Although neglected in diagnostic criteria lists, theoretical models, and treatment approaches, attenuated positive emotions and cognitions distinguish social anxiety and social anxiety disorder from ...other anxiety conditions (and cannot be accounted for by comorbidity with depression). We present a self-control resource depletion model to explain how the intense self-regulatory efforts of high socially anxious individuals dampen positive experiences and events. We review existing research on individuals with social anxiety difficulties, focusing on impoverished positive experiences and quality of life, atypical reactions to overtly positive social outcomes, the absence of a normative bias toward the positive in social situations, and a meaningful subset of individuals who show signs of impulsive, short-lived positive events. We also discuss findings from the social psychology literature for how to enhance positive experiences, positive events, and self-regulatory capacity in individuals with social anxiety difficulties. The aim of the review is to broaden theory, research, and treatment efforts to the positive spectrum of human functioning.
► We review research on individuals with social anxiety difficulties, focusing on impoverished positive experiences, atypical reactions to overtly positive social outcomes, and the absence of a normative bias toward the positive in social situations. ► We discuss recommendations for enhancing positive experiences and events, and self-regulatory capacity by synthesizing work from social and personality psychology.
The purpose of this study was to examine measures of anatomical connectivity between the thalamus and lateral prefrontal cortex (LPFC) in schizophrenia and to assess their functional implications. We ...measured thalamocortical connectivity with diffusion tensor imaging (DTI) and probabilistic tractography in 15 patients with schizophrenia and 22 age- and sex-matched controls. The relationship between thalamocortical connectivity and prefrontal cortical blood-oxygenation-level-dependent (BOLD) functional activity as well as behavioral performance during working memory was examined in a subsample of 9 patients and 18 controls. Compared with controls, schizophrenia patients showed reduced total connectivity of the thalamus to only one of six cortical regions, the LPFC. The size of the thalamic region with at least 25% of model fibers reaching the LPFC was also reduced in patients compared with controls. The total thalamocortical connectivity to the LPFC predicted working memory task performance and also correlated with LPFC BOLD activation. Notably, the correlation with BOLD activation was accentuated in patients as compared with controls in the ventral LPFC. These results suggest that thalamocortical connectivity to the LPFC is altered in schizophrenia with functional consequences on working memory processing in LPFC.
Objective
Curiosity is the propensity to recognize and seek out new information and experience, including an intrinsic interest in learning and developing one's knowledge. With few exceptions, ...researchers have often ignored the social consequences of being curious.
Method
In four studies using cross‐sectional (N = 64), daily diary (Ns = 150 and 110, respectively), and behavioral experimental (N = 132) designs, we tested the hypothesis that individual differences in curiosity are linked to less aggression, even when people are provoked.
Results
We showed that both trait and daily curiosity were linked to less aggressive responses toward romantic relationship partners and people who caused psychological hurt. In time‐lagged analyses, daily curiosity predicted less aggression from one day to the next, with no evidence for the reverse direction. Studies 3 and 4 showed that the inverse association between curiosity and aggression was strongest in close relationships and in fledgling (as opposed to long‐lasting) romantic relationships. That is, highly curious people showed evidence of greater context sensitivity. Intensity of hurt feelings and other personality and relationship variables failed to account for these effects.
Conclusions
Curiosity is a neglected mechanism of resilience in understanding aggression.
Gamma-aminobutyric acid (GABA)-ergic transmission is critical for normal cortical function and is likely abnormal in a variety of neuropsychiatric disorders. We tested the in vivo effects of ...variations in two genes implicated in GABA function on GABA concentrations in prefrontal cortex of living subjects: glutamic acid decarboxylase 1 (GAD1), which encodes GAD67, and catechol-o-methyltransferase (COMT), which regulates synaptic dopamine in the cortex. We studied six single nucleotide polymorphisms (SNPs) in GAD1 previously associated with risk for schizophrenia or cognitive dysfunction and the val158met polymorphism in COMT in 116 healthy volunteers using proton magnetic resonance spectroscopy. Two of the GAD1 SNPs (rs1978340 (p=0.005) and rs769390 (p=0.004)) showed effects on GABA levels as did COMT val158met (p=0.04). We then tested three SNPs in GAD1 (rs1978340, rs11542313, and rs769390) for interaction with COMT val158met based on previous clinical results. In this model, rs11542313 and COMT val158met showed significant main effects (p=0.001 and 0.003, respectively) and a trend toward a significant interaction (p=0.05). Interestingly, GAD1 risk alleles for schizophrenia were associated with higher GABA/Cre, and Val-Val homozygotes had high GABA/Cre levels when on a GAD1 risk genotype background (N=6). These results support the importance of genetic variation in GAD1 and COMT in regulating prefrontal cortical GABA function. The directionality of the effects, however, is inconsistent with earlier evidence of decreased GABA activity in schizophrenia.
γ‐Aminobutyric acid (GABA) is the chief inhibitory neurotransmitter of the human brain, and GABA‐ergic dysfunction has been implicated in a variety of neuropsychiatric disorders. Recent MRS ...techniques have allowed the quantification of GABA concentrations in vivo, and could therefore provide biologically relevant information. Few reports have formally characterized the reproducibility of these techniques, and differences in field strength, acquisition and processing parameters may result in large differences in measured GABA values. Here, we used a J‐edited, single‐voxel spectroscopy method of measurement of GABA + macromolecules (GABA + ) in the anterior cingulate cortex (ACC) and right frontal white matter (rFWM) at 3 T. We measured the coefficient of variation within subjects (CVw) and intra‐class correlation coefficients on two repeated scans obtained from 10 healthy volunteers with processing procedures developed in‐house for the quantification of GABA + and other major metabolites. In addition, by segmenting the spectroscopic voxel into cerebrospinal fluid, gray matter and white matter, and employing a linear regression technique to extrapolate metabolite values to pure gray and white matter, we determined metabolite differences between gray and white matter in ACC and rFWM. CVw values for GABA + /creatine, GABA + /H2O, GABA + , creatine, partially co‐edited glutamate + glutamine (Glx)/creatine, partially co‐edited Glx and N‐acetylaspartic acid (NAA)/creatine were all below 12% in both ACC and rFWM. After extrapolation to pure gray and pure white matter, CVw values for all metabolites were below 16%. We found metabolite ratios between gray and white matter for GABA + /creatine, GABA + , creatine, partially co‐edited Glx and NAA/creatine to be 0.88 ± 0.21 (standard deviation), 1.52 ± 0.32, 1.77 ± 0.4, 2.69 ± 0.74 and 0.70 ± 0.05, respectively. This study validates a reproducible method for the quantification of brain metabolites, and provides information on gray/white matter differences that may be important in the interpretation of results in clinical populations. Published in 2011 by John Wiley & Sons, Ltd.
In this study, we quantified the reproducibility of an in vivo MRS acquisition and data processing method to measure γ‐aminobutyric acid + macromolecules (GABA +) in the anterior cingulate cortex and right frontal white matter. To explore the dependence of metabolite concentrations on voxel composition, we extrapolated GABA + values to pure gray and pure white matter. We found that GABA + quantification was highly reproducible and that GABA + concentrations were significantly higher in gray than in white matter.
Abstract To expose biases in self-perceptions of people high in social anxiety, information is needed on actual and perceived informant reports following social situations. We measured trait social ...anxiety (SA) in 90 college students arranged in pairs for “getting acquainted” conversations. Half participated in a small-talk task, where they took turns answering superficial questions; half participated in a closeness-generating task, where questions required gradual increases in self-disclosure. Afterward, students rated themselves and their partner on positive and negative attributes and how they think their partner viewed them. People with high SA judged themselves more negatively and less positively than their partner did (accuracy); when interacting with a partner endorsing low SA, they possessed enhanced negativity biases about how they expected to be viewed (meta-accuracy), and believed their partner's judgments were less positive than their own low self-judgments (perceived dissent). Conversely, people with low SA showed evidence of a self-enhancement bias about the impression they made on low SA strangers. Other moderators of the social cognitions of people with high SA included gender and the social situation (distortions being amplified in men and small-talk conversations). Our findings suggest that the study of SA cannot be understood using decontextualized approaches, instead requiring consideration of the synergy among the person, partner, and situation.
Background This study was conducted to corroborate prior evidence of an effect of the brain-derived neurotrophic factor (BDNF) valine (val) to methionine (met) amino acid substitution at codon 66 ...(val66met) polymorphism on measures of N -acetyl-aspartate (NAA) containing compounds in healthy subjects. Methods The NAA to creatine (Cre) ratio (NAA/Cre), NAA to choline (Cho) ratio (NAA/Cho), and Cho to Cre ratio (Cho/Cre) were measured in the left and right hippocampi, left and right dorsolateral prefrontal cortices, occipital lobe, anterior cingulate, and white matter of the centrum semiovale of 69 carefully screened healthy volunteers utilizing proton magnetic resonance spectroscopic imaging (MRSI) at 3 Tesla (T). Results Val/met subjects exhibited significantly reduced levels of left hippocampal NAA/Cre and NAA/Cho compared with val/val subjects. This effect was independent of age, IQ, number of voxels, hippocampal volume, or gray matter content in the voxels of interest. Analysis of other brain regions showed no effect of BDNF genotype on NAA measures. Conclusions We confirmed the association between the met-BDNF variant and reduced levels of hippocampal NAA found with a similar technique at 1.5T. The consonance of our results with prior findings adds to the evidence that the BDNF val/met genotype affects hippocampal biology with implications for a variety of neuropsychiatric disorders.
To expose biases in self-perceptions of people high in social anxiety, information is needed on actual and perceived informant reports following social situations. We measured trait social anxiety ...(SA) in 90 college students arranged in pairs for “getting acquainted” conversations. Half participated in a small-talk task, where they took turns answering superficial questions; half participated in a closeness-generating task, where questions required gradual increases in self-disclosure. Afterward, students rated themselves and their partner on positive and negative attributes and how they think their partner viewed them. People with high SA judged themselves more negatively and less positively than their partner did (accuracy); when interacting with a partner endorsing low SA, they possessed enhanced negativity biases about how they expected to be viewed (meta-accuracy), and believed their partner's judgments were less positive than their own low self-judgments (perceived dissent). Conversely, people with low SA showed evidence of a self-enhancement bias about the impression they made on low SA strangers. Other moderators of the social cognitions of people with high SA included gender and the social situation (distortions being amplified in men and small-talk conversations). Our findings suggest that the study of SA cannot be understood using decontextualized approaches, instead requiring consideration of the synergy among the person, partner, and situation.
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