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zadetkov: 17
1.
  • Nalfurafine is a G-protein ... Nalfurafine is a G-protein biased agonist having significantly greater bias at the human than rodent form of the kappa opioid receptor
    Schattauer, Selena S.; Kuhar, Jamie R.; Song, Allisa ... Cellular signalling, 04/2017, Letnik: 32
    Journal Article
    Recenzirano
    Odprti dostop

    Nalfurafine is a moderately selective kappa opioid receptor (KOR) analgesic with low incidence of dysphoric side effects in clinical development for the treatment of uremic pruritis. The basis for ...
Celotno besedilo
Dostopno za: GEOZS, IJS, IMTLJ, KILJ, KISLJ, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UL, UM, UPCLJ, UPUK, ZRSKP

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2.
  • Kappa Opioid Receptor-Induc... Kappa Opioid Receptor-Induced Aversion Requires p38 MAPK Activation in VTA Dopamine Neurons
    Ehrich, Jonathan M; Messinger, Daniel I; Knakal, Cerise R ... The Journal of neuroscience, 09/2015, Letnik: 35, Številka: 37
    Journal Article
    Recenzirano
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    The endogenous dynorphin-κ opioid receptor (KOR) system encodes the dysphoric component of the stress response and controls the risk of depression-like and addiction behaviors; however, the molecular ...
Celotno besedilo
Dostopno za: CMK, NUK, UL, UM, UPUK

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3.
  • Release of endogenous dynor... Release of endogenous dynorphin opioids in the prefrontal cortex disrupts cognition
    Abraham, Antony D; Casello, Sanne M; Schattauer, Selena S ... Neuropsychopharmacology (New York, N.Y.), 12/2021, Letnik: 46, Številka: 13
    Journal Article
    Recenzirano
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    Following repeated opioid use, some dependent individuals experience persistent cognitive deficits that contribute to relapse of drug-taking behaviors, and one component of this response may be ...
Celotno besedilo
Dostopno za: EMUNI, FIS, FZAB, GEOZS, GIS, IJS, IMTLJ, KILJ, KISLJ, MFDPS, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, SBMB, SBNM, UKNU, UL, UM, UPUK, VKSCE, ZAGLJ

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4.
  • Peroxiredoxin 6 mediates Gα... Peroxiredoxin 6 mediates Gαi protein-coupled receptor inactivation by cJun kinase
    Schattauer, Selena S; Land, Benjamin B; Reichard, Kathryn L ... Nature communications, 09/2017, Letnik: 8, Številka: 1
    Journal Article
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    Inactivation of opioid receptors limits the therapeutic efficacy of morphine-like analgesics and mediates the long duration of kappa opioid antidepressants by an uncharacterized, arrestin-independent ...
Celotno besedilo
Dostopno za: NUK, UL, UM, UPUK

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5.
  • Estrogen Regulation of GRK2... Estrogen Regulation of GRK2 Inactivates Kappa Opioid Receptor Signaling Mediating Analgesia, But Not Aversion
    Abraham, Antony D; Schattauer, Selena S; Reichard, Kathryn L ... The Journal of neuroscience, 2018-Sep-12, 2018-09-12, 20180912, Letnik: 38, Številka: 37
    Journal Article
    Recenzirano
    Odprti dostop

    Activation of κ opioid receptors (KORs) produces analgesia and aversion via distinct intracellular signaling pathways, but whether G protein-biased KOR agonists can be designed to have clinical ...
Celotno besedilo
Dostopno za: CMK, NUK, UL, UM, UPUK

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6.
  • Stress produces aversion an... Stress produces aversion and potentiates cocaine reward by releasing endogenous dynorphins in the ventral striatum to locally stimulate serotonin reuptake
    Schindler, Abigail G; Messinger, Daniel I; Smith, Jeffrey S ... The Journal of neuroscience, 2012-Dec-05, 2012-12-05, 20121205, Letnik: 32, Številka: 49
    Journal Article
    Recenzirano
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    Activation of the dynorphin/κ-opioid receptor (KOR) system by repeated stress exposure or agonist treatment produces place aversion, social avoidance, and reinstatement of extinguished cocaine place ...
Celotno besedilo
Dostopno za: CMK, NUK, UL, UM, UPUK

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7.
  • Reactive oxygen species (RO... Reactive oxygen species (ROS) generation is stimulated by κ opioid receptor activation through phosphorylated c-Jun N-terminal kinase and inhibited by p38 mitogen-activated protein kinase (MAPK) activation
    Schattauer, Selena S.; Bedini, Andrea; Summers, Floyd ... The Journal of biological chemistry, 11/2019, Letnik: 294, Številka: 45
    Journal Article
    Recenzirano
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    Activation of the mitogen-activated protein kinase (MAPK) c-Jun N-terminal kinase (JNK) by the Gi/o protein–coupled κ opioid receptor (KOR), μ opioid, and D2 dopamine receptors stimulates ...
Celotno besedilo
Dostopno za: GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP

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8.
  • Regulation of Kappa Opioid ... Regulation of Kappa Opioid Receptor Inactivation Depends on Sex and Cellular Site of Antagonist Action
    Reichard, Kathryn L.; Newton, Keionna A.; Rivera, Zeena M.G. ... Molecular pharmacology, 11/2020, Letnik: 98, Številka: 5
    Journal Article
    Recenzirano
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    The prototypical member of the receptor-inactivating kappa opioid receptor (KOR) antagonists, norbinaltorphimine (norBNI), produces prolonged receptor inactivation by a cJun kinase mechanism. These ...
Celotno besedilo
Dostopno za: NUK, UL, UM, UPUK

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9.
  • Ligand Directed Signaling D... Ligand Directed Signaling Differences between Rodent and Human κ-Opioid Receptors
    Schattauer, Selena S.; Miyatake, Mayumi; Shankar, Haripriya ... The Journal of biological chemistry, 12/2012, Letnik: 287, Številka: 50
    Journal Article
    Recenzirano
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    KOR activation of Gβγ dependent signaling results in analgesia, whereas the dysphoric effects of KOR agonists are mediated by a different pathway involving G protein receptor kinase and non-visual ...
Celotno besedilo
Dostopno za: GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP

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10.
  • Arrestin-mediated activatio... Arrestin-mediated activation of p38 MAPK: molecular mechanisms and behavioral consequences
    Chavkin, Charles; Schattauer, Selena S; Levin, Jamie R Handbook of experimental pharmacology, 2014, Letnik: 219
    Journal Article
    Recenzirano

    Studies of kappa opioid receptor signaling mechanisms during the last decade have demonstrated that agonist activation of the receptor results in Gβγ-dependent signaling and distinct ...
Preverite dostopnost
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zadetkov: 17

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