Previous reports suggest that MRI changes should be seen within 48h of symptoms arising. We report on two patients with proven discitis at the L5/S1 disc. MRI performed within 60h of the onset of ...symptoms did not demonstrate evidence of infection and therefore did not confirm the diagnosis of discitis. The reliability of early MRI to confirm infective discitis is questionable. The cases we report on did not display any of the typical changes of discitis on MRI within the first 48h after the onset of symptoms. Absence of typical infective changes on MRI does not necessarily exclude an infection within the disc space.
A zinc complex with the tripodal ligand bis2-(2-pyridyl)ethyl-(2-pyridyl)methylamine (pmap) reacts with carbon dioxide to form a new dinuclear carbonate bridged zinc complex, μ-CO
3{Zn(pmap)}
2(ClO
...4)
2. This complex was structurally characterized and shows a binding mode for carbonate, which so far has not been observed for zinc carbonate complexes.
In Austria, methadone, buprenorphine as well as oral slow-release morphine are used for the treatment of opioid dependence. This controlled examination marks the first time that oral slow-release ...morphine hydrochloride is applied for maintenance therapy in opioid dependent subjects.
In order to evaluate the effectiveness of this psychopharmacological medication, we examined patients over a three-week period. Outcome measures were retention rate, additional consumption and the evaluation of opioid withdrawal 24 hours after the last oral medication.
Sixty-seven patients were included; sixty-four patients completed the study, representing a retention rate of 94%. During the three-week period, a significant improvement in well-being and a significant reduction in heroin, cocaine and benzodiazepine craving (p < 0.0001) was evaluated. Furthermore, there was a significant reduction of additional consumption of benzodiazepines in supervised urinalysis. Additional consumption of cocaine remained unchanged. Laboratory results showed a significant reduction of CK over the course of investigation.
The high retention rate of 94% implies a good acceptance and efficacy of the substance. The reduced CK is consistent with a reduction in intravenous application of illegal substances. However, randomized double-blind, double-dummy studies with oral slow-release morphine are needed in order to meet criteria for evidence based medicine.
A comparison between humans and rabbits was performed based on stimulation of whole blood with well-known pyrogens from Gram-negative and Gram-positive bacteria, such as lipopolysaccharide (LPS) and ...lipoteichoic acid (LTA), respectively. The reactivity was measured as release of IL-1 beta and IL-8 by ELISA. The reactivity of the two species towards LPS was found to be similar, whereas their reactivity towards LTA differed considerably. Differences between the levels of IL-1 beta and IL-8 release were observed in both species. This finding suggests that the In vitro Pyrogen Test (IPT) which uses human blood to detect contaminations, e.g. of injectable drugs, might predict the human reaction to the contamination better than the "gold standard" rabbit pyrogen test.
We investigate efficiency and time dependence of metal enrichment processes in the intra-cluster medium (ICM). In this presentation, we concentrate on the effects of galactic winds. The mass loss ...rates due to galactic winds are calculated with a special algorithm, which takes into account cosmic rays and magnetic fields. This algorithm is embedded in a combined
N-body/hydrodynamic code which calculates the dynamics and evolution of a galaxy cluster. We give metallicity maps, which show the metal distribution in the ICM caused by galactic winds of quiet, i.e., non-starburst, disk galaxies.
We present a lensing survey consisting of the 22 most X-ray luminous galaxy clusters selected from the ROSAT Bright Survey. All clusters are located in the medium redshift regime (0.1
⩽
z
⩽
0.52) and ...hence the probability for finding strongly lensed objects of background sources (gravitational arcs) is very high. In these conference proceedings we present several lensing features in three clusters of this survey.
An increase in inbreeding level and advanced parental age are factors that increase the risk of having children with structural and numerical chromosomal abnormalities due to altered frequency of ...recombination and impaired behavior of chromosomes in meiosis. There is limited information on the effects of inbreeding on human chromosomal and genomic mutations. The purpose of the study was to assess the effect of inbreeding on the prevalence of chromosomal abnormalities in the districts of the Kharkiv region. Materials and methods. The study was conducted in four districts of the Kharkiv region – Balakliia, Vovchansk, Zmiiv, and Krasnograd (administrative and territorial structure is given as of July 1, 2020). Based on the data of analysis of 1,582 marriages between opposite-sex couples mean age at marriage, marital distance, and the random inbreeding coefficient (FST) were estimated. Of 654 children (aged 0–17 years) included in the study, 39 had chromosomal disorders that was the basis for the calculation of the prevalence of chromosomal abnormalities. Results and discussion. In four districts, the mean age at marriage for local residents was 27.8 ± 0.1 years. Men were 2.9 years older than women at marriage. The marital distance was 320.4 ± 28.4 km, varying from 263.17 ± 48.39 km in the Balakliia district to 400.12 ± 79.97 km in the Vovchansk district. The random inbreeding coefficient FST was 0.001292. In rural settlements, the random inbreeding coefficient FST was by 17.2 times higher than in urban settlements. The index rose by 80 percent over the last seven years. The prevalence of chromosomal pathology among children and adolescents was 0.08%, ranging from 0.05% in the Vovchansk district to 0.14% in the Krasnograd district. Among the cases included, there were patients with Down syndrome, Klinefelter syndrome, Turner syndrome, and Prader-Willi syndrome. The most common nosological entity was Down syndrome. The prevalence of chromosomal abnormalities in villages was by 2.6 times higher than in towns. A strong positive relationship was established between the random inbreeding coefficients FST and the prevalence of chromosomal disorders in the study area (r = 0.904). Conclusion. Almost two-fold increase in the inbreeding rate in the mentioned districts in just past seven years may contribute to accumulation of burden of chromosomal disorders of the population due to the presence of a positive correlation between the study population indicators
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