In this diary study, we examined the associations between daily work-related smartphone use and daily psychological detachment and daily work-related exhaustion within a group of smartphone owners. ...In addition, we studied the role of the perceived segmentation norm at the workplace as a moderator of the link between work-related smartphone use and detachment. A total of 70 employees using smartphones on initiative of their employer completed a diary questionnaire on 4 successive workdays (N = 268 data points). We hypothesized that work-related smartphone use is negatively related to psychological detachment and that psychological detachment, in turn, is negatively related to work-related exhaustion. Finally, we expected that especially employees who perceive a high segmentation norm at their workplace have difficulties to psychologically detach from work on days that they use their smartphone more intensively. Overall, the results of multilevel analyses supported these hypotheses. The findings emphasize the importance of a clear organizational policy regarding work-related smartphone use outside of work hours.
To determine the extent that demographics, clinical characteristics, comorbidities, and complications contribute to the risk of in-hospital mortality and morbidity in acute stroke.
Data of ...consecutive patients admitted to 14 stroke units cooperating within the Berlin Stroke Register were analyzed. The association of demographics, clinical characteristics, comorbidities, and complications with the risk of in-hospital death and poor outcome at discharge was assessed, and independent attributable risks were calculated, applying average sequential attributable fractions.
In a 3-year period, 16,518 consecutive patients with ischemic or hemorrhagic stroke were documented. In-hospital mortality was 5.4%, and 45.7% had a poor outcome (modifed Rankin Scale score ≥3). In patients with length of stay (LOS) ≤7 days, 37.5% of in-hospital deaths were attributed to stroke severity, 23.1% to sociodemographics (age and prestroke disability), and 28.9% to increased intracranial pressure (iICP) and other complications. In those with LOS >7 days, age and stroke severity accounted for 44.1%, whereas pneumonia (12.2%), other complications (12.6%), and iICP (8.3%) contributed to one-third of in-hospital deaths. For poor outcome, attributable risks were similar for prestroke disability, stroke severity, pneumonia, and other complications regardless of the patient's LOS.
Approximately two-thirds of early death and poor outcome in acute stroke is attributed to nonmodifiable predictors, whereas main modifiable factors are early complications such as iICP, pneumonia, or other complications, on which stroke unit treatment should focus to further improve the prognosis of acute stroke.
The Paleocene–Eocene thermal maximum (PETM) is represented in numerous shallow and deep marine sections of the south–central and western Pyrenees by a 2–4 m thick unit (locally up to 20 m) of clays ...or marly clays intercalated within a carbonate-dominated succession. This unit records a massive input into the Pyrenean Gulf of fine-grained terrestrial siliciclastics, attributed to an abrupt hydrological change during the PETM. However, the nature of such a change remains controversial. Here we show that, in addition to fine-grained deposits, large volumes of coarse-grained siliciclastics were brought into the basin and were mostly accumulated in incised valleys and in a long-lived deep-sea channel. The occurrence of these coarse-grained deposits has been known for some time, but their correlation with the PETM is reported here for the first time. The bulk of the incised valley deposits in the PETM interval are cross-bedded sands and pebbly sands, almost exclusively made of quartz. The criteria for indicting a relation to the PETM include their stratigraphic position between upper Thanetian and lower Ilerdian marine carbonates, organic carbon isotope data, and a high percentage of kaolinite in the clay matrix. The axially flowing deep-sea channel existed throughout Paleocene times in the Pyrenean Basin, within which coarse-grained calciclastic and siliciclastic turbidites were accumulated. This Paleocene succession is capped by thickly bedded quartz sandstones and pebbly sandstones, probably deposited by hyperpycnal flows, which are here assigned to the PETM based on their stratigraphic position and organic carbon isotopic data. The large and simultaneous increase in coarse- and fine-grained terrestrial siliciclastics delivered to the Pyrenean Gulf during the PETM is attributed to an increased intra-annual humidity gradient. During the PETM a longer and drier summer season facilitated the erosion of landscapes, whereas a dramatic enhancement of precipitation extremes during the wet season led to intensified flood events, with rivers carrying greater volumes of both bed and suspended loads. This scenario argues against the possibility that PETM kaolinites indicate a coeval warm and humid climate in northern Spain. Instead, the kaolinite reflects the erosion of thick Cretaceous lateritic profiles developed on the Hercynian basement.
From mid-Ordovician ∼470 Myr-old limestone >100 fossil L-chondritic meteorites have been recovered, representing the markedly enhanced flux of meteorites to Earth following the breakup of the ...L-chondrite parent body. Recently one anomalous meteorite, Österplana 065 (Öst 65), was found in the same beds that yield L chondrites. The cosmic-ray exposure age of Öst 65 shows that it may be a fragment of the impactor that broke up the L-chondrite parent body. Here we show that in a chromium versus oxygen-isotope plot Öst 65 falls outside all fields encompassing the known meteorite types. This may be the first documented example of an 'extinct' meteorite, that is, a meteorite type that does not fall on Earth today because its parent body has been consumed by collisions. The meteorites found on Earth today apparently do not give a full representation of the kind of bodies in the asteroid belt ∼500 Myr ago.
After endovascular treatment of intracranial aneurysms with the Woven EndoBridge (WEB) device, worsening of aneurysm occlusion or re-opening was reported to be possibly associated with WEB shape ...modification. This study analyzed quantitatively the WEB shape modification with time in association with anatomic results.
Thirty patients with 32 WEB-treated intracranial aneurysms fulfilled the inclusion criteria of cranial CT at baseline (day of intervention) and a follow-up CT at least >1 months' later (median follow-up time, 11.4 months; interquartile range, 6.5-21.5 months). Adequate occlusion was observed in 84.4%, and aneurysm remnant, in 15.6%. WEB shape modification was quantified by a semiautomated approach on CT scans. Time courses were evaluated graphically and analytically; association analyses were performed by linear mixed-effects regression models.
In 29/32 WEB devices (90.6%), the reduction in height was found to be at least 5%. The decrease in height with time was significantly associated with the time interval in days since the intervention (
< .0001): A stronger decrease in WEB height was associated with a longer time since the intervention (median reduction in 1 year, 19.2%; range, 8.6%-52.3%). No significant association was found with the quality of aneurysm occlusion, device size, rupture status of the aneurysm, aneurysm location, and reintervention rate.
Shape modification was common in WEB-treated intracranial aneurysms with a median height reduction of 19.2% in 1 year. The quality of aneurysm occlusion was not associated with WEB modification.
Liquid leaf targets show promise as high repetition rate targets for laser-based ion acceleration using the Target Normal Sheath Acceleration (TNSA) mechanism and are currently under development. In ...this work, we discuss the effects of different ion species and investigate how they can be leveraged for use as a possible laser-driven neutron source. To aid in this research, we develop a surrogate model for liquid leaf target laser-ion acceleration experiments, based on artificial neural networks. The model is trained using data from Particle-In-Cell (PIC) simulations. The fast inference speed of our deep learning model allows us to optimize experimental parameters for maximum ion energy and laser-energy conversion efficiency. An analysis of parameter influence on our model output, using Sobol’ and PAWN indices, provides deeper insights into the laser-plasma system.
The human membrane cofactor protein (MCP, CD46) is a central component of the innate immune system. CD46 protects autologous cells from complement attack by binding to complement proteins C3b and C4b ...and serving as a cofactor for their cleavage. Recent data show that CD46 also plays a role in mediating acquired immune responses, and in triggering autophagy. In addition to these physiologic functions, a significant number of pathogens, including select adenoviruses, measles virus, human herpes virus 6 (HHV-6), Streptococci, and Neisseria, use CD46 as a cell attachment receptor. We have determined the crystal structure of the extracellular region of CD46 in complex with the human adenovirus type 11 fiber knob. Extracellular CD46 comprises four short consensus repeats (SCR1-SCR4) that form an elongated structure resembling a hockey stick, with a long shaft and a short blade. Domains SCR1, SCR2 and SCR3 are arranged in a nearly linear fashion. Unexpectedly, however, the structure reveals a profound bend between domains SCR3 and SCR4, which has implications for the interactions with ligands as well as the orientation of the protein at the cell surface. This bend can be attributed to an insertion of five hydrophobic residues in a SCR3 surface loop. Residues in this loop have been implicated in interactions with complement, indicating that the bend participates in binding to C3b and C4b. The structure provides an accurate framework for mapping all known ligand binding sites onto the surface of CD46, thereby advancing an understanding of how CD46 acts as a receptor for pathogens and physiologic ligands of the immune system.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
Forty fossil meteorites with a total original mass of ∼7.7 kg have been recovered in the first systematic search for fossil meteorites, pursued in an active quarry in Lower Ordovician (480 Ma) marine ...limestone in southern Sweden. The meteorites represent at least 12 different falls over a seafloor area of ∼6000 m2 during ≤1.75 Myr, making the quarry one of the most meteorite dense areas known in the world. Geochemical analyses of relict chromite grains indicate that all or most of the meteorites are ordinary chondrites and probably L chondrites. Mechanisms for meteorite delivery from the asteroid belt to Earth were the same 480 Ma as today, however, the flux was one to two orders of magnitude higher, most likely reflecting the disruption of the L chondrite parent body at about that time. This is a major event in late solar-system history, which may also have led to an enhanced flux of asteroids to Earth during ∼30 Myr.
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