The following studies compare developmental patterns of a hepatic monoxygenase system using (1) the aminopyrine (Ap) breath test, (2) in vivo Ap pharmacokinetics (clearances) and (3) in vitro Ap ...demethylation by hepatic microsomes. Together, the three methodological approaches indicate that hepatic metabolism of Ap increases from the fetal stage through 70 days of age with the male showing a significantly greater drug metabolizing capacity than the female. However, sex and developmental patterns derived by the three methodologies do not necessarily correlate quantitatively, due to a number of complex variables (i.e., liver size, drug volume of distribution, etc.) less likely encountered in the adult of fixed age and mature sexual development.
A one-million-circuit CMOS ASIC logic family Gregor, R.; Ng, C.; Libous, J. ...
Proceedings of IEEE Custom Integrated Circuits Conference - CICC '93,
1993
Conference Proceeding
Metallization and device channel length enhancements to an existing 0.5-/spl mu/m CMOS process are exploited in the design of a high-density ASIC (application-specific integrated circuit) logic ...family. Wired circuit density exceeds one-million equivalent two-input NANDs, with typical gate delays of 250 ps at 3.3 V. A total of 17 different chip sizes are offered, along with several surface-mount package options. Both IBM and industry-standard design systems are supported, along with a cost effective LSSD-based test methodology.
