The hydrothermal vent clam Calyptogena magnifica (Bivalvia: Mollusca) is a member of the Vesicomyidae. Species within this family form symbioses with chemosynthetic Gammaproteobacteria. They exist in ...environments such as hydrothermal vents and cold seeps and have a rudimentary gut and feeding groove, indicating a large dependence on their endosymbionts for nutrition. The C. magnifica symbiont, Candidatus Ruthia magnifica, was the first intracellular sulfur-oxidizing endosymbiont to have its genome sequenced (Newton et al. 2007). Here we expand upon the original report and provide additional details complying with the emerging MIGS/MIMS standards. The complete genome exposed the genetic blueprint of the metabolic capabilities of the symbiont. Genes which were predicted to encode the proteins required for all the metabolic pathways typical of free-living chemoautotrophs were detected in the symbiont genome. These include major pathways including carbon fixation, sulfur oxidation, nitrogen assimilation, as well as amino acid and cofactor/vitamin biosynthesis. This genome sequence is invaluable in the study of these enigmatic associations and provides insights into the origin and evolution of autotrophic endosymbiosis.
The cGAS-STING pathway responds to cytosolic DNA to elicit host immunity to infection. The activation of STING can trigger a number of critical cellular responses including inflammation, noncanonical ...autophagy, lipid metabolism, senescence, and cell death. STING-mediated immunity through the production of type I IFNs and NF-κB-driven proinflammatory cytokines is primarily driven via the effector protein TBK1. We have previously found that IKKε, a homologue of TBK1, can also facilitate STING–NF-κB responses. Therefore, a thorough understanding of how IKKε participates in STING signalling is essential. Here we used a combination of genetic and biochemical approaches to provide mechanistic details into how IKKε confers non-IFN (e.g., NF-κB and MAPK) STING responses in macrophages, including in the absence of TBK1. We demonstrate a conserved mechanism of STING binding between TBK1 and IKKε. These findings strengthen our understanding of cGAS-STING signalling and the preservation of host immunity in cases of TBK1-deficiency.
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•IKKε and TBK1 bind the same STING signaling complexes to drive non-IFN responses•IKKε is recruited to STING via the defined TBK1-binding motif (TBM)•Residues essential for STING-binding are conserved between TBK1 and IKKε•IKKε forms a unique hydrophobic interaction with the C-terminal tail (CTT) of STING
The Effect of Negative Feedback on Modeling Behavior Dolly, John P.; Saunders, Joseph C.; Meredith, Vana H.
The Journal of educational research (Washington, D.C.),
07/1978, Letnik:
71, Številka:
6
Journal Article
Recenzirano
The study was designed to determine if social learning theory and cognitive dissonance theory would adequately predict the modeling behavior of subjects on a novel task. The study was limited to a ...task on which subjects were provided negative feedback concerning their ability to identify the personality characteristics of others. A total of 60 undergraduate students were given the opportunity to imitate models competent on the task or models poor on the task but more similar to the subjects' performance. Most subjects imitated the poor models ip < .01), indicating support for dissonance and social learning theories.
Celotno besedilo
Dostopno za:
BFBNIB, DOBA, IZUM, KILJ, NMLJ, NUK, PILJ, PNG, SAZU, UILJ, UKNU, UL, UM, UPUK
Several experiments were conducted to evaluate alternative methods for training preservice teachers in questioning skills. Some treatment groups received videotape and handbook instruction and ...regular microteaching practice with junior high school students. Two other groups received the same instruction and either peer microteaching or classroom observation experience. One group received instruction entirely through a traditional lecture-discussion method. Comparisons of pre- and post training videotapes of teach ing performance revealed that regular and peer microteaching produced the most consistent and substantial gains in use of questioning skills. The observation and lecture-discussion treatments were less effective.
Celotno besedilo
Dostopno za:
BFBNIB, DOBA, IZUM, KILJ, NMLJ, NUK, PILJ, PNG, SAZU, UILJ, UKNU, UL, UM, UPUK
Experimental carbon and nitrogen core electron binding energies measured by high energy photoelectron spectroscopy are reported together with ab initio and semi-empirical molecular orbital studies ...for a series of organic pseudohalides. The derived wavefunctions are used in a discussion of molecular potential models which are employed in the interpretation of core photoelectron spectra. The application of localized wavefunctions in this context is described.
Reviews McKay, K. J.; Barrett, D. S.; Manning, C. E. ...
Journal of the Australasian Universities Language and Literature Association,
19/5/1/, Letnik:
33, Številka:
1
Book Review
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