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zadetkov: 146
1.
  • The immunopathology of sepsis and potential therapeutic targets
    van der Poll, Tom; van de Veerdonk, Frank L; Scicluna, Brendon P ... Nature reviews. Immunology, 07/2017, Letnik: 17, Številka: 7
    Journal Article
    Recenzirano

    Sepsis is defined as a life-threatening organ dysfunction that is caused by a dysregulated host response to infection. In sepsis, the immune response that is initiated by an invading pathogen fails ...
Celotno besedilo
Dostopno za: NUK, SBMB, UL, UM, UPUK
2.
  • Bronchial epithelial DNA me... Bronchial epithelial DNA methyltransferase 3b dampens pulmonary immune responses during Pseudomonas aeruginosa infection
    Qin, Wanhai; Brands, Xanthe; Van't Veer, Cornelis ... PLOS pathogens, 04/2021, Letnik: 17, Številka: 4
    Journal Article
    Recenzirano
    Odprti dostop

    DNA methyltransferase (Dnmt)3b mediates de novo DNA methylation and modulation of Dnmt3b in respiratory epithelial cells has been shown to affect the expression of multiple genes. Respiratory ...
Celotno besedilo
Dostopno za: DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK

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3.
  • Incidence, Risk Factors, an... Incidence, Risk Factors, and Attributable Mortality of Secondary Infections in the Intensive Care Unit After Admission for Sepsis
    van Vught, Lonneke A; Klein Klouwenberg, Peter M. C; Spitoni, Cristian ... JAMA, 04/2016, Letnik: 315, Številka: 14
    Journal Article
    Recenzirano
    Odprti dostop

    IMPORTANCE: Sepsis is considered to induce immune suppression, leading to increased susceptibility to secondary infections with associated late mortality. OBJECTIVE: To determine the clinical and ...
Celotno besedilo
Dostopno za: CMK

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4.
  • The Role of Host Cell DNA M... The Role of Host Cell DNA Methylation in the Immune Response to Bacterial Infection
    Qin, Wanhai; Scicluna, Brendon P; van der Poll, Tom Frontiers in immunology, 07/2021, Letnik: 12
    Journal Article
    Recenzirano
    Odprti dostop

    Host cells undergo complex transcriptional reprogramming upon infection. Epigenetic changes play a key role in the immune response to bacteria, among which DNA modifications that include methylation ...
Celotno besedilo
Dostopno za: NUK, UL, UM, UPUK

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5.
  • The gut microbiota plays a ... The gut microbiota plays a protective role in the host defence against pneumococcal pneumonia
    Schuijt, Tim J; Lankelma, Jacqueline M; Scicluna, Brendon P ... Gut, 04/2016, Letnik: 65, Številka: 4
    Journal Article
    Recenzirano
    Odprti dostop

    Pneumonia accounts for more deaths than any other infectious disease worldwide. The intestinal microbiota supports local mucosal immunity and is increasingly recognised as an important modulator of ...
Celotno besedilo
Dostopno za: CMK, NUK, UL, UM, UPUK

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6.
Celotno besedilo
Dostopno za: GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP
7.
  • Understanding Heterogeneity... Understanding Heterogeneity in Biologic Phenotypes of Acute Respiratory Distress Syndrome by Leukocyte Expression Profiles
    Bos, Lieuwe D J; Scicluna, Brendon P; Ong, David S Y ... American journal of respiratory and critical care medicine, 07/2019, Letnik: 200, Številka: 1
    Journal Article
    Recenzirano
    Odprti dostop

    Two biologic phenotypes of acute respiratory distress syndrome (ARDS) have been identified based on plasma protein markers in four previous studies. To determine if blood leukocyte gene expression is ...
Celotno besedilo
Dostopno za: NUK, UL, UM, UPUK
8.
  • Intravenous Infusion of Hum... Intravenous Infusion of Human Adipose Mesenchymal Stem Cells Modifies the Host Response to Lipopolysaccharide in Humans: A Randomized, Single‐Blind, Parallel Group, Placebo Controlled Trial
    Perlee, Desiree; van Vught, Lonneke A.; Scicluna, Brendon P. ... Stem cells, November 2018, Letnik: 36, Številka: 11
    Journal Article
    Recenzirano
    Odprti dostop

    In experimental models, mesenchymal stem cells (MSCs) can modulate various immune responses implicated in the pathogenesis of sepsis. Intravenous injection of lipopolysaccharide (LPS) into healthy ...
Celotno besedilo
Dostopno za: UL

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9.
  • Biomarkers in Sepsis
    van Engelen, Tjitske S R; Wiersinga, Willem Joost; Scicluna, Brendon P ... Critical care clinics 34, Številka: 1
    Journal Article
    Recenzirano

    A biomarker is a characteristic by which a (patho)physiologic process can be identified. Biomarkers can be of diagnostic value (to discriminate infection from noninfectious conditions or to determine ...
Celotno besedilo
Dostopno za: SBCE
10.
  • The Itaconate Pathway Is a ... The Itaconate Pathway Is a Central Regulatory Node Linking Innate Immune Tolerance and Trained Immunity
    Domínguez-Andrés, Jorge; Novakovic, Boris; Li, Yang ... Cell metabolism, 01/2019, Letnik: 29, Številka: 1
    Journal Article
    Recenzirano
    Odprti dostop

    Sepsis involves simultaneous hyperactivation of the immune system and immune paralysis, leading to both organ dysfunction and increased susceptibility to secondary infections. Acute activation ...
Celotno besedilo
Dostopno za: GEOZS, IJS, IMTLJ, KILJ, KISLJ, NLZOH, NUK, OILJ, PNG, SAZU, SBCE, SBJE, UILJ, UL, UM, UPCLJ, UPUK, ZAGLJ, ZRSKP

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zadetkov: 146

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