. Despite its medicinal use, there are few or none botanic, chemical nor biological studies for this species. Aims: In this paper it were comprised the morpho-anatomical characterization of leaves and stems and genetic identification of a DNA fraction of the leaves of V. patens, in order to provide the elements for proper characterization and contribute to the establishment of quality control. Methods: The macromorphological description was made in leaves and stems from the fresh plant. The micromorphological evaluation was performed by paraffin inclusion of the material with cross-section that were clarify in sodium hypochlorite for its posterior safranin and cresil’s blue stained and its glycerinated gel fixation respectively. On obtaining the DNA chloroplast it was followed the internal protocol established by Molecular Biology CIBE´s laboratory. In order to sequence isolated DNA fragments from leaves of V. patens, Macrogen Maryland, USA´S company services were hired. Results: Leaves and stems of the new specie’s micro morphological characteristics were described for the first time and new macro morphological characters were described too from stems particularly. Conclusions: Using molecular and macro-micromorphological assessments is corroborated the identity of the V. patens species growing in Ecuador coast.
There has been a considerable increase on research of the ecological consequences of microplastics released into the environment, but only a handful of works have focused on the nano-sized particles ...of polymer-based materials. Though their presence has been difficult to adequately ascertain, due to the inherent technical difficulties for isolating and quantifying them, there is an overall consensus that these are not only present in the environment – either directly released or as the result of weathering of larger fragments – but that they also pose a significant threat to the environment and human health, as well. The reduced size of these particulates (<1μm) makes them susceptible of ingestion by organisms that are at the base of the food-chain. Moreover, the characteristic high surface area-to-volume ratio of nanoparticles may add to their potential hazardous effects, as other contaminants, such as persistent organic pollutants, could be adsorbed and undergo bioaccumulation and bioamplification phenomena.
In this review, we describe the most relevant sources of nanoplastics and offer some insights into their fate once released into the environment. Furthermore, we overview the most prominent effects of these small particulates, while identifying the key challenges scientists currently face in the research of nanoplastics in the environment. Lastly, we give a brief summary of the economic impacts of the pollution caused by plastic litter – a potential key source of nanoplastics – in the oceans, the most common destination of these contaminants.
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•There has been a considerable increase of research on the fate o nanosized plastics.•These can pose a significant threat to both the environment and human health.•We reviewed their sources, fates and effects.•We identified the key challenges researchers face in this field.•Insights into the future of nanoplastics-related research are presented.
The role of thyroid hormone in metabolism and metabolic syndrome Teixeira, Patrícia de Fátima dos Santos; dos Santos, Patrícia Borges; Pazos-Moura, Carmen Cabanelas
Therapeutic Advances in Endocrinology and Metabolism,
05/2020, Letnik:
11
Book Review, Journal Article
Recenzirano
Odprti dostop
Metabolic syndrome (MetS) and thyroid dysfunction are common in clinical practice. The objectives of this review are to discuss some proposed mechanisms by which thyroid dysfunctions may lead to ...MetS, to describe the bidirectional relationship between thyroid hormones (THs) and adiposity and finally, to resume a list of recent studies in humans that evaluated possible associations between thyroid hormone status and MetS or its clinical components. Not solely THs, but also its metabolites regulate metabolic rate, influencing adiposity. The mechanisms enrolled are related to its direct effect on adenosine triphosphate (ATP) utilization, uncoupling synthesis of ATP, mitochondrial biogenesis, and its inotropic and chronotropic effects. THs also act controlling core body temperature, appetite, and sympathetic activity. In a bidirectional way, thyroid function is affected by adiposity. Leptin is one of the hallmarks, but the pro-inflammatory cytokines and also insulin resistance impact thyroid function and perhaps its structure. MetS development and weight gain have been positively associated with thyroid-stimulating hormone (TSH) in several studies. Adverse glucose metabolism may be related to hyperthyroidism, but also to reduction of thyroid function or higher serum TSH, as do abnormal serum triglyceride levels. Hypo- and hyperthyroidism have been related to higher blood pressure (BP), that may be consequence of genomic or nongenomic action of THs on the vasculature and in the heart. In summary, the interaction between THs and components of MetS is complex and not fully understood. More longitudinal studies controlling each of all confounding variables that interact with endpoints or exposure factors are still necessary.
Plastic yearly production has surpassed the 300milliontons mark and recycling has all but failed in constituting a viable solution for the disposal of plastic waste. As these materials continue to ...accumulate in the environment, namely, in rivers and oceans, in the form of macro-, meso-, micro- and nanoplastics, it becomes of the utmost urgency to find new ways to curtail this environmental threat. Multiple efforts have been made to identify and isolate microorganisms capable of utilizing synthetic polymers and recent results point towards the viability of a solution for this problem based on the biodegradation of plastics resorting to selected microbial strains.
Herein, the response of the fungus Zalerion maritimum to different times of exposition to polyethylene (PE) pellets, in a minimum growth medium, was evaluated, based on the quantified mass differences in both the fungus and the microplastic pellets used. Additionally, molecular changes were assessed through attenuated total reflectance Fourier transform Infrared Spectroscopy (FTIR-ATR) and Nuclear Magnetic Resonance (NMR).
Results showed that, under the tested conditions, Z. maritimum is capable of utilizing PE, resulting in the decrease, in both mass and size, of the pellets. These results indicate that this naturally occurring fungus may actively contribute to the biodegradation of microplastics, requiring minimum nutrients.
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•Plastic pollution is of growing concern as it accumulates in the environment.•Multiple microorganisms have been described as potential bioremediation solutions.•The potential of Zalerion maritimum in the biodegradation of polyethylene was tested.•Z. maritimum used polyethylene as evidenced by FTIR, NMR and SEM results.•The results highlight the prospective use of Z. maritimum as a bioremediation tool.
Adipose, skeletal, and hepatic muscle tissues are the main endocrine organs that produce adipokines, myokines, and hepatokines. These biomarkers can be harmful or beneficial to an organism and still ...perform crosstalk, acting through the endocrine, paracrine, and autocrine pathways. This study aims to review the crosstalk between adipokines, myokines, and hepatokines. Far beyond understanding the actions of each biomarker alone, it is important to underline that these cytokines act together in the body, resulting in a complex network of actions in different tissues, which may have beneficial or non-beneficial effects on the genesis of various physiological disorders and their respective outcomes, such as type 2 diabetes mellitus (DM2), obesity, metabolic syndrome, and cardiovascular diseases (CVD). Overweight individuals secrete more pro-inflammatory adipokines than those of a healthy weight, leading to an impaired immune response and greater susceptibility to inflammatory and infectious diseases. Myostatin is elevated in pro-inflammatory environments, sharing space with pro-inflammatory organokines, such as tumor necrosis factor-alpha (TNF-α), interleukin-1 (IL-1), resistin, and chemerin. Fibroblast growth factor FGF21 acts as a beta-oxidation regulator and decreases lipogenesis in the liver. The crosstalk mentioned above can interfere with homeostatic disorders and can play a role as a potential therapeutic target that can assist in the methods of diagnosing metabolic syndrome and CVD.
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